RUNX2-AS1

Summary

RUNX2-AS1 (RUNX2 antisense RNA 1, HGNC:53512) is a long non-coding RNA gene on chromosome 6p21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53512
Approved symbol	RUNX2-AS1
Name	RUNX2 antisense RNA 1
Location	6p21.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000261080
Ensembl biotype	lncRNA
Entrez	105375077
RNAcentral	URS00026A26B6 — lncRNA, 3132 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000563807

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000563807 — 2 exons

Exon	Start	End
ENSE00002612948	45576027	45576770
ENSE00002617611	45573346	45574114

Expression profiles

Bgee: expression breadth broad, 32 present calls, max score 74.11.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0051 / max 3.1576, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
73790	0.0051	3

Top tissues by expression

32 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.11	gold quality
right testis	UBERON:0004534	69.67	gold quality
testis	UBERON:0000473	69.36	gold quality
left testis	UBERON:0004533	69.10	gold quality
bone marrow cell	CL:0002092	64.06	silver quality
multicellular organism	UBERON:0000468	63.30	gold quality
cortical plate	UBERON:0005343	60.30	silver quality
ventricular zone	UBERON:0003053	58.91	silver quality
ganglionic eminence	UBERON:0004023	56.65	silver quality
gastrocnemius	UBERON:0001388	50.89	gold quality
monocyte	CL:0000576	49.15	silver quality
blood	UBERON:0000178	49.15	silver quality
heart left ventricle	UBERON:0002084	48.78	silver quality
islet of Langerhans	UBERON:0000006	45.85	silver quality
skin of leg	UBERON:0001511	45.56	gold quality
zone of skin	UBERON:0000014	45.11	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	44.85	silver quality
kidney	UBERON:0002113	44.78	silver quality
body of pancreas	UBERON:0001150	44.13	silver quality
right atrium auricular region	UBERON:0006631	43.72	silver quality
tibial nerve	UBERON:0001323	41.80	gold quality
omental fat pad	UBERON:0010414	41.32	silver quality
subcutaneous adipose tissue	UBERON:0002190	40.78	gold quality
adrenal gland	UBERON:0002369	40.58	silver quality
transverse colon	UBERON:0001157	40.23	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	39.91	silver quality
body of stomach	UBERON:0001161	39.47	silver quality
muscle layer of sigmoid colon	UBERON:0035805	39.30	silver quality
left lobe of thyroid gland	UBERON:0001120	38.90	silver quality
thyroid gland	UBERON:0002046	36.75	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.46

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• our results indicated a key role of exosomal lncRUNX2-AS1 in transferring from multiple myeloma cells to mesenchymal stem cells in osteogenic differentiation, through a unique exosomal lncRUNX2-AS1/RUNX2 pathway. (PMID:29895968)
• Thus, PTH stimulated the expression of lnc-SUPT3H-1:16, miR-6797-5p and Runx2, and due to the sponging mechanism of lnc- SUPT3H-1:16 towards miR-6797-5p, Runx2 was protected, resulting in the promotion of osteoblast differentiation. (PMID:30562548)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.