RSF1-IT2

Summary

RSF1-IT2 (RSF1 intronic transcript 2, HGNC:41438) is a long non-coding RNA gene on chromosome 11q14.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41438
Approved symbol	RSF1-IT2
Name	RSF1 intronic transcript 2
Location	11q14.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000254985
Ensembl biotype	lncRNA
Entrez	100874307
RNAcentral	URS000043545D — lncRNA, 566 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000529656

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000529656 — 2 exons

Exon	Start	End
ENSE00002153428	77717712	77718046
ENSE00002159975	77718181	77718411

Expression profiles

Bgee: expression breadth ubiquitous, 120 present calls, max score 82.47.

Top tissues by expression

120 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.47	gold quality
bone marrow	UBERON:0002371	72.45	gold quality
bone marrow cell	CL:0002092	72.27	silver quality
colonic epithelium	UBERON:0000397	69.47	silver quality
ganglionic eminence	UBERON:0004023	68.14	gold quality
adrenal tissue	UBERON:0018303	67.43	gold quality
muscle tissue	UBERON:0002385	66.01	gold quality
skeletal muscle tissue	UBERON:0001134	64.52	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	64.23	gold quality
cortical plate	UBERON:0005343	62.34	gold quality
hindlimb stylopod muscle	UBERON:0004252	62.13	gold quality
corpus callosum	UBERON:0002336	61.69	gold quality
calcaneal tendon	UBERON:0003701	61.54	gold quality
monocyte	CL:0000576	60.88	gold quality
urinary bladder	UBERON:0001255	59.98	silver quality
tonsil	UBERON:0002372	58.86	silver quality
blood	UBERON:0000178	56.56	gold quality
prefrontal cortex	UBERON:0000451	55.64	gold quality
duodenum	UBERON:0002114	55.33	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	54.69	gold quality
islet of Langerhans	UBERON:0000006	54.68	gold quality
endometrium	UBERON:0001295	53.86	gold quality
lymph node	UBERON:0000029	53.73	gold quality
liver	UBERON:0002107	53.48	silver quality
kidney	UBERON:0002113	53.43	gold quality
placenta	UBERON:0001987	52.72	gold quality
sural nerve	UBERON:0015488	52.49	silver quality
primary visual cortex	UBERON:0002436	51.96	gold quality
gall bladder	UBERON:0002110	51.80	gold quality
cortex of kidney	UBERON:0001225	51.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• HMGB1 regulates SNAI1 during NSCLC metastasis, both directly, through transcriptional activation, and indirectly, in a RSF1-IT2-dependent manner. (PMID:32306523)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.