S100A7A

Summary

S100A7A (S100 calcium binding protein A7A, HGNC:21657) is a protein-coding gene on chromosome 1q21.3, encoding Protein S100-A7A (Q86SG5). May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.

Enables identical protein binding activity. Predicted to be involved in endothelial cell migration. Predicted to act upstream of or within inflammatory response. Located in cytosol.

Source: NCBI Gene 338324 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 32 total
• MANE Select transcript: NM_176823

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21657
Approved symbol	S100A7A
Name	S100 calcium binding protein A7A
Location	1q21.3
Locus type	gene with protein product
Status	Approved
Aliases	S100A7f
Ensembl gene	ENSG00000184330
Ensembl biotype	protein_coding
OMIM	617427
Entrez	338324

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000329256, ENST00000368728, ENST00000368729

RefSeq mRNA: 1 — MANE Select: NM_176823 NM_176823

CCDS: CCDS30872

Canonical transcript exons

ENST00000368729 — 3 exons

Exon	Start	End
ENSE00001447855	153419145	153423222
ENSE00001447857	153416520	153416563
ENSE00001629944	153418066	153418223

Expression profiles

Bgee: expression breadth broad, 70 present calls, max score 87.58.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 4.0497 / max 5641.4179, expressed in 70 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
5395	4.0497	70

Top tissues by expression

202 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.58	gold quality
penis	UBERON:0000989	76.22	gold quality
sperm	CL:0000019	76.04	silver quality
gingival epithelium	UBERON:0001949	75.65	gold quality
gingiva	UBERON:0001828	73.08	gold quality
buccal mucosa cell	CL:0002336	72.25	gold quality
mammalian vulva	UBERON:0000997	72.01	gold quality
body of tongue	UBERON:0011876	66.98	gold quality
superior surface of tongue	UBERON:0007371	66.76	gold quality
tongue	UBERON:0001723	66.51	gold quality
cauda epididymis	UBERON:0004360	60.76	gold quality
upper leg skin	UBERON:0004262	59.36	silver quality
esophagus squamous epithelium	UBERON:0006920	57.82	silver quality
cardia of stomach	UBERON:0001162	57.69	gold quality
trigeminal ganglion	UBERON:0001675	56.17	gold quality
ventral tegmental area	UBERON:0002691	56.17	gold quality
tonsil	UBERON:0002372	55.56	gold quality
saphenous vein	UBERON:0007318	55.33	gold quality
pericardium	UBERON:0002407	55.23	gold quality
layer of synovial tissue	UBERON:0007616	55.17	gold quality
thymus	UBERON:0002370	54.92	gold quality
dorsal root ganglion	UBERON:0000044	54.89	gold quality
nipple	UBERON:0002030	54.88	gold quality
epithelium of nasopharynx	UBERON:0001951	54.87	gold quality
synovial joint	UBERON:0002217	54.83	gold quality
inferior vagus X ganglion	UBERON:0005363	54.83	gold quality
pylorus	UBERON:0001166	54.69	gold quality
medulla oblongata	UBERON:0001896	54.56	gold quality
subthalamic nucleus	UBERON:0001906	54.55	gold quality
superior vestibular nucleus	UBERON:0007227	54.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	23.31

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

148 targeting S100A7A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-574-5P	100.00	66.01	989
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-613	99.91	71.50	1710
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-1343-3P	99.89	66.78	1815
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-3681-3P	99.88	70.46	2254
HSA-MIR-7845-5P	99.88	64.88	771
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-221-5P	99.86	65.45	1052
HSA-MIR-8073	99.86	65.21	1118

Literature-anchored findings (GeneRIF, showing 6)

• Molecular cloning and characterization of alternatively spliced S100A15 isoforms from psoriatic skin. (PMID:12923069)
• The S100A15 protein has been expressed & purified to homogeneity in 2 crystal forms. Crystals of form I are triclinic. Crystals of form II are monoclinic & have a solvent content of 51.8%, corresponding to the presence of 1 monomer in the asymmetric unit. (PMID:16682778)
• Overexpression of hS100A15 in chronic inflammatory skin diseases and regulation by inflammatory cytokines and calcium suggest that hS100A15 is involved in Th1-associated epithelial responses and epidermal maturation in normal and diseased human skin (PMID:17620096)
• E. coli modulates S100A15 and IL-8 expression of keratinocytes by recognition through TLR4. (PMID:17625598)
• study defines RAGE (receptor for advanced glycation end products) as the hS100A7 receptor, whereas hS100A15 functions through a Gi protein-coupled receptor (PMID:18606705)
• S100A15 retains the ability to coordinate zinc through incorporation of an exogenous ligand resulting in a unique zinc-binding site among S100 proteins. (PMID:22747601)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	s100s	ENSDARG00000036773
danio_rerio	s100a10a	ENSDARG00000037425
danio_rerio	s100t	ENSDARG00000055589

Paralogs (21): CRNN (ENSG00000143536), S100A8 (ENSG00000143546), S100A7 (ENSG00000143556), S100B (ENSG00000160307), S100A1 (ENSG00000160678), S100A11 (ENSG00000163191), S100A9 (ENSG00000163220), S100A12 (ENSG00000163221), S100P (ENSG00000163993), S100G (ENSG00000169906), S100Z (ENSG00000171643), S100A3 (ENSG00000188015), S100A16 (ENSG00000188643), SNTN (ENSG00000188817), S100A13 (ENSG00000189171), S100A14 (ENSG00000189334), S100A4 (ENSG00000196154), S100A5 (ENSG00000196420), S100A2 (ENSG00000196754), S100A10 (ENSG00000197747), S100A6 (ENSG00000197956)

Protein

Protein identifiers

Protein S100-A7A — Q86SG5 (reviewed: Q86SG5)

Alternative names: S100 calcium-binding protein A15, S100 calcium-binding protein A7-like 1, S100 calcium-binding protein A7A

All UniProt accessions (1): Q86SG5

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.

Subcellular location. Cytoplasm.

Tissue specificity. Overexpressed in psoriasis.

Similarity. Belongs to the S-100 family.

RefSeq proteins (1): NP_789793* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001751	S100/CaBP7/8-like_CS	Conserved_site
IPR002048	EF_hand_dom	Domain
IPR011992	EF-hand-dom_pair	Homologous_superfamily
IPR013787	S100_Ca-bd_sub	Domain
IPR018247	EF_Hand_1_Ca_BS	Binding_site
IPR034325	S-100_dom	Domain

Pfam: PF01023

UniProt features (22 total): binding site 11, helix 5, domain 2, sequence variant 2, chain 1, strand 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
4AQI	X-RAY DIFFRACTION	1.7

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86SG5-F1	95.19	0.95

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (11): 69; 74; 87; 91; 18; 28; 38; 63; 65; 66; 67

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-6799990	Metal sequestration by antimicrobial proteins
R-HSA-168249	Innate Immune System
R-HSA-168256	Immune System
R-HSA-6803157	Antimicrobial peptides

MSigDB gene sets: 45 (showing top): REACTOME_INNATE_IMMUNE_SYSTEM, RICKMAN_HEAD_AND_NECK_CANCER_C, chr1q21, GOMF_CALCIUM_DEPENDENT_PROTEIN_BINDING, REACTOME_METAL_SEQUESTRATION_BY_ANTIMICROBIAL_PROTEINS, REACTOME_ANTIMICROBIAL_PEPTIDES, GLI1_TARGET_GENES, MIR206, MIR1_3P, MIR613, MIR765, MIR4524A_3P, MIR4517, MIR3185, MIR6783_3P

GO Biological Process (1): endothelial cell migration (GO:0043542)

GO Molecular Function (6): calcium ion binding (GO:0005509), identical protein binding (GO:0042802), transition metal ion binding (GO:0046914), calcium-dependent protein binding (GO:0048306), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): cytoplasm (GO:0005737), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Antimicrobial peptides	1
Immune System	1
Innate Immune System	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
metal ion binding	2
protein binding	2
cellular anatomical structure	2
cell migration	1
calcium ion binding	1
binding	1
cation binding	1
intracellular anatomical structure	1
cytoplasm	1

Protein interactions and networks

STRING

468 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
S100A7A	S100A14	Q9HCY8	643
S100A7A	CRCT1	Q9UGL9	621
S100A7A	LTAP1	Q9BWL3	581
S100A7A	S100A12	P80511	581
S100A7A	KRT16	P08779	577
S100A7A	S100A10	P08206	576
S100A7A	S100A5	P33763	575
S100A7A	S100Z	Q8WXG8	573
S100A7A	S100A13	Q99584	546
S100A7A	S100A2	P29034	520
S100A7A	KLK9	Q9UKQ9	520
S100A7A	S100A16	Q96FQ6	519
S100A7A	S100A3	P33764	517
S100A7A	S100A1	P23297	516
S100A7A	HRNR	Q86YZ3	507

IntAct

92 interactions, top by confidence:

A	B	Type	Score
EIF4E2	GIGYF1	psi-mi:“MI:0914”(association)	0.730
CCNC	MED19	psi-mi:“MI:0914”(association)	0.640
S100A7L2	S100A7A	psi-mi:“MI:0915”(physical association)	0.630
S100A7A	S100A7L2	psi-mi:“MI:0915”(physical association)	0.630
S100A7A	CLVS2	psi-mi:“MI:0915”(physical association)	0.560
CLVS2	S100A7A	psi-mi:“MI:0915”(physical association)	0.560
UGT1A10	A2ML1	psi-mi:“MI:0914”(association)	0.530
TBC1D22B	A2ML1	psi-mi:“MI:0914”(association)	0.530
SSBP2	CLEC18A	psi-mi:“MI:0914”(association)	0.530
NPTN	TNPO2	psi-mi:“MI:0914”(association)	0.530
CDK11A	HSP90AA1	psi-mi:“MI:0914”(association)	0.530
S100A7A	MYH9	psi-mi:“MI:0407”(direct interaction)	0.440
S100A7A	SLC8A1	psi-mi:“MI:0407”(direct interaction)	0.440
RASGEF1C	S100A7A	psi-mi:“MI:0915”(physical association)	0.400
CEP20	S100A7A	psi-mi:“MI:0915”(physical association)	0.400
CCNYL1	A2ML1	psi-mi:“MI:0914”(association)	0.350
CDK15	A2ML1	psi-mi:“MI:0914”(association)	0.350
SUSD3	IGLL5	psi-mi:“MI:0914”(association)	0.350
PRKAR1A	RBFOX3	psi-mi:“MI:0914”(association)	0.350
PRKCI	POLRMT	psi-mi:“MI:0914”(association)	0.350
HTRA4	PSMD12	psi-mi:“MI:0914”(association)	0.350
HTRA4	ATOX1	psi-mi:“MI:0914”(association)	0.350
KLHL11	PIPSL	psi-mi:“MI:0914”(association)	0.350
FMNL2	A2ML1	psi-mi:“MI:0914”(association)	0.350

BioGRID (86): S100A7A (Affinity Capture-MS), S100A7A (Affinity Capture-MS), S100A7A (Affinity Capture-MS), S100A7A (Affinity Capture-MS), S100A7A (Affinity Capture-MS), S100A7A (Affinity Capture-MS), S100A7A (Affinity Capture-MS), S100A7A (Affinity Capture-MS), S100A7A (Affinity Capture-MS), S100A7A (Two-hybrid), S100A7L2 (Two-hybrid), S100A7A (Affinity Capture-MS), S100A7A (Affinity Capture-MS), S100A7A (Affinity Capture-MS), S100A7A (Affinity Capture-MS)

ESM2 similar proteins: A5PJN0, A7K6Y8, A7K6Y9, F1SSF9, O73763, O76038, O77791, P05109, P06702, P27005, P28318, P28782, P31725, P33763, P43367, P45961, P50115, P50116, P50117, P63083, P63084, P79105, P80511, Q01449, Q06A97, Q0VFG3, Q14ST5, Q28050, Q3MHP3, Q4R6C5, Q5E9G1, Q5SY68, Q5XJX1, Q63ZJ3, Q6AXZ3, Q6DJ05, Q6R556, Q6S5I3, Q75KU4, Q803V3

Diamond homologs: A7K6Y8, A7K6Y9, O77791, P02632, P02633, P02634, P22793, P24480, P29377, P31151, P31725, P50116, P50117, P79105, P80511, P97816, Q14ST5, Q28050, Q503K9, Q6S5I3, Q865V3, Q86SG5, Q8WXG8, O77691, P05964, P06703, P14069, P28318, P30801, P62818, P62819, Q2EN75, P02638, P02639, P04271, P04631, P05109, P05942, P06702, P07091

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

32 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	22
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

349 predictions. Top by Δscore:

Variant	Effect	Δscore
1:153418220:CTGTG:C	donor_loss	1.0000
1:153418222:GT:G	donor_gain	1.0000
1:153418222:GTGT:G	donor_loss	1.0000
1:153418223:TG:T	donor_loss	1.0000
1:153418224:G:GG	donor_gain	1.0000
1:153418225:TGAG:T	donor_loss	1.0000
1:153419202:GA:G	donor_gain	1.0000
1:153419299:G:GT	donor_gain	1.0000
1:153419299:G:T	donor_gain	1.0000
1:153419349:A:AG	donor_gain	1.0000
1:153418061:T:A	acceptor_gain	0.9900
1:153418190:G:GT	donor_gain	0.9900
1:153418194:G:GT	donor_gain	0.9900
1:153418219:CCTGT:C	donor_gain	0.9900
1:153418220:CTGT:C	donor_gain	0.9900
1:153418226:G:GC	donor_loss	0.9900
1:153418227:AGT:A	donor_loss	0.9900
1:153419140:CACA:C	acceptor_loss	0.9900
1:153419142:CA:C	acceptor_loss	0.9900
1:153419143:A:AG	acceptor_gain	0.9900
1:153419144:G:GG	acceptor_gain	0.9900
1:153419144:G:GT	acceptor_loss	0.9900
1:153419203:A:G	donor_gain	0.9900
1:153419344:G:GT	donor_gain	0.9900
1:153419345:A:T	donor_gain	0.9900
1:153419349:A:G	donor_gain	0.9900
1:153416562:TGGTA:T	donor_loss	0.9800
1:153416563:GGTA:G	donor_loss	0.9800
1:153416564:G:GG	donor_gain	0.9800
1:153416564:GTA:G	donor_loss	0.9800

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000278785 (1:153415717 G>A,C,T), RS1000353643 (1:153415604 G>T), RS1000583329 (1:153415123 G>A), RS1000694675 (1:153414646 CTCAT>C), RS1000940933 (1:153423200 A>G), RS1001179576 (1:153418503 CCT>C), RS1001277579 (1:153421884 C>T), RS1001309991 (1:153421751 C>A), RS1002447248 (1:153417743 G>T), RS1002952679 (1:153420920 A>G), RS1003016349 (1:153420600 G>C), RS1003276788 (1:153419609 G>A,T), RS1003584041 (1:153415893 A>G), RS1004482270 (1:153416105 C>T), RS1004814475 (1:153415232 G>A)

Disease associations

OMIM: gene MIM:617427 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST008916_87	Asthma	2.000000e-13
GCST011383_8	Mastocytosis	8.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

14 total (human), top 14 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects expression, increases expression	3
Nickel	increases expression	2
hydroquinone	decreases expression	1
CGP 52608	increases reaction, affects binding	1
Glyphosate	increases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Cadmium	increases abundance, increases expression	1
Sodium Dodecyl Sulfate	decreases expression, increases expression	1
Tetrachlorodibenzodioxin	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Aflatoxin B1	decreases methylation	1
Cadmium Chloride	increases abundance, increases expression	1
Particulate Matter	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.