RPL26L1

Summary

RPL26L1 (ribosomal protein L26 like 1, HGNC:17050) is a protein-coding gene on chromosome 5q35.1, encoding Ribosomal protein uL24-like (Q9UNX3). It is a selective cancer dependency (DepMap: 62.1% of cell lines).

This gene encodes a protein that shares high sequence similarity with ribosomal protein L26. Alternative splicing results in multiple transcript variants encoding the same protein.

Source: NCBI Gene 51121 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 38 total
• Cancer dependency (DepMap): dependent in 62.1% of screened cell lines
• MANE Select transcript: NM_016093

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17050
Approved symbol	RPL26L1
Name	ribosomal protein L26 like 1
Location	5q35.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000037241
Ensembl biotype	protein_coding
Entrez	51121

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 protein_coding

ENST00000265100, ENST00000519156, ENST00000519239, ENST00000519522, ENST00000519974, ENST00000521476, ENST00000906540, ENST00000906541, ENST00000935963, ENST00000935964, ENST00000935965, ENST00000935966, ENST00000935967, ENST00000935968, ENST00000935969, ENST00000935970, ENST00000971027, ENST00000971028

RefSeq mRNA: 4 — MANE Select: NM_016093 NM_001317980, NM_001317981, NM_001317982, NM_016093

CCDS: CCDS4382

Canonical transcript exons

ENST00000265100 — 4 exons

Exon	Start	End
ENSE00001003664	172959424	172959468
ENSE00001003665	172959865	172960041
ENSE00001003666	172969413	172969771
ENSE00002414922	172968459	172968599

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 97.22.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 26.8522 / max 199.4382, expressed in 1814 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
60276	23.8027	1813
60274	1.2819	918
60275	1.2083	765
60277	0.4646	269
60278	0.0947	29

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	97.22	gold quality
right testis	UBERON:0004534	97.08	gold quality
testis	UBERON:0000473	96.91	gold quality
islet of Langerhans	UBERON:0000006	96.71	gold quality
cortical plate	UBERON:0005343	95.60	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	95.00	gold quality
ganglionic eminence	UBERON:0004023	94.79	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	94.36	gold quality
stromal cell of endometrium	CL:0002255	93.87	gold quality
right adrenal gland	UBERON:0001233	93.85	gold quality
left adrenal gland	UBERON:0001234	93.54	gold quality
right adrenal gland cortex	UBERON:0035827	93.48	gold quality
left adrenal gland cortex	UBERON:0035825	93.37	gold quality
mucosa of transverse colon	UBERON:0004991	92.93	gold quality
prefrontal cortex	UBERON:0000451	92.79	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	92.74	gold quality
adrenal gland	UBERON:0002369	92.48	gold quality
adult mammalian kidney	UBERON:0000082	92.32	gold quality
cortex of kidney	UBERON:0001225	91.71	gold quality
placenta	UBERON:0001987	91.68	gold quality
hypothalamus	UBERON:0001898	91.53	gold quality
esophagus mucosa	UBERON:0002469	91.44	gold quality
frontal cortex	UBERON:0001870	91.40	gold quality
nucleus accumbens	UBERON:0001882	91.34	gold quality
adenohypophysis	UBERON:0002196	91.29	gold quality
cerebral cortex	UBERON:0000956	91.19	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	91.10	gold quality
anterior cingulate cortex	UBERON:0009835	91.06	gold quality
vermiform appendix	UBERON:0001154	91.05	gold quality
Ammon’s horn	UBERON:0001954	90.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	11.46

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

13 targeting RPL26L1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-548AJ-5P	99.78	71.12	3085
HSA-MIR-548F-5P	99.78	71.02	3093
HSA-MIR-548G-5P	99.78	71.12	3085
HSA-MIR-548X-5P	99.78	71.12	3085
HSA-MIR-5093	99.67	69.26	2291
HSA-MIR-12123	99.52	71.79	2990
HSA-MIR-12117	99.50	67.57	868
HSA-MIR-6833-5P	99.50	68.93	1161
HSA-MIR-4491	96.53	66.20	935
HSA-MIR-4657	96.53	66.57	895

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 62.1% of screened cell lines.

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	rpl26	ENSDARG00000102317
drosophila_melanogaster	RpL26	FBGN0036825
caenorhabditis_elegans		WBGENE00004440

Paralogs (1): RPL26 (ENSG00000161970)

Protein

Protein identifiers

Ribosomal protein uL24-like — Q9UNX3 (reviewed: Q9UNX3)

Alternative names: 60S ribosomal protein L26-like 1, Large ribosomal subunit protein uL24-like 1

All UniProt accessions (3): E5RHH1, E5RIT6, Q9UNX3

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the universal ribosomal protein uL24 family.

RefSeq proteins (4): NP_001304909, NP_001304910, NP_001304911, NP_057177* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005756	Ribosomal_uL24_euk_arc	Family
IPR005824	KOW	Domain
IPR005825	Ribosomal_uL24_CS	Conserved_site
IPR008991	Translation_prot_SH3-like_sf	Homologous_superfamily
IPR014722	Rib_uL2_dom2	Homologous_superfamily
IPR041988	Ribosomal_uL24_KOW	Domain

Pfam: PF00467, PF16906

UniProt features (5 total): region of interest 2, cross-link 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UNX3-F1	92.92	0.86

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 136, 142

Function

Pathways and Gene Ontology

Reactome pathways

16 pathways

ID	Pathway
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902	Peptide chain elongation
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823	Viral mRNA Translation
R-HSA-2408557	Selenocysteine synthesis
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689	Formation of a pool of free 40S subunits
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764	Eukaryotic Translation Termination
R-HSA-9010553	Regulation of expression of SLITs and ROBOs
R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
R-HSA-9954709	Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
R-HSA-9954714	PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
R-HSA-9954716	ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA

MSigDB gene sets: 107 (showing top): GOBP_CYTOPLASMIC_TRANSLATION, GOBP_RIBOSOME_BIOGENESIS, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_TRANSLATION, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, YANAGISAWA_LUNG_CANCER_RECURRENCE, TIEN_INTESTINE_PROBIOTICS_24HR_UP, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, GOBP_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS, REACTOME_METABOLISM_OF_RNA, GOCC_LARGE_RIBOSOMAL_SUBUNIT, GOCC_RIBOSOME, MOREAUX_MULTIPLE_MYELOMA_BY_TACI_DN, GOCC_CYTOSOLIC_LARGE_RIBOSOMAL_SUBUNIT, GOCC_RIBOSOMAL_SUBUNIT

GO Biological Process (3): cytoplasmic translation (GO:0002181), ribosomal large subunit biogenesis (GO:0042273), translation (GO:0006412)

GO Molecular Function (3): RNA binding (GO:0003723), structural constituent of ribosome (GO:0003735), protein binding (GO:0005515)

GO Cellular Component (5): cytosolic large ribosomal subunit (GO:0022625), extracellular exosome (GO:0070062), ribosome (GO:0005840), large ribosomal subunit (GO:0015934), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-11 pathways:

Category	Pathways
Ribosome-associated quality control	3
Translation	2
Cap-dependent Translation Initiation	2
Nonsense-Mediated Decay (NMD)	2
Eukaryotic Translation Initiation	1
Eukaryotic Translation Elongation	1
Influenza Viral RNA Transcription and Replication	1
Selenoamino acid metabolism	1
rRNA processing in the nucleus and cytosol	1
Signaling by ROBO receptors	1
Cellular response to starvation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
translation	1
ribonucleoprotein complex biogenesis	1
ribosome biogenesis	1
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
nucleic acid binding	1
structural molecule activity	1
ribosome	1
binding	1
large ribosomal subunit	1
cytosolic ribosome	1
extracellular vesicle	1
intracellular membraneless organelle	1
ribosomal subunit	1
protein-containing complex	1

Protein interactions and networks

STRING

3966 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RPL26L1	RPS24	P16632	766
RPL26L1	RPL21	P46778	728
RPL26L1	RPS15A	P39027	690
RPL26L1	RPL27	P08526	683
RPL26L1	RPS2	P15880	668
RPL26L1	RPL18A	Q02543	650
RPL26L1	RPS20	P17075	640
RPL26L1	RPL36A	P09896	625
RPL26L1	RPL36AL	Q969Q0	624
RPL26L1	RPS3A	P33443	620
RPL26L1	MRPL27	Q9P0M9	573
RPL26L1	RPS3	P23396	570
RPL26L1	RPS4X	P12631	535
RPL26L1	A0A087WVV2	A0A087WVV2	535
RPL26L1	RPS6	P08227	526

IntAct

178 interactions, top by confidence:

A	B	Type	Score
RPL9	DHPS	psi-mi:“MI:0914”(association)	0.870
EAF1	ELL2	psi-mi:“MI:0914”(association)	0.840
H2AX	PPM1G	psi-mi:“MI:0914”(association)	0.730
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
RPL10A	RRP8	psi-mi:“MI:0914”(association)	0.640
RPL14	RRP8	psi-mi:“MI:0914”(association)	0.640
NOP53	RRP8	psi-mi:“MI:0914”(association)	0.640
NOL12	RRP8	psi-mi:“MI:0914”(association)	0.640
DHX8	AHCYL1	psi-mi:“MI:0914”(association)	0.640
BYSL	PARN	psi-mi:“MI:0914”(association)	0.640
RPS7	RPL5	psi-mi:“MI:0914”(association)	0.640
HTT	RPL26L1	psi-mi:“MI:0915”(physical association)	0.560
RPS6	IPO7	psi-mi:“MI:0914”(association)	0.530
PLEKHO1	UBA6	psi-mi:“MI:0914”(association)	0.530
NSA2	TYW5	psi-mi:“MI:0914”(association)	0.530
FGF3	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MECP2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MAGEB10	GTPBP10	psi-mi:“MI:0914”(association)	0.530
ZNF169	ZNF316	psi-mi:“MI:0914”(association)	0.530
ZNF324B	ZNF316	psi-mi:“MI:0914”(association)	0.530
H1-6	ZNF724	psi-mi:“MI:0914”(association)	0.530
ZNF512	ZNF724	psi-mi:“MI:0914”(association)	0.530
RBM34	NVL	psi-mi:“MI:0914”(association)	0.530
DDX31	IGLL5	psi-mi:“MI:0914”(association)	0.530
RRP8	NVL	psi-mi:“MI:0914”(association)	0.530
H1-4	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
ILF2	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
RPS2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530

BioGRID (660): RPL26L1 (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS)

ESM2 similar proteins: A5JSS2, A6H769, E2RKA8, G1SHQ2, G1SNY0, G1SQH0, G1SVB0, O09167, O14602, P12749, P14115, P18445, P20280, P30742, P41567, P46776, P46778, P47813, P47832, P49171, P49666, P61251, P61254, P61255, P61256, P61257, P62081, P62082, P62083, P62854, P62855, P62856, P62910, P62911, P62912, Q3SZQ6, Q4R723, Q56JV1, Q56K03, Q5E938

Diamond homologs: A0A1D8PCQ5, A0B9V9, A0RVY4, A1RS05, A1RWS4, A2BMD0, A2SPL3, A3DNB8, A3MWZ8, A4FWB0, A4WLL3, A4YCX7, A5UL77, A6UQ55, A6UWU9, A6VGZ6, A7I5Q0, A8ACD3, A8MB21, A9A5I4, B1L777, G1SQH0, O05633, O26122, O28365, O59429, P05743, P10972, P12749, P14034, P41960, P47832, P49629, P51414, P53221, P54038, P60663, P60746, P61254, P61255

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
RPL26L1	“form complex”	“60S cytosolic large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 224 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	23	18.9×	2e-21
Viral mRNA Translation	23	18.9×	2e-21
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	23	18.7×	2e-21
Selenocysteine synthesis	23	17.9×	4e-21
Eukaryotic Translation Termination	23	17.9×	4e-21
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	23	17.6×	5e-21
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	23	17.6×	5e-21
SRP-dependent cotranslational protein targeting to membrane	27	17.6×	8e-24

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	24	21.9×	7e-23
ribosome biogenesis	5	15.4×	2e-03
translation	28	14.2×	1e-21
ribosomal large subunit biogenesis	6	13.1×	9e-04
ribosomal small subunit biogenesis	10	11.2×	4e-06
rRNA processing	14	9.8×	5e-08
mRNA export from nucleus	6	8.7×	5e-03
mRNA splicing, via spliceosome	17	7.7×	3e-08

Disease & clinical

Clinical variants and AI predictions

ClinVar

38 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	26
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

553 predictions. Top by Δscore:

Variant	Effect	Δscore
5:172959853:C:CA	acceptor_gain	1.0000
5:172959860:T:TA	acceptor_gain	1.0000
5:172959861:GTA:G	acceptor_loss	1.0000
5:172959862:TA:T	acceptor_loss	1.0000
5:172959863:A:AG	acceptor_gain	1.0000
5:172959863:A:C	acceptor_loss	1.0000
5:172959863:AGAG:A	acceptor_gain	1.0000
5:172959863:AGAGG:A	acceptor_gain	1.0000
5:172959864:G:GG	acceptor_gain	1.0000
5:172959864:GA:G	acceptor_gain	1.0000
5:172959864:GAGG:G	acceptor_gain	1.0000
5:172959864:GAGGG:G	acceptor_gain	1.0000
5:172960037:TCC:T	donor_gain	1.0000
5:172960039:CAGG:C	donor_loss	1.0000
5:172960042:G:GA	donor_loss	1.0000
5:172960042:G:GG	donor_gain	1.0000
5:172960043:T:G	donor_loss	1.0000
5:172968595:GCAAG:G	donor_gain	1.0000
5:172968596:CAAG:C	donor_loss	1.0000
5:172968597:AAG:A	donor_loss	1.0000
5:172968599:GGTAT:G	donor_loss	1.0000
5:172968600:G:GA	donor_loss	1.0000
5:172968601:T:G	donor_loss	1.0000
5:172969410:CAGGT:C	acceptor_loss	1.0000
5:172969411:AGGT:A	acceptor_gain	1.0000
5:172969412:G:A	acceptor_loss	1.0000
5:172969412:GGT:G	acceptor_gain	1.0000
5:172969412:GGTG:G	acceptor_gain	1.0000
5:172966459:GCC:G	donor_gain	0.9900
5:172968453:TCTTA:T	acceptor_loss	0.9900

AlphaMissense

949 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:172959974:T:A	L34H	0.999
5:172960030:G:C	D53H	0.999
5:172960037:T:A	V55D	0.999
5:172968468:G:A	G60R	0.999
5:172968468:G:C	G60R	0.999
5:172968469:G:A	G60E	0.999
5:172968515:A:C	R75S	0.999
5:172968515:A:T	R75S	0.999
5:172960019:T:A	I49N	0.998
5:172960022:G:C	R50P	0.998
5:172960031:A:C	D53A	0.998
5:172960031:A:T	D53V	0.998
5:172968469:G:T	G60V	0.998
5:172968493:G:A	G68D	0.998
5:172968499:T:A	V70E	0.998
5:172968514:G:C	R75T	0.998
5:172968514:G:T	R75I	0.998
5:172968574:T:A	V95D	0.998
5:172959949:C:A	R26S	0.997
5:172959989:G:C	R39P	0.997
5:172960021:C:A	R50S	0.997
5:172960031:A:G	D53G	0.997
5:172960032:C:A	D53E	0.997
5:172960032:C:G	D53E	0.997
5:172968460:T:A	V57E	0.997
5:172968492:G:C	G68R	0.997
5:172968508:T:A	V73E	0.997
5:172968529:T:A	I80N	0.997
5:172968541:G:C	R84P	0.997
5:172968550:G:C	R87P	0.997

dbSNP variants (sampled 300 via entrez): RS1000107937 (5:172956193 C>T), RS1000197591 (5:172964486 A>G), RS1000285579 (5:172961083 G>A), RS1000466681 (5:172967013 G>A), RS1000803160 (5:172965759 C>G), RS1000852051 (5:172965930 A>G), RS1000986372 (5:172958852 T>G), RS1001248464 (5:172955997 T>A), RS1001341317 (5:172956941 A>G), RS1001519493 (5:172962075 A>G), RS1001568259 (5:172969003 T>C), RS1001656667 (5:172956667 G>A,C), RS1001992156 (5:172955198 G>A,T), RS1002129750 (5:172953327 A>G), RS1002222044 (5:172961743 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects expression, decreases expression	2
aristolochic acid I	decreases expression	1
bisphenol F	affects cotreatment, increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
beta-lapachone	increases expression	1
arsenite	affects binding, increases reaction	1
benzo(e)pyrene	decreases methylation	1
aflatoxin B2	decreases methylation	1
cyclic 3’,5’-uridine monophosphate	affects binding	1
calfactant	affects cotreatment, increases expression	1
K 7174	decreases expression	1
ICG 001	decreases expression	1
MT19c compound	increases expression	1
Temozolomide	decreases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Benzo(a)pyrene	affects methylation	1
Dexamethasone	affects cotreatment, increases expression	1
Indomethacin	increases expression, affects cotreatment	1
Ivermectin	decreases expression	1
Methapyrilene	decreases methylation	1
Ribonucleotides	affects binding	1
Smoke	increases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
Nanotubes, Carbon	increases expression, affects cotreatment	1
Particulate Matter	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.