RPL34-DT

Summary

RPL34-DT (RPL34 divergent transcript, HGNC:26749) is a long non-coding RNA gene on chromosome 4q25.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26749
Approved symbol	RPL34-DT
Name	RPL34 divergent transcript
Location	4q25
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ37673, RP11-462C24.1
Ensembl gene	ENSG00000234492
Ensembl biotype	lncRNA
Entrez	285456
RNAcentral	URS000075E96E — lncRNA, 3773 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 26 lncRNA

ENST00000506795, ENST00000507248, ENST00000509984, ENST00000510212, ENST00000701215, ENST00000701601, ENST00000810230, ENST00000810231, ENST00000810232, ENST00000810233, ENST00000810234, ENST00000810235, ENST00000810236, ENST00000810237, ENST00000810238, ENST00000810239, ENST00000810240, ENST00000810241, ENST00000810242, ENST00000810243, ENST00000810244, ENST00000810245, ENST00000810246, ENST00000810247, ENST00000810248, ENST00000810249

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000506795 — 4 exons

Exon	Start	End
ENSE00002030690	108620308	108620429
ENSE00002045206	108540168	108540814
ENSE00002073626	108556791	108557064
ENSE00002439219	108541500	108541592

Expression profiles

Bgee: expression breadth ubiquitous, 153 present calls, max score 76.68.

FANTOM5 (CAGE): breadth broad, TPM avg 1.8343 / max 108.5483, expressed in 664 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
53583	1.8025	655
53584	0.0318	9

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.68	gold quality
sural nerve	UBERON:0015488	76.02	gold quality
islet of Langerhans	UBERON:0000006	66.65	gold quality
bone marrow cell	CL:0002092	65.21	silver quality
left testis	UBERON:0004533	64.44	gold quality
right testis	UBERON:0004534	64.18	gold quality
testis	UBERON:0000473	63.12	gold quality
cortical plate	UBERON:0005343	62.24	gold quality
calcaneal tendon	UBERON:0003701	61.17	gold quality
ganglionic eminence	UBERON:0004023	60.85	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.60	gold quality
prefrontal cortex	UBERON:0000451	57.49	gold quality
leukocyte	CL:0000738	57.34	gold quality
monocyte	CL:0000576	56.61	gold quality
vermiform appendix	UBERON:0001154	56.46	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	56.24	gold quality
pancreas	UBERON:0001264	55.45	gold quality
adult mammalian kidney	UBERON:0000082	54.89	gold quality
corpus callosum	UBERON:0002336	54.87	gold quality
spinal cord	UBERON:0002240	54.73	gold quality
stromal cell of endometrium	CL:0002255	54.70	silver quality
right atrium auricular region	UBERON:0006631	54.67	gold quality
lymph node	UBERON:0000029	54.65	gold quality
cardiac atrium	UBERON:0002081	54.29	gold quality
tendon	UBERON:0000043	53.79	gold quality
heart left ventricle	UBERON:0002084	53.76	gold quality
cardiac ventricle	UBERON:0002082	53.27	gold quality
buccal mucosa cell	CL:0002336	53.21	gold quality
heart	UBERON:0000948	53.21	gold quality
caecum	UBERON:0001153	52.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.11

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• A three-lncRNA signature (LOC285194, RP11-462C24.1 and Nbla12061) identified via stepwise regression analysis showed potential as a diagnostic marker for colorectal cancer. (PMID:27683121)
• In vitro experiments suggested RPL34-AS1 inhibits esophageal cancer cell proliferation, migration and invasion through down-regulating RPL34 expression. In conclusion, RPL34-AS1 functions as tumor suppressor in esophageal cancer. (PMID:31574377)
• lncRNA RPL34-AS1 inhibits cell proliferation and invasion while promoting apoptosis by competitively binding miR-3663-3p/RGS4 in papillary thyroid cancer. (PMID:31587286)
• RP11-462C24.1 suppresses proliferation and invasion of colorectal carcinoma cells by regulating HSP70 through PI3K/AKT signaling pathway. (PMID:32946066)
• Long non-coding RNA RPL34-AS1 ameliorates oxygen-glucose deprivation-induced neuronal injury via modulating miR-223-3p/IGF1R axis. (PMID:36006565)
• LncRNA RPL34-AS1 suppresses the proliferation, migration and invasion of esophageal squamous cell carcinoma via targeting miR-575/ACAA2 axis. (PMID:36162992)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.