RORB-AS1

Summary

RORB-AS1 (RORB antisense RNA 1, HGNC:49803) is a long non-coding RNA gene on chromosome 9q21.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49803
Approved symbol	RORB-AS1
Name	RORB antisense RNA 1
Location	9q21.13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224825
Ensembl biotype	lncRNA
Entrez	103752585
RNAcentral	URS00007E4B41 — lncRNA, 824 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 22 lncRNA

ENST00000417576, ENST00000715876, ENST00000715877, ENST00000715878, ENST00000722221, ENST00000722222, ENST00000722223, ENST00000722224, ENST00000722225, ENST00000722226, ENST00000722227, ENST00000722228, ENST00000722229, ENST00000722230, ENST00000773817, ENST00000773818, ENST00000773819, ENST00000773820, ENST00000773821, ENST00000773822, ENST00000773823, ENST00000773824

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000417576 — 3 exons

Exon	Start	End
ENSE00001729251	74498242	74499127
ENSE00001805381	74485551	74485680
ENSE00004028206	74486128	74486289

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 91.98.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5360 / max 39.1473, expressed in 143 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
101008	0.2268	80
101009	0.1723	54
101006	0.1209	55
101007	0.0160	10

Top tissues by expression

89 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.98	silver quality
primary visual cortex	UBERON:0002436	69.17	gold quality
superior frontal gyrus	UBERON:0002661	68.84	gold quality
prefrontal cortex	UBERON:0000451	65.12	gold quality
cortical plate	UBERON:0005343	64.37	gold quality
heart left ventricle	UBERON:0002084	62.47	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.95	gold quality
right adrenal gland cortex	UBERON:0035827	61.80	gold quality
frontal cortex	UBERON:0001870	61.72	gold quality
ventricular zone	UBERON:0003053	61.71	gold quality
right adrenal gland	UBERON:0001233	61.07	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.04	gold quality
heart	UBERON:0000948	60.86	gold quality
ganglionic eminence	UBERON:0004023	60.27	gold quality
cerebral cortex	UBERON:0000956	59.11	gold quality
adrenal gland	UBERON:0002369	59.02	gold quality
right atrium auricular region	UBERON:0006631	58.80	gold quality
left adrenal gland	UBERON:0001234	58.41	gold quality
endometrium	UBERON:0001295	56.69	gold quality
left adrenal gland cortex	UBERON:0035825	56.62	gold quality
apex of heart	UBERON:0002098	56.07	gold quality
right frontal lobe	UBERON:0002810	55.89	gold quality
anterior cingulate cortex	UBERON:0009835	55.37	gold quality
brain	UBERON:0000955	53.17	gold quality
saliva-secreting gland	UBERON:0001044	53.10	gold quality
blood	UBERON:0000178	52.62	gold quality
right hemisphere of cerebellum	UBERON:0014890	51.40	gold quality
cerebellar hemisphere	UBERON:0002245	51.30	gold quality
multicellular organism	UBERON:0000468	51.09	gold quality
gall bladder	UBERON:0002110	51.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.80

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.