RORA-AS2

Summary

RORA-AS2 (RORA antisense RNA 2, HGNC:51411) is a long non-coding RNA gene on chromosome 15q22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51411
Approved symbol	RORA-AS2
Name	RORA antisense RNA 2
Location	15q22.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000259482
Ensembl biotype	lncRNA
Entrez	100996876
RNAcentral	URS000075B7D4 — lncRNA, 1039 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000558104, ENST00000561413, ENST00000663342

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000558104 — 2 exons

Exon	Start	End
ENSE00002566699	60681569	60681995
ENSE00002569922	60686727	60686888

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 81.50.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0185 / max 20.7499, expressed in 4 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
147026	0.0185	4

Top tissues by expression

87 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.50	gold quality
left testis	UBERON:0004533	75.44	gold quality
testis	UBERON:0000473	75.33	gold quality
right testis	UBERON:0004534	74.72	gold quality
skeletal muscle tissue	UBERON:0001134	70.23	gold quality
ganglionic eminence	UBERON:0004023	62.39	gold quality
hindlimb stylopod muscle	UBERON:0004252	61.80	gold quality
urinary bladder	UBERON:0001255	61.17	silver quality
calcaneal tendon	UBERON:0003701	55.62	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	55.26	gold quality
liver	UBERON:0002107	52.81	gold quality
blood	UBERON:0000178	50.92	gold quality
multicellular organism	UBERON:0000468	50.59	gold quality
muscle of leg	UBERON:0001383	49.47	gold quality
thoracic mammary gland	UBERON:0005200	49.19	silver quality
gastrocnemius	UBERON:0001388	48.41	gold quality
prefrontal cortex	UBERON:0000451	47.74	gold quality
adrenal tissue	UBERON:0018303	47.63	silver quality
kidney	UBERON:0002113	47.33	gold quality
adrenal gland	UBERON:0002369	47.09	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	46.96	gold quality
endometrium	UBERON:0001295	46.42	silver quality
left adrenal gland	UBERON:0001234	46.17	gold quality
corpus callosum	UBERON:0002336	46.10	silver quality
heart left ventricle	UBERON:0002084	45.52	gold quality
myometrium	UBERON:0001296	45.38	gold quality
left adrenal gland cortex	UBERON:0035825	45.38	gold quality
right adrenal gland	UBERON:0001233	45.19	gold quality
islet of Langerhans	UBERON:0000006	45.16	gold quality
lung	UBERON:0002048	44.62	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.13

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.