RNVU1-4

Summary

RNVU1-4 (RNA, variant U1 small nuclear 4, HGNC:48312) is a small nuclear RNA gene on chromosome 1q21.1.

Predicted to enable pre-mRNA 5’-splice site binding activity. Predicted to be involved in mRNA 5’-splice site recognition. Predicted to be part of U1 snRNP.

Source: NCBI Gene 101954264 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48312
Approved symbol	RNVU1-4
Name	RNA, variant U1 small nuclear 4
Location	1q21.1
Locus type	RNA, small nuclear
Status	Approved
Aliases	vU1.4, RNU1-102, vU1.5, RNU1-50
Ensembl gene	ENSG00000277610
Ensembl biotype	snRNA
Entrez	101954264
RNAcentral	URS0000681820 — snRNA, 164 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000612985

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612985 — 1 exons

Exon	Start	End
ENSE00003743572	120942600	120942763

Expression profiles

Bgee: expression breadth ubiquitous, 110 present calls, max score 91.17.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2553 / max 283.8331, expressed in 351 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
201647	1.2553	351

Top tissues by expression

110 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	91.17	gold quality
monocyte	CL:0000576	89.38	gold quality
leukocyte	CL:0000738	88.56	gold quality
adrenal tissue	UBERON:0018303	78.17	gold quality
stromal cell of endometrium	CL:0002255	77.87	gold quality
granulocyte	CL:0000094	77.79	gold quality
myometrium	UBERON:0001296	76.47	gold quality
blood	UBERON:0000178	75.96	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.32	gold quality
calcaneal tendon	UBERON:0003701	74.14	gold quality
fundus of stomach	UBERON:0001160	71.94	gold quality
left uterine tube	UBERON:0001303	71.93	gold quality
islet of Langerhans	UBERON:0000006	71.71	gold quality
stomach	UBERON:0000945	70.49	gold quality
corpus callosum	UBERON:0002336	70.42	gold quality
lymph node	UBERON:0000029	69.80	gold quality
pancreas	UBERON:0001264	69.69	gold quality
prefrontal cortex	UBERON:0000451	69.44	gold quality
vermiform appendix	UBERON:0001154	69.40	gold quality
muscle of leg	UBERON:0001383	69.40	gold quality
omental fat pad	UBERON:0010414	69.19	gold quality
body of pancreas	UBERON:0001150	68.83	gold quality
lung	UBERON:0002048	68.48	gold quality
endometrium	UBERON:0001295	67.95	gold quality
adipose tissue	UBERON:0001013	67.86	gold quality
urinary bladder	UBERON:0001255	67.85	gold quality
liver	UBERON:0002107	67.84	gold quality
body of stomach	UBERON:0001161	67.42	gold quality
left coronary artery	UBERON:0001626	66.89	gold quality
tibial artery	UBERON:0007610	66.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.59

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (147): RNU1-75P (ENSG00000194297), RNU1-15P (ENSG00000195024), RNU1-58P (ENSG00000199283), RNU1-150P (ENSG00000199361), RNU1-108P (ENSG00000199426), RNU1-62P (ENSG00000199469), RNU1-70P (ENSG00000199488), RNU1-94P (ENSG00000199497), RNU1-14P (ENSG00000199629), RNU1-35P (ENSG00000199652), RNU1-38P (ENSG00000199687), RNU1-76P (ENSG00000199773), RNU1-134P (ENSG00000199805), RNU1-47P (ENSG00000199836), RNU1-72P (ENSG00000199846), RNVU1-22 (ENSG00000199879), RNU1-17P (ENSG00000199892), RNU1-18P (ENSG00000199932), RNU1-19P (ENSG00000200176), RNU1-20P (ENSG00000200184), RNU1-21P (ENSG00000200197), RNU1-22P (ENSG00000200204), RNU1-23P (ENSG00000200231), RNU1-83P (ENSG00000200296), RNU1-49P (ENSG00000200338), RNU1-105P (ENSG00000200340), RNVU1-33 (ENSG00000200597), RNU1-124P (ENSG00000200731), RNU1-31P (ENSG00000200745), RNU1-65P (ENSG00000200789), RNU1-130P (ENSG00000200800), RNU1-32P (ENSG00000200807), RNU1-146P (ENSG00000200885), RNU1-42P (ENSG00000200903), RNU1-7P (ENSG00000200975), RNVU1-34 (ENSG00000200997), RNU1-96P (ENSG00000201033), RNU1-33P (ENSG00000201119), RNU1-151P (ENSG00000201142), RNU1-24P (ENSG00000201155)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.