ROCR

Summary

ROCR (regulator of chondrogenesis RNA, HGNC:52946) is a long non-coding RNA gene on chromosome 17q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52946
Approved symbol	ROCR
Name	regulator of chondrogenesis RNA
Location	17q24.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000228639
Ensembl biotype	lncRNA
Entrez	102723505
RNAcentral	URS000075C0E6 — lncRNA, 374 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 25 lncRNA

ENST00000412640, ENST00000424417, ENST00000430908, ENST00000540802, ENST00000543512, ENST00000630770, ENST00000674584, ENST00000674753, ENST00000674854, ENST00000675006, ENST00000675756, ENST00000715471, ENST00000715472, ENST00000715473, ENST00000715474, ENST00000715475, ENST00000715476, ENST00000715477, ENST00000715478, ENST00000715479, ENST00000715480, ENST00000715481, ENST00000715482, ENST00000715483, ENST00000715484

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412640 — 5 exons

Exon	Start	End
ENSE00002210457	72040516	72040582
ENSE00002214461	72057459	72057719
ENSE00002224735	72037314	72037363
ENSE00002234771	72040690	72040849
ENSE00002250656	72045428	72045524

Expression profiles

Bgee: expression breadth ubiquitous, 112 present calls, max score 90.97.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2192 / max 83.2686, expressed in 31 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
167848	0.1634	23
167847	0.0367	15
167846	0.0190	3

Top tissues by expression

116 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
saliva-secreting gland	UBERON:0001044	90.97	gold quality
minor salivary gland	UBERON:0001830	90.74	gold quality
body of pancreas	UBERON:0001150	90.51	gold quality
thoracic mammary gland	UBERON:0005200	85.65	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	83.62	gold quality
skin of leg	UBERON:0001511	81.16	gold quality
sural nerve	UBERON:0015488	81.14	gold quality
pancreas	UBERON:0001264	81.01	gold quality
zone of skin	UBERON:0000014	80.36	gold quality
skin of abdomen	UBERON:0001416	79.69	gold quality
quadriceps femoris	UBERON:0001377	78.78	gold quality
tonsil	UBERON:0002372	72.07	gold quality
cerebellar vermis	UBERON:0004720	71.79	gold quality
ganglionic eminence	UBERON:0004023	68.74	gold quality
liver	UBERON:0002107	63.50	gold quality
stromal cell of endometrium	CL:0002255	63.34	gold quality
ventricular zone	UBERON:0003053	62.77	gold quality
right lobe of liver	UBERON:0001114	62.44	gold quality
adenohypophysis	UBERON:0002196	61.87	gold quality
bone marrow	UBERON:0002371	61.55	silver quality
hindlimb stylopod muscle	UBERON:0004252	61.46	gold quality
lower esophagus mucosa	UBERON:0035834	60.06	gold quality
lymph node	UBERON:0000029	59.13	gold quality
nucleus accumbens	UBERON:0001882	59.05	gold quality
skeletal muscle tissue	UBERON:0001134	57.82	gold quality
thymus	UBERON:0002370	57.81	silver quality
multicellular organism	UBERON:0000468	57.50	gold quality
caudate nucleus	UBERON:0001873	57.49	gold quality
prefrontal cortex	UBERON:0000451	56.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The authors identify a positive feedback loop in breast cancer (BC) cells that controls the expression of both linc02095 and SOX9 The results unearth tumor-promoting activities of a nuclear lncRNA linc02095 by facilitating the expression of key oncogenic transcription factor in BC. (PMID:31690584)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.