ROMO1

Summary

ROMO1 (reactive oxygen species modulator 1, HGNC:16185) is a protein-coding gene on chromosome 20q11.22, encoding Reactive oxygen species modulator 1 (P60602). Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. It is a common-essential gene (DepMap: required in 94.3% of cancer cell lines).

The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage.

Source: NCBI Gene 140823 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 14 total
• Cancer dependency (DepMap): dependent in 94.3% of screened cell lines (common-essential)
• MANE Select transcript: NM_080748

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16185
Approved symbol	ROMO1
Name	reactive oxygen species modulator 1
Location	20q11.22
Locus type	gene with protein product
Status	Approved
Aliases	bA353C18.2, MTGMP
Ensembl gene	ENSG00000125995
Ensembl biotype	protein_coding
OMIM	618894
Entrez	140823

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 protein_coding

ENST00000336695, ENST00000374072, ENST00000374077, ENST00000374078, ENST00000397416, ENST00000938750, ENST00000938751, ENST00000938752, ENST00000938753, ENST00000938754

RefSeq mRNA: 1 — MANE Select: NM_080748 NM_080748

CCDS: CCDS13264

Canonical transcript exons

ENST00000374077 — 3 exons

Exon	Start	End
ENSE00001462380	35699405	35699456
ENSE00001528622	35700798	35700980
ENSE00001598007	35699633	35699763

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 99.10.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 110.1531 / max 846.1969, expressed in 1827 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
184318	106.7811	1827
184319	2.4818	1351
184317	0.8901	609

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	99.10	gold quality
upper arm skin	UBERON:0004263	99.06	gold quality
mucosa of transverse colon	UBERON:0004991	99.00	gold quality
adenohypophysis	UBERON:0002196	98.93	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	98.86	gold quality
pituitary gland	UBERON:0000007	98.60	gold quality
left adrenal gland cortex	UBERON:0035825	98.58	gold quality
left adrenal gland	UBERON:0001234	98.56	gold quality
right adrenal gland	UBERON:0001233	98.54	gold quality
right atrium auricular region	UBERON:0006631	98.49	gold quality
right adrenal gland cortex	UBERON:0035827	98.45	gold quality
left coronary artery	UBERON:0001626	98.44	gold quality
lower esophagus mucosa	UBERON:0035834	98.43	gold quality
hindlimb stylopod muscle	UBERON:0004252	98.42	gold quality
ascending aorta	UBERON:0001496	98.39	gold quality
adrenal cortex	UBERON:0001235	98.36	gold quality
thoracic aorta	UBERON:0001515	98.36	gold quality
mucosa of stomach	UBERON:0001199	98.34	gold quality
metanephros cortex	UBERON:0010533	98.25	gold quality
coronary artery	UBERON:0001621	98.23	gold quality
right testis	UBERON:0004534	98.22	gold quality
gastrocnemius	UBERON:0001388	98.20	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	98.19	gold quality
endocervix	UBERON:0000458	98.18	gold quality
cardiac atrium	UBERON:0002081	98.18	gold quality
muscle of leg	UBERON:0001383	98.17	gold quality
left testis	UBERON:0004533	98.16	gold quality
lower esophagus	UBERON:0013473	98.16	gold quality
lower esophagus muscularis layer	UBERON:0035833	98.16	gold quality
aorta	UBERON:0000947	98.14	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	19.20
E-CURD-122	yes	13.13
E-HCAD-13	yes	12.03
E-MTAB-10042	yes	11.15
E-MTAB-10596	no	867.86

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 94.3% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 40)

• cellular adaptive response to Romo1-induced ROS is a mechanism of drug resistance to 5-FU (PMID:17537404)
• The results of this study suggest that Romo1-induced ROS may play an important role in redox signaling in cancer cells. (PMID:18313394)
• age-related ROS levels increase, and this contributes to replicative senescence, which is directly associated with Romo1 expression. (PMID:18836179)
• Mitochondrial ROS generated by Romo1 expression are required for normal cell proliferation. Romo1 plays an important role in redox signalling during normal cell proliferation. (PMID:19513905)
• Results suggest that MTGM is an integral mitochondrial inner-membrane protein that coordinately regulates mitochondrial morphology and cell proliferation. (PMID:19535734)
• Romo1-derived reactive oxygen species play an important role in apoptotic cell death triggered by withdrawal of cell survival factors. (PMID:19904609)
• Romo1 and Bcl-X(L)) are directly associated with TNF-alpha-induced ROS production. Romo1 is a molecular bridge between TNF-alpha signaling and the mitochondria for ROS production that triggers TNF-alpha-mediated apoptosis. (PMID:20203691)
• increased Bcl-XL expression, which is observed in many cancer cells, confers resistance to oxidative stress in the cancer cells by suppressing Romo1-mediated oxidative stress. (PMID:21399876)
• Romo1 expression induced by Myc during G1 phase stimulates Skp2-mediated Myc degradation in a negative-feedback mechanism (PMID:21558421)
• A 19 amino acid peptide (pCM19) at positions 42-60 of hGlyrichin is crucial for its antibacterial activity. (PMID:22083756)
• Romo1 mediates mitochondrial reactive oxygen species production and apoptosis induced by oxidative stress in lung epithelial cells. (PMID:23867822)
• This study is the first to demonstrate that strict modulation of DKK1 expression in different cell types partially maintains cell survival via tight regulation of the ROS-producing ROMO1 and radiation resistance. (PMID:24269823)
• that ROS modulator protein 1 (ROMO1) links ROS and mitochondrial morphology and ultrastructure by modulating cristae remodeling and mitochondrial fusion (PMID:24473193)
• data identify ROMO1 as a critical molecular switch that couples metabolic stress and mitochondrial morphology, linking mitochondrial fusion to cell survival. (PMID:24473195)
• Serum Romo1 discriminated NSCLC patients from the population without cancer with considerable sensitivity and specificity. Serum Romo1 could be a potential diagnostic biomarker for NSCLC. (PMID:24951318)
• Romo1 may be a principal regulatory factor in the maintenance of constitutive NF-kappaB activation in tumor cells (PMID:25044121)
• Results demonstrate that expression of Romo1 is frequently upregulated in human glioblastomas and its elevation promotes malignant tumor progression by promoting cell cycle progression and by enhancing tumorigenicity (PMID:25193023)
• Genetic polymorphisms of Romo1 gene were associated with significant risk of gastric cancer. (PMID:25374412)
• Increased Romo1 expression in surgically resected NSCLC was found to be significantly associated with early recurrence and poor survival. Romo1 overexpression could be a potential adverse prognostic marker in this setting. (PMID:25468147)
• These results demonstrate that tumor cell invasion in response to oxidative stress is associated with Romo1 expression and the NF-kappaB signaling pathway. (PMID:25673177)
• High ROMO1 expression is associated with Fanconi anemia. (PMID:25687884)
• The rs6060566 polymorphism of the Romo-1 gene was found to be an independent risk factor for DR in Caucasians with T2DM. (PMID:25824963)
• Romo1 overexpression was associated with poor response to treatment and shorter survival in advanced NSCLC patients treated with platinum-based chemotherapy. Romo1 could be a potential adverse predictive marker in this setting. (PMID:27188201)
• elevated in pleural effusion when lung cancer present (PMID:28121949)
• the diagnostic sensitivity and specificity of serum reactive oxygen species modulator 1 were only 41.38% and 86.21%, respectively, with the cutoff value of 27.22 ng/mL. The sensitivity and specificity of pleural fluid carcinoembryonic antigen were 69.23% and 88.00%, respectively, at the cutoff value of 3.05 ng/mL, while serum carcinoembryonic antigen were 80.77% and 72.00% at the cutoff value of 2.60 ng/mL. (PMID:28459208)
• Increased Romo1 expression was found to be associated with high lymph node ratio. Cancer invasiveness appeared to be a key reason for the poor survival related to highly expressed Romo1 (PMID:28472059)
• the increase of serum Romo1 in obstructive sleep apnea syndrome (OSAS) patients was positively correlated with disease severity; serum Romo1 may be an important parameter for monitoring the severity of OSAS and treatment efficiency (PMID:29302924)
• Romo1 establishes a new category of viroporin-like nonselective cation channel in eukaryotes. (PMID:29545371)
• in the absence of ROMO1, mitochondria lose the inner membrane YME1L protease, which participates in OPA1 processing and ROMO1 turnover. While ROMO1 is dispensable for general protein import along the presequence pathway, we show that it participates in the dynamics of TIM21 during respiratory chain biogenesis and is specifically required for import of YME1L. (PMID:30598479)
• These results showed that mitochondrial reactiveo xygen species (mtROS) production was also enhanced by the SRA dependent ERK activation through upregulation and activation of reactive oxygen species modulator 1(ROMO1), a mitochondrial membrane protein and a key mediator of mtROS. (PMID:30850160)
• serum Romo1 levels increase in COPD patients and these levels are associated with lung function, inflammation, and oxidative stress in COPD. (PMID:31049771)
• Long noncoding RNA LINC00319 regulates ROMO1 expression and promotes bladder cancer progression via miR-4492/ROMO1 axis. (PMID:31608995)
• Clinical value of combined detection of reactive oxygen species modulator 1 and adenosine deaminase in pleural effusion in the identification of NSCLC associated malignant pleural effusion. (PMID:31709646)
• Overexpression of ROMO1 and OMA1 are Potentially Biomarkers and Predict Unfavorable Prognosis in Gastric Cancer. (PMID:31729644)
• Overexpression of reactive oxygen species modulator 1 is associated with advanced grades of bladder cancer. (PMID:32770525)
• Reactive oxygen species modulator 1 expression predicts lymph node metastasis and survival in early-stage non-small cell lung cancer. (PMID:33259495)
• The C allele of the reactive oxygen species modulator 1 (ROMO1) polymorphism rs6060566 is a biomarker predicting coronary artery stenosis in Slovenian subjects with type 2 diabetes mellitus. (PMID:33302957)
• Network models of prostate cancer immune microenvironments identify ROMO1 as heterogeneity and prognostic marker. (PMID:34996995)
• Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer. (PMID:36963289)
• The effects of ROMO1 on cervical cancer progression. (PMID:37285738)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	romo1	ENSDARG00000038076
mus_musculus	Romo1	ENSMUSG00000067847
rattus_norvegicus	Romo1	ENSRNOG00000045555

Protein

Protein identifiers

Reactive oxygen species modulator 1 — P60602 (reviewed: P60602)

Alternative names: Epididymis tissue protein Li 175, Glyrichin, Mitochondrial targeting GxxxG motif protein, Protein MGR2 homolog

All UniProt accessions (1): P60602

UniProt curated annotations — full annotation on UniProt →

Function. Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation. Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.

Subcellular location. Mitochondrion inner membrane.

Tissue specificity. Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line. Highly expressed in brain tumors.

Induction. By the anticancer drug fluorouracil (5FU).

Miscellaneous. Enforced expression in IMR-90 cells leads to increased levels of ROS and induces premature cell senescence and nuclear DNA damage.

Similarity. Belongs to the MGR2 family.

Isoforms (2)

UniProt ID	Names	Canonical?
P60602-1	1	yes
P60602-2	2

RefSeq proteins (1): NP_542786* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR018450	Romo1/Mgr2	Family

Pfam: PF10247

UniProt features (6 total): initiator methionine 1, chain 1, transmembrane region 1, region of interest 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P60602-F1	78.43	0.20

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 145 (showing top): GOBP_ANTIMICROBIAL_HUMORAL_RESPONSE, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, NIKOLSKY_BREAST_CANCER_20Q11_AMPLICON, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_MONOATOMIC_CATION_TRANSPORT, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GOBP_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION, GOBP_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE, GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS, GOCC_MITOCHONDRIAL_ENVELOPE

GO Biological Process (13): intracellular protein transport (GO:0006886), protein import into mitochondrial matrix (GO:0030150), killing of cells of another organism (GO:0031640), cellular response to reactive oxygen species (GO:0034614), defense response to bacterium (GO:0042742), protein insertion into mitochondrial inner membrane (GO:0045039), defense response to Gram-negative bacterium (GO:0050829), defense response to Gram-positive bacterium (GO:0050830), obsolete cytolysis by host of symbiont cells (GO:0051838), antimicrobial humoral immune response mediated by antimicrobial peptide (GO:0061844), replicative senescence (GO:0090399), monoatomic cation transmembrane transport (GO:0098655), positive regulation of reactive oxygen species metabolic process (GO:2000379)

GO Molecular Function (2): monoatomic cation transmembrane transporter activity (GO:0008324), protein binding (GO:0005515)

GO Cellular Component (4): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), TIM23 mitochondrial import inner membrane translocase complex (GO:0005744), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
mitochondrial protein import pathway	2
defense response to bacterium	2
intracellular protein localization	1
protein transport	1
intracellular transport	1
protein transmembrane import into intracellular organelle	1
protein localization to mitochondrion	1
import into the mitochondrion	1
cell killing	1
disruption of cell in another organism	1
response to reactive oxygen species	1
cellular response to oxidative stress	1
cellular response to oxygen-containing compound	1
defense response	1
response to bacterium	1
inner mitochondrial membrane organization	1
antimicrobial humoral response	1
cell cycle process	1
monoatomic cation transport	1
monoatomic ion transmembrane transport	1
positive regulation of metabolic process	1
reactive oxygen species metabolic process	1
regulation of reactive oxygen species metabolic process	1
monoatomic ion transmembrane transporter activity	1
monoatomic cation transmembrane transport	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
inner mitochondrial membrane protein complex	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1684 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ROMO1	TIMM21	Q9BVV7	798
ROMO1	TIMM17A	Q99595	781
ROMO1	TIMM50	Q3ZCQ8	609
ROMO1	PAM16	Q9Y3D7	580
ROMO1	TIMM17B	O60830	563
ROMO1	TIMM44	O43615	560
ROMO1	DNAJC19	Q96DA6	553
ROMO1	BCL2L1	Q07817	538
ROMO1	TOMM22	Q9NS69	532
ROMO1	COX7C	P15954	532
ROMO1	COX6B1	P14854	524
ROMO1	COXFA4	O00483	523
ROMO1	NDUFB8	O95169	513
ROMO1	COX6C	P09669	511
ROMO1	NDUFB9	Q9Y6M9	508

IntAct

19 interactions, top by confidence:

A	B	Type	Score
ROMO1	RHBDD2	psi-mi:“MI:0915”(physical association)	0.560
ROMO1	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
ROMO1	ERAP1	psi-mi:“MI:0915”(physical association)	0.400
ROMO1	E2	psi-mi:“MI:0915”(physical association)	0.370
COQ9	NDUFS8	psi-mi:“MI:0914”(association)	0.350
COQ9	ACOT7	psi-mi:“MI:0914”(association)	0.350
NDUFA4	NDUFS8	psi-mi:“MI:0914”(association)	0.350
SLC35G1	FAM234B	psi-mi:“MI:0914”(association)	0.350
SLC35G2	GPR89A	psi-mi:“MI:0914”(association)	0.350
SLC6A11	ILVBL	psi-mi:“MI:0914”(association)	0.350
SLC7A14	ESYT2	psi-mi:“MI:0914”(association)	0.350
TIMM17A	ROMO1	psi-mi:“MI:0915”(physical association)	0.000
ELOVL5	ROMO1	psi-mi:“MI:0915”(physical association)	0.000
ROMO1	RHBDD2	psi-mi:“MI:0915”(physical association)	0.000
ROMO1	CIDEB	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (37): ROMO1 (Affinity Capture-MS), ROMO1 (Affinity Capture-MS), ROMO1 (Affinity Capture-MS), ERAP1 (Affinity Capture-MS), ROMO1 (Affinity Capture-MS), ROMO1 (Affinity Capture-MS), ROMO1 (Negative Genetic), ROMO1 (Positive Genetic), ROMO1 (Negative Genetic), ROMO1 (Positive Genetic), ROMO1 (Negative Genetic), ROMO1 (Negative Genetic), ROMO1 (Negative Genetic), ROMO1 (Negative Genetic), ROMO1 (Negative Genetic)

ESM2 similar proteins: A0A1D8PI78, A1XJK0, A1XQR6, A2RVP7, A4QNF3, O44477, O48528, P0CR88, P0CR89, P25710, P32897, P60602, P60603, P79082, P81928, P87130, P87146, Q02889, Q0MQB8, Q0MQB9, Q0MQC0, Q12328, Q2UAP8, Q38820, Q3SZV8, Q4V7T9, Q54QM0, Q5NVQ1, Q6BT35, Q6BZY4, Q6CRJ6, Q6FT37, Q6NYD1, Q75E80, Q7T2P6, Q80W89, Q86Y39, Q8HXG6, Q8IN78, Q9C1E8

Diamond homologs: A1XQR6, A4QNF3, P60602, P60603, P79082, Q02889, Q3SZV8, Q4V7T9, Q6NYD1, Q54M86

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
ROMO1	“form complex”	“TIM23 complex”	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

14 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	10
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

413 predictions. Top by Δscore:

Variant	Effect	Δscore
20:35699427:C:G	donor_gain	0.9900
20:35699448:CGAGG:C	donor_loss	0.9900
20:35699449:GAGGT:G	donor_loss	0.9900
20:35699450:AGGTG:A	donor_loss	0.9900
20:35699451:GGTGA:G	donor_loss	0.9900
20:35699452:GT:G	donor_loss	0.9900
20:35699452:GTGAG:G	donor_gain	0.9900
20:35699453:T:A	donor_loss	0.9900
20:35699627:CCGCA:C	acceptor_loss	0.9900
20:35699628:CGCAG:C	acceptor_loss	0.9900
20:35699629:GCA:G	acceptor_loss	0.9900
20:35699630:CA:C	acceptor_loss	0.9900
20:35699631:A:AG	acceptor_gain	0.9900
20:35699631:AGATG:A	acceptor_loss	0.9900
20:35699632:G:C	acceptor_loss	0.9900
20:35699632:G:GG	acceptor_gain	0.9900
20:35699632:GAT:G	acceptor_gain	0.9900
20:35699759:CTCAG:C	donor_loss	0.9900
20:35699760:TCAG:T	donor_loss	0.9900
20:35699763:GGTGA:G	donor_loss	0.9900
20:35699764:GT:G	donor_loss	0.9900
20:35699765:T:A	donor_loss	0.9900
20:35700549:A:AG	acceptor_gain	0.9900
20:35700549:ACT:A	acceptor_gain	0.9900
20:35699447:GCGAG:G	donor_gain	0.9800
20:35699454:GAGG:G	donor_loss	0.9800
20:35699455:AGGTA:A	donor_loss	0.9800
20:35699456:GGTAG:G	donor_loss	0.9800
20:35699457:G:C	donor_loss	0.9800
20:35699458:T:A	donor_loss	0.9800

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1001969293 (20:35700133 T>C), RS1002621101 (20:35699436 C>A,G,T), RS1002673199 (20:35699272 G>T), RS1003686803 (20:35700597 A>G), RS1003896019 (20:35698794 G>A,C), RS1005157608 (20:35700030 A>C), RS1005305644 (20:35700253 T>C), RS1006703192 (20:35699452 G>A,T), RS1006820376 (20:35699297 T>A,C), RS1008111787 (20:35698259 A>G), RS1008374206 (20:35700717 A>C,G,T), RS1008490199 (20:35700408 T>G), RS1008840364 (20:35701376 T>C,G), RS1010107516 (20:35699208 C>T), RS1011787705 (20:35700389 T>C)

Disease associations

OMIM: gene MIM:618894 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010002_66	Refractive error	2.000000e-20

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects expression, decreases expression	2
sodium arsenite	affects expression, increases abundance, increases expression	2
Dexamethasone	increases expression, affects cotreatment	2
aristolochic acid I	decreases expression	1
bisphenol F	affects cotreatment, increases expression	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
lead acetate	increases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
arsenite	affects binding, increases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
4-aminophenylarsenoxide	affects binding, decreases reaction	1
chloropicrin	affects expression	1
K 7174	decreases expression	1
Sunitinib	decreases expression	1
Arsenic Trioxide	decreases reaction, affects binding	1
Arsenic	increases abundance, increases expression	1
Doxorubicin	increases expression	1
Chlorpyrifos	increases expression	1
Hydralazine	affects cotreatment, increases expression	1
Indomethacin	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Potassium Dichromate	decreases expression	1
Smoke	decreases expression	1
Valproic Acid	increases expression, affects cotreatment	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
Cyclosporine	decreases expression	1
Cadmium Chloride	increases expression	1
Copper Sulfate	decreases expression	1
Lactic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.