SACS-AS1

Summary

SACS-AS1 (SACS antisense RNA 1, HGNC:39835) is a long non-coding RNA gene on chromosome 13q12.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39835
Approved symbol	SACS-AS1
Name	SACS antisense RNA 1
Location	13q12.12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000229558
Ensembl biotype	lncRNA
Entrez	100506680
RNAcentral	URS000075C13A — lncRNA, 2246 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000443092

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000443092 — 2 exons

Exon	Start	End
ENSE00004280635	23426967	23428869
ENSE00004280636	23418940	23419301

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 81.23.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0132 / max 17.4270, expressed in 4 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
134397	0.0132	4

Top tissues by expression

188 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.23	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.19	gold quality
lower lobe of lung	UBERON:0008949	63.63	silver quality
cortical plate	UBERON:0005343	59.85	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.52	gold quality
ventricular zone	UBERON:0003053	58.38	silver quality
ganglionic eminence	UBERON:0004023	57.96	gold quality
popliteal artery	UBERON:0002250	53.84	gold quality
tibial artery	UBERON:0007610	53.72	gold quality
aorta	UBERON:0000947	53.47	gold quality
thoracic aorta	UBERON:0001515	53.19	gold quality
ascending aorta	UBERON:0001496	53.13	gold quality
descending thoracic aorta	UBERON:0002345	51.80	gold quality
muscle of leg	UBERON:0001383	51.37	gold quality
left coronary artery	UBERON:0001626	50.51	gold quality
gastrocnemius	UBERON:0001388	50.30	gold quality
smooth muscle tissue	UBERON:0001135	50.17	gold quality
right coronary artery	UBERON:0001625	49.91	gold quality
coronary artery	UBERON:0001621	49.80	gold quality
mucosa of stomach	UBERON:0001199	49.16	gold quality
body of stomach	UBERON:0001161	48.21	gold quality
testis	UBERON:0000473	47.67	gold quality
ovary	UBERON:0000992	47.61	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	47.53	gold quality
lower esophagus muscularis layer	UBERON:0035833	47.49	gold quality
islet of Langerhans	UBERON:0000006	47.45	gold quality
lower esophagus	UBERON:0013473	47.45	gold quality
skin of hip	UBERON:0001554	46.98	silver quality
lung	UBERON:0002048	46.84	silver quality
right testis	UBERON:0004534	46.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.63

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The relationship between the lncRNA model and prognosis as well as clinical characteristics of patients with HCC was analyzed. Finally, a predictive nomogram in the the cancer genome atlas cohort was established and verified internallyBased on the RNA sequencing survival analysis, a 9- lncRNAs prognosis model, including TMCC1-AS1, AC008892.1, AL031985.3, L34079.2, U95743.1, KDM4A-AS1, SACS-AS1, AC005534.1, LINC01116. (PMID:32481346)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.