ROR1-AS1

Summary

ROR1-AS1 (ROR1 antisense RNA 1, HGNC:40508) is a long non-coding RNA gene on chromosome 1p31.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40508
Approved symbol	ROR1-AS1
Name	ROR1 antisense RNA 1
Location	1p31.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000223949
Ensembl biotype	lncRNA
Entrez	101927034
RNAcentral	URS000075CF40 — lncRNA, 2100 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000412349, ENST00000424995, ENST00000657702, ENST00000674987, ENST00000675261, ENST00000675824, ENST00000676235, ENST00000818568, ENST00000818569

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412349 — 6 exons

Exon	Start	End
ENSE00001619873	64094442	64095204
ENSE00001650514	64111112	64111369
ENSE00001678426	64108320	64108393
ENSE00001682812	64110883	64110957
ENSE00001783317	64110650	64110793
ENSE00001806696	64111946	64112207

Expression profiles

Bgee: expression breadth ubiquitous, 139 present calls, max score 83.20.

Top tissues by expression

230 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.20	gold quality
left testis	UBERON:0004533	79.80	gold quality
right testis	UBERON:0004534	77.89	gold quality
testis	UBERON:0000473	77.34	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	74.49	gold quality
sural nerve	UBERON:0015488	73.87	gold quality
islet of Langerhans	UBERON:0000006	73.11	gold quality
buccal mucosa cell	CL:0002336	71.57	silver quality
colonic epithelium	UBERON:0000397	70.53	gold quality
ganglionic eminence	UBERON:0004023	60.75	gold quality
tendon of biceps brachii	UBERON:0008188	59.91	gold quality
pancreas	UBERON:0001264	59.40	gold quality
ventricular zone	UBERON:0003053	59.40	gold quality
calcaneal tendon	UBERON:0003701	58.33	gold quality
vermiform appendix	UBERON:0001154	58.08	gold quality
hindlimb stylopod muscle	UBERON:0004252	57.94	gold quality
stromal cell of endometrium	CL:0002255	57.65	gold quality
lower lobe of lung	UBERON:0008949	56.56	silver quality
tendon	UBERON:0000043	56.27	gold quality
leukocyte	CL:0000738	55.30	gold quality
gall bladder	UBERON:0002110	55.18	gold quality
smooth muscle tissue	UBERON:0001135	55.10	gold quality
adrenal tissue	UBERON:0018303	54.80	gold quality
monocyte	CL:0000576	54.52	gold quality
right coronary artery	UBERON:0001625	53.21	gold quality
lung	UBERON:0002048	52.83	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	52.76	gold quality
caecum	UBERON:0001153	52.69	gold quality
lower esophagus mucosa	UBERON:0035834	50.82	gold quality
sperm	CL:0000019	50.71	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.85

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Data found that expression of lncRNA ROR1AS1 was significantly increased in hepatocellular carcinoma (HCC) patients and associated with several clinical features and an undesirable prognosis; therefore, lncRNA ROR1AS1 may serve as a useful biomarker for the prognosis of patients with HCC. (PMID:31746401)
• ROR1-AS1 directly bound with miR-504 and act as a molecular sponge to decrease miR-504 expression. High expression of ROR1-AS1 was remarkably correlated with higher histological grade, advanced tumor stage, and positive lymph node metastasis. (PMID:31929567)
• Results suggested that ROR1-AS1 could act as a sponge for miR-375 and promo//e cell migration and invasion through suppressing the process of EMT in LAC. (PMID:31983094)
• Long noncoding RNA ROR1-AS1 enhances STC2-mediated cell growth and autophagy in cervical cancer through miR-670-3p. (PMID:33081599)
• LncRNA ROR1-AS1 accelerates osteosarcoma invasion and proliferation through modulating miR-504. (PMID:33401251)
• ROR1-AS1 knockdown inhibits growth and invasion and promotes apoptosis in NSCLC cells by suppression of the PI3K/Akt/mTOR pathway. (PMID:33491326)
• ROR1-AS1 might promote in vivo and in vitro proliferation and invasion of cholangiocarcinoma cells. (PMID:37770853)
• Exosomal lncRNA ROR1-AS1 from cancer-associated fibroblasts inhibits ferroptosis of lung cancer cells through the IGF2BP1/SLC7A11 signal axis. (PMID:38729321)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.