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RPS19BP1

gene
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Also known as AROSFLJ21770MGC52010

Summary

RPS19BP1 (ribosomal protein S19 binding protein 1, HGNC:28749) is a protein-coding gene on chromosome 22q13.1, encoding Active regulator of SIRT1 (Q86WX3). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. It is a selective cancer dependency (DepMap: 64.0% of cell lines).

Enables enzyme binding activity. Involved in ribosomal small subunit biogenesis. Located in cytosol; nucleolus; and nucleoplasm. Part of small-subunit processome.

Source: NCBI Gene 91582 — RefSeq curated summary.

At a glance

  • GWAS associations: 4
  • Clinical variants (ClinVar): 21 total
  • Cancer dependency (DepMap): dependent in 64.0% of screened cell lines
  • MANE Select transcript: NM_194326

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:28749
Approved symbolRPS19BP1
Nameribosomal protein S19 binding protein 1
Location22q13.1
Locus typegene with protein product
StatusApproved
AliasesAROS, FLJ21770, MGC52010
Ensembl geneENSG00000187051
Ensembl biotypeprotein_coding
OMIM610225
Entrez91582

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 4 retained_intron, 3 protein_coding, 1 nonsense_mediated_decay

ENST00000334678, ENST00000420879, ENST00000459956, ENST00000472291, ENST00000488602, ENST00000491966, ENST00000919332, ENST00000919333

RefSeq mRNA: 1 — MANE Select: NM_194326 NM_194326

CCDS: CCDS13997

Canonical transcript exons

ENST00000334678 — 4 exons

ExonStartEnd
ENSE000013389973953268739532748
ENSE000018260883952909339529623
ENSE000034654093953239539532523
ENSE000035354133952982039529917

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 97.75.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 65.1602 / max 327.0438, expressed in 1827 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter IDTPM avgSamples expressed
19429363.88951826
1942941.1509803
1942950.119865

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
muscle layer of sigmoid colonUBERON:003580597.75gold quality
lower esophagus muscularis layerUBERON:003583397.73gold quality
C1 segment of cervical spinal cordUBERON:000646997.72gold quality
lower esophagusUBERON:001347397.72gold quality
lower esophagus mucosaUBERON:003583497.71gold quality
mucosa of transverse colonUBERON:000499197.68gold quality
anterior cingulate cortexUBERON:000983597.67gold quality
esophagogastric junction muscularis propriaUBERON:003584197.61gold quality
right adrenal glandUBERON:000123397.57gold quality
left adrenal glandUBERON:000123497.53gold quality
body of stomachUBERON:000116197.51gold quality
left adrenal gland cortexUBERON:003582597.49gold quality
apex of heartUBERON:000209897.45gold quality
right frontal lobeUBERON:000281097.43gold quality
right adrenal gland cortexUBERON:003582797.42gold quality
left coronary arteryUBERON:000162697.38gold quality
prefrontal cortexUBERON:000045197.29gold quality
metanephros cortexUBERON:001053397.28gold quality
amygdalaUBERON:000187697.27gold quality
body of pancreasUBERON:000115097.24gold quality
Brodmann (1909) area 9UBERON:001354097.23gold quality
right lobe of thyroid glandUBERON:000111997.22gold quality
left lobe of thyroid glandUBERON:000112097.20gold quality
right lobe of liverUBERON:000111497.13gold quality
coronary arteryUBERON:000162197.06gold quality
hypothalamusUBERON:000189897.06gold quality
adrenal cortexUBERON:000123597.01gold quality
spinal cordUBERON:000224096.98gold quality
tibial nerveUBERON:000132396.97gold quality
ascending aortaUBERON:000149696.97gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 2.

ExperimentMarker?Max mean expression
E-MTAB-8205yes286.04
E-ANND-3yes13.68
E-MTAB-6524no252.66
E-GEOD-93593no6.89

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

14 targeting RPS19BP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-426799.9666.532368
HSA-MIR-23A-3P99.9574.243163
HSA-MIR-23B-3P99.9574.243163
HSA-MIR-23C99.9573.923192
HSA-MIR-472999.6972.184233
HSA-MIR-613299.6065.831554
HSA-MIR-6836-5P99.6065.621538
HSA-MIR-425499.1165.151315
HSA-MIR-939-3P98.9765.072347
HSA-MIR-570198.9769.541502
HSA-MIR-5088-5P97.9764.28487
HSA-MIR-6736-3P96.9865.221342
HSA-MIR-6858-3P96.3764.41771
HSA-MIR-1180-3P95.9866.8865

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 64.0% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 8)

  • Active regulator of SIRT1 (AROS) is the first direct SIRT1 regulator to be identified that modulates p53-mediated growth regulation. (PMID:17964266)
  • we found that the SIRT1 modulators AROS and DBC1 have an impact on hsp70 transcription, HSF1 acetylation status, and HSF1 recruitment to the hsp70 promoter. (PMID:23349863)
  • This study analyses Sirt1 modulation by several putative Sirt1 regulators, showing that the regulator protein AROS has an unusual conformation and that the Sirt1 catalytic domain is sufficient for modulation by resveratrol. (PMID:23548308)
  • study demonstrated a cancer-specific role for AROS in the regulation of survival in a panel of human cell lines; data suggest that AROS, as well as SIRT1, promotes survival in cancer cells while being redundant for viability in non-cancer cells (PMID:24258275)
  • In vitro SIRT1 activity assays disclose AROS as an inhibitor of SIRT1. (PMID:24681097)
  • AROS is a significant biomarker for tumor aggressiveness in non-cirrhotic hepatocellular carcinoma. (PMID:26339164)
  • Results provide evidence that RomA methylates AROS, a nonhistone target, during infection of human cells. (PMID:29733858)
  • Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein. (PMID:36361557)

Cross-species orthologs

3 orthologs

OrganismSymbolGene ID
danio_reriorps19bp1ENSDARG00000091124
mus_musculusRps19bp1ENSMUSG00000051518
rattus_norvegicusRps19bp1ENSRNOG00000017847

Protein

Protein identifiers

Active regulator of SIRT1 — Q86WX3 (reviewed: Q86WX3)

Alternative names: 40S ribosomal protein S19-binding protein 1

All UniProt accessions (2): Q86WX3, F8WFE7

UniProt curated annotations — full annotation on UniProt →

Function. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1. Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity.

Subunit / interactions. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with RPS19; the interaction is direct and mediates the integration of RPS19 in state post-A1. Interacts with SIRT1.

Subcellular location. Nucleus. Nucleolus.

Tissue specificity. Widely expressed (at protein level).

Post-translational modifications. Citrullinated by PADI4.

Similarity. Belongs to the AROS family.

RefSeq proteins (1): NP_919307* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR023262AROSFamily

Pfam: PF15684

UniProt features (5 total): modified residue 2, chain 1, region of interest 1, sequence variant 1

Structure

Experimental structures (PDB)

2 structures.

PDBMethodResolution (Å)
7MQAELECTRON MICROSCOPY2.7
8BBKX-RAY DIFFRACTION3.27

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q86WX3-F174.500.07

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 7, 84

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

IDPathway
R-HSA-3371453Regulation of HSF1-mediated heat shock response
R-HSA-2262752Cellular responses to stress
R-HSA-3371556Cellular response to heat stress
R-HSA-8953897Cellular responses to stimuli

MSigDB gene sets: 76 (showing top): GOBP_RIBOSOME_BIOGENESIS, WEI_MYCN_TARGETS_WITH_E_BOX, GOBP_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS, DOUGLAS_BMI1_TARGETS_UP, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, GOCC_PRERIBOSOME, GOCC_SMALL_SUBUNIT_PROCESSOME, chr22q13, GOCC_NUCLEOLUS, GOCC_RIBONUCLEOPROTEIN_COMPLEX, SCGGAAGY_ELK1_02, LU_EZH2_TARGETS_UP, PECE_MAMMARY_STEM_CELL_UP, REACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE, REACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

GO Biological Process (1): ribosomal small subunit biogenesis (GO:0042274)

GO Molecular Function (3): RNA binding (GO:0003723), enzyme binding (GO:0019899), protein binding (GO:0005515)

GO Cellular Component (5): nucleoplasm (GO:0005654), nucleolus (GO:0005730), cytosol (GO:0005829), small-subunit processome (GO:0032040), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-3 pathways:

CategoryPathways
Cellular response to heat stress1
Cellular responses to stimuli1
Cellular responses to stress1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
nuclear lumen2
cellular anatomical structure2
ribonucleoprotein complex biogenesis1
ribosome biogenesis1
nucleic acid binding1
protein binding1
binding1
intracellular membraneless organelle1
cytoplasm1
nucleolus1
preribosome1
t-UTP complex1
nuclear protein-containing complex1
intracellular membrane-bounded organelle1

Protein interactions and networks

STRING

812 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
RPS19BP1SIRT1Q96EB6792
RPS19BP1CCAR2Q8N163771
RPS19BP1RPS19P39019709
RPS19BP1NAMPTP43490575
RPS19BP1SIRT3Q9NTG7559
RPS19BP1SENP1Q9P0U3559
RPS19BP1NMNAT1Q9HAN9554
RPS19BP1RPL7AP11518549
RPS19BP1RPS3AP33443548
RPS19BP1SIRT2Q8IXJ6506
RPS19BP1ELAVL1Q15717506
RPS19BP1XRCC6P12956456
RPS19BP1CRTC2Q53ET0431
RPS19BP1ERO1AQ96HE7428
RPS19BP1UBE4BO95155424

IntAct

66 interactions, top by confidence:

ABTypeScore
RPS19BP1SIRT1psi-mi:“MI:0915”(physical association)0.730
SIRT1RPS19BP1psi-mi:“MI:0915”(physical association)0.730
RPS19BP1SIRT1psi-mi:“MI:0403”(colocalization)0.730
SIRT1RPS19BP1psi-mi:“MI:0407”(direct interaction)0.730
CBX3E2F6psi-mi:“MI:0914”(association)0.640
SIAH1RPS19BP1psi-mi:“MI:0915”(physical association)0.560
RPS19BP1psi-mi:“MI:0915”(physical association)0.560
RPS19BP1psi-mi:“MI:0915”(physical association)0.560
RPS19BP1SIAH1psi-mi:“MI:0915”(physical association)0.560
KRTAP10-8RPS19BP1psi-mi:“MI:0915”(physical association)0.560
NOTCH2NLCRPS19BP1psi-mi:“MI:0915”(physical association)0.560
ADAMTSL4RPS19BP1psi-mi:“MI:0915”(physical association)0.560
KRTAP1-3RPS19BP1psi-mi:“MI:0915”(physical association)0.560
KRT31RPS19BP1psi-mi:“MI:0915”(physical association)0.560
KRTAP1-1RPS19BP1psi-mi:“MI:0915”(physical association)0.560
CYSRT1RPS19BP1psi-mi:“MI:0915”(physical association)0.560
MTUS2RPS19BP1psi-mi:“MI:0915”(physical association)0.560
RPS19BP1HALpsi-mi:“MI:0915”(physical association)0.560
RPS19BP1DCTN6psi-mi:“MI:0914”(association)0.530
Cbx1psi-mi:“MI:0914”(association)0.350

BioGRID (116): RPS19BP1 (Two-hybrid), RPS19BP1 (Reconstituted Complex), RPS19BP1 (Affinity Capture-Western), SIRT1 (Affinity Capture-Western), RPS19BP1 (Two-hybrid), KRTAP10-3 (Two-hybrid), RPS19BP1 (Affinity Capture-MS), RPS19BP1 (Affinity Capture-MS), RPS19BP1 (Affinity Capture-MS), RPS19BP1 (Affinity Capture-MS), RPS19BP1 (Affinity Capture-MS), RPS19BP1 (Affinity Capture-MS), RPS19BP1 (Affinity Capture-MS), RPS19BP1 (Affinity Capture-MS), RPS19BP1 (Affinity Capture-MS)

ESM2 similar proteins: A0JNL1, A1L2F3, A6H7J2, A9C3N6, B5G1P1, B5X7E4, B5XBI1, E7F5E1, O14279, P58468, P86346, Q07FY3, Q0P4A6, Q28E54, Q28IC1, Q2TBN9, Q2YDJ0, Q3UY34, Q58CQ0, Q5BK57, Q5EAY2, Q5FWN9, Q5I034, Q5ZMG5, Q62627, Q751T1, Q7TT28, Q7ZWE7, Q80VC9, Q86WX3, Q8C3W1, Q8C5R2, Q8C6B9, Q8K0S9, Q8N1G1, Q8N6N3, Q8NEG2, Q8WUQ7, Q96C57, Q96FT9

Diamond homologs: A6H7J2, Q28IC1, Q5ZMG5, Q86WX3, Q8C6B9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

21 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance16
Likely benign2
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

655 predictions. Top by Δscore:

VariantEffectΔscore
22:39529831:CAGA:Cdonor_gain1.0000
22:39529839:G:Cdonor_gain1.0000
22:39529913:CTCGT:Cacceptor_gain1.0000
22:39529915:CGT:Cacceptor_gain1.0000
22:39529915:CGTCT:Cacceptor_loss1.0000
22:39529916:GTC:Gacceptor_loss1.0000
22:39529918:C:CAacceptor_loss1.0000
22:39529918:C:CCacceptor_gain1.0000
22:39532389:ACTT:Adonor_loss1.0000
22:39532391:TTACC:Tdonor_loss1.0000
22:39532392:TA:Tdonor_loss1.0000
22:39532393:A:ACdonor_gain1.0000
22:39532393:AC:Adonor_gain1.0000
22:39532394:C:CCdonor_gain1.0000
22:39532394:C:Gdonor_loss1.0000
22:39532394:CC:Cdonor_gain1.0000
22:39532519:GGGGG:Gacceptor_gain1.0000
22:39532520:GGGG:Gacceptor_gain1.0000
22:39532521:GGG:Gacceptor_gain1.0000
22:39532522:GG:Gacceptor_gain1.0000
22:39532524:C:CCacceptor_gain1.0000
22:39532526:G:Cacceptor_gain1.0000
22:39532526:G:GCacceptor_gain1.0000
22:39532685:AC:Adonor_gain1.0000
22:39532686:CC:Cdonor_gain1.0000
22:39529633:G:Cacceptor_gain0.9900
22:39529815:CCAA:Cdonor_loss0.9900
22:39529818:A:Tdonor_loss0.9900
22:39529819:CCTG:Cdonor_gain0.9900
22:39529820:C:Gdonor_loss0.9900

AlphaMissense

859 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
22:39529516:G:CF129L0.997
22:39529516:G:TF129L0.997
22:39529517:A:GF129S0.997
22:39529518:A:GF129L0.997
22:39529540:G:CF121L0.997
22:39529540:G:TF121L0.997
22:39529542:A:GF121L0.997
22:39529541:A:GF121S0.996
22:39529517:A:CF129C0.994
22:39529525:G:CF126L0.994
22:39529525:G:TF126L0.994
22:39529526:A:GF126S0.994
22:39529527:A:GF126L0.994
22:39529526:A:CF126C0.991
22:39529506:A:GY133H0.990
22:39529541:A:CF121C0.990
22:39529602:G:TR101S0.985
22:39529622:A:GI94T0.982
22:39529542:A:CF121V0.981
22:39532714:C:GG9R0.981
22:39529505:T:GY133S0.980
22:39529542:A:TF121I0.980
22:39529506:A:CY133D0.979
22:39529501:G:CF134L0.977
22:39529501:G:TF134L0.977
22:39529503:A:GF134L0.977
22:39529505:T:CY133C0.974
22:39529518:A:CF129V0.973
22:39529874:G:CN75K0.966
22:39529874:G:TN75K0.966

dbSNP variants (sampled 300 via entrez): RS1000258840 (22:39533220 A>G,T), RS1000596569 (22:39534577 T>A), RS1000822683 (22:39529237 C>G,T), RS1000962710 (22:39530995 C>G,T), RS1001081913 (22:39530816 G>C), RS1001336993 (22:39532519 G>A,T), RS1002523965 (22:39532691 G>A,C), RS1002986486 (22:39532805 G>A,T), RS1004334362 (22:39531337 T>C), RS1004601488 (22:39532535 G>A), RS1004666727 (22:39531054 G>A), RS1004973802 (22:39532278 A>G), RS1005034972 (22:39532896 G>A), RS1005372253 (22:39534111 G>C), RS1005497273 (22:39533109 A>G)

Disease associations

OMIM: gene MIM:610225 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

StudyTraitp-value
GCST005316_261Intelligence (MTAG)5.000000e-08
GCST005316_266Intelligence (MTAG)5.000000e-08
GCST006803_27Schizophrenia2.000000e-12
GCST009600_37Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy)9.000000e-11

EFO canonical traits (1, from GWAS)

EFO IDTrait name
EFO:0004337intelligence

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

18 total (human), top 18 by PubMed support.

ChemicalActions (top 5)PubMed papers
Valproic Acidaffects cotreatment, increases expression, increases methylation2
aristolochic acid Iincreases expression1
triphenyl phosphateaffects expression1
bisphenol Adecreases expression1
beta-lapachonedecreases expression1
arseniteaffects binding, increases reaction1
sodium arseniteincreases expression1
K 7174decreases expression1
ICG 001decreases expression1
Doxorubicinincreases expression1
Hydralazineaffects cotreatment, increases expression1
Ribonucleotidesaffects binding1
Smokedecreases expression1
Tobacco Smoke Pollutionincreases expression1
Urethaneincreases expression1
Cyclosporineincreases expression1
Aflatoxin B1increases expression1
Cadmium Chlorideincreases expression1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot