RRP15

Summary

RRP15 (ribosomal RNA processing 15 homolog, HGNC:24255) is a protein-coding gene on chromosome 1q41, encoding RRP15-like protein (Q9Y3B9). It is a common-essential gene (DepMap: required in 94.2% of cancer cell lines).

This gene encodes a protein that co-purifies with human nucleoli. A similar protein in budding yeast is a component of pre-60S ribosomal particles, and is required for the early maturation steps of the 60S subunit.

Source: NCBI Gene 51018 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 45 total — 2 pathogenic
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 94.2% of screened cell lines (common-essential)
• MANE Select transcript: NM_016052

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24255
Approved symbol	RRP15
Name	ribosomal RNA processing 15 homolog
Location	1q41
Locus type	gene with protein product
Status	Approved
Aliases	CGI-115
Ensembl gene	ENSG00000067533
Ensembl biotype	protein_coding
OMIM	611193
Entrez	51018

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000366932, ENST00000491428, ENST00000925041, ENST00000925042, ENST00000925043, ENST00000925044, ENST00000925045

RefSeq mRNA: 1 — MANE Select: NM_016052 NM_016052

CCDS: CCDS1520

Canonical transcript exons

ENST00000366932 — 5 exons

Exon	Start	End
ENSE00001000133	218305028	218305125
ENSE00001000134	218307431	218307632
ENSE00001000135	218302294	218302559
ENSE00001443017	218330948	218337983
ENSE00001443018	218285293	218285455

Expression profiles

Bgee: expression breadth ubiquitous, 277 present calls, max score 91.50.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 24.4053 / max 997.1908, expressed in 1782 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
8594	24.4053	1782

Top tissues by expression

291 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	91.50	gold quality
oocyte	CL:0000023	90.00	gold quality
calcaneal tendon	UBERON:0003701	89.74	gold quality
cartilage tissue	UBERON:0002418	87.01	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.12	gold quality
germinal epithelium of ovary	UBERON:0001304	85.51	gold quality
gastrocnemius	UBERON:0001388	85.35	gold quality
esophagus squamous epithelium	UBERON:0006920	85.18	gold quality
heart right ventricle	UBERON:0002080	85.11	gold quality
muscle of leg	UBERON:0001383	84.98	gold quality
palpebral conjunctiva	UBERON:0001812	84.29	gold quality
squamous epithelium	UBERON:0006914	84.19	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.86	gold quality
biceps brachii	UBERON:0001507	83.85	gold quality
myocardium	UBERON:0002349	83.64	silver quality
adrenal tissue	UBERON:0018303	83.35	gold quality
muscle organ	UBERON:0001630	83.13	gold quality
gingival epithelium	UBERON:0001949	83.05	gold quality
tendon	UBERON:0000043	83.02	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	82.86	gold quality
oviduct epithelium	UBERON:0004804	82.41	gold quality
amniotic fluid	UBERON:0000173	82.20	gold quality
islet of Langerhans	UBERON:0000006	82.11	gold quality
hindlimb stylopod muscle	UBERON:0004252	82.04	gold quality
nephron tubule	UBERON:0001231	81.95	gold quality
ventricular zone	UBERON:0003053	81.89	gold quality
mucosa of sigmoid colon	UBERON:0004993	81.86	gold quality
epithelium of esophagus	UBERON:0001976	81.84	gold quality
oral cavity	UBERON:0000167	81.56	gold quality
gingiva	UBERON:0001828	81.49	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-HCAD-13	yes	729.84
E-CURD-7	yes	589.96
E-ENAD-21	yes	534.35
E-ANND-3	yes	8.31
E-MTAB-6142	no	53.36

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

315 targeting RRP15, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 94.2% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 5)

• The budding yeast homolog of human RRP15 is required for maturation of 60S ribosomal particles (PMID:15769876)
• Data suggest that ribosomal RNA-processing protein 15 (RRP15) might be a potential target for cancer therapy. (PMID:28099941)
• Inhibition of ribosomal RNA processing 15 Homolog (RRP15), which is overexpressed in hepatocellular carcinoma, suppresses tumour growth via induction of senescence and apoptosis. (PMID:34343634)
• RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated beta-catenin suppression. (PMID:36750557)
• Inhibition of Ribosomal RNA Processing 15 Homolog (RRP15) Suppressed Tumor Growth, Invasion and Epithelial to Mesenchymal Transition (EMT) of Colon Cancer. (PMID:36834940)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	rrp15	ENSDARG00000013478
mus_musculus	Rrp15	ENSMUSG00000001305
rattus_norvegicus	Rrp15	ENSRNOG00000002450
drosophila_melanogaster	CG3817	FBGN0038275

Protein

Protein identifiers

RRP15-like protein — Q9Y3B9 (reviewed: Q9Y3B9)

Alternative names: Ribosomal RNA-processing protein 15

All UniProt accessions (1): Q9Y3B9

UniProt curated annotations — full annotation on UniProt →

Post-translational modifications. Citrullinated by PADI4.

Similarity. Belongs to the RRP15 family.

RefSeq proteins (1): NP_057136* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR012459	Rrp15	Family

Pfam: PF07890

UniProt features (29 total): modified residue 11, cross-link 5, compositionally biased region 4, sequence variant 3, region of interest 2, initiator methionine 1, chain 1, sequence conflict 1, coiled-coil region 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
8FKQ	ELECTRON MICROSCOPY	2.76
8FKP	ELECTRON MICROSCOPY	2.85
8FKS	ELECTRON MICROSCOPY	2.88
8FKR	ELECTRON MICROSCOPY	2.89

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y3B9-F1	67.76	0.15

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (16): 9, 11, 19, 58, 67, 104, 206, 266, 276, 280, 108, 179, 208, 239, 239, 2

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 235 (showing top): GSE45365_NK_CELL_VS_CD11B_DC_DN, ELVIDGE_HYPOXIA_DN, GOBP_RIBOSOME_BIOGENESIS, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, WEI_MYCN_TARGETS_WITH_E_BOX, GOBP_MATURATION_OF_LSU_RRNA, MODULE_171, GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN, GARY_CD5_TARGETS_DN, DODD_NASOPHARYNGEAL_CARCINOMA_UP, TIEN_INTESTINE_PROBIOTICS_24HR_UP, GOBP_MATURATION_OF_5_8S_RRNA, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS

GO Biological Process (3): maturation of 5.8S rRNA (GO:0000460), maturation of LSU-rRNA (GO:0000470), rRNA processing (GO:0006364)

GO Molecular Function (0):

GO Cellular Component (1): preribosome, large subunit precursor (GO:0030687)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
rRNA processing	2
ribosomal large subunit biogenesis	1
RNA processing	1
rRNA metabolic process	1
ribosome biogenesis	1
preribosome	1

Protein interactions and networks

STRING

2296 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RRP15	CSNK2A1	P19138	780
RRP15	SURF6	O75683	774
RRP15	PAK1IP1	Q9NWT1	696
RRP15	GNL2	Q13823	676
RRP15	NSA2	O95478	666
RRP15	EBNA1BP2	Q99848	657
RRP15	NOP2	P46087	647
RRP15	WDR12	Q9GZL7	626
RRP15	SPATA17	Q96L03	625
RRP15	WDR74	Q6RFH5	614
RRP15	GPATCH2	Q9NW75	608
RRP15	NMD3	Q96D46	591
RRP15	RRP12	Q5JTH9	568
RRP15	PWP1	Q13610	558
RRP15	SDAD1	Q9NVU7	557

IntAct

85 interactions, top by confidence:

A	B	Type	Score
SART3	PRPF4	psi-mi:“MI:0914”(association)	0.730
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
RPL28	MAGEB2	psi-mi:“MI:0914”(association)	0.560
PPAN	PPM1G	psi-mi:“MI:0914”(association)	0.530
MAGEB2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
RPL10	RPS6	psi-mi:“MI:0914”(association)	0.350
NOP56	C12orf43	psi-mi:“MI:0914”(association)	0.350
HNRNPU		psi-mi:“MI:0914”(association)	0.350
SGTB	ARHGAP32	psi-mi:“MI:0914”(association)	0.350
SYNCRIP	ARHGAP32	psi-mi:“MI:0914”(association)	0.350
JUN		psi-mi:“MI:0914”(association)	0.350
RRP1B	ZNF785	psi-mi:“MI:0914”(association)	0.350
MKI67	ARHGAP10	psi-mi:“MI:0914”(association)	0.350
OASL	LARP1	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
COPS5	FBLL1	psi-mi:“MI:0914”(association)	0.350
CUL3	PXDNL	psi-mi:“MI:0914”(association)	0.350
PPAN	IGF2BP3	psi-mi:“MI:0914”(association)	0.350
C6orf11	RRP8	psi-mi:“MI:0914”(association)	0.350
TAF1D		psi-mi:“MI:0914”(association)	0.350
USP2	LONP1	psi-mi:“MI:0914”(association)	0.350
PTPN6	RPL35A	psi-mi:“MI:0914”(association)	0.350
N	POLRMT	psi-mi:“MI:0914”(association)	0.350
N	MRPL45	psi-mi:“MI:0914”(association)	0.350
EIF2AK2	NKRF	psi-mi:“MI:0914”(association)	0.350
SYK	PLEKHD1	psi-mi:“MI:0914”(association)	0.350
SRPK1	SNRPGP15	psi-mi:“MI:0914”(association)	0.350

BioGRID (183): RRP15 (Affinity Capture-MS), RRP15 (Affinity Capture-MS), DDX27 (Co-fractionation), DDX54 (Co-fractionation), NIFK (Co-fractionation), PAK1IP1 (Co-fractionation), RBM28 (Co-fractionation), RPF2 (Co-fractionation), RRP15 (Co-fractionation), RRP15 (Co-fractionation), RRP15 (Co-fractionation), RRP15 (Co-fractionation), RRP15 (Proximity Label-MS), RRP15 (Affinity Capture-MS), RRP15 (Affinity Capture-MS)

ESM2 similar proteins: A0AUP1, A4II15, A7MCB7, E1C760, F6RRD7, F7AEX0, P14629, P78316, Q1L8X2, Q28DG8, Q2IA00, Q3T071, Q3U155, Q3ZCI6, Q4R6T7, Q4R8R3, Q4R8V8, Q4V7N4, Q5PQS7, Q5R939, Q5RA37, Q5XI65, Q5ZIH9, Q5ZIM6, Q6DFL5, Q6IEG0, Q6PBE2, Q6PII3, Q7SYB2, Q7ZXA8, Q80VN0, Q8C6C7, Q8C9J3, Q8CIL4, Q8IXW5, Q8R3N1, Q8R3N6, Q8VYD3, Q93VM9, Q95JM8

Diamond homologs: P91318, Q3T062, Q5M947, Q61RF0, Q7ZV20, Q9CYX7, Q9Y3B9, Q296J6, Q9VFE6

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 115 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	17	28.8×	9e-19
Viral mRNA Translation	17	28.8×	9e-19
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	17	28.4×	9e-19
Selenocysteine synthesis	17	27.2×	1e-18
Eukaryotic Translation Termination	17	27.2×	1e-18
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	17	26.7×	1e-18
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	17	26.7×	1e-18
Formation of a pool of free 40S subunits	17	25.4×	3e-18

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	19	33.8×	2e-21
ribosomal large subunit biogenesis	7	29.9×	4e-07
ribosomal small subunit biogenesis	10	21.9×	5e-09
translation	19	18.8×	1e-16
negative regulation of viral genome replication	5	18.0×	6e-04
rRNA processing	13	17.7×	9e-11
negative regulation of translation	8	15.1×	6e-06
RNA processing	6	12.6×	6e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

45 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	0
Uncertain significance	33
Likely benign	0
Benign	1

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
1199385	Single allele	Pathogenic
565226	GRCh37/hg19 1q41(chr1:218486800-218632368)x1	Pathogenic

SpliceAI

1297 predictions. Top by Δscore:

Variant	Effect	Δscore
1:218285453:AAG:A	donor_gain	1.0000
1:218285453:AAGGT:A	donor_loss	1.0000
1:218285454:AG:A	donor_loss	1.0000
1:218285455:GGTAA:G	donor_loss	1.0000
1:218285456:G:C	donor_loss	1.0000
1:218285457:T:G	donor_loss	1.0000
1:218302283:T:TA	acceptor_gain	1.0000
1:218302284:G:A	acceptor_gain	1.0000
1:218302289:TATA:T	acceptor_loss	1.0000
1:218302290:A:AG	acceptor_gain	1.0000
1:218302291:T:G	acceptor_gain	1.0000
1:218302292:A:AG	acceptor_gain	1.0000
1:218302292:AG:A	acceptor_gain	1.0000
1:218302293:G:GT	acceptor_gain	1.0000
1:218302293:GG:G	acceptor_gain	1.0000
1:218302293:GGA:G	acceptor_gain	1.0000
1:218302293:GGAA:G	acceptor_gain	1.0000
1:218307425:CTACA:C	acceptor_loss	1.0000
1:218307430:GGGGT:G	acceptor_gain	1.0000
1:218307611:G:GT	donor_gain	1.0000
1:218307630:CAGGT:C	donor_loss	1.0000
1:218307631:AGGT:A	donor_loss	1.0000
1:218307632:GGTAA:G	donor_loss	1.0000
1:218307633:G:T	donor_loss	1.0000
1:218307634:T:A	donor_loss	1.0000
1:218317413:G:GT	donor_gain	1.0000
1:218330936:A:AG	acceptor_gain	1.0000
1:218331036:A:T	donor_gain	1.0000
1:218331102:G:GT	donor_gain	1.0000
1:218331103:A:T	donor_gain	1.0000

AlphaMissense

1900 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:218307453:G:C	A176P	0.999
1:218307457:T:A	V177D	0.999
1:218305119:C:A	A166E	0.998
1:218307433:G:A	G169D	0.998
1:218307445:T:C	L173S	0.998
1:218307447:T:C	F174L	0.998
1:218307449:T:A	F174L	0.998
1:218307449:T:G	F174L	0.998
1:218330978:T:A	W246R	0.998
1:218330978:T:C	W246R	0.998
1:218331028:G:C	W262C	0.998
1:218331028:G:T	W262C	0.998
1:218305107:T:C	L162P	0.997
1:218305118:G:C	A166P	0.997
1:218307432:G:C	G169R	0.997
1:218307448:T:C	F174S	0.997
1:218307555:T:C	F210L	0.997
1:218307556:T:C	F210S	0.997
1:218307557:C:A	F210L	0.997
1:218307557:C:G	F210L	0.997
1:218330980:G:C	W246C	0.997
1:218330980:G:T	W246C	0.997
1:218331026:T:A	W262R	0.997
1:218331026:T:C	W262R	0.997
1:218307447:T:A	F174I	0.996
1:218307454:C:A	A176D	0.996
1:218307568:T:C	L214S	0.996
1:218302428:T:A	W92R	0.995
1:218302428:T:C	W92R	0.995
1:218307439:T:A	V171E	0.995

dbSNP variants (sampled 300 via entrez): RS1000084257 (1:218334567 A>G,T), RS1000119690 (1:218314450 G>A,T), RS1000172028 (1:218318303 CT>C), RS1000174107 (1:218314132 G>A,T), RS1000212412 (1:218294503 A>G,T), RS1000346425 (1:218333433 A>G), RS1000401757 (1:218320497 A>T), RS1000439863 (1:218299141 A>C), RS1000453435 (1:218315652 C>T), RS1000491125 (1:218296312 T>G), RS1000510777 (1:218316904 T>C), RS1000682541 (1:218322677 C>G), RS1000749644 (1:218320807 C>A), RS1000811660 (1:218328589 G>C), RS1000913554 (1:218302950 G>A,C)

Disease associations

OMIM: gene MIM:611193 | disease phenotypes: MIM:614816

GenCC curated gene-disease

Mondo (1): Loeys-Dietz syndrome 4 (MONDO:0013897)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST002481_4	Acne (severe)	4.000000e-08
GCST007692_9	Chronic obstructive pulmonary disease	5.000000e-06
GCST90000025_852	Appendicular lean mass	3.000000e-11
GCST90020028_457	Hip circumference adjusted for BMI	3.000000e-08

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004980	appendicular lean mass
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067113 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.93	Kd	1177	nM	CHEMBL5653589
5.93	ED50	1177	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149323: Binding affinity to human RRP15 incubated for 45 mins by Kinobead based pull down assay	kd	1.1768	uM

CTD chemical–gene interactions

51 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, affects cotreatment, increases expression, affects expression	6
bisphenol A	decreases expression	2
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression, increases expression	2
Estradiol	increases expression	2
Tetrachlorodibenzodioxin	affects expression, decreases expression	2
Tretinoin	decreases expression	2
Particulate Matter	decreases expression, increases abundance, affects cotreatment	2
afuresertib	decreases expression	1
FR900359	affects phosphorylation	1
alpha phellandrene	decreases expression	1
trichostatin A	decreases expression, increases expression	1
2-butenal	decreases expression	1
arsenite	affects binding, increases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
zinc chloride	decreases expression, decreases reaction	1
sodium arsenite	decreases expression	1
cobaltous chloride	decreases expression, decreases reaction	1
butyraldehyde	decreases expression	1
coumarin	decreases phosphorylation	1
CGP 52608	affects binding, increases reaction	1
dorsomorphin	affects cotreatment, increases expression	1
LDN 193189	affects cotreatment, decreases expression	1
MT19c compound	increases expression	1
3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	decreases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Ethanol	affects cotreatment, decreases expression, increases abundance	1
Atrazine	decreases expression	1
Caffeine	decreases phosphorylation	1
Cisplatin	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652365	Binding	Binding affinity to human RRP15 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.