SAMMSON

Summary

SAMMSON (survival associated mitochondrial melanoma specific oncogenic non-coding RNA, HGNC:49644) is a long non-coding RNA gene on chromosome 3p13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49644
Approved symbol	SAMMSON
Name	survival associated mitochondrial melanoma specific oncogenic non-coding RNA
Location	3p13
Locus type	RNA, long non-coding
Status	Approved
Aliases	uc.116
Ensembl gene	ENSG00000240405
Ensembl biotype	lncRNA
OMIM	616895
Entrez	101927152
RNAcentral	URS00026A1F9C — lncRNA, 2779 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 35 — 35 lncRNA

ENST00000483525, ENST00000488861, ENST00000641005, ENST00000641014, ENST00000641043, ENST00000641053, ENST00000641128, ENST00000641194, ENST00000641222, ENST00000641260, ENST00000641286, ENST00000641295, ENST00000641336, ENST00000641395, ENST00000641431, ENST00000641457, ENST00000641532, ENST00000641601, ENST00000641635, ENST00000641648, ENST00000641715, ENST00000641901, ENST00000641923, ENST00000641929, ENST00000642004, ENST00000642089, ENST00000642114, ENST00000671630, ENST00000769907, ENST00000769908, ENST00000769909, ENST00000769910, ENST00000769911, ENST00000842478, ENST00000842479

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000483525 — 4 exons

Exon	Start	End
ENSE00001931318	70013520	70013672
ENSE00001950897	70012357	70012598
ENSE00004131452	69999732	69999867
ENSE00004131456	70013794	70015318

Expression profiles

Bgee: expression breadth ubiquitous, 126 present calls, max score 79.08.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4899 / max 49.8800, expressed in 144 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
37270	0.4899	144

Top tissues by expression

220 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.08	gold quality
sural nerve	UBERON:0015488	77.07	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.44	gold quality
thoracic aorta	UBERON:0001515	67.17	gold quality
ascending aorta	UBERON:0001496	67.14	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.59	gold quality
aorta	UBERON:0000947	63.56	gold quality
spinal cord	UBERON:0002240	62.38	gold quality
descending thoracic aorta	UBERON:0002345	61.98	gold quality
popliteal artery	UBERON:0002250	61.07	gold quality
tibial artery	UBERON:0007610	61.04	gold quality
lower esophagus mucosa	UBERON:0035834	59.53	gold quality
lower esophagus	UBERON:0013473	58.61	gold quality
lower esophagus muscularis layer	UBERON:0035833	58.58	gold quality
mucosa of stomach	UBERON:0001199	58.47	gold quality
hindlimb stylopod muscle	UBERON:0004252	58.21	gold quality
testis	UBERON:0000473	56.92	gold quality
cortical plate	UBERON:0005343	56.44	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	56.40	gold quality
left testis	UBERON:0004533	56.15	gold quality
ganglionic eminence	UBERON:0004023	56.11	silver quality
right testis	UBERON:0004534	55.77	gold quality
calcaneal tendon	UBERON:0003701	55.49	silver quality
leukocyte	CL:0000738	55.42	gold quality
monocyte	CL:0000576	55.31	gold quality
esophagus	UBERON:0001043	54.90	gold quality
body of stomach	UBERON:0001161	54.52	gold quality
endometrium	UBERON:0001295	54.19	gold quality
left coronary artery	UBERON:0001626	53.60	gold quality
lower lobe of lung	UBERON:0008949	53.59	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.05

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• silencing of the lineage addiction oncogene SAMMSON disrupts vital mitochondrial functions in a cancer-cell-specific manner; this silencing is therefore expected to deliver highly effective and tissue-restricted anti-melanoma therapeutic responses (PMID:27008969)
• SAMMSON promotes a balanced increase in ribosomal RNA (rRNA) maturation and protein synthesis in the cytosol and mitochondria by modulating the localization of CARF, an RNA-binding protein that sequesters the exo-ribonuclease XRN2 in the nucleoplasm, which under normal circumstances limits nucleolar rRNA maturation. (PMID:30374086)
• LncRNA SAMMSON negatively regulates miR-9-3p in hepatocellular carcinoma cells and has prognostic values. (PMID:31164410)
• plasma SAMMSON has diagnostic value for glioblastoma and SAMMSON overexpression may promote glioblastoma cell proliferation by downregulating miR-622. (PMID:31283714)
• Long noncoding RNA SAMMSON promotes papillary thyroid carcinoma progression through p300/Sp1 axis and serves as a novel diagnostic and prognostic biomarker. (PMID:31478331)
• LncRNA SAMMSON Knockdown Inhibits the Malignancy of Glioblastoma Cells by Inactivation of the PI3K/Akt Pathway. (PMID:32236901)
• Values of long noncoding RNA SAMMSON in the clinicopathologic features and the prognostic implications of human gastric cancer. (PMID:32572923)
• LncRNA SAMMSON Mediates Adaptive Resistance to RAF Inhibition in BRAF-Mutant Melanoma Cells. (PMID:34087780)
• The oncogenic role of SAMMSON lncRNA in tumorigenesis: A comprehensive review with especial focus on melanoma. (PMID:37772815)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.