RPPH1

Summary

RPPH1 (ribonuclease P RNA component H1, HGNC:19273) is a gene on chromosome 14q11.2.

H1RNA is the RNA component of the RNase P ribonucleoprotein, an endoribonuclease that cleaves tRNA precursor molecules to form the mature 5-prime termini of their tRNA sequences (Baer et al., 1989 [PubMed 2308839]).

Source: NCBI Gene 85495 — RefSeq curated summary.

At a glance

• Gene type: non-coding (ribozyme) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19273
Approved symbol	RPPH1
Name	ribonuclease P RNA component H1
Location	14q11.2
Locus type	RNA, misc
Status	Approved
Aliases	H1RNA, RPPH1-1
Ensembl gene	ENSG00000277209
Ensembl biotype	ribozyme
OMIM	608513
Entrez	85495
RNAcentral	URS000013F331 — ncRNA, 341 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 ribozyme

ENST00000516869

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000516869 — 1 exons

Exon	Start	End
ENSE00002089146	20343075	20343407

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 99.98.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 120.3404 / max 1935.5762, expressed in 1827 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
142019	90.2704	1825
142018	30.0700	1754

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	99.98	gold quality
colonic epithelium	UBERON:0000397	99.96	gold quality
adrenal tissue	UBERON:0018303	99.96	gold quality
bone marrow cell	CL:0002092	99.95	gold quality
sural nerve	UBERON:0015488	99.83	gold quality
primary visual cortex	UBERON:0002436	98.33	gold quality
hindlimb stylopod muscle	UBERON:0004252	97.26	gold quality
superior frontal gyrus	UBERON:0002661	96.93	gold quality
monocyte	CL:0000576	90.79	gold quality
leukocyte	CL:0000738	89.32	gold quality
cortex of kidney	UBERON:0001225	88.66	gold quality
blood	UBERON:0000178	88.49	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.31	gold quality
kidney	UBERON:0002113	88.03	gold quality
tonsil	UBERON:0002372	87.39	gold quality
bone marrow	UBERON:0002371	87.30	gold quality
right hemisphere of cerebellum	UBERON:0014890	87.30	gold quality
skeletal muscle tissue	UBERON:0001134	87.19	gold quality
liver	UBERON:0002107	85.69	gold quality
cerebellar cortex	UBERON:0002129	85.59	gold quality
cerebellum	UBERON:0002037	85.55	gold quality
cerebellar hemisphere	UBERON:0002245	85.11	gold quality
mucosa of transverse colon	UBERON:0004991	84.38	gold quality
adult mammalian kidney	UBERON:0000082	84.13	gold quality
putamen	UBERON:0001874	83.31	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.02	gold quality
caudate nucleus	UBERON:0001873	80.95	gold quality
right frontal lobe	UBERON:0002810	80.91	gold quality
brain	UBERON:0000955	80.08	gold quality
frontal cortex	UBERON:0001870	79.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• LncRNA RPPH1 promotes colorectal cancer metastasis by interacting with TUBB3 and by promoting exosomes-mediated macrophage M2 polarization. (PMID:31685807)
• LncRNA Rpph1 protects amyloid-beta induced neuronal injury in SK-N-SH cells via miR-122/Wnt1 axis. (PMID:31718352)
• LncRNA RPPH1 attenuates Abeta25-35-induced endoplasmic reticulum stress and apoptosis in SH-SY5Y cells via miR-326/PKM2. (PMID:32336203)
• Value of long non-coding RNA Rpph1 in esophageal cancer and its effect on cancer cell sensitivity to radiotherapy. (PMID:32351293)
• LncRNA RPPH1 predicts poor prognosis and regulates cell proliferation and migration by repressing P21 expression in gastric cancer. (PMID:33215423)
• Accumulation of Mitochondrial RPPH1 RNA Is Associated with Cellular Senescence. (PMID:33466722)
• PUM1 and RNase P genes as potential cell-free DNA markers in breast cancer. (PMID:33522650)
• Mediation of circ_RPPH1 on miR-146b-3p/E2F2 pathway to hinder the growth and metastasis of breast carcinoma cells. (PMID:34433131)
• CircRPPH1 promotes the stemness of gastric cancer cells by targeting miR-375/SLC7A11 axis. (PMID:36190453)
• C-Fos-activated circRPPH1 contributes to glioma stemness. (PMID:36454517)
• LncRNA RPPH1 acts as a molecular sponge for miR-122 to regulate Wnt1/beta-catenin signaling in hepatocellular carcinoma. (PMID:36619232)
• Diagnostic and prognostic value of deregulated long non-coding RNA RPPH1 in patients with severe community-acquired pneumonia: a retrospective cohort study. (PMID:37291525)
• The long non-coding RPPH1 is decreased in leukocytes and increased in plasma from women developing pre-eclampsiadagger. (PMID:38685609)
• Circ_RPPH1 facilitates progression of breast cancer via miR-1296-5p/TRIM14 axis. (PMID:38816350)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.