SACK1A-AS1

Summary

SACK1A-AS1 (SACK1A antisense RNA 1, HGNC:48658) is a long non-coding RNA gene on chromosome 8q24.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48658
Approved symbol	SACK1A-AS1
Name	SACK1A antisense RNA 1
Location	8q24.13
Locus type	RNA, long non-coding
Status	Approved
Aliases	HCCC11
Ensembl gene	ENSG00000204949
Ensembl biotype	lncRNA
Entrez	100131726
RNAcentral	URS000075ADF1 — lncRNA, 1175 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000517519, ENST00000520576, ENST00000523330, ENST00000654317, ENST00000661117, ENST00000687267, ENST00000785094, ENST00000785095

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000517519 — 3 exons

Exon	Start	End
ENSE00001476173	123201644	123201982
ENSE00004160547	123202208	123202743
ENSE00004160548	123201171	123201454

Expression profiles

Bgee: expression breadth broad, 95 present calls, max score 94.19.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1251 / max 128.0284, expressed in 11 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
94705	0.0486	7
94707	0.0417	4
94706	0.0275	8
94708	0.0072	2

Top tissues by expression

95 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	94.19	gold quality
lower esophagus mucosa	UBERON:0035834	93.01	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.66	gold quality
esophagus mucosa	UBERON:0002469	84.41	gold quality
right lobe of liver	UBERON:0001114	83.55	gold quality
liver	UBERON:0002107	82.64	gold quality
vagina	UBERON:0000996	79.67	gold quality
esophagus	UBERON:0001043	78.46	gold quality
ectocervix	UBERON:0012249	64.85	gold quality
sural nerve	UBERON:0015488	64.76	silver quality
tonsil	UBERON:0002372	64.09	gold quality
uterine cervix	UBERON:0000002	62.69	gold quality
minor salivary gland	UBERON:0001830	57.06	gold quality
blood	UBERON:0000178	56.98	gold quality
duodenum	UBERON:0002114	56.92	gold quality
bone marrow	UBERON:0002371	56.69	gold quality
right adrenal gland	UBERON:0001233	56.65	gold quality
right adrenal gland cortex	UBERON:0035827	56.54	gold quality
left adrenal gland cortex	UBERON:0035825	55.13	gold quality
skin of abdomen	UBERON:0001416	55.10	gold quality
monocyte	CL:0000576	54.93	gold quality
left adrenal gland	UBERON:0001234	54.88	gold quality
multicellular organism	UBERON:0000468	54.49	gold quality
gall bladder	UBERON:0002110	54.22	gold quality
kidney	UBERON:0002113	53.51	gold quality
urinary bladder	UBERON:0001255	53.24	gold quality
islet of Langerhans	UBERON:0000006	52.39	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	52.28	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	51.93	gold quality
zone of skin	UBERON:0000014	51.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.79

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• LncRNA FAM83A-AS1 promotes lung adenocarcinoma by increasing FAM83A expression. (PMID:30659636)
• FAM83A-AS1 promotes lung adenocarcinoma cell migration and invasion by targeting miR-150-5p and modifying MMP14. (PMID:31522616)
• LncRNA FAM83A-AS1 aggravates the malignant development of esophageal cancer by binding to miR-495-3p. (PMID:33015782)
• LncRNA FAM83A-AS1 promotes lung adenocarcinoma progression by enhancing the pre-mRNA stability of FAM83A. (PMID:33687144)
• Long non-coding RNA FAM83A antisense RNA 1 (lncRNA FAM83A-AS1) targets microRNA-141-3p to regulate lung adenocarcinoma cell proliferation, migration, invasion, and epithelial-mesenchymal transition progression. (PMID:35164653)
• FAM83A antisense RNA 1 (FAM83A-AS1) silencing impairs cell proliferation and induces autophagy via MET-AMPKa signaling in lung adenocarcinoma. (PMID:35635086)
• High-risk pathological subtype associated FAM83A-AS1 promotes malignancy and glycolysis of lung adenocarcinoma via miR-202-3p/HK2 axis. (PMID:36960858)
• LncRNA FAM83A-AS1 promotes epithelial-mesenchymal transition of pancreatic cancer cells via Hippo pathway. (PMID:37245082)
• Sense and anti-sense: Role of FAM83A and FAM83A-AS1 in Wnt, EGFR, PI3K, EMT pathways and tumor progression. (PMID:38432129)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.