RNVU1-23

Summary

RNVU1-23 (RNA, variant U1 small nuclear 23, HGNC:48434) is a small nuclear RNA gene on chromosome 1q21.2.

Predicted to enable pre-mRNA 5’-splice site binding activity. Predicted to be involved in mRNA 5’-splice site recognition. Predicted to be part of U1 snRNP.

Source: NCBI Gene 106481620 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48434
Approved symbol	RNVU1-23
Name	RNA, variant U1 small nuclear 23
Location	1q21.2
Locus type	RNA, small nuclear
Status	Approved
Ensembl gene	ENSG00000252826
Ensembl biotype	snRNA
Entrez	106481620
RNAcentral	URS00006EF1CF — snRNA, 135 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000517017

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000517017 — 1 exons

Exon	Start	End
ENSE00002089294	143720510	143720644

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 84.35.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4194 / max 49.2911, expressed in 112 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
14112	0.4194	112

Top tissues by expression

46 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.35	gold quality
monocyte	CL:0000576	80.05	gold quality
lung	UBERON:0002048	74.34	gold quality
stomach	UBERON:0000945	73.97	gold quality
blood	UBERON:0000178	71.76	gold quality
endometrium	UBERON:0001295	68.57	gold quality
adrenal tissue	UBERON:0018303	68.50	gold quality
ascending aorta	UBERON:0001496	67.32	gold quality
intestine	UBERON:0000160	66.54	gold quality
calcaneal tendon	UBERON:0003701	66.15	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.35	gold quality
urinary bladder	UBERON:0001255	64.35	gold quality
colon	UBERON:0001155	63.88	gold quality
body of pancreas	UBERON:0001150	63.84	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.82	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.78	gold quality
spleen	UBERON:0002106	62.97	gold quality
corpus callosum	UBERON:0002336	62.50	gold quality
left adrenal gland	UBERON:0001234	62.44	gold quality
cerebellar hemisphere	UBERON:0002245	62.32	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.27	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.24	gold quality
esophagus mucosa	UBERON:0002469	61.65	gold quality
esophagus	UBERON:0001043	61.37	gold quality
tibial artery	UBERON:0007610	61.06	gold quality
vagina	UBERON:0000996	60.61	gold quality
liver	UBERON:0002107	60.60	gold quality
transverse colon	UBERON:0001157	59.71	gold quality
omental fat pad	UBERON:0010414	59.58	gold quality
skin of abdomen	UBERON:0001416	58.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (147): RNU1-75P (ENSG00000194297), RNU1-15P (ENSG00000195024), RNU1-58P (ENSG00000199283), RNU1-150P (ENSG00000199361), RNU1-108P (ENSG00000199426), RNU1-62P (ENSG00000199469), RNU1-70P (ENSG00000199488), RNU1-94P (ENSG00000199497), RNU1-14P (ENSG00000199629), RNU1-35P (ENSG00000199652), RNU1-38P (ENSG00000199687), RNU1-76P (ENSG00000199773), RNU1-134P (ENSG00000199805), RNU1-47P (ENSG00000199836), RNU1-72P (ENSG00000199846), RNVU1-22 (ENSG00000199879), RNU1-17P (ENSG00000199892), RNU1-18P (ENSG00000199932), RNU1-19P (ENSG00000200176), RNU1-20P (ENSG00000200184), RNU1-21P (ENSG00000200197), RNU1-22P (ENSG00000200204), RNU1-23P (ENSG00000200231), RNU1-83P (ENSG00000200296), RNU1-49P (ENSG00000200338), RNU1-105P (ENSG00000200340), RNVU1-33 (ENSG00000200597), RNU1-124P (ENSG00000200731), RNU1-31P (ENSG00000200745), RNU1-65P (ENSG00000200789), RNU1-130P (ENSG00000200800), RNU1-32P (ENSG00000200807), RNU1-146P (ENSG00000200885), RNU1-42P (ENSG00000200903), RNU1-7P (ENSG00000200975), RNVU1-34 (ENSG00000200997), RNU1-96P (ENSG00000201033), RNU1-33P (ENSG00000201119), RNU1-151P (ENSG00000201142), RNU1-24P (ENSG00000201155)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.