RSPH10B

Summary

RSPH10B (radial spoke head 10 homolog B, HGNC:27362) is a protein-coding gene on chromosome 7p22.1, encoding Radial spoke head 10 homolog B (P0C881). May function as part of the axonemal radial spoke complex 3 (RS3).

Predicted to enable kinase activity. Located in sperm flagellum.

Source: NCBI Gene 222967 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 77 total
• MANE Select transcript: NM_173565

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27362
Approved symbol	RSPH10B
Name	radial spoke head 10 homolog B
Location	7p22.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000155026
Ensembl biotype	protein_coding
Entrez	222967

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 10 protein_coding, 3 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000337579, ENST00000404406, ENST00000405415, ENST00000455618, ENST00000477641, ENST00000535104, ENST00000539630, ENST00000539903, ENST00000541997, ENST00000542644, ENST00000887201, ENST00000887202, ENST00000913478, ENST00000952032

RefSeq mRNA: 1 — MANE Select: NM_173565 NM_173565

CCDS: CCDS34598

Canonical transcript exons

ENST00000404406 — 21 exons

Exon	Start	End
ENSE00001651904	5964502	5964570
ENSE00001681914	5966863	5967201
ENSE00001684259	5945064	5945178
ENSE00001695752	5967318	5967437
ENSE00001703525	5958993	5959078
ENSE00001731322	5943911	5943990
ENSE00001732618	5965637	5965712
ENSE00003503820	5953075	5953219
ENSE00003515424	5935020	5935148
ENSE00003525979	5948220	5948409
ENSE00003586569	5956005	5956181
ENSE00003600890	5937758	5937901
ENSE00003627562	5957907	5958027
ENSE00003633458	5943324	5943472
ENSE00003635205	5932782	5932875
ENSE00003637551	5960691	5960864
ENSE00003674895	5928196	5928394
ENSE00003691293	5938722	5938829
ENSE00003691384	5951295	5951416
ENSE00003978279	5926136	5926548
ENSE00003978280	5970618	5970689

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 90.09.

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	90.09	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	83.67	gold quality
right testis	UBERON:0004534	83.53	gold quality
left testis	UBERON:0004533	82.80	gold quality
testis	UBERON:0000473	82.27	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.01	gold quality
fallopian tube	UBERON:0003889	72.01	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	71.31	silver quality
right lung	UBERON:0002167	64.07	gold quality
left uterine tube	UBERON:0001303	60.55	gold quality
endometrium	UBERON:0001295	60.14	gold quality
adenohypophysis	UBERON:0002196	59.68	gold quality
caudate nucleus	UBERON:0001873	59.50	gold quality
Ammon’s horn	UBERON:0001954	59.46	gold quality
hypothalamus	UBERON:0001898	59.05	gold quality
pituitary gland	UBERON:0000007	58.47	gold quality
superior frontal gyrus	UBERON:0002661	58.31	gold quality
amygdala	UBERON:0001876	58.09	gold quality
temporal lobe	UBERON:0001871	57.96	gold quality
nucleus accumbens	UBERON:0001882	57.08	gold quality
spleen	UBERON:0002106	56.39	gold quality
ventricular zone	UBERON:0003053	55.84	gold quality
brain	UBERON:0000955	55.20	gold quality
lung	UBERON:0002048	54.97	gold quality
cerebral cortex	UBERON:0000956	54.46	gold quality
right frontal lobe	UBERON:0002810	54.20	gold quality
frontal cortex	UBERON:0001870	54.06	gold quality
right adrenal gland	UBERON:0001233	53.93	gold quality
Brodmann (1909) area 9	UBERON:0013540	53.91	gold quality
right lobe of liver	UBERON:0001114	53.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.11

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

22 targeting RSPH10B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-557	99.96	70.01	1640
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-4496	99.88	68.89	2236
HSA-MIR-4307	99.82	70.45	3374
HSA-MIR-4639-5P	99.81	67.37	1028
HSA-MIR-3934-3P	99.76	65.51	1351
HSA-MIR-3680-3P	99.75	72.51	3095
HSA-MIR-148A-3P	99.74	73.77	1700
HSA-MIR-148B-3P	99.74	73.75	1700
HSA-MIR-152-3P	99.74	73.75	1703
HSA-MIR-6720-5P	99.65	66.22	1459
HSA-MIR-6512-3P	99.65	66.07	1468
HSA-MIR-4276	99.56	67.66	2514
HSA-MIR-3678-3P	99.31	67.10	1432
HSA-MIR-8065	99.19	70.38	1289
HSA-MIR-6811-3P	98.62	66.54	944
HSA-MIR-4511	98.32	67.97	1500
HSA-MIR-4708-5P	97.77	67.82	831
HSA-MIR-3936	97.64	64.47	732

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Rsph10b	ENSMUSG00000075569
rattus_norvegicus	Rsph10b	ENSRNOG00000001036

Paralogs (7): MORN1 (ENSG00000116151), MORN3 (ENSG00000139714), SETD7 (ENSG00000145391), RSPH1 (ENSG00000160188), RSPH10B2 (ENSG00000169402), ALS2CL (ENSG00000178038), MORN2 (ENSG00000188010)

Protein

Protein identifiers

Radial spoke head 10 homolog B — P0C881 (reviewed: P0C881)

All UniProt accessions (2): P0C881, F5GZE0

UniProt curated annotations — full annotation on UniProt →

Function. May function as part of the axonemal radial spoke complex 3 (RS3). Radial spoke complexes are important for ciliary motility.

Subunit / interactions. Interacts with RSPH6A. Does not appear to be part of the axonemal radial spoke complexes 1 or 2.

Subcellular location. Cytoplasm. Cytoskeleton. Cilium axoneme. Cell projection. Cilium. Flagellum.

RefSeq proteins (1): NP_775836* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003409	MORN	Repeat

Pfam: PF02493

UniProt features (19 total): repeat 10, compositionally biased region 4, region of interest 3, chain 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0C881-F1	72.00	0.41

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 15 (showing top): chr7p22, SENGUPTA_NASOPHARYNGEAL_CARCINOMA_DN, IVANOVA_HEMATOPOIESIS_STEM_CELL_SHORT_TERM, GOCC_CYTOPLASMIC_REGION, GOCC_MOTILE_CILIUM, GOCC_CILIUM, DODD_NASOPHARYNGEAL_CARCINOMA_DN, JOHNSTONE_PARVB_TARGETS_3_DN, GOCC_9PLUS2_MOTILE_CILIUM, MIR6720_5P, DESCARTES_MAIN_FETAL_CILIATED_EPITHELIAL_CELLS, DESCARTES_FETAL_LUNG_CILIATED_EPITHELIAL_CELLS, DESCARTES_FETAL_STOMACH_CILIATED_EPITHELIAL_CELLS, GOCC_AXONEME, YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (8): cilium (GO:0005929), axoneme (GO:0005930), sperm flagellum (GO:0036126), 9+2 motile cilium (GO:0097729), cytoplasm (GO:0005737), cytoskeleton (GO:0005856), motile cilium (GO:0031514), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
intraciliary transport particle	1
membrane-bounded organelle	1
plasma membrane bounded cell projection	1
cytoskeleton	1
microtubule	1
ciliary plasm	1
9+2 motile cilium	1
radial spoke	1
motile cilium	1
inner dynein arm	1
outer dynein arm	1
axonemal central pair	1
axonemal doublet microtubule	1
intracellular anatomical structure	1
intracellular membraneless organelle	1
cilium	1

Protein interactions and networks

STRING

466 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RSPH10B	ANKRD61	A6NGH8	697
RSPH10B	CFAP74	Q9C0B2	625
RSPH10B	CFAP99	D6REC4	594
RSPH10B	TSNAXIP1	Q2TAA8	537
RSPH10B	RSPH14	Q9UHP6	529
RSPH10B	CCDC146	Q8IYE0	510
RSPH10B	FAM217A	Q8IXS0	505
RSPH10B	ZSWIM2	Q8NEG5	497
RSPH10B	OR6M1	Q8NGM8	474
RSPH10B	CFAP65	Q6ZU64	471
RSPH10B	SSNA1	O43805	461
RSPH10B	LRRC23	Q53EV4	460
RSPH10B	CFAP161	Q6P656	457
RSPH10B	RSPH6A	Q9H0K4	451
RSPH10B	OR8H3	Q8N146	445

IntAct

3 interactions, top by confidence:

A	B	Type	Score
MKLN1	HTRA2	psi-mi:“MI:0914”(association)	0.510
MKLN1	RSPH10B	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (3): RSPH10B (Affinity Capture-MS), RSPH10B (Affinity Capture-MS), RSPH10B (Positive Genetic)

ESM2 similar proteins: A1A5R8, A1L1R5, A2A3K4, A2VDZ4, A5PKL1, A7E379, A8KBE0, B2GUY1, B2RC85, E1B9D8, E9PYQ0, O00444, O00522, O01326, O54852, P0C881, P59111, Q04688, Q08CH7, Q14693, Q1JPG1, Q5R9Z7, Q5RFV8, Q61XX9, Q64702, Q66HB5, Q68FF0, Q6DTM3, Q6EEF3, Q6EMB2, Q6NSI8, Q6S5J6, Q6TNJ1, Q6ZT98, Q8BRB7, Q8CDA1, Q8CDM1, Q8CDP0, Q8K3E5, Q8N157

Diamond homologs: B2RC85, E9PYQ0, P0C881, Q08CH7, Q1JPG1, Q66HB5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

77 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	61
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2947 predictions. Top by Δscore:

Variant	Effect	Δscore
7:5925630:A:AG	acceptor_gain	1.0000
7:5925631:G:GG	acceptor_gain	1.0000
7:5925631:GAA:G	acceptor_gain	1.0000
7:5925631:GAAGA:G	acceptor_gain	1.0000
7:5926544:TCAGC:T	acceptor_gain	1.0000
7:5926545:CAGC:C	acceptor_gain	1.0000
7:5926545:CAGCC:C	acceptor_gain	1.0000
7:5926546:AGC:A	acceptor_gain	1.0000
7:5926547:GC:G	acceptor_gain	1.0000
7:5926547:GCC:G	acceptor_loss	1.0000
7:5926548:CC:C	acceptor_gain	1.0000
7:5926548:CCTA:C	acceptor_loss	1.0000
7:5926549:C:CC	acceptor_gain	1.0000
7:5932884:T:TC	acceptor_gain	1.0000
7:5932885:T:C	acceptor_gain	1.0000
7:5932886:T:C	acceptor_gain	1.0000
7:5932886:T:TC	acceptor_gain	1.0000
7:5937898:CCAG:C	acceptor_gain	1.0000
7:5937899:CAGC:C	acceptor_gain	1.0000
7:5943314:A:AC	donor_gain	1.0000
7:5943315:G:C	donor_gain	1.0000
7:5943322:A:AC	donor_gain	1.0000
7:5943323:C:CC	donor_gain	1.0000
7:5943326:T:A	donor_gain	1.0000
7:5943350:T:C	donor_gain	1.0000
7:5945179:C:CC	acceptor_gain	1.0000
7:5948219:CCA:C	donor_gain	1.0000
7:5948225:AATAT:A	donor_gain	1.0000
7:5948406:CCAC:C	acceptor_gain	1.0000
7:5948407:CACC:C	acceptor_gain	1.0000

AlphaMissense

5850 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:5956031:A:G	W311R	0.998
7:5956031:A:T	W311R	0.998
7:5957996:A:G	W231R	0.998
7:5957996:A:T	W231R	0.998
7:5960717:A:G	W183R	0.998
7:5960717:A:T	W183R	0.998
7:5957924:A:G	W255R	0.997
7:5957924:A:T	W255R	0.997
7:5960722:C:T	G181D	0.997
7:5958002:C:G	G229R	0.996
7:5959030:A:G	W208R	0.996
7:5959030:A:T	W208R	0.996
7:5960857:A:G	F136S	0.996
7:5964537:C:A	G122W	0.996
7:5964563:A:G	F113S	0.996
7:5965642:A:C	Y109D	0.996
7:5957922:C:A	W255C	0.995
7:5957922:C:G	W255C	0.995
7:5957969:C:A	G240W	0.995
7:5960761:C:T	G168E	0.995
7:5960762:C:A	G168W	0.995
7:5960795:C:G	G157R	0.995
7:5960801:A:C	Y155D	0.995
7:5960847:A:C	N139K	0.995
7:5960847:A:T	N139K	0.995
7:5964507:A:C	Y132D	0.995
7:5956029:C:A	W311C	0.994
7:5956029:C:G	W311C	0.994
7:5956085:G:T	R293S	0.994
7:5957994:C:A	W231C	0.994

dbSNP variants (sampled 300 via entrez): RS1000097732 (7:5954349 A>G), RS1000298679 (7:5934324 A>G), RS1000311292 (7:5972460 C>T), RS1000430281 (7:5971577 T>C), RS1000585458 (7:5937566 C>A,G,T), RS1001856639 (7:5942508 G>T), RS1002372639 (7:5941803 ATGT>A), RS1002540345 (7:5963366 C>G,T), RS1003036034 (7:5928828 G>A,T), RS1003063335 (7:5961034 G>A), RS1003502975 (7:5928689 T>G), RS1003661994 (7:5948137 G>T), RS1003950836 (7:5953043 G>C,T), RS1004211332 (7:5945519 T>C), RS1004765511 (7:5947843 T>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST005951_155	Body mass index	1.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

15 total (human), top 15 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression, increases methylation	2
Smoke	decreases expression, increases abundance, increases expression	2
aristolochic acid I	increases expression	1
propionaldehyde	increases expression	1
afimoxifene	decreases expression, decreases reaction	1
butyraldehyde	increases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
Air Pollutants	increases expression, increases abundance	1
Cadmium	decreases expression	1
Estrogens	decreases expression, decreases reaction	1
Lipopolysaccharides	affects response to substance, increases expression	1
Silicon Dioxide	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Cadmium Chloride	increases expression	1
Acrylamide	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.