RNY4

Summary

RNY4 (RNA, Ro60-associated Y4, HGNC:10244) is a non-coding RNA gene on chromosome 7q36.1.

At a glance

• Gene type: non-coding (misc_RNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10244
Approved symbol	RNY4
Name	RNA, Ro60-associated Y4
Location	7q36.1
Locus type	RNA, Y
Status	Approved
Aliases	hY4
Ensembl gene	ENSG00000252316
Ensembl biotype	misc_RNA
OMIM	601823
Entrez	6086
RNAcentral	URS0000007D24 — ncRNA, 96 nt, 32 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 misc_RNA

ENST00000516507

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000516507 — 1 exons

Exon	Start	End
ENSE00002088784	148963315	148963410

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 99.76.

Top tissues by expression

114 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	99.76	gold quality
sural nerve	UBERON:0015488	99.59	gold quality
corpus callosum	UBERON:0002336	94.79	gold quality
granulocyte	CL:0000094	92.15	gold quality
calcaneal tendon	UBERON:0003701	92.15	gold quality
endometrium	UBERON:0001295	90.30	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.21	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	88.46	gold quality
monocyte	CL:0000576	87.08	gold quality
Brodmann (1909) area 9	UBERON:0013540	85.76	gold quality
right hemisphere of cerebellum	UBERON:0014890	83.83	gold quality
skeletal muscle tissue	UBERON:0001134	83.34	gold quality
liver	UBERON:0002107	83.16	gold quality
cerebellar hemisphere	UBERON:0002245	82.79	gold quality
blood	UBERON:0000178	82.51	gold quality
stomach	UBERON:0000945	82.06	gold quality
kidney	UBERON:0002113	81.61	gold quality
metanephros cortex	UBERON:0010533	81.57	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	81.29	gold quality
muscle of leg	UBERON:0001383	81.24	gold quality
vermiform appendix	UBERON:0001154	81.01	gold quality
bone marrow	UBERON:0002371	80.28	gold quality
body of stomach	UBERON:0001161	80.19	gold quality
gastrocnemius	UBERON:0001388	80.04	gold quality
islet of Langerhans	UBERON:0000006	79.52	gold quality
right frontal lobe	UBERON:0002810	79.42	gold quality
frontal cortex	UBERON:0001870	79.35	gold quality
small intestine Peyer’s patch	UBERON:0003454	78.98	gold quality
cerebral cortex	UBERON:0000956	78.81	gold quality
small intestine	UBERON:0002108	78.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.95

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• low expression of RNY1, RNY3 and RNY4 was associated with muscle-invasive BCA, lymph node metastases and advanced grade. Furthermore, expression of RNY1 and RNY3 was predictive for BCA patients’ overall (also RNY4) and cancer-specific survival as estimated using Kaplan-Meier and univariate (but not multivariate) Cox regression analyses. (PMID:29126388)
• yRNA3 up-regulation in cultured dermal fibroblasts and yRNA4 down-regulation in the sera of scleroderma patients. (PMID:33516635)

Cross-species orthologs

0 orthologs

Paralogs (813): Y_RNA (ENSG00000195401), Y_RNA (ENSG00000199200), Y_RNA (ENSG00000199201), Y_RNA (ENSG00000199203), Y_RNA (ENSG00000199204), Y_RNA (ENSG00000199220), Y_RNA (ENSG00000199222), Y_RNA (ENSG00000199223), Y_RNA (ENSG00000199224), Y_RNA (ENSG00000199241), Y_RNA (ENSG00000199245), Y_RNA (ENSG00000199263), Y_RNA (ENSG00000199273), Y_RNA (ENSG00000199285), Y_RNA (ENSG00000199290), Y_RNA (ENSG00000199291), Y_RNA (ENSG00000199303), Y_RNA (ENSG00000199331), Y_RNA (ENSG00000199332), Y_RNA (ENSG00000199349), Y_RNA (ENSG00000199357), Y_RNA (ENSG00000199362), Y_RNA (ENSG00000199366), Y_RNA (ENSG00000199378), Y_RNA (ENSG00000199398), RNY4P19 (ENSG00000199400), Y_RNA (ENSG00000199409), Y_RNA (ENSG00000199410), Y_RNA (ENSG00000199424), Y_RNA (ENSG00000199440), Y_RNA (ENSG00000199442), Y_RNA (ENSG00000199444), Y_RNA (ENSG00000199459), Y_RNA (ENSG00000199461), Y_RNA (ENSG00000199466), Y_RNA (ENSG00000199471), Y_RNA (ENSG00000199472), Y_RNA (ENSG00000199476), Y_RNA (ENSG00000199487), Y_RNA (ENSG00000199490)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.