RNVU1-2A

Summary

RNVU1-2A (RNA, variant U1 small nuclear 2A, HGNC:54430) is a small nuclear RNA gene on chromosome 1q21.1.

Predicted to enable pre-mRNA 5’-splice site binding activity. Predicted to be involved in mRNA 5’-splice site recognition. Predicted to be part of U1 snRNP.

Source: NCBI Gene 6063 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54430
Approved symbol	RNVU1-2A
Name	RNA, variant U1 small nuclear 2A
Location	1q21.1
Locus type	RNA, small nuclear
Status	Approved
Aliases	vU1.2a, RNVU1.2a
Ensembl gene	ENSG00000278099
Ensembl biotype	snRNA
Entrez	6063
RNAcentral	URS000012964C — snRNA, 165 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000617626

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617626 — 1 exons

Exon	Start	End
ENSE00003741241	144551779	144551943

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 95.93.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.9616 / max 167.2747, expressed in 927 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
201659	3.9616	927

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	95.93	gold quality
adrenal tissue	UBERON:0018303	91.26	gold quality
liver	UBERON:0002107	90.41	gold quality
lung	UBERON:0002048	88.44	gold quality
stomach	UBERON:0000945	87.86	gold quality
kidney	UBERON:0002113	82.32	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.16	gold quality
heart	UBERON:0000948	78.88	gold quality
monocyte	CL:0000576	76.71	gold quality
adult mammalian kidney	UBERON:0000082	76.16	gold quality
blood	UBERON:0000178	74.43	gold quality
bone marrow	UBERON:0002371	74.27	gold quality
calcaneal tendon	UBERON:0003701	73.81	gold quality
prefrontal cortex	UBERON:0000451	72.97	gold quality
muscle of leg	UBERON:0001383	70.44	gold quality
islet of Langerhans	UBERON:0000006	69.70	gold quality
gastrocnemius	UBERON:0001388	66.78	gold quality
lymph node	UBERON:0000029	66.67	gold quality
intestine	UBERON:0000160	66.21	gold quality
left uterine tube	UBERON:0001303	65.41	gold quality
colon	UBERON:0001155	65.16	gold quality
tibial nerve	UBERON:0001323	63.71	gold quality
multicellular organism	UBERON:0000468	63.52	gold quality
heart left ventricle	UBERON:0002084	63.49	gold quality
skin of abdomen	UBERON:0001416	63.05	gold quality
body of stomach	UBERON:0001161	62.92	gold quality
tibial artery	UBERON:0007610	62.88	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.12	gold quality
subcutaneous adipose tissue	UBERON:0002190	61.65	gold quality
omental fat pad	UBERON:0010414	61.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.25

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (147): RNU1-75P (ENSG00000194297), RNU1-15P (ENSG00000195024), RNU1-58P (ENSG00000199283), RNU1-150P (ENSG00000199361), RNU1-108P (ENSG00000199426), RNU1-62P (ENSG00000199469), RNU1-70P (ENSG00000199488), RNU1-94P (ENSG00000199497), RNU1-14P (ENSG00000199629), RNU1-35P (ENSG00000199652), RNU1-38P (ENSG00000199687), RNU1-76P (ENSG00000199773), RNU1-134P (ENSG00000199805), RNU1-47P (ENSG00000199836), RNU1-72P (ENSG00000199846), RNVU1-22 (ENSG00000199879), RNU1-17P (ENSG00000199892), RNU1-18P (ENSG00000199932), RNU1-19P (ENSG00000200176), RNU1-20P (ENSG00000200184), RNU1-21P (ENSG00000200197), RNU1-22P (ENSG00000200204), RNU1-23P (ENSG00000200231), RNU1-83P (ENSG00000200296), RNU1-49P (ENSG00000200338), RNU1-105P (ENSG00000200340), RNVU1-33 (ENSG00000200597), RNU1-124P (ENSG00000200731), RNU1-31P (ENSG00000200745), RNU1-65P (ENSG00000200789), RNU1-130P (ENSG00000200800), RNU1-32P (ENSG00000200807), RNU1-146P (ENSG00000200885), RNU1-42P (ENSG00000200903), RNU1-7P (ENSG00000200975), RNVU1-34 (ENSG00000200997), RNU1-96P (ENSG00000201033), RNU1-33P (ENSG00000201119), RNU1-151P (ENSG00000201142), RNU1-24P (ENSG00000201155)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.