RNVU1-8

Summary

RNVU1-8 (RNA, variant U1 small nuclear 8, HGNC:48315) is a small nuclear RNA gene on chromosome 1q21.1.

Predicted to enable pre-mRNA 5’-splice site binding activity. Predicted to be involved in mRNA 5’-splice site recognition. Predicted to be part of U1 snRNP.

Source: NCBI Gene 101447996 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48315
Approved symbol	RNVU1-8
Name	RNA, variant U1 small nuclear 8
Location	1q21.1
Locus type	RNA, small nuclear
Status	Approved
Aliases	vU1.8, RNU1-145
Ensembl gene	ENSG00000286172
Ensembl biotype	snRNA
Entrez	101447996
RNAcentral	URS0000759C03 — snRNA, 141 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snRNA

ENST00000651973

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000651973 — 1 exons

Exon	Start	End
ENSE00003844687	147084616	147084756

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 89.89.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.6553 / max 499.1548, expressed in 1266 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
14198	9.6553	1266

Top tissues by expression

87 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	89.89	gold quality
calcaneal tendon	UBERON:0003701	86.20	gold quality
lung	UBERON:0002048	84.00	gold quality
kidney	UBERON:0002113	81.90	gold quality
liver	UBERON:0002107	81.80	gold quality
minor salivary gland	UBERON:0001830	80.58	gold quality
fundus of stomach	UBERON:0001160	80.27	gold quality
prefrontal cortex	UBERON:0000451	79.82	gold quality
cortex of kidney	UBERON:0001225	79.49	gold quality
adult mammalian kidney	UBERON:0000082	78.93	gold quality
stomach	UBERON:0000945	77.32	gold quality
heart	UBERON:0000948	77.13	gold quality
granulocyte	CL:0000094	76.29	gold quality
blood	UBERON:0000178	76.22	gold quality
skeletal muscle tissue	UBERON:0001134	75.99	gold quality
monocyte	CL:0000576	75.13	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.38	gold quality
body of stomach	UBERON:0001161	73.88	gold quality
sural nerve	UBERON:0015488	72.98	gold quality
islet of Langerhans	UBERON:0000006	72.78	gold quality
bone marrow	UBERON:0002371	72.34	gold quality
vermiform appendix	UBERON:0001154	70.85	gold quality
placenta	UBERON:0001987	70.23	gold quality
intestine	UBERON:0000160	69.22	gold quality
right adrenal gland cortex	UBERON:0035827	68.96	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.95	gold quality
lymph node	UBERON:0000029	68.63	gold quality
myometrium	UBERON:0001296	68.63	gold quality
skin of abdomen	UBERON:0001416	68.45	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.90

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.