RNVU1-33

Summary

RNVU1-33 (RNA, variant U1 small nuclear 33, HGNC:48429) is a small nuclear RNA gene on chromosome 6p21.2.

Predicted to enable pre-mRNA 5’-splice site binding activity. Predicted to be involved in mRNA 5’-splice site recognition. Predicted to be part of U1 snRNP.

Source: NCBI Gene 106480178 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48429
Approved symbol	RNVU1-33
Name	RNA, variant U1 small nuclear 33
Location	6p21.2
Locus type	RNA, small nuclear
Status	Approved
Aliases	U1A5
Ensembl gene	ENSG00000200597
Ensembl biotype	snRNA
Entrez	106480178
RNAcentral	URS00006BDF17 — snRNA, 170 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000363727

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000363727 — 1 exons

Exon	Start	End
ENSE00001438490	37915573	37915742

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 89.17.

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.17	gold quality
sural nerve	UBERON:0015488	87.83	gold quality
cortex of kidney	UBERON:0001225	83.77	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.70	gold quality
adult mammalian kidney	UBERON:0000082	80.24	gold quality
kidney	UBERON:0002113	79.97	gold quality
superior frontal gyrus	UBERON:0002661	76.87	gold quality
liver	UBERON:0002107	76.28	gold quality
blood	UBERON:0000178	75.31	gold quality
monocyte	CL:0000576	74.03	gold quality
colon	UBERON:0001155	72.95	gold quality
corpus callosum	UBERON:0002336	72.25	gold quality
prefrontal cortex	UBERON:0000451	71.50	gold quality
adrenal tissue	UBERON:0018303	70.45	gold quality
intestine	UBERON:0000160	69.81	gold quality
stomach	UBERON:0000945	69.75	gold quality
bone marrow	UBERON:0002371	68.46	gold quality
body of pancreas	UBERON:0001150	67.73	gold quality
heart	UBERON:0000948	67.13	gold quality
lung	UBERON:0002048	65.58	gold quality
endometrium	UBERON:0001295	64.67	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.48	gold quality
gastrocnemius	UBERON:0001388	64.42	gold quality
multicellular organism	UBERON:0000468	63.99	gold quality
body of uterus	UBERON:0009853	63.70	gold quality
calcaneal tendon	UBERON:0003701	62.75	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.92	gold quality
left coronary artery	UBERON:0001626	61.80	gold quality
right lobe of liver	UBERON:0001114	61.52	gold quality
ascending aorta	UBERON:0001496	61.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.95

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
rattus_norvegicus	U1	ENSRNOG00000052928

Paralogs (147): RNU1-75P (ENSG00000194297), RNU1-15P (ENSG00000195024), RNU1-58P (ENSG00000199283), RNU1-150P (ENSG00000199361), RNU1-108P (ENSG00000199426), RNU1-62P (ENSG00000199469), RNU1-70P (ENSG00000199488), RNU1-94P (ENSG00000199497), RNU1-14P (ENSG00000199629), RNU1-35P (ENSG00000199652), RNU1-38P (ENSG00000199687), RNU1-76P (ENSG00000199773), RNU1-134P (ENSG00000199805), RNU1-47P (ENSG00000199836), RNU1-72P (ENSG00000199846), RNVU1-22 (ENSG00000199879), RNU1-17P (ENSG00000199892), RNU1-18P (ENSG00000199932), RNU1-19P (ENSG00000200176), RNU1-20P (ENSG00000200184), RNU1-21P (ENSG00000200197), RNU1-22P (ENSG00000200204), RNU1-23P (ENSG00000200231), RNU1-83P (ENSG00000200296), RNU1-49P (ENSG00000200338), RNU1-105P (ENSG00000200340), RNU1-124P (ENSG00000200731), RNU1-31P (ENSG00000200745), RNU1-65P (ENSG00000200789), RNU1-130P (ENSG00000200800), RNU1-32P (ENSG00000200807), RNU1-146P (ENSG00000200885), RNU1-42P (ENSG00000200903), RNU1-7P (ENSG00000200975), RNVU1-34 (ENSG00000200997), RNU1-96P (ENSG00000201033), RNU1-33P (ENSG00000201119), RNU1-151P (ENSG00000201142), RNU1-24P (ENSG00000201155), RNU1-132P (ENSG00000201170)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.