RPF2

Summary

RPF2 (ribosome production factor 2 homolog, HGNC:20870) is a protein-coding gene on chromosome 6q21, encoding Ribosome production factor 2 homolog (Q9H7B2). Involved in ribosomal large subunit assembly. It is a common-essential gene (DepMap: required in 98.1% of cancer cell lines).

Enables 5S rRNA binding activity. Involved in protein localization to nucleolus; regulation of signal transduction by p53 class mediator; and ribosomal large subunit biogenesis. Located in chromosome; nucleolus; and nucleoplasm.

Source: NCBI Gene 84154 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 63 total
• Cancer dependency (DepMap): dependent in 98.1% of screened cell lines (common-essential)
• MANE Select transcript: NM_032194

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20870
Approved symbol	RPF2
Name	ribosome production factor 2 homolog
Location	6q21
Locus type	gene with protein product
Status	Approved
Aliases	FLJ21087, bA397G5.4
Ensembl gene	ENSG00000197498
Ensembl biotype	protein_coding
OMIM	618471
Entrez	84154

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 9 protein_coding, 2 nonsense_mediated_decay

ENST00000368864, ENST00000425871, ENST00000441448, ENST00000607388, ENST00000885102, ENST00000885103, ENST00000885104, ENST00000923612, ENST00000923613, ENST00000923614, ENST00000923615

RefSeq mRNA: 2 — MANE Select: NM_032194 NM_001289111, NM_032194

CCDS: CCDS5088

Canonical transcript exons

ENST00000441448 — 10 exons

Exon	Start	End
ENSE00001019312	110989028	110989065
ENSE00001841675	111025403	111028263
ENSE00003695201	111015754	111015856
ENSE00003697466	110999711	110999787
ENSE00003697855	110997183	110997264
ENSE00003698761	110991747	110991786
ENSE00003699829	111008038	111008137
ENSE00003701898	110985006	110985138
ENSE00003787476	111024183	111024327
ENSE00003848306	110982038	110982129

Expression profiles

Bgee: expression breadth ubiquitous, 255 present calls, max score 96.15.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 44.8421 / max 1905.7424, expressed in 1808 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
69270	44.2916	1807
69269	0.5505	302

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibialis anterior	UBERON:0001385	96.15	silver quality
deltoid	UBERON:0001476	95.77	gold quality
left ventricle myocardium	UBERON:0006566	95.26	gold quality
sperm	CL:0000019	94.99	gold quality
cartilage tissue	UBERON:0002418	94.95	gold quality
myocardium	UBERON:0002349	94.48	gold quality
esophagus squamous epithelium	UBERON:0006920	94.35	gold quality
tendon of biceps brachii	UBERON:0008188	94.35	gold quality
upper arm skin	UBERON:0004263	93.98	gold quality
cardiac muscle of right atrium	UBERON:0003379	93.70	gold quality
tendon	UBERON:0000043	92.75	gold quality
gingival epithelium	UBERON:0001949	92.74	gold quality
quadriceps femoris	UBERON:0001377	92.49	gold quality
tibia	UBERON:0000979	92.44	gold quality
biceps brachii	UBERON:0001507	92.41	gold quality
endometrium	UBERON:0001295	92.34	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	92.34	gold quality
parietal pleura	UBERON:0002400	92.27	gold quality
gingiva	UBERON:0001828	92.26	gold quality
vastus lateralis	UBERON:0001379	92.06	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	91.66	gold quality
calcaneal tendon	UBERON:0003701	91.65	gold quality
skeletal muscle tissue	UBERON:0001134	91.47	gold quality
islet of Langerhans	UBERON:0000006	91.46	gold quality
layer of synovial tissue	UBERON:0007616	91.35	gold quality
muscle tissue	UBERON:0002385	91.30	gold quality
mucosa of sigmoid colon	UBERON:0004993	91.29	gold quality
oviduct epithelium	UBERON:0004804	91.03	gold quality
cauda epididymis	UBERON:0004360	90.82	gold quality
pancreas	UBERON:0001264	90.79	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-GEOD-93593	yes	8.93
E-CURD-112	yes	8.09
E-MTAB-6142	no	277.84
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

103 targeting RPF2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-3617-3P	99.98	67.86	918
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-6755-5P	99.95	65.59	464
HSA-MIR-6772-5P	99.94	67.01	577
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 98.1% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 2)

• BXDC1 and EBNA1BP2 function in a dynamic scaffold for ribosome biogenesis. (PMID:19170763)
• Clinical significance of ribosome production factor 2 homolog in hepatocellular carcinoma. (PMID:38307254)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	rpf2	ENSDARG00000043960
mus_musculus	Rpf2	ENSMUSG00000038510
rattus_norvegicus	Rpf2	ENSRNOG00000000587
drosophila_melanogaster	Non3	FBGN0038585
caenorhabditis_elegans	Y54E10A.10	WBGENE00021830

Protein

Protein identifiers

Ribosome production factor 2 homolog — Q9H7B2 (reviewed: Q9H7B2)

Alternative names: Brix domain-containing protein 1, Ribosome biogenesis protein RPF2 homolog

All UniProt accessions (4): Q9H7B2, Q5VXM9, Q5VXN0, U3KQN5

UniProt curated annotations — full annotation on UniProt →

Function. Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.

Subunit / interactions. Component of a hexameric 5S RNP precursor complex, composed of 5S RNA, RRS1, RPF2/BXDC1, RPL5, RPL11 and HEATR3; this complex acts as a precursor for ribosome assembly.

Subcellular location. Nucleus. Nucleolus.

Similarity. Belongs to the RPF2 family.

RefSeq proteins (2): NP_001276040, NP_115570* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007109	Brix	Domain
IPR039770	Rpf2	Family

Pfam: PF04427

UniProt features (8 total): compositionally biased region 2, sequence variant 2, chain 1, domain 1, region of interest 1, sequence conflict 1

Structure

Experimental structures (PDB)

5 structures.

PDB	Method	Resolution (Å)
8RL2	ELECTRON MICROSCOPY	2.84
8FL0	ELECTRON MICROSCOPY	2.91
9QIW	ELECTRON MICROSCOPY	3.04
8IR1	ELECTRON MICROSCOPY	3.3
8IR3	ELECTRON MICROSCOPY	3.5

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H7B2-F1	90.67	0.76

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 140 (showing top): GOBP_RIBOSOME_BIOGENESIS, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, SHEPARD_CRASH_AND_BURN_MUTANT_UP, GOBP_RIBOSOME_ASSEMBLY, GOBP_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, GOBP_MATURATION_OF_LSU_RRNA, GOBP_PROTEIN_RNA_COMPLEX_ORGANIZATION, GOBP_ORGANELLE_ASSEMBLY, GOBP_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR, GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOBP_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, GOBP_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS

GO Biological Process (8): ribosomal large subunit assembly (GO:0000027), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000463), ribosomal large subunit biogenesis (GO:0042273), regulation of signal transduction by p53 class mediator (GO:1901796), protein localization to nucleolus (GO:1902570), maturation of LSU-rRNA (GO:0000470), rRNA processing (GO:0006364), ribosome biogenesis (GO:0042254)

GO Molecular Function (4): RNA binding (GO:0003723), 5S rRNA binding (GO:0008097), rRNA binding (GO:0019843), protein binding (GO:0005515)

GO Cellular Component (4): nucleoplasm (GO:0005654), chromosome (GO:0005694), nucleolus (GO:0005730), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
ribosomal large subunit biogenesis	2
ribonucleoprotein complex biogenesis	2
ribosome biogenesis	2
nuclear lumen	2
intracellular membraneless organelle	2
protein-RNA complex assembly	1
ribosome assembly	1
maturation of LSU-rRNA	1
signal transduction by p53 class mediator	1
regulation of intracellular signal transduction	1
protein localization to nucleus	1
rRNA processing	1
RNA processing	1
rRNA metabolic process	1
nucleic acid binding	1
rRNA binding	1
RNA binding	1
binding	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

3150 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RPF2	RRS1	Q15050	984
RPF2	RPL11	P25121	920
RPF2	NSA2	O95478	900
RPF2	GNL2	Q13823	899
RPF2	RPL5	P46777	884
RPF2	EBNA1BP2	Q99848	867
RPF2	MRTO4	Q9UKD2	827
RPF2	GTPBP4	Q9BZE4	824
RPF2	RSL24D1	Q9UHA3	810
RPF2	NIP7	Q9Y221	794
RPF2	WDR12	Q9GZL7	772
RPF2	MDN1	Q9NU22	766
RPF2	PAK1IP1	Q9NWT1	740
RPF2	NMD3	Q96D46	725
RPF2	PDCD11	Q14690	718

IntAct

206 interactions, top by confidence:

A	B	Type	Score
SART3	PRPF4	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
RPF2	RRS1	psi-mi:“MI:0915”(physical association)	0.670
RPL14	RRP8	psi-mi:“MI:0914”(association)	0.640
H1-1	RRP8	psi-mi:“MI:0914”(association)	0.640
NOP53	RRP8	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
MECP2	KPNA3	psi-mi:“MI:0914”(association)	0.640
RBM34	RRP8	psi-mi:“MI:0914”(association)	0.640
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
DLG2	RPF2	psi-mi:“MI:0915”(physical association)	0.560
RPL28	MAGEB2	psi-mi:“MI:0914”(association)	0.560
NSA2	TYW5	psi-mi:“MI:0914”(association)	0.530
MECP2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
H1-6	ZNF724	psi-mi:“MI:0914”(association)	0.530
RBM34	NVL	psi-mi:“MI:0914”(association)	0.530
RRP8	NVL	psi-mi:“MI:0914”(association)	0.530
RPL37A	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
ZNF2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
MACROH2A2	PPM1G	psi-mi:“MI:0914”(association)	0.530
PRR11	NVL	psi-mi:“MI:0914”(association)	0.530
MAK16	NVL	psi-mi:“MI:0914”(association)	0.530
KNOP1	DHX15	psi-mi:“MI:0914”(association)	0.530
RPL30	RRP8	psi-mi:“MI:0914”(association)	0.530
ZBTB48	ZBTB24	psi-mi:“MI:0914”(association)	0.530
PDGFB	DKC1	psi-mi:“MI:0914”(association)	0.530

BioGRID (304): RPF2 (Affinity Capture-RNA), RPF2 (Affinity Capture-MS), RPF2 (Affinity Capture-MS), RPF2 (Affinity Capture-MS), RPF2 (Affinity Capture-MS), RPF2 (Affinity Capture-MS), RPF2 (Affinity Capture-MS), RPF2 (Affinity Capture-MS), RPF2 (Affinity Capture-MS), RPF2 (Affinity Capture-MS), RPF2 (Affinity Capture-MS), RPF2 (Affinity Capture-MS), RPF2 (Affinity Capture-MS), RPF2 (Affinity Capture-MS), KIAA0020 (Co-fractionation)

ESM2 similar proteins: A0A5F9D2E6, A1XQU3, O13784, O42387, O43395, O59865, P02377, P12001, P16149, P21533, P35980, P47911, P62847, P62848, P62849, P62850, P69090, P69091, P82915, Q2HJ41, Q2KIA6, Q2YDN6, Q2YGT9, Q3T0U2, Q4R5H5, Q56JU9, Q58DQ3, Q5E973, Q5EAV6, Q5R5F1, Q5RAQ8, Q5REY4, Q5XGS8, Q5ZJ85, Q6Y263, Q8LC83, Q90YQ0, Q90YU3, Q922U1, Q943Z6

Diamond homologs: G0SF80, P36160, Q2YDN6, Q54DJ0, Q9AWM9, Q9H7B2, Q9JJ80, Q9LUG5, Q9N3F0, Q9UUG1, Q9VEB3

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 187 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	19	21.1×	2e-18
Viral mRNA Translation	19	21.1×	2e-18
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	19	20.9×	2e-18
Selenocysteine synthesis	19	20.0×	4e-18
Eukaryotic Translation Termination	19	20.0×	4e-18
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	19	19.6×	4e-18
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	19	19.6×	4e-18
Formation of a pool of free 40S subunits	19	18.7×	8e-18

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	19	20.8×	3e-17
ribosomal large subunit biogenesis	7	18.4×	1e-05
rRNA processing	16	13.4×	2e-11
translation	21	12.8×	6e-15
ribosomal small subunit biogenesis	9	12.1×	9e-06
negative regulation of translation	10	11.6×	3e-06
negative regulation of viral genome replication	5	11.1×	4e-03
RNA processing	8	10.4×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

63 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	46
Likely benign	2
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1719 predictions. Top by Δscore:

Variant	Effect	Δscore
6:110982125:GTAGT:G	donor_gain	1.0000
6:110982126:TAGT:T	donor_gain	1.0000
6:110982128:GT:G	donor_gain	1.0000
6:110982129:TGTA:T	donor_loss	1.0000
6:110982130:G:GG	donor_gain	1.0000
6:110982130:GT:G	donor_loss	1.0000
6:110982131:T:A	donor_loss	1.0000
6:110984999:T:TA	acceptor_gain	1.0000
6:110985004:A:AG	acceptor_gain	1.0000
6:110985005:G:GG	acceptor_gain	1.0000
6:110985005:GA:G	acceptor_gain	1.0000
6:110985005:GAA:G	acceptor_gain	1.0000
6:110985005:GAAA:G	acceptor_gain	1.0000
6:110985134:ATGTG:A	donor_gain	1.0000
6:110985135:TGTG:T	donor_gain	1.0000
6:110985135:TGTGG:T	donor_loss	1.0000
6:110985136:GTG:G	donor_gain	1.0000
6:110985136:GTGG:G	donor_gain	1.0000
6:110985137:TGGT:T	donor_gain	1.0000
6:110985138:GGTA:G	donor_gain	1.0000
6:110985139:G:C	donor_loss	1.0000
6:110985139:G:GG	donor_gain	1.0000
6:110989066:G:GG	donor_gain	1.0000
6:110991785:TGG:T	donor_loss	1.0000
6:110997262:TAGG:T	donor_loss	1.0000
6:110997264:GGTA:G	donor_loss	1.0000
6:110997265:G:C	donor_loss	1.0000
6:110997266:T:A	donor_loss	1.0000
6:110999705:TTCCA:T	acceptor_loss	1.0000
6:110999706:TCCA:T	acceptor_loss	1.0000

AlphaMissense

2020 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:111024266:G:C	R227T	1.000
6:111024266:G:T	R227M	1.000
6:110991764:C:A	P71H	0.999
6:110997226:G:A	G93D	0.999
6:110997244:G:C	R99P	0.999
6:110997264:G:C	G106R	0.999
6:110999711:G:A	G106D	0.999
6:110999714:G:C	R107P	0.999
6:111015847:G:C	R196P	0.999
6:111024267:G:C	R227S	0.999
6:111024267:G:T	R227S	0.999
6:111025452:G:A	G264E	0.999
6:111025460:C:G	H267D	0.999
6:110985094:G:A	G38R	0.998
6:110985094:G:C	G38R	0.998
6:110985095:G:A	G38E	0.998
6:110991764:C:G	P71R	0.998
6:110997225:G:C	G93R	0.998
6:110997242:G:C	K98N	0.998
6:110997242:G:T	K98N	0.998
6:110997254:T:A	N102K	0.998
6:110997254:T:G	N102K	0.998
6:110997256:T:C	L103P	0.998
6:110999735:T:C	L114P	0.998
6:111024263:G:T	R226M	0.998
6:111024278:C:A	A231E	0.998
6:111025420:T:A	N253K	0.998
6:111025420:T:G	N253K	0.998
6:111025462:T:A	H267Q	0.998
6:111025462:T:G	H267Q	0.998

dbSNP variants (sampled 300 via entrez): RS1000058466 (6:111025807 C>T), RS1000212519 (6:110990898 TG>T), RS1000235831 (6:111021038 G>A), RS1000236581 (6:110980369 C>A), RS1000266863 (6:111020867 A>C,G), RS1000373976 (6:111015203 G>A), RS1000471709 (6:111020635 T>G), RS1000477761 (6:111003336 G>A,C,T), RS1000495852 (6:111013760 G>T), RS1000606033 (6:111019659 C>T), RS1000648908 (6:110985925 G>C), RS1000669139 (6:111025282 T>C), RS1000683298 (6:110984024 G>C), RS1000745153 (6:111015450 T>C), RS1000804510 (6:110992206 C>T)

Disease associations

OMIM: gene MIM:618471 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST006879_15	Blood metabolite levels	6.000000e-25
GCST006879_16	Blood metabolite levels	5.000000e-08
GCST006879_17	Blood metabolite levels	2.000000e-26
GCST006879_23	Blood metabolite levels	7.000000e-31
GCST006879_24	Blood metabolite levels	3.000000e-25
GCST006879_3	Blood metabolite levels	8.000000e-29
GCST006879_4	Blood metabolite levels	7.000000e-37
GCST009391_1985	Metabolite levels	5.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0005058	tyrosine measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

55 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases abundance, affects expression, decreases expression, affects cotreatment	3
sodium arsenite	increases abundance, increases expression, decreases expression, affects cotreatment	3
bisphenol S	decreases methylation, increases expression, affects cotreatment	3
Air Pollutants	increases expression, decreases expression, increases abundance	2
Arsenic	affects cotreatment, increases abundance, increases expression	2
Estradiol	increases expression, affects expression	2
Tobacco Smoke Pollution	increases expression, affects expression	2
Tretinoin	decreases expression	2
Valproic Acid	increases expression, affects expression	2
Cyclosporine	increases expression	2
Aflatoxin B1	affects cotreatment, decreases expression, increases expression	2
Particulate Matter	increases abundance, increases expression, decreases expression	2
ginger extract	affects cotreatment, affects expression, increases abundance	1
triphenyl phosphate	affects expression	1
deoxynivalenol	increases expression	1
sodium arsenate	decreases expression	1
beta-lapachone	decreases expression, increases expression	1
arsenite	affects binding, increases reaction	1
methylparaben	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
4-aminophenylarsenoxide	affects binding, decreases reaction	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
chloropicrin	increases expression	1
perfluoro-n-nonanoic acid	increases expression	1
bisphenol B	increases expression	1
abrine	increases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
jinfukang	decreases expression, affects cotreatment	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.