SAMD4B

Summary

SAMD4B (sterile alpha motif domain containing 4B, HGNC:25492) is a protein-coding gene on chromosome 19q13.2, encoding Protein Smaug homolog 2 (Q5PRF9). Has transcriptional repressor activity. It is a selective cancer dependency (DepMap: 21.3% of cell lines).

Enables RNA binding activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within cerebellar neuron development. Located in cytosol.

Source: NCBI Gene 55095 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 98 total
• Cancer dependency (DepMap): dependent in 21.3% of screened cell lines
• MANE Select transcript: NM_001384574

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25492
Approved symbol	SAMD4B
Name	sterile alpha motif domain containing 4B
Location	19q13.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10211, MGC99832, SMGB, hSmaug2
Ensembl gene	ENSG00000179134
Ensembl biotype	protein_coding
OMIM	619231
Entrez	55095

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 16 protein_coding, 4 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000314471, ENST00000594204, ENST00000595476, ENST00000596271, ENST00000596319, ENST00000596368, ENST00000598605, ENST00000598913, ENST00000599712, ENST00000600018, ENST00000601613, ENST00000610417, ENST00000863006, ENST00000863007, ENST00000863008, ENST00000863009, ENST00000936210, ENST00000936211, ENST00000936212, ENST00000936213, ENST00000961383

RefSeq mRNA: 30 — MANE Select: NM_001384574 NM_001303614, NM_001384565, NM_001384566, NM_001384568, NM_001384569, NM_001384570, NM_001384571, NM_001384573, NM_001384574, NM_001384575, NM_001384576, NM_001384577, NM_001384578, NM_001384580, NM_001384581, NM_001384582, NM_001384583, NM_001384584, NM_001384585, NM_001384586, NM_001384587, NM_001384588, NM_001384589, NM_001384590, NM_001384591, NM_001384592, NM_001384593, NM_001384594, NM_001384595, NM_018028

CCDS: CCDS33020, CCDS77295

Canonical transcript exons

ENST00000610417 — 14 exons

Exon	Start	End
ENSE00000341670	39369655	39370125
ENSE00000705462	39375650	39375889
ENSE00001141508	39356689	39357089
ENSE00001233488	39378504	39378589
ENSE00001233494	39377485	39377824
ENSE00001233510	39376705	39376791
ENSE00001510605	39354006	39354066
ENSE00002445110	39383208	39383291
ENSE00002504139	39380990	39381113
ENSE00003194560	39342421	39342576
ENSE00003485300	39379966	39380084
ENSE00003663194	39380587	39380785
ENSE00003716431	39383499	39385700
ENSE00003789856	39376437	39376546

Expression profiles

Bgee: expression breadth ubiquitous, 267 present calls, max score 99.03.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.9176 / max 148.7481, expressed in 1789 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
175698	12.8597	1783
175699	1.0579	694

Top tissues by expression

289 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	99.03	gold quality
adenohypophysis	UBERON:0002196	98.56	gold quality
tibial nerve	UBERON:0001323	98.51	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	98.46	gold quality
right frontal lobe	UBERON:0002810	98.37	gold quality
ectocervix	UBERON:0012249	98.27	gold quality
mucosa of stomach	UBERON:0001199	98.26	gold quality
left ovary	UBERON:0002119	98.26	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	98.11	gold quality
endocervix	UBERON:0000458	98.09	gold quality
right ovary	UBERON:0002118	98.05	gold quality
anterior cingulate cortex	UBERON:0009835	98.03	gold quality
lower esophagus	UBERON:0013473	98.03	gold quality
lower esophagus muscularis layer	UBERON:0035833	98.03	gold quality
skin of leg	UBERON:0001511	98.00	gold quality
cingulate cortex	UBERON:0003027	98.00	gold quality
right testis	UBERON:0004534	97.96	gold quality
left lobe of thyroid gland	UBERON:0001120	97.88	gold quality
right lobe of thyroid gland	UBERON:0001119	97.87	gold quality
left uterine tube	UBERON:0001303	97.86	gold quality
left testis	UBERON:0004533	97.83	gold quality
popliteal artery	UBERON:0002250	97.82	gold quality
tibial artery	UBERON:0007610	97.82	gold quality
skin of abdomen	UBERON:0001416	97.81	gold quality
body of uterus	UBERON:0009853	97.77	gold quality
pituitary gland	UBERON:0000007	97.74	gold quality
right uterine tube	UBERON:0001302	97.74	gold quality
amygdala	UBERON:0001876	97.72	gold quality
muscle layer of sigmoid colon	UBERON:0035805	97.70	gold quality
right coronary artery	UBERON:0001625	97.67	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.23
E-GEOD-137537	yes	3.81

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

168 targeting SAMD4B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-4271	99.88	68.32	2244

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 21.3% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 2)

• Results suggest that SAMD4B is a widely expressed gene involved in AP-1-, p53-and p21-mediated transcriptional signaling activity. (PMID:20510020)
• miR451 suppresses the malignant characteristics of colorectal cancer via targeting SAMD4B. (PMID:34109425)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	SAMD4B	ENSDARG00000086735
mus_musculus	Samd4b	ENSMUSG00000109336
rattus_norvegicus	Samd4b	ENSRNOG00000079475
drosophila_melanogaster	smg	FBGN0016070
caenorhabditis_elegans		WBGENE00022538

Paralogs (1): SAMD4A (ENSG00000020577)

Protein

Protein identifiers

Protein Smaug homolog 2 — Q5PRF9 (reviewed: Q5PRF9)

Alternative names: Sterile alpha motif domain-containing protein 4B

All UniProt accessions (6): Q5PRF9, M0QX45, M0QY61, M0QZ22, M0QZW7, M0R0X3

UniProt curated annotations — full annotation on UniProt →

Function. Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A.

Subcellular location. Cytoplasm. Nucleus.

Tissue specificity. Widely expressed in embryonic and adult tissues.

Similarity. Belongs to the SMAUG family.

RefSeq proteins (30): NP_001290543, NP_001371494, NP_001371495, NP_001371497, NP_001371498, NP_001371499, NP_001371500, NP_001371502, NP_001371503, NP_001371504, NP_001371505, NP_001371506, NP_001371507, NP_001371509, NP_001371510, NP_001371511, NP_001371512, NP_001371513, NP_001371514, NP_001371515, NP_001371516, NP_001371517, NP_001371518, NP_001371519, NP_001371520, NP_001371521, NP_001371522, NP_001371523, NP_001371524, NP_060498 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001660	SAM	Domain
IPR013761	SAM/pointed_sf	Homologous_superfamily
IPR037093	PHAT_dom_sf	Homologous_superfamily
IPR037634	Smaug_SAM	Domain
IPR050897	SMAUG/VTS1_RNA-bind	Family
IPR058599	PHAT_Smg/ZCCHC2-like	Domain

Pfam: PF00536, PF26034

UniProt features (25 total): modified residue 13, compositionally biased region 7, region of interest 3, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5PRF9-F1	65.47	0.36

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (13): 172, 271, 278, 279, 281, 407, 555, 557, 563, 592, 600, 602, 628

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 193 (showing top): GOBP_REGULATION_OF_MRNA_CATABOLIC_PROCESS, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_NEGATIVE_REGULATION_OF_TRANSLATION, GOBP_TRANSLATION, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION, GOMF_TRANSLATION_REGULATOR_ACTIVITY, GOBP_REGULATION_OF_CATABOLIC_PROCESS, GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS, GCM_NUMA1, GOBP_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS, GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY, KUUSELO_PANCREATIC_CANCER_19Q13_AMPLIFICATION, GOBP_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING, GCM_NF2, CCCAGAG_MIR326

GO Biological Process (3): nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289), negative regulation of translation (GO:0017148), regulation of mRNA stability (GO:0043488)

GO Molecular Function (4): RNA binding (GO:0003723), mRNA binding (GO:0003729), translation repressor activity (GO:0030371), protein binding (GO:0005515)

GO Cellular Component (4): P-body (GO:0000932), nucleus (GO:0005634), cytosol (GO:0005829), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	1
nuclear-transcribed mRNA catabolic process	1
translation	1
regulation of translation	1
negative regulation of gene expression	1
negative regulation of protein metabolic process	1
regulation of RNA stability	1
regulation of mRNA catabolic process	1
nucleic acid binding	1
RNA binding	1
negative regulation of translation	1
translation regulator activity	1
binding	1
cytoplasmic ribonucleoprotein granule	1
intracellular membrane-bounded organelle	1
cytoplasm	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1050 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SAMD4B	NANOS1	Q8WY41	722
SAMD4B	EIF4ENIF1	Q9NRA8	580
SAMD4B	USH1G	Q495M9	494
SAMD4B	ANK2	Q01484	490
SAMD4B	ANK1	P16157	470
SAMD4B	ANK3	Q12955	470
SAMD4B	CEBPZOS	A8MTT3	453
SAMD4B	E9PNW1	E9PNW1	425
SAMD4B	GOLGA3	Q08378	409
SAMD4B	TMEM63C	Q9P1W3	406
SAMD4B	WDR5B	Q86VZ2	406
SAMD4B	RNPC3	Q96LT9	396
SAMD4B	PUM2	Q8TB72	380
SAMD4B	C1QTNF12	Q5T7M4	378
SAMD4B	CAPN9	O14815	375

IntAct

74 interactions, top by confidence:

A	B	Type	Score
SAMD4B	YWHAQ	psi-mi:“MI:0914”(association)	0.850
SAMD4B	YWHAG	psi-mi:“MI:0914”(association)	0.840
YWHAQ	WDR62	psi-mi:“MI:0914”(association)	0.830
SAMD4B	YWHAZ	psi-mi:“MI:0915”(physical association)	0.760
SAMD4B	YWHAE	psi-mi:“MI:0915”(physical association)	0.740
YWHAG	BLTP3B	psi-mi:“MI:0914”(association)	0.640
YWHAH	PLEKHG3	psi-mi:“MI:0914”(association)	0.610
YWHAB	BLTP3B	psi-mi:“MI:0914”(association)	0.610
YWHAH	BLTP3B	psi-mi:“MI:0914”(association)	0.570
LRRC8E	SAMD4B	psi-mi:“MI:0915”(physical association)	0.560
CCDC179	SAMD4B	psi-mi:“MI:0915”(physical association)	0.560
	SAMD4B	psi-mi:“MI:0915”(physical association)	0.560
SAMD4B	USP53	psi-mi:“MI:0915”(physical association)	0.560
SAMD4B	BCL2L10	psi-mi:“MI:0915”(physical association)	0.560
SAMD4B	RSRC2	psi-mi:“MI:0915”(physical association)	0.560
SAMD4B	LRRC8E	psi-mi:“MI:0915”(physical association)	0.560
YWHAG	SHTN1	psi-mi:“MI:0914”(association)	0.560
YWHAQ	IGLC7	psi-mi:“MI:0914”(association)	0.530
YWHAB	SHTN1	psi-mi:“MI:0914”(association)	0.530
YWHAZ	BLTP3B	psi-mi:“MI:0914”(association)	0.530
YWHAB	PLEKHG3	psi-mi:“MI:0914”(association)	0.480
YWHAQ	PLEKHG3	psi-mi:“MI:0914”(association)	0.480
SFN	SAMD4B	psi-mi:“MI:0915”(physical association)	0.400
SAMD4B	CFTR	psi-mi:“MI:0915”(physical association)	0.370
RGMA	BDP1	psi-mi:“MI:0914”(association)	0.350
Nfyc	BDP1	psi-mi:“MI:0914”(association)	0.350

BioGRID (178): SAMD4B (Synthetic Growth Defect), SAMD4B (Proximity Label-MS), SAMD4B (Proximity Label-MS), SAMD4B (Proximity Label-MS), SAMD4B (Proximity Label-MS), SAMD4B (Affinity Capture-MS), SAMD4B (Affinity Capture-MS), SAMD4B (Affinity Capture-MS), SAMD4B (Affinity Capture-MS), SAMD4A (Affinity Capture-MS), PDP1 (Affinity Capture-MS), YWHAG (Affinity Capture-MS), YWHAE (Affinity Capture-MS), ACTA2 (Affinity Capture-MS), YWHAZ (Affinity Capture-MS)

ESM2 similar proteins: A0JNT9, A0JPP8, A1X157, O15169, O75145, O75335, P39880, P60469, Q07DZ5, Q08CF3, Q08E13, Q09YM8, Q2M1P5, Q2QLG9, Q2VUH7, Q32PN7, Q3TMW1, Q3UHC7, Q3UIL6, Q3UIW5, Q3UJV1, Q5DU25, Q5FWS6, Q5JU85, Q5PRF9, Q5XI59, Q5ZJ07, Q674X7, Q68UI8, Q69ZS8, Q6IPM2, Q6NZT2, Q6P402, Q6P730, Q6ZP65, Q80XS6, Q80Y83, Q8JZP9, Q8K1S6, Q8R4R9

Diamond homologs: B3NFQ7, B4HKJ7, B4QMP1, B5DF21, P60320, Q0IHW3, Q23972, Q4P965, Q4WJS2, Q5BGC4, Q5FWP2, Q5PRF9, Q6CHK0, Q758Y4, Q7RZQ3, Q80XS6, Q8CBY1, Q95LV5, Q9UPU9, J9VVN9, Q08831, Q5AI80, Q6BSL1, Q6CY29, Q6FM94, Q9P6R7, Q4IBN1

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 56 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Activation of BAD and translocation to mitochondria	7	130.0×	4e-12
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	7	114.7×	6e-12
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	7	114.7×	6e-12
Activation of BH3-only proteins	7	84.8×	6e-11
RHO GTPases activate PKNs	7	54.2×	2e-09
Intrinsic Pathway for Apoptosis	7	50.0×	3e-09
FOXO-mediated transcription	5	41.0×	2e-06
SARS-CoV-1-host interactions	7	30.0×	9e-08

GO biological processes:

GO term	Partners	Fold	FDR
protein targeting	5	37.4×	5e-05
intracellular protein localization	9	19.2×	4e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

98 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	82
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2409 predictions. Top by Δscore:

Variant	Effect	Δscore
19:39342574:GCG:G	donor_gain	1.0000
19:39342574:GCGGT:G	donor_loss	1.0000
19:39342575:CGGTG:C	donor_loss	1.0000
19:39342577:G:GG	donor_gain	1.0000
19:39342578:T:G	donor_loss	1.0000
19:39357086:GCTG:G	donor_gain	1.0000
19:39357088:TGGTG:T	donor_loss	1.0000
19:39357089:GGTG:G	donor_loss	1.0000
19:39357090:G:A	donor_loss	1.0000
19:39357090:G:GG	donor_gain	1.0000
19:39357091:TGA:T	donor_loss	1.0000
19:39357092:GAG:G	donor_loss	1.0000
19:39369652:TAGC:T	acceptor_loss	1.0000
19:39369653:A:AG	acceptor_gain	1.0000
19:39369653:AGCC:A	acceptor_loss	1.0000
19:39369654:G:GG	acceptor_gain	1.0000
19:39369654:GC:G	acceptor_gain	1.0000
19:39369654:GCC:G	acceptor_gain	1.0000
19:39369654:GCCA:G	acceptor_gain	1.0000
19:39369976:A:G	donor_gain	1.0000
19:39376429:T:TA	acceptor_gain	1.0000
19:39376434:A:G	acceptor_gain	1.0000
19:39376436:GAT:G	acceptor_gain	1.0000
19:39376436:GATGT:G	acceptor_gain	1.0000
19:39376543:TCAGG:T	donor_loss	1.0000
19:39376545:AGGTG:A	donor_loss	1.0000
19:39376546:GG:G	donor_loss	1.0000
19:39376547:GTG:G	donor_loss	1.0000
19:39376548:T:G	donor_loss	1.0000
19:39376570:G:T	donor_gain	1.0000

AlphaMissense

4492 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:39356900:T:C	F3L	1.000
19:39356902:C:A	F3L	1.000
19:39356902:C:G	F3L	1.000
19:39356942:T:A	W17R	1.000
19:39356942:T:C	W17R	1.000
19:39356956:G:C	E21D	1.000
19:39356956:G:T	E21D	1.000
19:39356958:A:C	Q22P	1.000
19:39356967:C:A	A25D	1.000
19:39356970:T:C	L26P	1.000
19:39356973:T:C	L27P	1.000
19:39356979:T:C	L29P	1.000
19:39356982:T:C	L30P	1.000
19:39357011:T:C	F40L	1.000
19:39357012:T:C	F40S	1.000
19:39357013:C:A	F40L	1.000
19:39357013:C:G	F40L	1.000
19:39357015:T:C	L41P	1.000
19:39357027:T:C	L45P	1.000
19:39357078:C:A	A62D	1.000
19:39369706:T:C	L83P	1.000
19:39369718:T:A	L87H	1.000
19:39369718:T:C	L87P	1.000
19:39369724:T:C	L89P	1.000
19:39369727:T:A	L90H	1.000
19:39369727:T:C	L90P	1.000
19:39369759:T:C	Y101H	1.000
19:39369759:T:G	Y101D	1.000
19:39369772:T:C	L105P	1.000
19:39369784:T:C	L109P	1.000

dbSNP variants (sampled 300 via entrez): RS1000004715 (19:39387518 C>T), RS1000143167 (19:39352860 C>T), RS1000161518 (19:39351359 C>T), RS1000213780 (19:39375509 G>T), RS1000288087 (19:39368780 A>G), RS1000291759 (19:39381981 G>A), RS1000366314 (19:39363801 G>C), RS1000452786 (19:39352632 C>T), RS1000536828 (19:39387971 CTA>C), RS1000624244 (19:39383439 C>T), RS1000655322 (19:39383748 G>A), RS1000714486 (19:39352763 G>C,T), RS1000777245 (19:39358942 T>C), RS1000799107 (19:39341379 C>T), RS1000812754 (19:39376936 G>C)

Disease associations

OMIM: gene MIM:619231 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST001762_907	Obesity-related traits	6.000000e-06
GCST011352_11	Alanine aminotransferase levels	2.000000e-12

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0003940	physical activity

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Acetaminophen	increases expression, decreases expression	3
Air Pollutants	affects expression, increases abundance, increases expression	2
FR900359	affects phosphorylation	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
sodium arsenite	increases expression	1
cobaltous chloride	increases expression	1
coumarin	affects phosphorylation	1
di-n-butylphosphoric acid	affects expression	1
ICG 001	decreases expression	1
abrine	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Caffeine	affects phosphorylation	1
Doxorubicin	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Ozone	affects expression, increases abundance	1
Potassium Dichromate	decreases expression	1
Quercetin	increases phosphorylation	1
Ribonucleotides	affects binding	1
Smoke	decreases expression	1
Tetrachlorodibenzodioxin	affects expression	1
Dronabinol	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Ursodeoxycholic Acid	affects expression	1
Aflatoxin B1	decreases methylation	1
Gold Compounds	increases expression	1
Particulate Matter	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.