RPAP3-DT

Summary

RPAP3-DT (RPAP3 divergent transcript, HGNC:55477) is a long non-coding RNA gene on chromosome 12q13.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55477
Approved symbol	RPAP3-DT
Name	RPAP3 divergent transcript
Location	12q13.11
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000257433
Ensembl biotype	lncRNA
Entrez	105369748
RNAcentral	URS00026A289D — lncRNA, 3767 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 31 — 30 lncRNA, 1 retained_intron

ENST00000547799, ENST00000552133, ENST00000552502, ENST00000553045, ENST00000614562, ENST00000621159, ENST00000653286, ENST00000659426, ENST00000663280, ENST00000667854, ENST00000685152, ENST00000685937, ENST00000688402, ENST00000690085, ENST00000690770, ENST00000692059, ENST00000692962, ENST00000700766, ENST00000717856, ENST00000809965, ENST00000809968, ENST00000809971, ENST00000809973, ENST00000809974, ENST00000809977, ENST00000809979, ENST00000809980, ENST00000809982, ENST00000809984, ENST00000809986, ENST00000809987

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000547799 — 6 exons

Exon	Start	End
ENSE00002355274	47717492	47717636
ENSE00002371312	47706085	47706163
ENSE00002388575	47719600	47719699
ENSE00002402920	47739543	47742294
ENSE00002419287	47738915	47739011
ENSE00002420208	47719147	47719272

Expression profiles

Bgee: expression breadth ubiquitous, 161 present calls, max score 82.90.

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	82.90	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.06	gold quality
esophagus mucosa	UBERON:0002469	78.91	gold quality
monocyte	CL:0000576	77.11	gold quality
leukocyte	CL:0000738	76.97	gold quality
metanephros cortex	UBERON:0010533	75.71	gold quality
granulocyte	CL:0000094	74.28	gold quality
bone marrow cell	CL:0002092	73.68	gold quality
esophagus	UBERON:0001043	73.10	gold quality
left ovary	UBERON:0002119	73.01	gold quality
right lobe of liver	UBERON:0001114	72.69	gold quality
skin of abdomen	UBERON:0001416	71.92	gold quality
mucosa of transverse colon	UBERON:0004991	71.84	gold quality
skin of leg	UBERON:0001511	71.76	gold quality
right ovary	UBERON:0002118	71.36	gold quality
right uterine tube	UBERON:0001302	71.12	gold quality
metanephros	UBERON:0000081	71.05	gold quality
spleen	UBERON:0002106	71.05	gold quality
vagina	UBERON:0000996	70.72	gold quality
medial globus pallidus	UBERON:0002477	70.69	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	70.62	gold quality
apex of heart	UBERON:0002098	70.52	gold quality
amygdala	UBERON:0001876	70.05	gold quality
sperm	CL:0000019	70.03	gold quality
blood	UBERON:0000178	69.95	gold quality
islet of Langerhans	UBERON:0000006	69.93	gold quality
stromal cell of endometrium	CL:0002255	69.88	gold quality
ectocervix	UBERON:0012249	69.85	gold quality
spinal cord	UBERON:0002240	69.68	gold quality
putamen	UBERON:0001874	69.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.36

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LOC105369748 was shown to promote MBD2 expression through competitively binding to microRNA(miR)-5095 in hepatocellular carcinoma. (PMID:30912130)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.