RNVU1-34

Summary

RNVU1-34 (RNA, variant U1 small nuclear 34, HGNC:48427) is a small nuclear RNA gene on chromosome 17q22.

Predicted to enable pre-mRNA 5’-splice site binding activity. Predicted to be involved in mRNA 5’-splice site recognition. Predicted to be part of U1 snRNP.

Source: NCBI Gene 106480177 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48427
Approved symbol	RNVU1-34
Name	RNA, variant U1 small nuclear 34
Location	17q22
Locus type	RNA, small nuclear
Status	Approved
Aliases	U1A7
Ensembl gene	ENSG00000200997
Ensembl biotype	snRNA
Entrez	106480177
RNAcentral	URS000068EFAF — snRNA, 164 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000364127

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000364127 — 1 exons

Exon	Start	End
ENSE00001438890	58679527	58679690

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 91.77.

FANTOM5 (CAGE): breadth broad, TPM avg 7.5140 / max 335.7409, expressed in 733 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
167305	7.5140	733

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle tissue	UBERON:0002385	91.77	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	80.79	gold quality
sural nerve	UBERON:0015488	77.88	gold quality
monocyte	CL:0000576	73.65	gold quality
bone marrow	UBERON:0002371	71.76	gold quality
prostate gland	UBERON:0002367	70.97	gold quality
calcaneal tendon	UBERON:0003701	70.62	gold quality
lung	UBERON:0002048	70.60	gold quality
adrenal tissue	UBERON:0018303	69.99	gold quality
upper lobe of left lung	UBERON:0008952	69.46	gold quality
skin of abdomen	UBERON:0001416	68.65	gold quality
placenta	UBERON:0001987	68.51	gold quality
adrenal gland	UBERON:0002369	68.30	gold quality
blood	UBERON:0000178	68.27	gold quality
stomach	UBERON:0000945	67.48	gold quality
gastrocnemius	UBERON:0001388	67.06	gold quality
skin of leg	UBERON:0001511	66.64	gold quality
left adrenal gland	UBERON:0001234	65.82	gold quality
heart	UBERON:0000948	65.07	gold quality
thoracic mammary gland	UBERON:0005200	64.35	gold quality
body of stomach	UBERON:0001161	64.09	gold quality
tibial artery	UBERON:0007610	63.32	gold quality
multicellular organism	UBERON:0000468	63.28	gold quality
saliva-secreting gland	UBERON:0001044	63.03	gold quality
subcutaneous adipose tissue	UBERON:0002190	62.91	gold quality
tibial nerve	UBERON:0001323	62.60	gold quality
vagina	UBERON:0000996	62.56	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	62.52	gold quality
heart left ventricle	UBERON:0002084	62.35	gold quality
ascending aorta	UBERON:0001496	62.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.35

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm23099	ENSMUSG00000065388
rattus_norvegicus	U1	ENSRNOG00000052756
rattus_norvegicus	U1	ENSRNOG00000057737

Paralogs (147): RNU1-75P (ENSG00000194297), RNU1-15P (ENSG00000195024), RNU1-58P (ENSG00000199283), RNU1-150P (ENSG00000199361), RNU1-108P (ENSG00000199426), RNU1-62P (ENSG00000199469), RNU1-70P (ENSG00000199488), RNU1-94P (ENSG00000199497), RNU1-14P (ENSG00000199629), RNU1-35P (ENSG00000199652), RNU1-38P (ENSG00000199687), RNU1-76P (ENSG00000199773), RNU1-134P (ENSG00000199805), RNU1-47P (ENSG00000199836), RNU1-72P (ENSG00000199846), RNVU1-22 (ENSG00000199879), RNU1-17P (ENSG00000199892), RNU1-18P (ENSG00000199932), RNU1-19P (ENSG00000200176), RNU1-20P (ENSG00000200184), RNU1-21P (ENSG00000200197), RNU1-22P (ENSG00000200204), RNU1-23P (ENSG00000200231), RNU1-83P (ENSG00000200296), RNU1-49P (ENSG00000200338), RNU1-105P (ENSG00000200340), RNVU1-33 (ENSG00000200597), RNU1-124P (ENSG00000200731), RNU1-31P (ENSG00000200745), RNU1-65P (ENSG00000200789), RNU1-130P (ENSG00000200800), RNU1-32P (ENSG00000200807), RNU1-146P (ENSG00000200885), RNU1-42P (ENSG00000200903), RNU1-7P (ENSG00000200975), RNU1-96P (ENSG00000201033), RNU1-33P (ENSG00000201119), RNU1-151P (ENSG00000201142), RNU1-24P (ENSG00000201155), RNU1-132P (ENSG00000201170)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.