RNVU1-25

Summary

RNVU1-25 (RNA, variant U1 small nuclear 25, HGNC:54428) is a small nuclear RNA gene on chromosome 1q21.1.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54428
Approved symbol	RNVU1-25
Name	RNA, variant U1 small nuclear 25
Location	1q21.1
Locus type	RNA, small nuclear
Status	Approved
Ensembl gene	ENSG00000274428
Ensembl biotype	snRNA
Entrez	115409981
RNAcentral	URS00006B75C2 — snRNA, 160 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000620022

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000620022 — 1 exons

Exon	Start	End
ENSE00003728632	146409903	146410062

Expression profiles

Bgee: expression breadth ubiquitous, 103 present calls, max score 90.20.

FANTOM5 (CAGE): breadth broad, TPM avg 1.8388 / max 53.8211, expressed in 537 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
201675	1.8388	537

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	90.20	gold quality
granulocyte	CL:0000094	84.71	gold quality
leukocyte	CL:0000738	82.15	gold quality
monocyte	CL:0000576	81.94	gold quality
bone marrow	UBERON:0002371	81.50	gold quality
adrenal tissue	UBERON:0018303	79.99	gold quality
corpus callosum	UBERON:0002336	77.54	gold quality
liver	UBERON:0002107	75.07	gold quality
skeletal muscle tissue	UBERON:0001134	74.34	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.03	gold quality
muscle of leg	UBERON:0001383	73.17	gold quality
blood	UBERON:0000178	72.17	gold quality
islet of Langerhans	UBERON:0000006	71.69	gold quality
prefrontal cortex	UBERON:0000451	71.69	gold quality
right lobe of liver	UBERON:0001114	71.46	gold quality
gastrocnemius	UBERON:0001388	70.43	gold quality
duodenum	UBERON:0002114	69.23	gold quality
skin of abdomen	UBERON:0001416	68.97	gold quality
placenta	UBERON:0001987	68.76	gold quality
adenohypophysis	UBERON:0002196	67.44	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.36	gold quality
stomach	UBERON:0000945	67.31	gold quality
lung	UBERON:0002048	66.91	gold quality
lymph node	UBERON:0000029	66.78	gold quality
cerebellum	UBERON:0002037	66.72	gold quality
heart left ventricle	UBERON:0002084	66.69	gold quality
cerebellar cortex	UBERON:0002129	66.68	gold quality
body of pancreas	UBERON:0001150	66.61	gold quality
cerebellar hemisphere	UBERON:0002245	66.55	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.28

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
danio_rerio	U1	ENSDARG00000084068

Paralogs (147): RNU1-75P (ENSG00000194297), RNU1-15P (ENSG00000195024), RNU1-58P (ENSG00000199283), RNU1-150P (ENSG00000199361), RNU1-108P (ENSG00000199426), RNU1-62P (ENSG00000199469), RNU1-70P (ENSG00000199488), RNU1-94P (ENSG00000199497), RNU1-14P (ENSG00000199629), RNU1-35P (ENSG00000199652), RNU1-38P (ENSG00000199687), RNU1-76P (ENSG00000199773), RNU1-134P (ENSG00000199805), RNU1-47P (ENSG00000199836), RNU1-72P (ENSG00000199846), RNVU1-22 (ENSG00000199879), RNU1-17P (ENSG00000199892), RNU1-18P (ENSG00000199932), RNU1-19P (ENSG00000200176), RNU1-20P (ENSG00000200184), RNU1-21P (ENSG00000200197), RNU1-22P (ENSG00000200204), RNU1-23P (ENSG00000200231), RNU1-83P (ENSG00000200296), RNU1-49P (ENSG00000200338), RNU1-105P (ENSG00000200340), RNVU1-33 (ENSG00000200597), RNU1-124P (ENSG00000200731), RNU1-31P (ENSG00000200745), RNU1-65P (ENSG00000200789), RNU1-130P (ENSG00000200800), RNU1-32P (ENSG00000200807), RNU1-146P (ENSG00000200885), RNU1-42P (ENSG00000200903), RNU1-7P (ENSG00000200975), RNVU1-34 (ENSG00000200997), RNU1-96P (ENSG00000201033), RNU1-33P (ENSG00000201119), RNU1-151P (ENSG00000201142), RNU1-24P (ENSG00000201155)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.