RNVU1-6

Summary

RNVU1-6 (RNA, variant U1 small nuclear 6, HGNC:48314) is a small nuclear RNA gene on chromosome 1q21.1.

Predicted to enable pre-mRNA 5’-splice site binding activity. Predicted to be involved in mRNA 5’-splice site recognition. Predicted to be located in nucleus. Predicted to be part of U1 snRNP.

Source: NCBI Gene 101954276 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48314
Approved symbol	RNVU1-6
Name	RNA, variant U1 small nuclear 6
Location	1q21.1
Locus type	RNA, small nuclear
Status	Approved
Aliases	vU1.6, RNU1-99
Ensembl gene	ENSG00000201558
Ensembl biotype	snRNA
Entrez	101954276
RNAcentral	URS0000667BF0 — snRNA, 164 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000364688

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000364688 — 1 exons

Exon	Start	End
ENSE00001807431	146052081	146052244

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 95.07.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.0580 / max 887.3863, expressed in 1542 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
14195	14.0580	1542

Top tissues by expression

89 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	95.07	gold quality
adult mammalian kidney	UBERON:0000082	93.31	gold quality
kidney	UBERON:0002113	79.74	gold quality
monocyte	CL:0000576	79.43	gold quality
sural nerve	UBERON:0015488	78.86	gold quality
adrenal tissue	UBERON:0018303	78.81	gold quality
prefrontal cortex	UBERON:0000451	77.19	gold quality
lymph node	UBERON:0000029	77.01	gold quality
bone marrow	UBERON:0002371	76.55	gold quality
liver	UBERON:0002107	75.94	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	75.86	gold quality
granulocyte	CL:0000094	75.66	gold quality
calcaneal tendon	UBERON:0003701	72.46	gold quality
lung	UBERON:0002048	72.28	gold quality
stomach	UBERON:0000945	70.59	gold quality
islet of Langerhans	UBERON:0000006	68.91	gold quality
placenta	UBERON:0001987	67.49	gold quality
muscle of leg	UBERON:0001383	65.89	gold quality
heart	UBERON:0000948	65.79	gold quality
right lobe of liver	UBERON:0001114	64.94	gold quality
vermiform appendix	UBERON:0001154	64.82	gold quality
gastrocnemius	UBERON:0001388	64.78	gold quality
left adrenal gland cortex	UBERON:0035825	63.55	gold quality
blood	UBERON:0000178	62.56	gold quality
rectum	UBERON:0001052	62.47	gold quality
body of stomach	UBERON:0001161	61.88	gold quality
right atrium auricular region	UBERON:0006631	61.14	gold quality
body of pancreas	UBERON:0001150	61.12	gold quality
heart left ventricle	UBERON:0002084	60.66	gold quality
left uterine tube	UBERON:0001303	60.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.99

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (147): RNU1-75P (ENSG00000194297), RNU1-15P (ENSG00000195024), RNU1-58P (ENSG00000199283), RNU1-150P (ENSG00000199361), RNU1-108P (ENSG00000199426), RNU1-62P (ENSG00000199469), RNU1-70P (ENSG00000199488), RNU1-94P (ENSG00000199497), RNU1-14P (ENSG00000199629), RNU1-35P (ENSG00000199652), RNU1-38P (ENSG00000199687), RNU1-76P (ENSG00000199773), RNU1-134P (ENSG00000199805), RNU1-47P (ENSG00000199836), RNU1-72P (ENSG00000199846), RNVU1-22 (ENSG00000199879), RNU1-17P (ENSG00000199892), RNU1-18P (ENSG00000199932), RNU1-19P (ENSG00000200176), RNU1-20P (ENSG00000200184), RNU1-21P (ENSG00000200197), RNU1-22P (ENSG00000200204), RNU1-23P (ENSG00000200231), RNU1-83P (ENSG00000200296), RNU1-49P (ENSG00000200338), RNU1-105P (ENSG00000200340), RNVU1-33 (ENSG00000200597), RNU1-124P (ENSG00000200731), RNU1-31P (ENSG00000200745), RNU1-65P (ENSG00000200789), RNU1-130P (ENSG00000200800), RNU1-32P (ENSG00000200807), RNU1-146P (ENSG00000200885), RNU1-42P (ENSG00000200903), RNU1-7P (ENSG00000200975), RNVU1-34 (ENSG00000200997), RNU1-96P (ENSG00000201033), RNU1-33P (ENSG00000201119), RNU1-151P (ENSG00000201142), RNU1-24P (ENSG00000201155)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.