RUVBL1-AS1

Summary

RUVBL1-AS1 (RUVBL1 antisense RNA 1, HGNC:40514) is a long non-coding RNA gene on chromosome 3q21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40514
Approved symbol	RUVBL1-AS1
Name	RUVBL1 antisense RNA 1
Location	3q21.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000239608
Ensembl biotype	lncRNA
Entrez	100874089
RNAcentral	URS000037DEB2 — lncRNA, 588 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000485218

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000485218 — 2 exons

Exon	Start	End
ENSE00001835420	128078739	128079056
ENSE00001879187	128075810	128076079

Expression profiles

Bgee: expression breadth ubiquitous, 105 present calls, max score 67.20.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1249 / max 29.7174, expressed in 42 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
38427	0.0619	18
38425	0.0495	17
38426	0.0135	6

Top tissues by expression

105 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	67.20	gold quality
colonic epithelium	UBERON:0000397	65.73	silver quality
bone marrow cell	CL:0002092	64.82	silver quality
calcaneal tendon	UBERON:0003701	57.96	gold quality
bone marrow	UBERON:0002371	57.04	gold quality
cortex of kidney	UBERON:0001225	54.49	gold quality
islet of Langerhans	UBERON:0000006	54.35	gold quality
gall bladder	UBERON:0002110	54.30	gold quality
prefrontal cortex	UBERON:0000451	54.14	gold quality
lymph node	UBERON:0000029	53.49	gold quality
monocyte	CL:0000576	53.33	gold quality
granulocyte	CL:0000094	52.87	gold quality
smooth muscle tissue	UBERON:0001135	51.88	gold quality
blood	UBERON:0000178	51.72	silver quality
superior frontal gyrus	UBERON:0002661	50.59	gold quality
liver	UBERON:0002107	49.44	silver quality
muscle of leg	UBERON:0001383	49.39	gold quality
adult mammalian kidney	UBERON:0000082	48.12	gold quality
gastrocnemius	UBERON:0001388	48.12	gold quality
frontal cortex	UBERON:0001870	47.88	gold quality
right adrenal gland	UBERON:0001233	47.66	gold quality
descending thoracic aorta	UBERON:0002345	47.39	gold quality
right lobe of liver	UBERON:0001114	47.09	gold quality
urinary bladder	UBERON:0001255	47.03	gold quality
uterine cervix	UBERON:0000002	47.00	silver quality
endometrium	UBERON:0001295	46.66	gold quality
primary visual cortex	UBERON:0002436	46.42	silver quality
placenta	UBERON:0001987	46.38	gold quality
adrenal tissue	UBERON:0018303	46.13	silver quality
ectocervix	UBERON:0012249	46.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.44

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.