S100A13

Summary

S100A13 (S100 calcium binding protein A13, HGNC:10490) is a protein-coding gene on chromosome 1q21.3, encoding Protein S100-A13 (Q99584). Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

Source: NCBI Gene 6284 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 28 total
• MANE Select transcript: NM_001024211

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10490
Approved symbol	S100A13
Name	S100 calcium binding protein A13
Location	1q21.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000189171
Ensembl biotype	protein_coding
OMIM	601989
Entrez	6284

Gene structure

Transcript identifiers

Ensembl transcripts: 44 — 41 protein_coding, 3 protein_coding_CDS_not_defined

ENST00000339556, ENST00000392622, ENST00000392623, ENST00000440685, ENST00000469931, ENST00000472233, ENST00000476133, ENST00000484413, ENST00000491177, ENST00000497086, ENST00000607839, ENST00000883331, ENST00000883332, ENST00000883333, ENST00000883334, ENST00000883335, ENST00000883336, ENST00000883337, ENST00000883338, ENST00000883339, ENST00000883340, ENST00000883341, ENST00000883342, ENST00000914275, ENST00000914276, ENST00000914277, ENST00000914278, ENST00000914279, ENST00000914280, ENST00000914281, ENST00000914282, ENST00000914283, ENST00000914284, ENST00000914285, ENST00000914286, ENST00000914287, ENST00000914288, ENST00000914289, ENST00000914290, ENST00000914291, ENST00000914292, ENST00000972165, ENST00000972166, ENST00000972167

RefSeq mRNA: 5 — MANE Select: NM_001024211 NM_001024210, NM_001024211, NM_001024212, NM_001024213, NM_005979

CCDS: CCDS30874

Canonical transcript exons

ENST00000476133 — 3 exons

Exon	Start	End
ENSE00001447797	153618799	153619038
ENSE00003916833	153627483	153627505
ENSE00004031446	153626320	153626533

Expression profiles

Bgee: expression breadth ubiquitous, 153 present calls, max score 99.42.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 57.4385 / max 332.3969, expressed in 1814 samples.

FANTOM5 promoters (17 alternative TSS)

Promoter ID	TPM avg	Samples expressed
14699	22.1872	1466
14700	18.7516	1537
14707	7.9715	1749
14701	2.3442	1260
14698	2.0136	850
14697	1.6002	672
14703	0.7583	145
14702	0.5764	376
14693	0.2642	113
14694	0.2542	108

Top tissues by expression

153 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of thyroid gland	UBERON:0001119	99.42	gold quality
left lobe of thyroid gland	UBERON:0001120	99.40	gold quality
thyroid gland	UBERON:0002046	99.38	gold quality
calcaneal tendon	UBERON:0003701	99.36	gold quality
substantia nigra	UBERON:0002038	99.30	gold quality
putamen	UBERON:0001874	99.19	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	99.17	gold quality
amygdala	UBERON:0001876	99.16	gold quality
spinal cord	UBERON:0002240	99.13	gold quality
temporal lobe	UBERON:0001871	99.09	gold quality
right uterine tube	UBERON:0001302	99.07	gold quality
metanephros cortex	UBERON:0010533	99.00	gold quality
caudate nucleus	UBERON:0001873	98.98	gold quality
nucleus accumbens	UBERON:0001882	98.98	gold quality
hypothalamus	UBERON:0001898	98.94	gold quality
right atrium auricular region	UBERON:0006631	98.91	gold quality
mucosa of stomach	UBERON:0001199	98.87	gold quality
apex of heart	UBERON:0002098	98.87	gold quality
subcutaneous adipose tissue	UBERON:0002190	98.83	gold quality
adipose tissue	UBERON:0001013	98.76	gold quality
thoracic mammary gland	UBERON:0005200	98.76	gold quality
Ammon’s horn	UBERON:0001954	98.70	gold quality
omental fat pad	UBERON:0010414	98.70	gold quality
stromal cell of endometrium	CL:0002255	98.64	gold quality
endometrium epithelium	UBERON:0004811	98.58	gold quality
muscle layer of sigmoid colon	UBERON:0035805	98.53	gold quality
sigmoid colon	UBERON:0001159	98.50	gold quality
right lung	UBERON:0002167	98.43	gold quality
minor salivary gland	UBERON:0001830	98.42	gold quality
fallopian tube	UBERON:0003889	98.42	gold quality

Single-cell (SCXA)

Detected in 21 experiment(s), a significant marker in 20.

Experiment	Marker?	Max mean expression
E-MTAB-8060	yes	530.62
E-GEOD-109979	yes	269.74
E-MTAB-6701	yes	126.22
E-HCAD-1	yes	80.03
E-MTAB-8410	yes	64.96
E-MTAB-10553	yes	42.47
E-ANND-3	yes	41.60
E-GEOD-134144	yes	36.28
E-CURD-46	yes	35.02
E-MTAB-10287	yes	33.31
E-HCAD-10	yes	27.30
E-GEOD-81547	yes	23.39
E-MTAB-7316	yes	22.57
E-CURD-112	yes	17.87
E-HCAD-9	yes	17.24

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): PBRM1

Literature-anchored findings (GeneRIF, showing 18)

• detected in both cells and fibers of the hippocampus at 12 weeks gestation, slightly stronger at 20 weeks, and then decreased with age. In the temporal cortex, strong in all cellular layers at 12 to 24 weeks, declined with age from 28 weeks onwards. (PMID:12645008)
• Stress-induced export of IL-1alpha involves the intracellular association with the Cu2+-binding protein, S100A13; the expression of a S100A13 mutant functions as a dominant-negative repressor of IL-1alpha release. (PMID:12746488)
• S100A13 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells (PMID:15033494)
• data show that the expression of endoglin and S100A13 protein corresponds to the activation of the endothelial cells in the process of endometriotic angiogenesis (PMID:15821778)
• In human astrocytic gliomas, S100A13 was significantly up-regulated in high-grade vascularized gliomas. Moreover, S100A13 expression significantly correlated with microvessel density and tumour grading. (PMID:16773219)
• Human S100A13 was heterologously expressed in Escherichia coli, purified and crystallized by the hanging-drop vapour-diffusion method. (PMID:17077500)
• S100A13 is a homodimer with four EF-hand motifs in an asymmetric unit, displaying a folding pattern similar to other S100 members. S100A13 has the unique structural feature with all alpha-helices being amphiphilic. (PMID:17374362)
• Despite the high similarity of the backbone conformation in each protomer, the crystal structures of human S100A13 at pH 7.5 and at pH 6.0 exhibit recognizable differences in the relative orientation of the protomers within the dimer (PMID:18259052)
• S100A13 is expressed in melanocytic lesions when the angiogenic switch occurs and it may cooperate with VEGF-A in supporting the formation of new blood vessels, favoring the shift from radial to vertical tumor growth. (PMID:20208480)
• S100A13 promotes the release of FGF-1 protein, but does not affect the transportation of FGF-1 protein in human umbilical vein endothelial cells. (PMID:20863990)
• the IL1alpha-S100A13 tetrameric complex is the key complex formed during the non-classical pathway of IL1alpha release (PMID:21270123)
• S100A13 is involved in cutaneous malignant melanoma resistance to DTIC/TMZ. (PMID:24722184)
• S100A13 interacts with the C2 domain of RAGE. (PMID:24982031)
• This is the first report for the association between HMGA1 and S100A13 expression in the modulation of thyroid cancer growth and invasion. (PMID:27008379)
• High S100A13 expression is closely associated with high intratumoral angiogenesis and poor prognosis in patients with stage I NSCLC. Immunohistochemical evaluation of S100A13 expression, along with an examination of the perioperative extent of angiolymphatic invasion, has value for predicting prognosis. (PMID:30047626)
• These findings unveil a critical role of the non-classical secretory pathway of IL-1alpha in cellular senescence and SASP regulation. (PMID:30670674)
• An atypical pulmonary fibrosis is associated with co-inheritance of mutations in the calcium binding protein genes S100A3 and S100A13. (PMID:31073086)
• Genome-wide analysis of DNA methylation identifies S100A13 as an epigenetic biomarker in individuals with chronic (>/= 30 years) type 2 diabetes without diabetic retinopathy. (PMID:32493412)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	s100v1	ENSDARG00000070427
danio_rerio	s100v2	ENSDARG00000070702
mus_musculus	S100a13	ENSMUSG00000042312
rattus_norvegicus	S100a13	ENSRNOG00000079311

Paralogs (21): CRNN (ENSG00000143536), S100A8 (ENSG00000143546), S100A7 (ENSG00000143556), S100B (ENSG00000160307), S100A1 (ENSG00000160678), S100A11 (ENSG00000163191), S100A9 (ENSG00000163220), S100A12 (ENSG00000163221), S100P (ENSG00000163993), S100G (ENSG00000169906), S100Z (ENSG00000171643), S100A7A (ENSG00000184330), S100A3 (ENSG00000188015), S100A16 (ENSG00000188643), SNTN (ENSG00000188817), S100A14 (ENSG00000189334), S100A4 (ENSG00000196154), S100A5 (ENSG00000196420), S100A2 (ENSG00000196754), S100A10 (ENSG00000197747), S100A6 (ENSG00000197956)

Protein

Protein identifiers

Protein S100-A13 — Q99584 (reviewed: Q99584)

Alternative names: S100 calcium-binding protein A13

All UniProt accessions (1): Q99584

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine.

Subunit / interactions. Homodimer. Part of a copper-dependent multiprotein complex containing S100A13, FGF1 and SYT1. Interacts with FGF1 and SYT1. Interacts with IL1A.

Subcellular location. Cytoplasm. Secreted.

Tissue specificity. Expressed in heart and skeletal muscle.

Similarity. Belongs to the S-100 family.

RefSeq proteins (5): NP_001019381, NP_001019382, NP_001019383, NP_001019384, NP_005970 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011992	EF-hand-dom_pair	Homologous_superfamily
IPR013787	S100_Ca-bd_sub	Domain

Pfam: PF01023

UniProt features (21 total): binding site 7, helix 6, strand 4, chain 1, domain 1, turn 1, modified residue 1

Structure

Experimental structures (PDB)

12 structures.

PDB	Method	Resolution (Å)
2EGD	X-RAY DIFFRACTION	1.8
2H2K	X-RAY DIFFRACTION	2
1YUR	SOLUTION NMR
1YUS	SOLUTION NMR
1YUT	SOLUTION NMR
1YUU	SOLUTION NMR
2K8M	SOLUTION NMR
2KI4	SOLUTION NMR
2KI6	SOLUTION NMR
2KOT	SOLUTION NMR
2L5X	SOLUTION NMR
2LE9	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q99584-F1	80.91	0.09

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (7): 32; 37; 64; 66; 68; 70; 75

Post-translational modifications (1): 32

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 241 (showing top): CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_DN, KAAB_HEART_ATRIUM_VS_VENTRICLE_UP, GOBP_CANONICAL_NF_KAPPAB_SIGNAL_TRANSDUCTION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, DACOSTA_UV_RESPONSE_VIA_ERCC3_UP, GOBP_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_INTERLEUKIN_1_PRODUCTION, GOBP_LEUKOCYTE_MEDIATED_IMMUNITY, BOYLAN_MULTIPLE_MYELOMA_D_DN, GOLDRATH_ANTIGEN_RESPONSE, GOBP_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE, BROWNE_HCMV_INFECTION_48HR_DN, GOBP_MAST_CELL_ACTIVATION

GO Biological Process (5): positive regulation of cytokine production (GO:0001819), protein transport (GO:0015031), positive regulation of interleukin-1 alpha production (GO:0032730), positive regulation of canonical NF-kappaB signal transduction (GO:0043123), mast cell degranulation (GO:0043303)

GO Molecular Function (10): copper ion binding (GO:0005507), calcium ion binding (GO:0005509), zinc ion binding (GO:0008270), lipid binding (GO:0008289), fibroblast growth factor binding (GO:0017134), protein homodimerization activity (GO:0042803), calcium-dependent protein binding (GO:0048306), RAGE receptor binding (GO:0050786), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (9): extracellular region (GO:0005576), obsolete extracellular space (GO:0005615), nucleus (GO:0005634), nucleoplasm (GO:0005654), nucleolus (GO:0005730), cytoplasm (GO:0005737), cytosol (GO:0005829), plasma membrane (GO:0005886), perinuclear region of cytoplasm (GO:0048471)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	5
transition metal ion binding	2
binding	2
nuclear lumen	2
cytoplasm	2
cytokine production	1
regulation of cytokine production	1
positive regulation of gene expression	1
positive regulation of multicellular organismal process	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
interleukin-1 alpha production	1
regulation of interleukin-1 alpha production	1
positive regulation of interleukin-1 production	1
canonical NF-kappaB signal transduction	1
regulation of canonical NF-kappaB signal transduction	1
positive regulation of intracellular signal transduction	1
mast cell activation involved in immune response	1
mast cell mediated immunity	1
lysosome localization	1
leukocyte degranulation	1
establishment of organelle localization	1
metal ion binding	1
growth factor binding	1
identical protein binding	1
protein dimerization activity	1
calcium ion binding	1
protein binding	1
signaling receptor binding	1
cation binding	1
intracellular membrane-bounded organelle	1
intracellular membraneless organelle	1
intracellular anatomical structure	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

1026 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
S100A13	SYT1	P21579	982
S100A13	FGF1	P05230	922
S100A13	IL1A	P01583	818
S100A13	PBRM1	Q86U86	808
S100A13	SPHK1	Q9NYA1	763
S100A13	CRABP2	P29373	742
S100A13	S100A6	P06703	717
S100A13	S100A3	P33764	700
S100A13	S100A10	P08206	685
S100A13	S100A2	P29034	680
S100A13	S100Z	Q8WXG8	671
S100A13	CLEC1B	Q9P126	662
S100A13	HRNR	Q86YZ3	643
S100A13	S100A7	P31151	584
S100A13	S100B	P04271	570

IntAct

57 interactions, top by confidence:

A	B	Type	Score
KIFAP3	KIF3C	psi-mi:“MI:0914”(association)	0.640
SDC2	PDPK1	psi-mi:“MI:0914”(association)	0.640
PLEKHF2	S100A13	psi-mi:“MI:0915”(physical association)	0.560
S100A13	PLEKHF2	psi-mi:“MI:0915”(physical association)	0.560
S100A13	S100A14	psi-mi:“MI:0915”(physical association)	0.560
TNF	S100A13	psi-mi:“MI:0407”(direct interaction)	0.560
S100A13	TNF	psi-mi:“MI:0407”(direct interaction)	0.560
SNRNP27	UBA6	psi-mi:“MI:0914”(association)	0.530
MGST3	GAPDHS	psi-mi:“MI:0914”(association)	0.530
CCL5	C4A	psi-mi:“MI:0914”(association)	0.530
S100A13	TP53	psi-mi:“MI:0407”(direct interaction)	0.440
S100A13	SLC8A1	psi-mi:“MI:0407”(direct interaction)	0.440
S100A13	EEF1G	psi-mi:“MI:0915”(physical association)	0.400
	FER1L5	psi-mi:“MI:0915”(physical association)	0.400
	TK2	psi-mi:“MI:0915”(physical association)	0.400
S100A13	S100A13	psi-mi:“MI:0915”(physical association)	0.370
S100A13	IGBP1	psi-mi:“MI:0915”(physical association)	0.370
IRF9	S100A13	psi-mi:“MI:0915”(physical association)	0.370
	ESYT2	psi-mi:“MI:0914”(association)	0.350
E5	ESYT2	psi-mi:“MI:0914”(association)	0.350
APP	ESYT2	psi-mi:“MI:0914”(association)	0.350
SDC2	METTL8	psi-mi:“MI:0914”(association)	0.350
SPRY2	SNX3	psi-mi:“MI:0914”(association)	0.350

BioGRID (55): S100A13 (Two-hybrid), PLEKHF2 (Two-hybrid), S100A13 (Affinity Capture-MS), S100A13 (Affinity Capture-MS), S100A13 (Affinity Capture-MS), S100A13 (Affinity Capture-MS), S100A13 (Affinity Capture-MS), S100A13 (Affinity Capture-MS), S100A13 (Biochemical Activity), S100A13 (Affinity Capture-Western), S100A13 (Two-hybrid), S100A14 (Two-hybrid), SYT1 (Co-purification), FGF1 (Co-purification), S100A13 (Proximity Label-MS)

ESM2 similar proteins: O77691, O77791, P02638, P02639, P04271, P04354, P04467, P04631, P05937, P05942, P05964, P06702, P06703, P07091, P07171, P10462, P12658, P14069, P23297, P24479, P25815, P26447, P27004, P28318, P29034, P30801, P31151, P35466, P35467, P50114, P56565, P79105, P79880, P80310, P80511, P97352, Q0VCM0, Q14ST5, Q28050, Q2EN75

Diamond homologs: A7K6Y9, O77691, O77791, P02632, P02633, P02634, P02638, P02639, P04271, P04631, P05942, P05964, P06702, P06703, P07091, P10462, P14069, P20930, P23297, P24480, P25815, P26447, P27003, P28318, P28783, P29034, P29377, P30801, P33763, P33764, P35466, P35467, P50114, P50116, P50117, P56565, P62818, P62819, P63083, P63084

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
PBRM1	“up-regulates quantity by expression”	S100A13	“transcriptional regulation”

Disease & clinical

Clinical variants and AI predictions

ClinVar

28 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	16
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1121 predictions. Top by Δscore:

Variant	Effect	Δscore
1:153619034:ACATC:A	acceptor_gain	1.0000
1:153619035:CATC:C	acceptor_gain	1.0000
1:153619035:CATCC:C	acceptor_gain	1.0000
1:153619036:ATC:A	acceptor_gain	1.0000
1:153619037:TC:T	acceptor_gain	1.0000
1:153619038:CC:C	acceptor_gain	1.0000
1:153619039:C:CC	acceptor_gain	1.0000
1:153619039:CTGA:C	acceptor_loss	1.0000
1:153619040:T:C	acceptor_loss	1.0000
1:153619051:C:CT	acceptor_gain	1.0000
1:153626316:CTAC:C	donor_loss	1.0000
1:153626318:A:C	donor_loss	1.0000
1:153626319:CCTT:C	donor_loss	1.0000
1:153626529:CTGAC:C	acceptor_gain	1.0000
1:153626535:T:G	acceptor_loss	1.0000
1:153628497:G:GG	donor_gain	1.0000
1:153630659:GGAT:G	donor_gain	1.0000
1:153630660:G:GT	donor_gain	1.0000
1:153630660:GAT:G	donor_gain	1.0000
1:153630663:G:GG	donor_gain	1.0000
1:153619039:C:T	acceptor_gain	0.9900
1:153619048:C:CT	acceptor_gain	0.9900
1:153619051:C:T	acceptor_gain	0.9900
1:153619052:A:T	acceptor_gain	0.9900
1:153626318:A:AC	donor_gain	0.9900
1:153626319:C:CC	donor_gain	0.9900
1:153626530:TGAC:T	acceptor_gain	0.9900
1:153626531:GAC:G	acceptor_gain	0.9900
1:153626533:CCTG:C	acceptor_gain	0.9900
1:153626534:C:CC	acceptor_gain	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000143162 (1:153620784 G>A,T), RS1000212278 (1:153619295 G>A), RS1000284570 (1:153620411 A>C), RS1000918441 (1:153622332 C>T), RS1001120163 (1:153632245 A>G), RS1001272366 (1:153620862 T>C), RS1001530344 (1:153632397 G>A), RS1001587220 (1:153632503 C>T), RS1001829229 (1:153625659 C>T), RS1001903315 (1:153632676 C>G,T), RS1002184205 (1:153632941 G>A,C), RS1002210709 (1:153636317 G>A), RS1002257869 (1:153632654 G>A), RS1002348892 (1:153627471 C>G), RS1002516231 (1:153634101 C>T)

Disease associations

OMIM: gene MIM:601989 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST90002400_521	Plateletcrit	4.000000e-15

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007985	platelet crit

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

58 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, increases expression	4
sodium arsenite	decreases expression, increases expression	3
methylmercuric chloride	decreases expression	2
Air Pollutants	decreases expression, increases abundance	2
Copper	affects binding, affects cotreatment, affects folding, affects secretion	2
Doxorubicin	affects expression, increases expression	2
Rotenone	decreases expression, increases expression	2
Smoke	decreases expression, increases abundance	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression, increases expression	2
Aflatoxin B1	affects expression, increases methylation	2
Particulate Matter	decreases expression, increases abundance	2
aristolochic acid I	increases expression	1
FR900359	increases phosphorylation	1
dicrotophos	decreases expression	1
bisphenol A	increases expression	1
pyrogallol 1,3-dimethyl ether	affects cotreatment, decreases expression, affects localization, increases expression	1
beta-lapachone	increases expression	1
perfluorooctanoic acid	increases expression	1
cuprous chloride	affects binding, affects cotreatment, affects folding	1
phenanthrene	decreases expression	1
lewisite	increases expression	1
CGP 52608	affects binding, increases reaction	1
entinostat	increases expression	1
K 7174	increases expression	1
fenpyroximate	increases expression	1
pyrimidifen	increases expression	1
nutlin 3	affects cotreatment, increases secretion	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
bisphenol AF	increases expression	1
Decitabine	affects expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3GF	Abcam HEK293T S100A13 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.