SAMSN1

Summary

SAMSN1 (SAM domain, SH3 domain and nuclear localization signals 1, HGNC:10528) is a protein-coding gene on chromosome 21q11.2, encoding SAM domain-containing protein SAMSN-1 (Q9NSI8). Negative regulator of B-cell activation.

SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]).

Source: NCBI Gene 64092 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 63 total
• Druggable target: yes
• MANE Select transcript: NM_022136

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10528
Approved symbol	SAMSN1
Name	SAM domain, SH3 domain and nuclear localization signals 1
Location	21q11.2
Locus type	gene with protein product
Status	Approved
Aliases	NASH1, SASH2, SH3D6B, HACS1, SLy2
Ensembl gene	ENSG00000155307
Ensembl biotype	protein_coding
OMIM	607978
Entrez	64092

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 7 protein_coding, 5 protein_coding_CDS_not_defined, 2 retained_intron

ENST00000285670, ENST00000400562, ENST00000400564, ENST00000400566, ENST00000435732, ENST00000463807, ENST00000467280, ENST00000469393, ENST00000493640, ENST00000619120, ENST00000644288, ENST00000647101, ENST00000871911, ENST00000959353

RefSeq mRNA: 6 — MANE Select: NM_022136 NM_001256370, NM_001256579, NM_001286523, NM_001395857, NM_001395858, NM_022136

CCDS: CCDS42906, CCDS58786, CCDS74774, CCDS93082

Canonical transcript exons

ENST00000400566 — 8 exons

Exon	Start	End
ENSE00001020240	14516892	14517041
ENSE00001020242	14510310	14510461
ENSE00001020244	14500529	14500735
ENSE00001020245	14512444	14512573
ENSE00001308893	14521150	14521221
ENSE00001543516	14546205	14546315
ENSE00003605893	14498442	14498592
ENSE00003903802	14485228	14486114

Expression profiles

Bgee: expression breadth ubiquitous, 250 present calls, max score 96.04.

FANTOM5 (CAGE): breadth broad, TPM avg 58.9810 / max 5507.1735, expressed in 738 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
189768	55.8122	675
189769	2.4507	383
189779	0.5246	120
189778	0.1253	58
189780	0.0531	10
189781	0.0151	5

Top tissues by expression

281 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	96.04	gold quality
vermiform appendix	UBERON:0001154	94.99	gold quality
bone marrow cell	CL:0002092	94.48	gold quality
monocyte	CL:0000576	94.11	gold quality
mononuclear cell	CL:0000842	94.09	gold quality
leukocyte	CL:0000738	93.89	gold quality
right lung	UBERON:0002167	93.20	gold quality
blood	UBERON:0000178	93.17	gold quality
spleen	UBERON:0002106	91.87	gold quality
lymph node	UBERON:0000029	90.75	gold quality
epithelium of nasopharynx	UBERON:0001951	90.50	gold quality
nasopharynx	UBERON:0001728	90.48	gold quality
trabecular bone tissue	UBERON:0002483	89.53	gold quality
gall bladder	UBERON:0002110	89.36	gold quality
granulocyte	CL:0000094	88.58	gold quality
caecum	UBERON:0001153	88.43	gold quality
superficial temporal artery	UBERON:0001614	88.43	gold quality
upper lobe of left lung	UBERON:0008952	88.35	gold quality
lower lobe of lung	UBERON:0008949	87.93	gold quality
upper lobe of lung	UBERON:0008948	87.85	gold quality
periodontal ligament	UBERON:0008266	86.39	gold quality
colonic epithelium	UBERON:0000397	86.25	gold quality
rectum	UBERON:0001052	86.22	gold quality
omental fat pad	UBERON:0010414	85.97	gold quality
peritoneum	UBERON:0002358	85.89	gold quality
lung	UBERON:0002048	85.80	gold quality
adipose tissue of abdominal region	UBERON:0007808	84.78	gold quality
mucosa of sigmoid colon	UBERON:0004993	83.75	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.12	gold quality
small intestine Peyer’s patch	UBERON:0003454	82.80	gold quality

Single-cell (SCXA)

Detected in 26 experiment(s), a significant marker in 24.

Experiment	Marker?	Max mean expression
E-ANND-2	yes	3151.99
E-GEOD-130148	yes	2293.20
E-MTAB-7381	yes	780.18
E-MTAB-8142	yes	90.85
E-HCAD-1	yes	68.03
E-CURD-88	yes	43.05
E-GEOD-135922	yes	42.78
E-GEOD-84465	yes	36.53
E-HCAD-35	yes	30.30
E-CURD-122	yes	27.22
E-CURD-46	yes	21.88
E-MTAB-8410	yes	18.24
E-HCAD-10	yes	15.66
E-CURD-112	yes	15.52
E-MTAB-9067	yes	12.94

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

46 targeting SAMSN1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-590-3P	99.96	74.34	6478
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-613	99.91	71.50	1710
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-129-5P	99.88	70.26	3273
HSA-MIR-576-5P	99.84	70.46	2582
HSA-MIR-4694-3P	99.79	69.53	2640
HSA-MIR-4645-3P	99.76	69.33	993
HSA-MIR-4422	99.72	72.07	2908
HSA-MIR-4699-3P	99.71	70.15	3142
HSA-MIR-29B-2-5P	99.67	68.98	1726
HSA-MIR-3942-3P	99.57	69.03	2854
HSA-MIR-7159-5P	99.53	72.12	2472

Literature-anchored findings (GeneRIF, showing 8)

• HACS1 is up-regulated by B cell activation signals and is a participant in B cell activation and differentiation. (PMID:15381729)
• downregulation of SAMSN1 gene in human lung cancer. (PMID:18523997)
• In the nucleus, SLy2 interacts with the SAP30/HDAC1 complex and regulates the activity of HDAC1. (PMID:20478393)
• the immunoinhibitory roles of SLy2 in vivo and suggest that the physiological up-regulation of SLy2 observed upon B cell activation functions to counteract excessive B cell spreading. (PMID:21296879)
• High expression of SAMSN1 is a significant risk factor for the progression free and overall survival of glioblastoma multiforme (PMID:24278465)
• This is the first study to identify deletion of a key gene in the C57BL/KaLwRij mice that also displays reduced gene expression in patients with MM and is therefore likely to play an integral role in MM disease development. (PMID:25117979)
• Suppression of SAMSN1 Expression is Associated with the Malignant Phenotype of Hepatocellular Carcinoma. (PMID:25805236)
• HACS1 signaling adaptor protein recognizes a motif in the paired immunoglobulin receptor B cytoplasmic domain. (PMID:33188360)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	samsn1a	ENSDARG00000054543
danio_rerio	samsn1b	ENSDARG00000078647
mus_musculus	Samsn1	ENSMUSG00000022876
rattus_norvegicus	Samsn1	ENSRNOG00000030930

Paralogs (2): SASH1 (ENSG00000111961), SASH3 (ENSG00000122122)

Protein

Protein identifiers

SAM domain-containing protein SAMSN-1 — Q9NSI8 (reviewed: Q9NSI8)

Alternative names: Hematopoietic adaptor containing SH3 and SAM domains 1, Nash1, SAM domain, SH3 domain and nuclear localization signals protein 1, SH3-SAM adaptor protein

All UniProt accessions (3): Q9NSI8, A0A2R8Y4K8, S6FRS6

UniProt curated annotations — full annotation on UniProt →

Function. Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation.

Subunit / interactions. Interacts with FASLG. Interacts with phosphotyrosine containing proteins. Interacts (via SH3 domain) with CTTN. Interacts (phosphorylated at Ser-23) with YWHAB, YWHAE, YWHAG, YWHAH, YWHAZ and SFN. Interacts directly with SAP30 and HDAC1. Identified in a complex with SAP30 and HDAC1.

Subcellular location. Nucleus. Cytoplasm. Cell projection. Ruffle.

Tissue specificity. Detected in peripheral blood B-cells (at protein level). Detected in spleen, liver and peripheral blood.

Induction. Up-regulated in peripheral blood B-cells by IL4, IL13 and by CD40 stimulation.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9NSI8-1	1	yes
Q9NSI8-2	2, b
Q9NSI8-3	3

RefSeq proteins (5): NP_001243299, NP_001273452, NP_001382786, NP_001382787, NP_071419* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001452	SH3_domain	Domain
IPR001660	SAM	Domain
IPR013761	SAM/pointed_sf	Homologous_superfamily
IPR021090	SPIDER	Domain
IPR036028	SH3-like_dom_sf	Homologous_superfamily
IPR037623	SAMSN1_SAM	Domain
IPR051725	SAM-SH3_domain_protein	Family

Pfam: PF07647, PF07653, PF12485

UniProt features (29 total): modified residue 7, strand 5, sequence conflict 3, region of interest 3, compositionally biased region 3, domain 2, splice variant 2, chain 1, sequence variant 1, helix 1, short sequence motif 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
6UZJ	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NSI8-F1	64.11	0.27

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (7): 23, 34, 74, 76, 90, 119, 160

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 377 (showing top): GOBP_REGULATION_OF_CELL_ACTIVATION, GOBP_NEGATIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION, WALLACE_PROSTATE_CANCER_RACE_UP, GOBP_NEGATIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE, MCLACHLAN_DENTAL_CARIES_UP, LU_IL4_SIGNALING, GOBP_REGULATION_OF_PHOSPHORYLATION, GOBP_B_CELL_ACTIVATION, GOBP_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE, GOBP_NEGATIVE_REGULATION_OF_B_CELL_ACTIVATION, GOCC_RUFFLE, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP, NFKB_Q6, GOBP_REGULATION_OF_IMMUNE_RESPONSE, GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS

GO Biological Process (4): negative regulation of adaptive immune response (GO:0002820), negative regulation of peptidyl-tyrosine phosphorylation (GO:0050732), negative regulation of B cell activation (GO:0050869), regulation of intracellular signal transduction (GO:1902531)

GO Molecular Function (3): phosphotyrosine residue binding (GO:0001784), RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (5): ruffle (GO:0001726), nucleus (GO:0005634), cytoplasm (GO:0005737), cytosol (GO:0005829), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
adaptive immune response	1
regulation of adaptive immune response	1
negative regulation of immune response	1
negative regulation of protein phosphorylation	1
peptidyl-tyrosine phosphorylation	1
regulation of peptidyl-tyrosine phosphorylation	1
B cell activation	1
regulation of B cell activation	1
negative regulation of lymphocyte activation	1
regulation of signal transduction	1
intracellular signal transduction	1
protein phosphorylated amino acid binding	1
nucleic acid binding	1
binding	1
cell leading edge	1
plasma membrane bounded cell projection	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cytoplasm	1

Protein interactions and networks

STRING

1212 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SAMSN1	CRKL	P46109	636
SAMSN1	KIAA1143	Q96AT1	606
SAMSN1	CRK	P46108	563
SAMSN1	CRTAM	O95727	524
SAMSN1	TMEM204	Q9BSN7	509
SAMSN1	FCRL3	Q96P31	475
SAMSN1	STAT6	P42226	463
SAMSN1	DKKL1	Q9UK85	461
SAMSN1	PRSS36	Q5K4E3	456
SAMSN1	RBM11	P57052	450
SAMSN1	KLF12	Q9Y4X4	450
SAMSN1	CXCR3	P49682	446
SAMSN1	PDCD1	Q15116	438
SAMSN1	LILRB4	Q8NHJ6	435
SAMSN1	DEF8	Q6ZN54	420

IntAct

13 interactions, top by confidence:

A	B	Type	Score
SAMSN1	FASLG	psi-mi:“MI:0407”(direct interaction)	0.440
AGGF1	BLTP3B	psi-mi:“MI:2364”(proximity)	0.270
DGCR8	VWA8	psi-mi:“MI:2364”(proximity)	0.270
GPKOW	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
ILF3	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
LIN28B	MEX3A	psi-mi:“MI:2364”(proximity)	0.270
RPS3	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
SBDS	RPSA2	psi-mi:“MI:2364”(proximity)	0.270
YWHAG	RPSA2	psi-mi:“MI:2364”(proximity)	0.270
DDX6	RPSA2	psi-mi:“MI:2364”(proximity)	0.270
NPM1	SBNO1	psi-mi:“MI:2364”(proximity)	0.270
	SAMSN1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (21): SAMSN1 (Proximity Label-MS), SAMSN1 (Proximity Label-MS), SAMSN1 (Proximity Label-MS), SAMSN1 (Protein-peptide), SAMSN1 (Affinity Capture-RNA), SAMSN1 (Reconstituted Complex), SAMSN1 (Reconstituted Complex), SAMSN1 (Reconstituted Complex), SAMSN1 (Reconstituted Complex), SAMSN1 (Reconstituted Complex), SAMSN1 (Reconstituted Complex), SAMSN1 (Reconstituted Complex), YWHAG (Affinity Capture-Western), SAMSN1 (Affinity Capture-Western), SAP30 (Affinity Capture-Western)

ESM2 similar proteins: A4IIJ3, A8KBE0, B2RWW0, O35867, O94885, P57725, P59808, Q12923, Q13009, Q3UG20, Q3UMG5, Q3UVC0, Q5DTU0, Q5PQ89, Q5TB30, Q5VUJ6, Q60610, Q69ZW3, Q6AWC2, Q6ING4, Q6P2L6, Q6PF55, Q6VAB6, Q6ZMN7, Q803Q4, Q86W92, Q8BLB8, Q8BZ05, Q8C0D4, Q8C115, Q8C8U0, Q8IVE3, Q8IWW6, Q8IZD2, Q8K3X6, Q8N4X5, Q8NDI1, Q8R4H2, Q8TEW0, Q8WZ64

Diamond homologs: A0JN71, O75995, O94885, P57725, P59672, P59808, Q8K352, Q92625, Q9NSI8, Q9XYM0, Q5TGI4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

63 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	52
Likely benign	4
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2396 predictions. Top by Δscore:

Variant	Effect	Δscore
21:14486112:TAA:T	acceptor_gain	1.0000
21:14486112:TAAC:T	acceptor_loss	1.0000
21:14486114:AC:A	acceptor_loss	1.0000
21:14486115:C:CC	acceptor_gain	1.0000
21:14486116:T:A	acceptor_loss	1.0000
21:14498436:A:AC	donor_gain	1.0000
21:14498437:C:CC	donor_gain	1.0000
21:14498437:CTTA:C	donor_gain	1.0000
21:14498438:TTACT:T	donor_loss	1.0000
21:14498439:TA:T	donor_loss	1.0000
21:14498440:A:AC	donor_gain	1.0000
21:14498440:ACTT:A	donor_loss	1.0000
21:14498440:ACTTT:A	donor_gain	1.0000
21:14498441:C:CT	donor_gain	1.0000
21:14498441:CT:C	donor_gain	1.0000
21:14498441:CTT:C	donor_gain	1.0000
21:14498441:CTTT:C	donor_gain	1.0000
21:14498441:CTTTC:C	donor_gain	1.0000
21:14498444:T:A	donor_gain	1.0000
21:14498588:TATTC:T	acceptor_gain	1.0000
21:14498589:ATTC:A	acceptor_gain	1.0000
21:14498590:TTC:T	acceptor_gain	1.0000
21:14498591:TC:T	acceptor_gain	1.0000
21:14498591:TCC:T	acceptor_loss	1.0000
21:14498592:CC:C	acceptor_gain	1.0000
21:14498593:C:CA	acceptor_loss	1.0000
21:14498593:C:CC	acceptor_gain	1.0000
21:14498593:C:T	acceptor_gain	1.0000
21:14498595:G:C	acceptor_gain	1.0000
21:14498595:G:GC	acceptor_gain	1.0000

AlphaMissense

2485 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
21:14500649:G:C	F216L	1.000
21:14500649:G:T	F216L	1.000
21:14500651:A:G	F216L	1.000
21:14500656:A:G	F214S	1.000
21:14500690:A:G	W203R	1.000
21:14500690:A:T	W203R	1.000
21:14500652:T:A	K215N	0.999
21:14500652:T:G	K215N	0.999
21:14500653:T:A	K215I	0.999
21:14500654:T:C	K215E	0.999
21:14500655:G:C	F214L	0.999
21:14500655:G:T	F214L	0.999
21:14500657:A:G	F214L	0.999
21:14500662:C:T	G212E	0.999
21:14500683:C:T	G205E	0.999
21:14500688:C:A	W203C	0.999
21:14500688:C:G	W203C	0.999
21:14500696:C:G	G201R	0.999
21:14500696:C:T	G201R	0.999
21:14510320:A:G	L184P	0.999
21:14510320:A:T	L184H	0.999
21:14510340:A:C	S177R	0.999
21:14510340:A:T	S177R	0.999
21:14510342:T:G	S177R	0.999
21:14510349:G:C	F174L	0.999
21:14510349:G:T	F174L	0.999
21:14510351:A:G	F174L	0.999
21:14510368:G:T	A168D	0.999
21:14498519:A:G	L281P	0.998
21:14500650:A:G	F216S	0.998

dbSNP variants (sampled 300 via entrez): RS1000004130 (21:14602796 A>G), RS1000039544 (21:14553935 G>T), RS1000041523 (21:14489399 C>T), RS1000107926 (21:14631206 G>A,T), RS1000120253 (21:14625888 G>A,C), RS1000128797 (21:14576854 G>A,C), RS1000131043 (21:14504782 C>T), RS1000135821 (21:14631447 C>CT), RS1000144655 (21:14561712 A>G), RS1000159947 (21:14521307 T>C), RS1000165207 (21:14591565 T>C), RS1000173197 (21:14536863 A>G), RS1000176177 (21:14597484 G>A), RS1000181893 (21:14521440 C>A,T), RS1000219373 (21:14621678 T>C)

Disease associations

OMIM: gene MIM:607978 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST002690_19	Very long-chain saturated fatty acid levels (fatty acid 20:0)	7.000000e-07
GCST004224_1	Coronary atherosclerosis (increased number of diseased vessels) (traffic exposure interaction)	2.000000e-06

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0006796	very long-chain saturated fatty acid measurement
EFO:0007908	traffic air pollution measurement
EFO:0007938	coronary atherosclerosis measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067306 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
8.19	Kd	6.486	nM	CHEMBL5653589
8.19	ED50	6.486	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149340: Binding affinity to human SAMSN1 incubated for 45 mins by Kinobead based pull down assay	kd	0.0065	uM

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, decreases methylation	2
perfluorooctane sulfonic acid	decreases expression	2
Air Pollutants	affects expression, increases abundance, increases response to substance	2
Benzo(a)pyrene	increases expression	2
Estradiol	affects cotreatment, increases expression, decreases expression	2
Nickel	increases expression	2
Tretinoin	increases expression	2
triphenyl phosphate	affects expression	1
sodium arsenite	increases expression	1
cupric chloride	increases expression	1
nickel sulfate	increases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
Air Pollutants, Occupational	increases expression	1
Vehicle Emissions	increases abundance, increases response to substance	1
Caffeine	increases phosphorylation	1
Calcitriol	decreases expression	1
Carbamazepine	affects expression	1
Cisplatin	increases expression	1
Demecolcine	increases expression	1
Formaldehyde	increases expression	1
Naled	affects expression	1
Ozone	increases abundance, affects expression	1
Dronabinol	increases expression	1
Triclosan	decreases expression	1
Valproic Acid	affects expression	1
Vincristine	increases expression	1
Zinc	increases expression	1
Isotretinoin	increases expression	1
Aflatoxin B1	decreases methylation	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652382	Binding	Binding affinity to human SAMSN1 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.