RNY1

Summary

RNY1 (RNA, Ro60-associated Y1, HGNC:10242) is a non-coding RNA gene on chromosome 7q36.1.

Y RNAs are small noncoding RNAs that were originally identified as the RNA component of soluble ribonucleoproteins (RNPs) termed Ro RNPs. Ro RNPs are detected by autoimmune sera of patients suffering from rheumatic diseases, such as from systemic lupus erythematosus (MIM 152700) and Sjogren syndrome (MIM 270200). Ro RNPs consist of a Y RNA that is associated with the autoimmune antigen proteins Ro60 (TROVE2; MIM 600063) and La (SSB; MIM 109090), as well as other proteins. Four human Y RNAs have been identified: Y1, Y3 (RNY3; MIM 601822), Y4 (RNY4; MIM 601823), and Y5 (RNY5; MIM 601824). (Y2 is a truncated form of Y1.) Y RNAs are transcribed by RNA polymerase III and range in size from 83 to 112 nucleotides. They appear to have a functional role in chromosomal DNA replication (Christov et al., 2006 [PubMed 16943439]).

Source: NCBI Gene 6084 — RefSeq curated summary.

At a glance

• Gene type: non-coding (misc_RNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10242
Approved symbol	RNY1
Name	RNA, Ro60-associated Y1
Location	7q36.1
Locus type	RNA, Y
Status	Approved
Aliases	hY1
Ensembl gene	ENSG00000201098
Ensembl biotype	misc_RNA
OMIM	601821
Entrez	6084
RNAcentral	URS0000103047 — ncRNA, 113 nt, 36 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 misc_RNA

ENST00000364228

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000364228 — 1 exons

Exon	Start	End
ENSE00001807294	148987136	148987248

Expression profiles

Bgee: expression breadth ubiquitous, 103 present calls, max score 99.85.

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	99.85	gold quality
sural nerve	UBERON:0015488	99.66	gold quality
skeletal muscle tissue	UBERON:0001134	89.86	gold quality
granulocyte	CL:0000094	86.56	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	85.91	gold quality
liver	UBERON:0002107	85.25	gold quality
blood	UBERON:0000178	84.67	gold quality
lymph node	UBERON:0000029	82.42	gold quality
calcaneal tendon	UBERON:0003701	82.31	gold quality
lung	UBERON:0002048	81.93	gold quality
bone marrow	UBERON:0002371	81.79	gold quality
monocyte	CL:0000576	81.26	gold quality
kidney	UBERON:0002113	81.11	gold quality
endometrium	UBERON:0001295	80.49	gold quality
corpus callosum	UBERON:0002336	79.71	gold quality
stomach	UBERON:0000945	79.56	gold quality
putamen	UBERON:0001874	79.11	gold quality
Ammon’s horn	UBERON:0001954	78.97	gold quality
muscle of leg	UBERON:0001383	78.73	gold quality
adult mammalian kidney	UBERON:0000082	78.57	gold quality
caudate nucleus	UBERON:0001873	78.01	gold quality
Brodmann (1909) area 9	UBERON:0013540	77.36	gold quality
amygdala	UBERON:0001876	77.19	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	76.87	gold quality
substantia nigra	UBERON:0002038	76.19	gold quality
hypothalamus	UBERON:0001898	76.13	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	75.98	gold quality
cerebral cortex	UBERON:0000956	75.62	gold quality
anterior cingulate cortex	UBERON:0009835	75.42	gold quality
gastrocnemius	UBERON:0001388	75.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.07

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• low expression of RNY1, RNY3 and RNY4 was associated with muscle-invasive BCA, lymph node metastases and advanced grade. Furthermore, expression of RNY1 and RNY3 was predictive for BCA patients’ overall (also RNY4) and cancer-specific survival as estimated using Kaplan-Meier and univariate (but not multivariate) Cox regression analyses. (PMID:29126388)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Rny1	ENSMUSG00000065701
rattus_norvegicus	Y_RNA	ENSRNOG00000060430

Paralogs (813): Y_RNA (ENSG00000195401), Y_RNA (ENSG00000199200), Y_RNA (ENSG00000199201), Y_RNA (ENSG00000199203), Y_RNA (ENSG00000199204), Y_RNA (ENSG00000199220), Y_RNA (ENSG00000199222), Y_RNA (ENSG00000199223), Y_RNA (ENSG00000199224), Y_RNA (ENSG00000199241), Y_RNA (ENSG00000199245), Y_RNA (ENSG00000199263), Y_RNA (ENSG00000199273), Y_RNA (ENSG00000199285), Y_RNA (ENSG00000199290), Y_RNA (ENSG00000199291), Y_RNA (ENSG00000199303), Y_RNA (ENSG00000199331), Y_RNA (ENSG00000199332), Y_RNA (ENSG00000199349), Y_RNA (ENSG00000199357), Y_RNA (ENSG00000199362), Y_RNA (ENSG00000199366), Y_RNA (ENSG00000199378), Y_RNA (ENSG00000199398), RNY4P19 (ENSG00000199400), Y_RNA (ENSG00000199409), Y_RNA (ENSG00000199410), Y_RNA (ENSG00000199424), Y_RNA (ENSG00000199440), Y_RNA (ENSG00000199442), Y_RNA (ENSG00000199444), Y_RNA (ENSG00000199459), Y_RNA (ENSG00000199461), Y_RNA (ENSG00000199466), Y_RNA (ENSG00000199471), Y_RNA (ENSG00000199472), Y_RNA (ENSG00000199476), Y_RNA (ENSG00000199487), Y_RNA (ENSG00000199490)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.