RSL24D1

Summary

RSL24D1 (ribosomal L24 domain containing 1, HGNC:18479) is a protein-coding gene on chromosome 15q21.3, encoding Probable ribosome biogenesis protein RLP24 (Q9UHA3). Involved in the biogenesis of the 60S ribosomal subunit. It is a common-essential gene (DepMap: required in 100.0% of cancer cell lines).

This gene encodes a protein sharing a low level of sequence similarity with human ribosomal protein L24. Although this gene has been referred to as RPL24, L30, and 60S ribosomal protein L30 isolog in the sequence databases, it is distinct from the human genes officially named RPL24 (which itself has been referred to as ribosomal protein L30) and RPL30. The protein encoded by this gene localizes to the nucleolus and is thought to play a role in the biogenesis of the 60S ribosomal subunit. The precise function of this gene is currently unknown. This gene utilizes alternative polyadenylation signals and has multiple pseudogenes.

Source: NCBI Gene 51187 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 19 total
• Cancer dependency (DepMap): dependent in 100.0% of screened cell lines (common-essential)
• MANE Select transcript: NM_016304

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18479
Approved symbol	RSL24D1
Name	ribosomal L24 domain containing 1
Location	15q21.3
Locus type	gene with protein product
Status	Approved
Aliases	HRP-L30-iso, L30, RPL24L, RPL24
Ensembl gene	ENSG00000137876
Ensembl biotype	protein_coding
OMIM	613262
Entrez	51187

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 8 protein_coding, 2 protein_coding_CDS_not_defined, 2 retained_intron, 1 nonsense_mediated_decay

ENST00000260443, ENST00000562895, ENST00000562993, ENST00000564344, ENST00000565854, ENST00000569386, ENST00000677092, ENST00000677147, ENST00000677172, ENST00000677267, ENST00000677730, ENST00000677989, ENST00000932316

RefSeq mRNA: 1 — MANE Select: NM_016304 NM_016304

CCDS: CCDS10152

Canonical transcript exons

ENST00000260443 — 6 exons

Exon	Start	End
ENSE00000884822	55196810	55196941
ENSE00001164025	55180806	55182225
ENSE00003529911	55192720	55192833
ENSE00003530949	55183315	55183400
ENSE00003626593	55190975	55191047
ENSE00003657880	55185362	55185425

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 99.20.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 104.9187 / max 1506.8661, expressed in 1822 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
150066	104.8285	1822
150065	0.0902	26

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
germinal epithelium of ovary	UBERON:0001304	99.20	gold quality
calcaneal tendon	UBERON:0003701	98.76	gold quality
parietal pleura	UBERON:0002400	98.67	gold quality
cartilage tissue	UBERON:0002418	98.66	gold quality
cortical plate	UBERON:0005343	98.64	gold quality
tibia	UBERON:0000979	98.60	gold quality
ganglionic eminence	UBERON:0004023	98.59	gold quality
amniotic fluid	UBERON:0000173	98.56	gold quality
ventricular zone	UBERON:0003053	98.40	gold quality
epithelium of nasopharynx	UBERON:0001951	98.35	gold quality
nasopharynx	UBERON:0001728	98.33	gold quality
pleura	UBERON:0000977	98.32	gold quality
cauda epididymis	UBERON:0004360	98.32	gold quality
secondary oocyte	CL:0000655	98.29	gold quality
monocyte	CL:0000576	98.19	gold quality
mononuclear cell	CL:0000842	98.15	gold quality
embryo	UBERON:0000922	98.15	gold quality
superficial temporal artery	UBERON:0001614	98.07	gold quality
caput epididymis	UBERON:0004358	98.06	gold quality
ovary	UBERON:0000992	98.05	gold quality
left ovary	UBERON:0002119	98.03	gold quality
leukocyte	CL:0000738	98.02	gold quality
penis	UBERON:0000989	97.98	gold quality
visceral pleura	UBERON:0002401	97.98	gold quality
corpus epididymis	UBERON:0004359	97.96	gold quality
bone marrow	UBERON:0002371	97.90	gold quality
gingival epithelium	UBERON:0001949	97.84	gold quality
islet of Langerhans	UBERON:0000006	97.82	gold quality
tendon	UBERON:0000043	97.78	gold quality
bone element	UBERON:0001474	97.77	gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-10042	yes	5.53
E-MTAB-7606	no	402.51
E-MTAB-9689	no	340.78
E-GEOD-124858	no	231.22
E-HCAD-4	no	23.70
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

49 targeting RSL24D1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-5692A	100.00	74.40	6850
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-433-3P	99.98	69.37	1203
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-493-5P	99.96	72.47	2382
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-4495	99.82	72.08	3080
HSA-MIR-8084	99.73	69.57	1760
HSA-MIR-545-5P	99.66	70.18	2308
HSA-MIR-497-3P	99.61	69.71	1990
HSA-MIR-105-5P	99.54	69.24	2060
HSA-MIR-7853-5P	99.54	69.30	2055
HSA-MIR-519D-5P	99.41	69.30	2057
HSA-MIR-5695	99.41	67.48	1047
HSA-MIR-5697	99.39	67.74	1249
HSA-MIR-584-3P	99.35	67.69	1082
HSA-MIR-4777-5P	99.33	67.53	1148
HSA-MIR-1286	99.09	66.23	1046
HSA-MIR-511-5P	98.97	70.94	2268
HSA-MIR-224-3P	98.91	68.42	1815

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 100.0% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 1)

• RSL24D1 sustains steady-state ribosome biogenesis and pluripotency translational programs in embryonic stem cells. (PMID:36690642)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	rsl24d1	ENSDARG00000040439
mus_musculus	Rsl24d1	ENSMUSG00000032215
rattus_norvegicus	Rsl24d1	ENSRNOG00000052787
drosophila_melanogaster	RpL24-like	FBGN0037899
caenorhabditis_elegans	rpl-24.2	WBGENE00004437

Paralogs (1): RPL24 (ENSG00000114391)

Protein

Protein identifiers

Probable ribosome biogenesis protein RLP24 — Q9UHA3 (reviewed: Q9UHA3)

Alternative names: Ribosomal L24 domain-containing protein 1, Ribosomal protein L24-like

All UniProt accessions (6): Q9UHA3, A0A7I2V2C6, A0A7I2V359, A0A7I2V3F2, H3BMQ2, H3BPF2

UniProt curated annotations — full annotation on UniProt →

Function. Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles.

Subunit / interactions. Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homolog, RPL24.

Subcellular location. Nucleus. Nucleolus.

Similarity. Belongs to the eukaryotic ribosomal protein eL24 family.

RefSeq proteins (1): NP_057388* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000988	Ribosomal_eL24-rel_N	Domain
IPR011017	TRASH_dom	Domain
IPR023442	Ribosomal_eL24_CS	Conserved_site
IPR038630	L24e/L24_sf	Homologous_superfamily
IPR055345	Ribosomal_eL24-like_arc	Family
IPR056366	Ribosomal_eL24	Family

Pfam: PF01246

UniProt features (6 total): sequence conflict 5, chain 1

Structure

Experimental structures (PDB)

39 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
8FKV	ELECTRON MICROSCOPY	2.47
8FLE	ELECTRON MICROSCOPY	2.48
8FKW	ELECTRON MICROSCOPY	2.5
8FL3	ELECTRON MICROSCOPY	2.53
8FL7	ELECTRON MICROSCOPY	2.55
8FLB	ELECTRON MICROSCOPY	2.55
8FLD	ELECTRON MICROSCOPY	2.58
8FKX	ELECTRON MICROSCOPY	2.59
8FL6	ELECTRON MICROSCOPY	2.62
8FLA	ELECTRON MICROSCOPY	2.63
8FLF	ELECTRON MICROSCOPY	2.65
8FKY	ELECTRON MICROSCOPY	2.67
8FL2	ELECTRON MICROSCOPY	2.67
8FL9	ELECTRON MICROSCOPY	2.75
8FKQ	ELECTRON MICROSCOPY	2.76
8FLC	ELECTRON MICROSCOPY	2.76
8IDT	ELECTRON MICROSCOPY	2.8
8FKT	ELECTRON MICROSCOPY	2.81
8FKU	ELECTRON MICROSCOPY	2.82
8RL2	ELECTRON MICROSCOPY	2.84
8FKP	ELECTRON MICROSCOPY	2.85
8FKS	ELECTRON MICROSCOPY	2.88
8FKR	ELECTRON MICROSCOPY	2.89
8FL4	ELECTRON MICROSCOPY	2.89
8FL0	ELECTRON MICROSCOPY	2.91
8IDY	ELECTRON MICROSCOPY	3
8INF	ELECTRON MICROSCOPY	3
8FKZ	ELECTRON MICROSCOPY	3.04
9QIW	ELECTRON MICROSCOPY	3.04
6LU8	ELECTRON MICROSCOPY	3.13

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UHA3-F1	91.63	0.80

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 418 (showing top): GOBP_CYTOPLASMIC_TRANSLATION, GOBP_RIBOSOME_BIOGENESIS, MODULE_151, GOBP_RETINAL_GANGLION_CELL_AXON_GUIDANCE, MORF_UBE2I, GOBP_CELL_CYCLE_PHASE_TRANSITION, GOBP_STRIATED_MUSCLE_CELL_DIFFERENTIATION, HSIAO_HOUSEKEEPING_GENES, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, GOBP_RIBOSOME_ASSEMBLY, GOBP_NEUROGENESIS, GOBP_MALE_GAMETE_GENERATION, GOBP_CRANIAL_NERVE_DEVELOPMENT, GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION, GOBP_TRANSLATION

GO Biological Process (2): ribosomal large subunit biogenesis (GO:0042273), ribosome biogenesis (GO:0042254)

GO Molecular Function (2): structural constituent of ribosome (GO:0003735), protein binding (GO:0005515)

GO Cellular Component (3): nucleoplasm (GO:0005654), nucleolus (GO:0005730), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
ribonucleoprotein complex biogenesis	2
nuclear lumen	2
ribosome biogenesis	1
structural molecule activity	1
ribosome	1
binding	1
cellular anatomical structure	1
intracellular membraneless organelle	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

3001 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RSL24D1	GTPBP4	Q9BZE4	941
RSL24D1	NSA2	O95478	904
RSL24D1	WDR12	Q9GZL7	865
RSL24D1	MRTO4	Q9UKD2	848
RSL24D1	GNL2	Q13823	843
RSL24D1	NMD3	Q96D46	843
RSL24D1	PAK1IP1	Q9NWT1	841
RSL24D1	NIP7	Q9Y221	825
RSL24D1	RPF2	Q9H7B2	810
RSL24D1	NOP2	P46087	776
RSL24D1	LSG1	Q9H089	775
RSL24D1	WDR74	Q6RFH5	744
RSL24D1	MDN1	Q9NU22	700
RSL24D1	EBNA1BP2	Q99848	687
RSL24D1	NOP53	Q9NZM5	665

IntAct

102 interactions, top by confidence:

A	B	Type	Score
RSL24D1	DNMT3L	psi-mi:“MI:0915”(physical association)	0.780
DNMT3L	RSL24D1	psi-mi:“MI:0915”(physical association)	0.780
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
RSL24D1	FAM9B	psi-mi:“MI:0915”(physical association)	0.560
CDC23	RSL24D1	psi-mi:“MI:0915”(physical association)	0.560
FAM9B	RSL24D1	psi-mi:“MI:0915”(physical association)	0.560
RSL24D1	CDC23	psi-mi:“MI:0915”(physical association)	0.560
RPL28	MAGEB2	psi-mi:“MI:0914”(association)	0.560
FGF3	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MAGEB10	GTPBP10	psi-mi:“MI:0914”(association)	0.530
RRP8	NVL	psi-mi:“MI:0914”(association)	0.530
RPL37A	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
PRR11	NVL	psi-mi:“MI:0914”(association)	0.530
MAK16	NVL	psi-mi:“MI:0914”(association)	0.530
RPL30	RRP8	psi-mi:“MI:0914”(association)	0.530
PPAN	PPM1G	psi-mi:“MI:0914”(association)	0.530
MAGEB2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
RSL24D1		psi-mi:“MI:0915”(physical association)	0.370
RSL24D1	htpG	psi-mi:“MI:0915”(physical association)	0.370
MKI67	ARHGAP10	psi-mi:“MI:0914”(association)	0.350
CAND1	GTPBP10	psi-mi:“MI:0914”(association)	0.350
CPNE4	SUPT5H	psi-mi:“MI:0914”(association)	0.350
PPAN	IGF2BP3	psi-mi:“MI:0914”(association)	0.350

BioGRID (128): RSL24D1 (Two-hybrid), RSL24D1 (Two-hybrid), FAM9B (Two-hybrid), RSL24D1 (Affinity Capture-MS), RSL24D1 (Affinity Capture-MS), RSL24D1 (Affinity Capture-MS), RSL24D1 (Affinity Capture-MS), RSL24D1 (Two-hybrid), RSL24D1 (Co-fractionation), RSL24D1 (Affinity Capture-MS), RSL24D1 (Affinity Capture-MS), RSL24D1 (Affinity Capture-MS), RSL24D1 (Affinity Capture-MS), RSL24D1 (Affinity Capture-MS), RSL24D1 (Affinity Capture-MS)

ESM2 similar proteins: A1XQU3, G1SE28, G1SKF7, G1SZ12, O65743, O70333, P37108, P38666, P40590, P46301, P50888, P50914, P61122, P83731, P83732, Q2YGT9, Q3SZ12, Q3T0U2, Q3ZC66, Q42347, Q4R5C7, Q5RBX7, Q5RF04, Q5SQF8, Q5ZKB6, Q63507, Q66WF5, Q6F444, Q6P6G7, Q6QMZ4, Q6Y263, Q792Q4, Q7SDU2, Q862I1, Q8BP67, Q8GYL5, Q8ISQ3, Q8JGR4, Q90YU3, Q962T5

Diamond homologs: A0B603, A1RXH7, A2BK96, A3DMR8, A4FYI7, A4YCQ3, A5UJN1, A6USH5, A6UT49, A6VJU5, A9A7E7, B6YWH7, C3MRJ8, C3MY94, C3MZM3, C3N7P5, C3NFS8, C4KIV3, C5A1V7, C6A1J2, G1SE28, O22165, O26357, O29492, P14116, P54064, P61122, P61123, P61124, P83731, P83732, Q07915, Q10353, Q12Z95, Q17606, Q3SZ12, Q4JAV2, Q5JGR5, Q5RF04, Q66WF5

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 107 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	21	39.2×	7e-27
Viral mRNA Translation	21	39.2×	7e-27
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	21	38.8×	7e-27
Selenocysteine synthesis	21	37.1×	1e-26
Eukaryotic Translation Termination	21	37.1×	1e-26
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	21	36.4×	1e-26
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	21	36.4×	1e-26
Formation of a pool of free 40S subunits	21	34.6×	4e-26

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	21	39.7×	6e-26
ribosomal large subunit biogenesis	7	31.7×	2e-07
translation	22	23.1×	5e-22
ribosomal small subunit biogenesis	8	18.6×	7e-07
rRNA processing	10	14.4×	2e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

19 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	14
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1004 predictions. Top by Δscore:

Variant	Effect	Δscore
15:55183312:CACCT:C	donor_loss	1.0000
15:55183313:A:AC	donor_gain	1.0000
15:55183313:AC:A	donor_gain	1.0000
15:55183313:ACCT:A	donor_loss	1.0000
15:55183313:ACCTG:A	donor_gain	1.0000
15:55183314:C:A	donor_loss	1.0000
15:55183314:C:CA	donor_gain	1.0000
15:55183314:CC:C	donor_gain	1.0000
15:55183314:CCT:C	donor_gain	1.0000
15:55183314:CCTG:C	donor_gain	1.0000
15:55183314:CCTGC:C	donor_gain	1.0000
15:55183396:TCAAT:T	acceptor_gain	1.0000
15:55183397:CAAT:C	acceptor_gain	1.0000
15:55183397:CAATC:C	acceptor_gain	1.0000
15:55183398:AAT:A	acceptor_gain	1.0000
15:55183398:AATCT:A	acceptor_gain	1.0000
15:55183399:AT:A	acceptor_gain	1.0000
15:55183399:ATCTA:A	acceptor_gain	1.0000
15:55183400:TCTAC:T	acceptor_gain	1.0000
15:55183401:C:CC	acceptor_gain	1.0000
15:55183401:CT:C	acceptor_gain	1.0000
15:55183402:T:A	acceptor_gain	1.0000
15:55183405:A:T	acceptor_gain	1.0000
15:55183407:C:CT	acceptor_gain	1.0000
15:55183408:A:T	acceptor_gain	1.0000
15:55183412:CATAT:C	acceptor_gain	1.0000
15:55183413:A:C	acceptor_gain	1.0000
15:55185356:TCATA:T	donor_loss	1.0000
15:55185357:CATAC:C	donor_loss	1.0000
15:55185358:ATAC:A	donor_loss	1.0000

AlphaMissense

1103 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:55192764:A:G	W51R	1.000
15:55192764:A:T	W51R	1.000
15:55196824:G:T	R23S	1.000
15:55192750:G:C	F55L	0.999
15:55192750:G:T	F55L	0.999
15:55192752:A:G	F55L	0.999
15:55192760:G:A	T52I	0.999
15:55192762:C:A	W51C	0.999
15:55192762:C:G	W51C	0.999
15:55192778:G:T	P46H	0.999
15:55192780:A:C	N45K	0.999
15:55192780:A:T	N45K	0.999
15:55192795:A:C	F40L	0.999
15:55192795:A:T	F40L	0.999
15:55192797:A:G	F40L	0.999
15:55192807:A:C	C36W	0.999
15:55192808:C:T	C36Y	0.999
15:55192809:A:G	C36R	0.999
15:55192820:C:T	C32Y	0.999
15:55192821:A:G	C32R	0.999
15:55192822:A:C	F31L	0.999
15:55192822:A:T	F31L	0.999
15:55192823:A:G	F31S	0.999
15:55192824:A:G	F31L	0.999
15:55192828:G:C	F29L	0.999
15:55192828:G:T	F29L	0.999
15:55192830:A:G	F29L	0.999
15:55196816:A:C	D25E	0.999
15:55196816:A:T	D25E	0.999
15:55196817:T:A	D25V	0.999

dbSNP variants (sampled 300 via entrez): RS1000007114 (15:55194943 A>T), RS1000354723 (15:55189111 T>C), RS1000405235 (15:55191790 T>C), RS1000419426 (15:55186017 T>C), RS1000455958 (15:55185619 T>C), RS1000477500 (15:55181094 C>T), RS1000736175 (15:55193070 A>C,G), RS1000760403 (15:55187616 C>T), RS1001190004 (15:55192128 G>A,C), RS1001225223 (15:55194609 C>G,T), RS1001473808 (15:55197756 G>C,T), RS1001566534 (15:55180753 G>C), RS1001601982 (15:55183124 G>C), RS1001680598 (15:55186304 G>A), RS1001738055 (15:55197515 C>T)

Disease associations

OMIM: gene MIM:613262 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST001059_12	Neutrophil count	7.000000e-06
GCST003142_2	Proteinuria in chronic kidney disease	5.000000e-06
GCST005175_36	Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes	8.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004833	neutrophil count
EFO:0004723	coronary artery calcification

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

48 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases abundance, increases expression	4
Valproic Acid	affects expression, decreases expression	3
Air Pollutants	increases abundance, increases expression, decreases expression	2
Arsenic	decreases expression, increases abundance, increases expression	2
Tretinoin	decreases expression	2
Cyclosporine	increases expression	2
Particulate Matter	decreases expression, increases abundance, increases expression	2
aristolochic acid I	decreases expression	1
dicrotophos	decreases expression	1
uranyl acetate	affects expression	1
bisphenol A	affects expression	1
deoxynivalenol	increases expression	1
beta-lapachone	increases expression	1
arsenite	affects binding, increases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
nivalenol	increases expression	1
perfluorooctane sulfonic acid	increases expression	1
chloropicrin	affects expression	1
perfluoro-n-nonanoic acid	increases expression	1
deguelin	increases expression	1
fenpyroximate	increases expression	1
pyrimidifen	increases expression	1
torcetrapib	increases expression	1
ICG 001	increases expression	1
thifluzamide	increases expression	1
pyrachlostrobin	increases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
bisphenol S	affects cotreatment, increases expression	1
jinfukang	decreases expression	1
MT19c compound	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.