SAMD13

Summary

SAMD13 (sterile alpha motif domain containing 13, HGNC:24582) is a protein-coding gene on chromosome 1p31.1, encoding Sterile alpha motif domain-containing protein 13 (Q5VXD3).

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 18 total
• GTEx eGene: eQTL in 13 tissues, sQTL in 3 (q < 0.05)
• Constraint (gnomAD): pLI 0.33 (intermediate), LOEUF 1.03 (unconstrained)
• MANE Select transcript: NM_001134663

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24582
Approved symbol	SAMD13
Name	sterile alpha motif domain containing 13
Location	1p31.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000203943
Ensembl biotype	protein_coding
OMIM	620800
Entrez	148418

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 8 protein_coding, 2 retained_intron

MANE Select: ENST00000394834

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 2, TSL 2: 2, TSL 3: 4, TSL 4: 1

ENST00000394834, ENST00000370668, ENST00000370669, ENST00000370670, ENST00000370671, ENST00000370673, ENST00000454967, ENST00000463429, ENST00000479082, ENST00001109792

RefSeq mRNA: 3 — MANE Select: NM_001134663 NM_001010971, NM_001134663, NM_001134664

CCDS: CCDS30760, CCDS44166

Canonical transcript exons

ENST00000394834 — 4 exons

Exon	Start	End
ENSE00001453276	84301708	84301801
ENSE00001453280	84349631	84350798
ENSE00001453281	84325637	84325748
ENSE00003589303	84303203	84303287

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 89.67.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6020 / max 43.0608, expressed in 248 samples.

Highest expression (Bgee): rectum, primordial germ cell in gonad, male germ line stem cell (sensu Vertebrata) in testis, mucosa of transverse colon, corpus callosum.

Genetic regulation across tissues (GTEx eQTL / sQTL)

SAMD13 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 13 tissues and its splicing (sQTL) in 3 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

16 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Cells Cultured fibroblasts	eqtl	1.1e-06	-1.15	1:84298566:A:G
Esophagus Mucosa	eqtl	2.7e-05	-0.93	1:84298566:A:G
Stomach	eqtl	4.1e-05	-0.16	1:84420612:T:A
Prostate	eqtl	4.7e-05	-0.25	1:84441771:G:A
Cells EBV-transformed lymphocytes	eqtl	5.7e-05	+0.40	1:84295283:C:T
Skin Sun Exposed Lower leg	eqtl	1.4e-03	-0.74	1:84298566:A:G
Testis	eqtl	2.8e-03	-0.59	1:84298566:A:G
Thyroid	eqtl	3.9e-03	-0.51	1:84298566:A:G
Skin Not Sun Exposed Suprapubic	eqtl	4.4e-03	-0.83	1:84298566:A:G
Brain Spinal cord cervical c-1	eqtl	9.5e-03	-0.31	1:83353471:G:T
Nerve Tibial	eqtl	1.3e-02	+0.49	1:84316958:C:T
Testis	sqtl	1.7e-02	+1.62	1:84382544:A:G
Muscle Skeletal	sqtl	2.0e-02	+1.13	1:83978493:T:A
Spleen	eqtl	2.1e-02	+0.51	1:83539142:G:T
Pituitary	sqtl	4.3e-02	+0.96	1:84291036:A:G
Brain Caudate basal ganglia	eqtl	5.0e-02	-0.37	1:84769868:C:A

FANTOM5 promoters

2 alternative TSS:

Promoter ID	TPM avg	Samples expressed
3792	0.3922	169
3791	0.2098	78

Top tissues by expression

showing 100 of 133 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
rectum	UBERON:0001052	89.67	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.24	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.11	gold quality
mucosa of transverse colon	UBERON:0004991	84.57	gold quality
corpus callosum	UBERON:0002336	80.24	gold quality
right testis	UBERON:0004534	79.73	gold quality
testis	UBERON:0000473	79.51	gold quality
left testis	UBERON:0004533	79.13	gold quality
transverse colon	UBERON:0001157	77.69	gold quality
hindlimb stylopod muscle	UBERON:0004252	76.26	gold quality
gastrocnemius	UBERON:0001388	75.95	gold quality
muscle of leg	UBERON:0001383	75.39	gold quality
thyroid gland	UBERON:0002046	74.30	gold quality
skeletal muscle tissue	UBERON:0001134	74.16	gold quality
adrenal tissue	UBERON:0018303	74.10	gold quality
left lobe of thyroid gland	UBERON:0001120	74.08	gold quality
right adrenal gland cortex	UBERON:0035827	73.77	gold quality
right adrenal gland	UBERON:0001233	73.61	gold quality
right uterine tube	UBERON:0001302	73.29	gold quality
right lobe of thyroid gland	UBERON:0001119	73.15	gold quality
muscle tissue	UBERON:0002385	72.72	gold quality
left adrenal gland	UBERON:0001234	72.44	gold quality
ganglionic eminence	UBERON:0004023	72.26	gold quality
fundus of stomach	UBERON:0001160	72.09	gold quality
endometrium	UBERON:0001295	72.03	gold quality
ventricular zone	UBERON:0003053	71.91	gold quality
adrenal gland	UBERON:0002369	71.88	gold quality
left adrenal gland cortex	UBERON:0035825	71.85	gold quality
duodenum	UBERON:0002114	71.73	gold quality
body of stomach	UBERON:0001161	71.51	gold quality
colonic epithelium	UBERON:0000397	71.45	gold quality
islet of Langerhans	UBERON:0000006	71.32	gold quality
stomach	UBERON:0000945	71.24	gold quality
prefrontal cortex	UBERON:0000451	70.96	gold quality
saliva-secreting gland	UBERON:0001044	70.91	gold quality
colon	UBERON:0001155	70.39	gold quality
stromal cell of endometrium	CL:0002255	70.21	gold quality
minor salivary gland	UBERON:0001830	69.34	gold quality
intestine	UBERON:0000160	69.32	gold quality
nucleus accumbens	UBERON:0001882	69.29	gold quality
smooth muscle tissue	UBERON:0001135	69.20	gold quality
fallopian tube	UBERON:0003889	68.87	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	68.82	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.58	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.50	gold quality
frontal cortex	UBERON:0001870	68.48	gold quality
superior frontal gyrus	UBERON:0002661	67.76	gold quality
gall bladder	UBERON:0002110	67.60	gold quality
cerebral cortex	UBERON:0000956	67.43	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.35	gold quality
pancreas	UBERON:0001264	67.13	gold quality
tonsil	UBERON:0002372	66.96	gold quality
primary visual cortex	UBERON:0002436	66.81	gold quality
Ammon’s horn	UBERON:0001954	66.73	gold quality
brain	UBERON:0000955	66.52	gold quality
substantia nigra	UBERON:0002038	66.49	gold quality
cerebellar cortex	UBERON:0002129	66.48	gold quality
cerebellar hemisphere	UBERON:0002245	66.39	gold quality
cerebellum	UBERON:0002037	66.36	gold quality
caudate nucleus	UBERON:0001873	66.22	gold quality
hypothalamus	UBERON:0001898	66.19	gold quality
putamen	UBERON:0001874	65.99	gold quality
anterior cingulate cortex	UBERON:0009835	65.93	gold quality
body of pancreas	UBERON:0001150	65.53	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.02	gold quality
amygdala	UBERON:0001876	65.00	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.98	gold quality
right frontal lobe	UBERON:0002810	64.92	gold quality
temporal lobe	UBERON:0001871	64.91	gold quality
small intestine	UBERON:0002108	64.85	gold quality
prostate gland	UBERON:0002367	63.91	gold quality
vermiform appendix	UBERON:0001154	63.71	gold quality
body of uterus	UBERON:0009853	63.60	gold quality
metanephros cortex	UBERON:0010533	63.07	gold quality
urinary bladder	UBERON:0001255	62.92	gold quality
adult mammalian kidney	UBERON:0000082	62.86	gold quality
thoracic mammary gland	UBERON:0005200	62.55	gold quality
lymph node	UBERON:0000029	62.54	gold quality
multicellular organism	UBERON:0000468	62.53	gold quality
adenohypophysis	UBERON:0002196	62.50	gold quality
descending thoracic aorta	UBERON:0002345	62.22	gold quality
kidney	UBERON:0002113	62.08	gold quality
cortex of kidney	UBERON:0001225	61.79	gold quality
heart left ventricle	UBERON:0002084	61.55	gold quality
myometrium	UBERON:0001296	61.49	gold quality
left uterine tube	UBERON:0001303	61.29	gold quality
heart	UBERON:0000948	61.17	gold quality
placenta	UBERON:0001987	61.08	gold quality
muscle layer of sigmoid colon	UBERON:0035805	60.82	gold quality
pituitary gland	UBERON:0000007	60.71	gold quality
endocervix	UBERON:0000458	60.41	gold quality
thoracic aorta	UBERON:0001515	60.34	gold quality
mucosa of stomach	UBERON:0001199	60.14	gold quality
ascending aorta	UBERON:0001496	60.06	gold quality
esophagus mucosa	UBERON:0002469	60.02	gold quality
omental fat pad	UBERON:0010414	59.75	gold quality
spleen	UBERON:0002106	59.52	gold quality
right atrium auricular region	UBERON:0006631	59.52	gold quality
monocyte	CL:0000576	59.39	gold quality
adipose tissue	UBERON:0001013	59.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	5.14

HPA expression

RNA tissue specificity: Tissue enhanced

showing 60 of 79 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM	Protein (IHC)
Choroid plexus	tissue	22.9
Rectum	tissue	20.6	high
Colon	tissue	18.2	high
Salivary gland	tissue	16.5	not detected
Hippocampus	tissue	13.0	not detected
Testis	tissue	12.3	medium
Nucleus accumbens	tissue	11.6
Postcentral gyrus	tissue	9.3
Thyroid gland	tissue	9.1	low
Locus coeruleus	tissue	8.0
Stomach 1	tissue	5.7	medium
Skeletal muscle	tissue	5.4	low
Epididymis	tissue	3.9	not detected
Fallopian tube	tissue	3.9	low
Prostate	tissue	3.7	not detected
Small intestine	tissue	3.6	high
Adrenal gland	tissue	3.2	medium
Duodenum	tissue	3.1	high
Corpus callosum	tissue	3.1
Tongue	tissue	2.8
Thymus	tissue	2.6
Bone marrow	tissue	2.6	not detected
Spinal cord	tissue	2.3
Breast	tissue	2.2	low
Heart muscle	tissue	2.2	not detected
Periaqueductal gray	tissue	2.2
Septum	tissue	2.2
Smooth muscle	tissue	2.1	not detected
Medulla oblongata	tissue	2.1
Substantia nigra	tissue	2.1
Seminal vesicle	tissue	2.0	low
Hypothalamus	tissue	2.0
Pons	tissue	1.9
Midbrain	tissue	1.9
Ventral forebrain	tissue	1.8
Urinary bladder	tissue	1.7	medium
Pancreas	tissue	1.7	low
Gallbladder	tissue	1.7	not detected
Endometrium 1	tissue	1.6	low
Cervix	tissue	1.5	low
Putamen	tissue	1.5
Thalamus	tissue	1.5
Amygdala	tissue	1.4
Appendix	tissue	1.4	high
Basal ganglia	tissue	1.3	not detected
Superior colliculi	tissue	1.3
Kidney	tissue	1.3	high
Hippocampal formation	tissue	1.3
Skin 1	tissue	1.1	not detected
Lymph node	tissue	1.1	not detected
Parathyroid gland	tissue	1.1	not detected
Olfactory bulb	tissue	1.1
Prefrontal cortex	tissue	1.0
Cerebral cortex	tissue	1.0	low
Cerebellum	tissue	1.0	medium
Spleen	tissue	1.0	not detected
Entorhinal cortex	tissue	1.0
Temporal cortex	tissue	1.0
Insular cortex	tissue	1.0
Pituitary gland	tissue	0.9

Brain sub-regions (HPA Brain Atlas): detected in 191; highest nTPM — Somatomor cortex, precentral gyrus (white matter) (32.7), Corticomedial amygdala (22.3), Area parastriata, superior (21.7), Lateral thalamic nuclei (20.3), Hippocampus, CA2 (18.7).

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

Targeting SAMD13 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific).

showing 30 of 78 miRNAs:

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-182-5P	99.87	74.03	2589
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-579-3P	99.86	71.66	3628
HSA-MIR-664B-3P	99.84	71.65	3590
HSA-MIR-130B-5P	99.83	68.50	1888
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-4659A-3P	99.80	72.62	4248

Functional genomics

gnomAD constraint: pLI 0.332, LOEUF 1.03, missense Z 1.46 — population loss-of-function intolerance (pLI ≥ 0.9 = LoF-intolerant; lower LOEUF = more constrained). gnomAD

Regional missense constraint (gnomAD RMC): no regional variation along ENST00000394834 — one region, missense o/e 0.70.

Literature-anchored findings (GeneRIF, showing 1)

• SAMD13 serves as a useful prognostic biomarker for hepatocellular carcinoma. (PMID:37968735)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	samd13	ENSDARG00000062977
mus_musculus	Samd13	ENSMUSG00000048652
rattus_norvegicus	Samd13	ENSRNOG00000016432
drosophila_melanogaster	Sfmbt	FBGN0032475
caenorhabditis_elegans	lin-61	WBGENE00003041
caenorhabditis_elegans	mbtr-1	WBGENE00021661

Paralogs (18): SCMH1 (ENSG00000010803), MBTD1 (ENSG00000011258), SCML1 (ENSG00000047634), L3MBTL2 (ENSG00000100395), SCML2 (ENSG00000102098), PHC1 (ENSG00000111752), THAP10 (ENSG00000129028), PHC2 (ENSG00000134686), SAMD1 (ENSG00000141858), SCML4 (ENSG00000146285), L3MBTL4 (ENSG00000154655), SFMBT1 (ENSG00000163935), PHC3 (ENSG00000173889), L3MBTL1 (ENSG00000185513), SAMD7 (ENSG00000187033), SAMD11 (ENSG00000187634), SFMBT2 (ENSG00000198879), L3MBTL3 (ENSG00000198945)

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Oryctolagus cuniculus	Q6SPE9	86.4%	Diamond
Drosophila pseudoobscura pseudoobscura	Q29L50	78.9%	Diamond
Xenopus laevis	Q4V7W5	67.9%	Diamond
Gallus gallus	E1C2V1	67.1%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
PRKACB	protein-coding	5567
SPATA1	protein-coding	100505741
CTBS	protein-coding	1486
GNG5	protein-coding	2787
DNASE2B	protein-coding	58511
RPF1	protein-coding	80135

Protein

Protein identifiers

Sterile alpha motif domain-containing protein 13 — Q5VXD3 (reviewed: Q5VXD3)

All UniProt accessions (2): H7BZX5, Q5VXD3

Isoforms (4)

UniProt ID	Names	Canonical?
Q5VXD3-1	1	yes
Q5VXD3-2	2
Q5VXD3-3	3
Q5VXD3-4	4

RefSeq proteins (3): NP_001010971, NP_001128135, NP_001128136 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001660	SAM	Domain
IPR013761	SAM/pointed_sf	Homologous_superfamily
IPR050548	PcG_chromatin_remod_factors	Family

Pfam: PF00536

UniProt features (5 total): splice variant 3, chain 1, domain 1

Structure

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5VXD3-F1	78.42	0.53

Human Protein Atlas

Protein class: Predicted intracellular proteins, UniProt - Evidence at transcript level

Protein evidence: Evidence at protein level

Subcellular location (HPA, imaging): mitochondria

Antibody reliability (HPA): IH enhanced · IF approved

Function

Pathways and Gene Ontology

Reactome pathways

0 curated (TAS) of 0; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

MSigDB gene sets: 58 (showing top): JAATINEN_HEMATOPOIETIC_STEM_CELL_UP, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN, MARSON_BOUND_BY_FOXP3_STIMULATED, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_RED_DN, GEORGES_TARGETS_OF_MIR192_AND_MIR215, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN, CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_DN, TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP, STK33_NOMO_DN, DLX6_TARGET_GENES, FEV_TARGET_GENES, LHX9_TARGET_GENES, PRDM5_TARGET_GENES, ZFP91_TARGET_GENES, ZNF410_TARGET_GENES

GO Molecular Function (1): protein binding (GO:0005515)

GO top-level categories

1 GO namespaces:

Category	Terms
binding	1

Protein interactions and networks

STRING

showing 15 of 300 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SAMD13	TMEM97	Q5BJF2	404
SAMD13	NXPE4	Q6UWF7	388
SAMD13	REP15	Q6BDI9	360
SAMD13	PJA2	O43164	347
SAMD13	CAMK2N1	Q7Z7J9	342
SAMD13	KLF12	Q9Y4X4	317
SAMD13	TINAG	Q9UJW2	298
SAMD13	SAMD12	Q8N8I0	285
SAMD13	SPRR2G	Q9BYE4	285
SAMD13	WDHD1	O75717	249
SAMD13	TCN2	P20062	246
SAMD13	NXPH2	O95156	246
SAMD13	FAM135B	Q49AJ0	236
SAMD13	MARF1	Q9Y4F3	235
SAMD13	RPH3AL	Q9UNE2	232

IntAct

Human interaction partners of SAMD13 in IntAct, one row per partner (best MIscore; records = supporting IntAct interaction records).

1 partners by confidence:

Partner	Interaction type	MIscore	Records
L3MBTL3	association	0.640	1

BioGRID (9 interactions; top human partners by supporting records): L3MBTL3 (Affinity Capture-MS; 4 records), HNRNPL (Affinity Capture-RNA), L3MBTL4 (Affinity Capture-MS), SAMD1 (Affinity Capture-MS), SFMBT1 (Affinity Capture-MS), TIPARP (Proximity Label-MS)

Disease & clinical

Genetic variants

Variant evidence for SAMD13: 18 ClinVar records (0 pathogenic / likely pathogenic); 4 GWAS associations.

ClinVar

18 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	14
Likely benign	0
Benign	0

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 29 predictions of 433):

Position(s)	Effect	Δscore	Sites
1:84303196	acceptor_gain	0.9900
1:84308918	donor_gain	0.9900
1:84325748–84325751	donor_loss	0.9700	9
1:84349629–84349630	acceptor_loss	0.9700	6
1:84301763	donor_gain	0.9600
1:84325748	donor_loss	0.9600
1:84325751	donor_loss	0.9600
1:84325625	acceptor_loss	0.9500
1:84325634–84325636	acceptor_loss	0.9500	7
1:84349628	acceptor_loss	0.9500

HPA cancer prognostics

RNA cancer specificity: Low cancer specificity

Human Protein Atlas survival analysis — favorable = higher expression predicts better survival.

4 prognostic cancer types:

Cancer	Prognostic	p-value
Glioblastoma Multiforme (TCGA)	favorable	1.15e-05
Kidney Renal Clear Cell Carcinoma (TCGA)	favorable	5.09e-05
Pancreatic Adenocarcinoma (validation)	favorable	0.000351
Lung Adenocarcinoma (TCGA)	unfavorable	0.000924

Disease associations

OMIM: gene MIM:620800 | disease phenotypes:

GWAS associations

4 associations:

Study	Trait	p-value
GCST011768_20	Schizophrenia	9e-9
GCST009391_1136	Metabolite levels	3e-7
GCST010039_13	Adverse response to inhaled corticosteroid treatment x age interaction in asthma	4e-7
GCST001762_588	Obesity-related traits	4e-6

EFO canonical traits (from GWAS)

2 canonical traits:

EFO ID	Trait name
EFO:0010364	lysophosphatidylcholine 20:5 measurement
EFO:0008007	age at assessment

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (CPIC guideline: no)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, increases expression, affects expression	5
methylmercuric chloride	decreases expression	2
trichostatin A	increases expression	2
mercuric bromide	decreases expression, affects cotreatment	2
(+)-JQ1 compound	decreases expression	2
Phenylmercuric Acetate	decreases expression, affects cotreatment	2
Silicon Dioxide	decreases expression	2
p-Chloromercuribenzoic Acid	affects cotreatment, decreases expression	2
bisphenol A	decreases expression	1
ethyl-p-hydroxybenzoate	decreases expression	1
butyraldehyde	decreases expression	1
avobenzone	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	decreases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	affects cotreatment, increases expression	1
Vorinostat	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Benzo(a)pyrene	increases methylation	1
Calcitriol	decreases expression, affects cotreatment	1
Carbamazepine	affects expression	1
Catechin	affects cotreatment, decreases expression	1
Cisplatin	affects cotreatment, increases expression	1
Estradiol	affects cotreatment, decreases expression	1
Formaldehyde	decreases expression	1
Testosterone	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Aflatoxin B1	decreases methylation	1
Gold Compounds	decreases expression	1

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.