RNVU1-27

Summary

RNVU1-27 (RNA, variant U1 small nuclear 27, HGNC:54431) is a small nuclear RNA gene on chromosome 1q21.2.

Predicted to enable pre-mRNA 5’-splice site binding activity. Predicted to be involved in mRNA 5’-splice site recognition. Predicted to be part of U1 snRNP.

Source: NCBI Gene 124904621 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54431
Approved symbol	RNVU1-27
Name	RNA, variant U1 small nuclear 27
Location	1q21.2
Locus type	RNA, small nuclear
Status	Approved
Ensembl gene	ENSG00000274210
Ensembl biotype	snRNA
Entrez	124904621
RNAcentral	URS00006CA71A — snRNA, 165 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000622285

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000622285 — 1 exons

Exon	Start	End
ENSE00003745932	148522601	148522765

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 98.41.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 16.5945 / max 988.5223, expressed in 1461 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
201699	16.5945	1461

Top tissues by expression

114 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	98.41	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	98.01	gold quality
adrenal tissue	UBERON:0018303	94.06	gold quality
calcaneal tendon	UBERON:0003701	92.41	gold quality
cortical plate	UBERON:0005343	90.55	gold quality
sural nerve	UBERON:0015488	89.93	gold quality
ganglionic eminence	UBERON:0004023	87.02	gold quality
bone marrow	UBERON:0002371	86.17	gold quality
monocyte	CL:0000576	83.79	gold quality
mucosa of transverse colon	UBERON:0004991	79.23	gold quality
blood	UBERON:0000178	77.67	gold quality
liver	UBERON:0002107	77.46	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.33	gold quality
kidney	UBERON:0002113	75.73	gold quality
rectum	UBERON:0001052	74.90	gold quality
primary visual cortex	UBERON:0002436	74.54	gold quality
prefrontal cortex	UBERON:0000451	73.57	gold quality
islet of Langerhans	UBERON:0000006	73.29	gold quality
muscle tissue	UBERON:0002385	72.97	gold quality
superior frontal gyrus	UBERON:0002661	71.81	gold quality
stomach	UBERON:0000945	71.36	gold quality
adult mammalian kidney	UBERON:0000082	71.33	gold quality
lymph node	UBERON:0000029	70.95	gold quality
right uterine tube	UBERON:0001302	69.04	gold quality
right lobe of liver	UBERON:0001114	68.88	gold quality
lung	UBERON:0002048	68.64	gold quality
gall bladder	UBERON:0002110	68.60	gold quality
adrenal gland	UBERON:0002369	68.54	gold quality
heart	UBERON:0000948	68.23	gold quality
left uterine tube	UBERON:0001303	68.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (147): RNU1-75P (ENSG00000194297), RNU1-15P (ENSG00000195024), RNU1-58P (ENSG00000199283), RNU1-150P (ENSG00000199361), RNU1-108P (ENSG00000199426), RNU1-62P (ENSG00000199469), RNU1-70P (ENSG00000199488), RNU1-94P (ENSG00000199497), RNU1-14P (ENSG00000199629), RNU1-35P (ENSG00000199652), RNU1-38P (ENSG00000199687), RNU1-76P (ENSG00000199773), RNU1-134P (ENSG00000199805), RNU1-47P (ENSG00000199836), RNU1-72P (ENSG00000199846), RNVU1-22 (ENSG00000199879), RNU1-17P (ENSG00000199892), RNU1-18P (ENSG00000199932), RNU1-19P (ENSG00000200176), RNU1-20P (ENSG00000200184), RNU1-21P (ENSG00000200197), RNU1-22P (ENSG00000200204), RNU1-23P (ENSG00000200231), RNU1-83P (ENSG00000200296), RNU1-49P (ENSG00000200338), RNU1-105P (ENSG00000200340), RNVU1-33 (ENSG00000200597), RNU1-124P (ENSG00000200731), RNU1-31P (ENSG00000200745), RNU1-65P (ENSG00000200789), RNU1-130P (ENSG00000200800), RNU1-32P (ENSG00000200807), RNU1-146P (ENSG00000200885), RNU1-42P (ENSG00000200903), RNU1-7P (ENSG00000200975), RNVU1-34 (ENSG00000200997), RNU1-96P (ENSG00000201033), RNU1-33P (ENSG00000201119), RNU1-151P (ENSG00000201142), RNU1-24P (ENSG00000201155)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.