RUSC1-AS1

Summary

RUSC1-AS1 (RUSC1 antisense RNA 1, HGNC:26680) is a long non-coding RNA gene on chromosome 1q22.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26680
Approved symbol	RUSC1-AS1
Name	RUSC1 antisense RNA 1
Location	1q22
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ35976
Ensembl gene	ENSG00000225855
Ensembl biotype	lncRNA
Entrez	284618
RNAcentral	URS0000ABD863 — lncRNA, 1796 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 22 lncRNA

ENST00000443642, ENST00000446880, ENST00000450199, ENST00000543656, ENST00000746586, ENST00000746587, ENST00000746588, ENST00000746589, ENST00000746590, ENST00000746591, ENST00000746592, ENST00000746593, ENST00000746594, ENST00000746595, ENST00000746596, ENST00000746597, ENST00000746598, ENST00000746599, ENST00000746600, ENST00000746601, ENST00000746602, ENST00000746603

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000443642 — 6 exons

Exon	Start	End
ENSE00001598300	155319803	155319932
ENSE00001603353	155322243	155322437
ENSE00001640137	155321625	155321695
ENSE00001799226	155318265	155318396
ENSE00004087653	155324078	155324379
ENSE00004087664	155317859	155318005

Expression profiles

Bgee: expression breadth ubiquitous, 168 present calls, max score 87.27.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0304 / max 7.4237, expressed in 14 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
14961	0.0304	14

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oviduct epithelium	UBERON:0004804	87.27	gold quality
right lobe of liver	UBERON:0001114	86.20	gold quality
right adrenal gland cortex	UBERON:0035827	86.18	gold quality
right adrenal gland	UBERON:0001233	84.92	gold quality
mucosa of transverse colon	UBERON:0004991	84.69	gold quality
right uterine tube	UBERON:0001302	84.42	gold quality
metanephros cortex	UBERON:0010533	84.06	gold quality
upper lobe of left lung	UBERON:0008952	83.94	gold quality
lower esophagus mucosa	UBERON:0035834	83.59	gold quality
transverse colon	UBERON:0001157	83.43	gold quality
adrenal tissue	UBERON:0018303	83.10	gold quality
small intestine Peyer’s patch	UBERON:0003454	83.06	gold quality
right lobe of thyroid gland	UBERON:0001119	82.86	gold quality
apex of heart	UBERON:0002098	82.85	gold quality
body of pancreas	UBERON:0001150	82.68	gold quality
ectocervix	UBERON:0012249	82.65	gold quality
left adrenal gland cortex	UBERON:0035825	82.65	gold quality
left lobe of thyroid gland	UBERON:0001120	82.32	gold quality
tibial nerve	UBERON:0001323	82.28	gold quality
endocervix	UBERON:0000458	81.99	gold quality
left adrenal gland	UBERON:0001234	81.97	gold quality
upper lobe of lung	UBERON:0008948	81.79	gold quality
minor salivary gland	UBERON:0001830	81.70	gold quality
body of uterus	UBERON:0009853	81.70	gold quality
granulocyte	CL:0000094	81.62	gold quality
vagina	UBERON:0000996	81.47	gold quality
sural nerve	UBERON:0015488	81.45	gold quality
right lung	UBERON:0002167	81.28	gold quality
esophagus mucosa	UBERON:0002469	81.19	gold quality
skin of abdomen	UBERON:0001416	81.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	11.55

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Long noncoding RNA RUSC1-AS1 promotes tumorigenesis in cervical cancer by acting as a competing endogenous RNA of microRNA-744 and consequently increasing Bcl-2 expression. (PMID:32264732)
• LncRNA RUSC1-AS1 promotes the proliferation of hepatocellular carcinoma cells through modulating NOTCH signaling. (PMID:32701359)
• RUSC1-AS1 promotes the malignant progression of breast cancer depending on the regulation of the miR-326/XRCC5 pathway. (PMID:37429610)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.