RPL7L1

Summary

RPL7L1 (ribosomal protein L7 like 1, HGNC:21370) is a protein-coding gene on chromosome 6p21.1, encoding Ribosomal protein uL30-like (Q6DKI1). It is a common-essential gene (DepMap: required in 99.5% of cancer cell lines).

Enables RNA binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to act upstream of or within blastocyst formation. Located in mitochondrion.

Source: NCBI Gene 285855 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 51 total
• Cancer dependency (DepMap): dependent in 99.5% of screened cell lines (common-essential)
• MANE Select transcript: NM_001366481

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21370
Approved symbol	RPL7L1
Name	ribosomal protein L7 like 1
Location	6p21.1
Locus type	gene with protein product
Status	Approved
Aliases	dJ475N16.4
Ensembl gene	ENSG00000146223
Ensembl biotype	protein_coding
OMIM	617417
Entrez	285855

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 6 protein_coding, 3 retained_intron, 3 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000304734, ENST00000397415, ENST00000459829, ENST00000462348, ENST00000483998, ENST00000487619, ENST00000492836, ENST00000493763, ENST00000497417, ENST00000602561, ENST00000934499, ENST00000934500, ENST00000953717

RefSeq mRNA: 2 — MANE Select: NM_001366481 NM_001366481, NM_198486

CCDS: CCDS4873

Canonical transcript exons

ENST00000493763 — 6 exons

Exon	Start	End
ENSE00001833955	42879616	42879951
ENSE00001934591	42886256	42889900
ENSE00003464727	42883451	42883614
ENSE00003492646	42884613	42884750
ENSE00003526126	42880861	42880966
ENSE00003629291	42885974	42886083

Expression profiles

Bgee: expression breadth ubiquitous, 262 present calls, max score 98.25.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.1835 / max 87.8376, expressed in 1593 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
67825	2.5884	1350
67827	0.9643	560
67826	0.6309	342

Top tissues by expression

262 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
upper arm skin	UBERON:0004263	98.25	gold quality
kidney epithelium	UBERON:0004819	98.05	gold quality
bronchial epithelial cell	CL:0002328	97.53	gold quality
skin of hip	UBERON:0001554	97.36	gold quality
oral cavity	UBERON:0000167	97.34	gold quality
bronchus	UBERON:0002185	97.31	gold quality
mammalian vulva	UBERON:0000997	97.14	gold quality
mucosa of sigmoid colon	UBERON:0004993	97.08	gold quality
buccal mucosa cell	CL:0002336	97.06	gold quality
tibialis anterior	UBERON:0001385	96.99	gold quality
ileal mucosa	UBERON:0000331	96.91	gold quality
upper leg skin	UBERON:0004262	96.89	gold quality
islet of Langerhans	UBERON:0000006	96.86	gold quality
epithelial cell of pancreas	CL:0000083	96.77	gold quality
seminal vesicle	UBERON:0000998	96.68	gold quality
postcentral gyrus	UBERON:0002581	96.62	gold quality
Brodmann (1909) area 46	UBERON:0006483	96.61	gold quality
cartilage tissue	UBERON:0002418	96.58	gold quality
penis	UBERON:0000989	96.54	gold quality
caput epididymis	UBERON:0004358	96.50	gold quality
corpus epididymis	UBERON:0004359	96.46	gold quality
entorhinal cortex	UBERON:0002728	96.36	gold quality
cortical plate	UBERON:0005343	96.29	gold quality
nasal cavity epithelium	UBERON:0005384	96.29	gold quality
left ventricle myocardium	UBERON:0006566	96.21	gold quality
colonic mucosa	UBERON:0000317	96.17	gold quality
adult organism	UBERON:0007023	96.14	gold quality
cerebellar vermis	UBERON:0004720	96.10	gold quality
parietal lobe	UBERON:0001872	96.08	gold quality
gingiva	UBERON:0001828	96.07	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-7381	no	375.76
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

87 targeting RPL7L1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-552-5P	99.93	68.56	1583
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-129-5P	99.88	70.26	3273
HSA-MIR-4271	99.88	68.32	2244
HSA-MIR-3140-3P	99.88	68.47	2069
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-MIR-4420	99.82	70.08	1624
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-4307	99.82	70.45	3374
HSA-MIR-181B-2-3P	99.81	70.06	1646
HSA-MIR-181B-3P	99.81	70.06	1646
HSA-MIR-204-5P	99.79	71.62	2439
HSA-MIR-211-5P	99.79	71.65	2440
HSA-MIR-26A-5P	99.78	73.52	2303

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 99.5% of screened cell lines, common-essential.

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	rpl7l1	ENSDARG00000042864
mus_musculus	Rpl7l1	ENSMUSG00000063888
rattus_norvegicus	Rpl7l1	ENSRNOG00000016269
drosophila_melanogaster	RpL7	FBGN0005593
caenorhabditis_elegans	rpl-7	WBGENE00004418

Paralogs (1): RPL7 (ENSG00000147604)

Protein

Protein identifiers

Ribosomal protein uL30-like — Q6DKI1 (reviewed: Q6DKI1)

Alternative names: 60S ribosomal protein L7-like 1, Large ribosomal subunit protein uL30-like 1

All UniProt accessions (3): Q6DKI1, A0A1W2PQ76, R4GMU7

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the universal ribosomal protein uL30 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q6DKI1-1	1	yes
Q6DKI1-2	2

RefSeq proteins (2): NP_001353410, NP_940888 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005998	Ribosomal_uL30_euk	Family
IPR012988	Ribosomal_uL30_N_euk	Domain
IPR016082	Ribosomal_uL30_ferredoxin-like	Domain
IPR018038	Ribosomal_uL30_CS	Conserved_site
IPR035808	Ribosomal_uL30_euk_arc	Domain
IPR036919	Ribo_uL30_ferredoxin-like_sf	Homologous_superfamily
IPR039699	Ribosomal_uL30	Family

Pfam: PF00327, PF08079

UniProt features (5 total): sequence conflict 2, chain 1, modified residue 1, splice variant 1

Structure

Experimental structures (PDB)

25 structures.

PDB	Method	Resolution (Å)
8FKV	ELECTRON MICROSCOPY	2.47
8FLE	ELECTRON MICROSCOPY	2.48
8FKW	ELECTRON MICROSCOPY	2.5
8FL3	ELECTRON MICROSCOPY	2.53
8FL7	ELECTRON MICROSCOPY	2.55
8FLB	ELECTRON MICROSCOPY	2.55
8FLD	ELECTRON MICROSCOPY	2.58
8FKX	ELECTRON MICROSCOPY	2.59
8FL6	ELECTRON MICROSCOPY	2.62
8FLA	ELECTRON MICROSCOPY	2.63
8FKY	ELECTRON MICROSCOPY	2.67
8FL2	ELECTRON MICROSCOPY	2.67
8FKQ	ELECTRON MICROSCOPY	2.76
8FKT	ELECTRON MICROSCOPY	2.81
8FKU	ELECTRON MICROSCOPY	2.82
8FKP	ELECTRON MICROSCOPY	2.85
8FKS	ELECTRON MICROSCOPY	2.88
8FKR	ELECTRON MICROSCOPY	2.89
8FL4	ELECTRON MICROSCOPY	2.89
8INF	ELECTRON MICROSCOPY	3
8FKZ	ELECTRON MICROSCOPY	3.04
8INE	ELECTRON MICROSCOPY	3.2
8IPY	ELECTRON MICROSCOPY	3.2
8IR3	ELECTRON MICROSCOPY	3.5
8IPX	ELECTRON MICROSCOPY	4.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6DKI1-F1	87.51	0.70

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 63

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 163 (showing top): GOBP_RIBOSOME_BIOGENESIS, GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, TGCGCANK_UNKNOWN, GCM_GSPT1, GOBP_BLASTOCYST_FORMATION, GOBP_IN_UTERO_EMBRYONIC_DEVELOPMENT, GOBP_MATURATION_OF_LSU_RRNA, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, GOBP_BLASTOCYST_DEVELOPMENT, GCM_NUMA1, GCM_NF2, GOBP_EMBRYO_DEVELOPMENT, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, GOBP_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS, GCM_RBM8A

GO Biological Process (2): maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000463), blastocyst formation (GO:0001825)

GO Molecular Function (3): RNA binding (GO:0003723), structural constituent of ribosome (GO:0003735), protein binding (GO:0005515)

GO Cellular Component (5): nucleolus (GO:0005730), mitochondrion (GO:0005739), cytosolic large ribosomal subunit (GO:0022625), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membraneless organelle	2
maturation of LSU-rRNA	1
blastocyst development	1
anatomical structure formation involved in morphogenesis	1
nucleic acid binding	1
structural molecule activity	1
ribosome	1
binding	1
nuclear lumen	1
cytoplasm	1
intracellular membrane-bounded organelle	1
large ribosomal subunit	1
cytosolic ribosome	1
protein-containing complex	1

Protein interactions and networks

STRING

3691 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RPL7L1	SURF6	O75683	657
RPL7L1	RPL19	P14118	581
RPL7L1	TIA1	P31483	480
RPL7L1	AP3S1	Q92572	469
RPL7L1	MRPL15	Q9P015	442
RPL7L1	GRWD1	Q9BQ67	437
RPL7L1	GOSR2	O14653	431
RPL7L1	CFB	P00751	426
RPL7L1	RPL39	P02404	425
RPL7L1	IGFBP7	Q16270	421
RPL7L1	RPL23	P23131	417
RPL7L1	APOB	P04114	408
RPL7L1	CAPZA1	P52907	406
RPL7L1	RSL24D1	Q9UHA3	403
RPL7L1	RRP7A	Q9Y3A4	399

IntAct

144 interactions, top by confidence:

A	B	Type	Score
WDR12	PES1	psi-mi:“MI:0914”(association)	0.850
PES1	BOP1	psi-mi:“MI:0914”(association)	0.810
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
PTK2	TGFB1I1	psi-mi:“MI:0914”(association)	0.680
RPL7L1	RPL7A	psi-mi:“MI:0915”(physical association)	0.670
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
RPL7A	NOP56	psi-mi:“MI:0914”(association)	0.640
CCNDBP1	RPL7L1	psi-mi:“MI:0915”(physical association)	0.560
RPL28	MAGEB2	psi-mi:“MI:0914”(association)	0.560
MAGEA4	MAGEB16	psi-mi:“MI:0914”(association)	0.530
MAGEB10	GTPBP10	psi-mi:“MI:0914”(association)	0.530
RBM34	NVL	psi-mi:“MI:0914”(association)	0.530
PES1	AP3B1	psi-mi:“MI:0914”(association)	0.530
WDR55	PES1	psi-mi:“MI:0914”(association)	0.530
RPL37A	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
MACROH2A2	PPM1G	psi-mi:“MI:0914”(association)	0.530
PRR11	NVL	psi-mi:“MI:0914”(association)	0.530
RPL30	RRP8	psi-mi:“MI:0914”(association)	0.530
PUM3	RRP8	psi-mi:“MI:0914”(association)	0.530
N	NOP56	psi-mi:“MI:0914”(association)	0.530
N	RBM47	psi-mi:“MI:0914”(association)	0.530
KRR1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530
RPL7L1	ZBTB24	psi-mi:“MI:0914”(association)	0.530
ZBTB24	CBX6	psi-mi:“MI:0914”(association)	0.530

BioGRID (267): RPL7L1 (Affinity Capture-MS), RPL7L1 (Affinity Capture-MS), RPL7L1 (Affinity Capture-MS), RPL7L1 (Affinity Capture-MS), RPL7L1 (Affinity Capture-MS), RPL7L1 (Affinity Capture-MS), RPL7L1 (Affinity Capture-MS), RPL7L1 (Affinity Capture-MS), RPL7L1 (Affinity Capture-MS), RPL7L1 (Affinity Capture-MS), RPL7L1 (Affinity Capture-MS), RPL7L1 (Affinity Capture-MS), RPL7L1 (Affinity Capture-MS), RPL7L1 (Affinity Capture-MS), RPL7L1 (Affinity Capture-MS)

ESM2 similar proteins: A0A1D8PDL6, A0A1D8PK43, A0BD73, A0CEY2, A5GFQ0, A9A597, O01802, O42848, O42991, O43004, O60143, P05426, P05737, P0CX49, P0CX50, P0DJ13, P0DJ15, P0DJ17, P11874, P14148, P17937, P18124, P25457, P26784, P26785, P32100, P32101, P60039, P60040, Q12213, Q12ZT0, Q27389, Q4DZP2, Q4R506, Q58DT1, Q5AB87, Q5R9R4, Q5RAH8, Q5ZJ56, Q6BIF5

Diamond homologs: A0A1D8PDL6, A0BD73, A0CEY2, A5GFQ0, G1SV32, O01802, O60143, P05426, P05737, P0DJ13, P11874, P14148, P17937, P18124, P25457, P32100, P32101, P32102, P40693, P60039, P60040, Q12213, Q4R506, Q58DT1, Q5R9R4, Q5RAH8, Q5ZJ56, Q6BIF5, Q6BTA4, Q6C603, Q6DKI1, Q6FS36, Q6FSN6, Q755A7, Q75ET5, Q7SBD5, Q8SS93, Q9D8M4, Q9HH78, Q9LHP1

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 149 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	18	25.4×	8e-19
Viral mRNA Translation	18	25.4×	8e-19
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	18	25.1×	8e-19
Selenocysteine synthesis	18	24.0×	1e-18
Eukaryotic Translation Termination	18	24.0×	1e-18
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	18	23.6×	1e-18
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	18	23.6×	1e-18
Formation of a pool of free 40S subunits	18	22.4×	2e-18

GO biological processes:

GO term	Partners	Fold	FDR
ribosomal large subunit biogenesis	8	26.9×	7e-08
cytoplasmic translation	18	25.2×	8e-18
ribosomal small subunit biogenesis	11	19.0×	2e-09
rRNA processing	14	15.0×	1e-10
translation	19	14.8×	1e-14
negative regulation of translation	6	8.9×	4e-03
regulation of cell cycle	9	5.1×	5e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

51 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	40
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1103 predictions. Top by Δscore:

Variant	Effect	Δscore
6:42883446:TGTA:T	acceptor_loss	1.0000
6:42883447:GTAGC:G	acceptor_loss	1.0000
6:42883448:TA:T	acceptor_loss	1.0000
6:42883449:A:AG	acceptor_gain	1.0000
6:42883449:A:C	acceptor_loss	1.0000
6:42883450:G:GT	acceptor_gain	1.0000
6:42883450:GC:G	acceptor_gain	1.0000
6:42883450:GCA:G	acceptor_gain	1.0000
6:42883450:GCAGA:G	acceptor_gain	1.0000
6:42883610:GAAAG:G	donor_gain	1.0000
6:42883615:G:GA	donor_loss	1.0000
6:42883615:G:GG	donor_gain	1.0000
6:42883616:T:G	donor_loss	1.0000
6:42884607:TTTCA:T	acceptor_loss	1.0000
6:42884608:TTCAG:T	acceptor_loss	1.0000
6:42884609:TCAGG:T	acceptor_loss	1.0000
6:42884610:CAGGA:C	acceptor_loss	1.0000
6:42884611:A:AC	acceptor_loss	1.0000
6:42884611:AG:A	acceptor_gain	1.0000
6:42884612:G:GT	acceptor_loss	1.0000
6:42884612:GG:G	acceptor_gain	1.0000
6:42884746:TGGGG:T	donor_gain	1.0000
6:42884747:GGGG:G	donor_gain	1.0000
6:42884747:GGGGG:G	donor_gain	1.0000
6:42884748:GGG:G	donor_gain	1.0000
6:42884748:GGGG:G	donor_gain	1.0000
6:42884749:GG:G	donor_gain	1.0000
6:42884749:GGG:G	donor_gain	1.0000
6:42884750:GG:G	donor_gain	1.0000
6:42885971:T:G	acceptor_gain	1.0000

AlphaMissense

1664 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:42886003:T:C	L160P	0.997
6:42886013:A:C	K163N	0.997
6:42886013:A:T	K163N	0.997
6:42886286:T:C	L197P	0.997
6:42880896:T:C	L26P	0.996
6:42880906:G:C	R29S	0.996
6:42880906:G:T	R29S	0.996
6:42880928:G:C	A37P	0.996
6:42884749:G:A	G150R	0.996
6:42884749:G:C	G150R	0.996
6:42884750:G:A	G150E	0.996
6:42885994:T:A	V157D	0.996
6:42880900:A:C	K27N	0.995
6:42880900:A:T	K27N	0.995
6:42880937:G:C	A40P	0.995
6:42884746:T:A	W149R	0.995
6:42884746:T:C	W149R	0.995
6:42885997:G:C	R158P	0.995
6:42886012:A:T	K163I	0.995
6:42886015:G:C	R164P	0.995
6:42886018:G:A	G165E	0.995
6:42886061:T:A	N179K	0.995
6:42886061:T:G	N179K	0.995
6:42884741:T:A	V147E	0.994
6:42886014:C:A	R164S	0.994
6:42886273:T:C	C193R	0.994
6:42886283:A:C	D196A	0.994
6:42880927:A:C	K36N	0.993
6:42880927:A:T	K36N	0.993
6:42885979:C:A	P152Q	0.993

dbSNP variants (sampled 300 via entrez): RS1000375280 (6:42886954 A>G), RS1000572564 (6:42882413 G>A), RS1000639245 (6:42881319 G>A,C), RS1000677699 (6:42888457 T>A), RS1001010086 (6:42879502 C>T), RS1001229813 (6:42879770 A>T), RS1001249048 (6:42880221 C>T), RS1001309879 (6:42885726 G>T), RS1001347714 (6:42885756 C>T), RS1001378861 (6:42885484 A>G), RS1001575854 (6:42880367 C>T), RS1001656053 (6:42885503 C>G,T), RS1003140580 (6:42885104 T>C,G), RS1003223887 (6:42889812 C>T), RS1003363609 (6:42888994 A>G)

Disease associations

OMIM: gene MIM:617417 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST002449_4	Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid)	2.000000e-06
GCST007876_88	Estimated glomerular filtration rate	3.000000e-28

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0005680	omega-6 polyunsaturated fatty acid measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	decreases expression, affects expression, increases abundance	3
Particulate Matter	decreases expression, increases abundance, affects cotreatment	2
aristolochic acid I	increases expression	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
deoxynivalenol	increases expression	1
trichostatin A	affects expression	1
sodium arsenite	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
chloropicrin	increases expression	1
ICG 001	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Benzo(a)pyrene	increases methylation	1
Cadmium	increases abundance, increases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Diethylhexyl Phthalate	increases expression	1
Gasoline	affects cotreatment, decreases expression, increases abundance	1
Hydrogen Peroxide	affects expression	1
Ozone	affects expression, increases abundance	1
Plant Extracts	affects cotreatment, increases expression	1
Polycyclic Aromatic Hydrocarbons	increases abundance, affects cotreatment, decreases expression	1
Ribonucleotides	affects binding	1
Rotenone	increases expression	1
Smoke	decreases expression, increases abundance	1
Thiram	decreases expression	1
Tretinoin	decreases expression	1
Aflatoxin B1	affects cotreatment, decreases expression	1
Asbestos, Crocidolite	decreases expression	1
Antirheumatic Agents	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.