SAP130

Summary

SAP130 (Sin3A associated protein 130, HGNC:29813) is a protein-coding gene on chromosome 2q14.3, encoding Histone deacetylase complex subunit SAP130 (Q9H0E3). Acts as a transcriptional repressor.

SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).

Source: NCBI Gene 79595 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 136 total — 1 likely-pathogenic
• Druggable target: yes
• MANE Select transcript: NM_001330301

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29813
Approved symbol	SAP130
Name	Sin3A associated protein 130
Location	2q14.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ12761
Ensembl gene	ENSG00000136715
Ensembl biotype	protein_coding
OMIM	609697
Entrez	79595

Gene structure

Transcript identifiers

Ensembl transcripts: 36 — 36 protein_coding

ENST00000259234, ENST00000259235, ENST00000357702, ENST00000424298, ENST00000450957, ENST00000643581, ENST00000866430, ENST00000866431, ENST00000866432, ENST00000866433, ENST00000866434, ENST00000866435, ENST00000866436, ENST00000866437, ENST00000866438, ENST00000866439, ENST00000866440, ENST00000866441, ENST00000866442, ENST00000866443, ENST00000866444, ENST00000866445, ENST00000866446, ENST00000866447, ENST00000866448, ENST00000866449, ENST00000866450, ENST00000866451, ENST00000866452, ENST00000934352, ENST00000934353, ENST00000934354, ENST00000934355, ENST00000934356, ENST00000934357, ENST00000972237

RefSeq mRNA: 7 — MANE Select: NM_001330301 NM_001145928, NM_001330299, NM_001330300, NM_001330301, NM_001330302, NM_001330303, NM_024545

CCDS: CCDS2153, CCDS54397, CCDS82510, CCDS86881

Canonical transcript exons

ENST00000643581 — 21 exons

Exon	Start	End
ENSE00000925839	127986785	127986962
ENSE00000925842	127989564	127989866
ENSE00000925843	127993187	127993308
ENSE00001206113	127977985	127978089
ENSE00001621408	128010269	128010393
ENSE00001627566	127942424	127942537
ENSE00001660862	127949869	127949994
ENSE00001664915	128017680	128017915
ENSE00001677145	128013030	128013154
ENSE00001682582	127999741	127999845
ENSE00001683324	128016389	128016547
ENSE00001708529	128014803	128014914
ENSE00001720134	127945456	127945559
ENSE00001732040	127954986	127955344
ENSE00001738051	128027940	128028059
ENSE00001740238	128000056	128000146
ENSE00001740960	127950160	127950408
ENSE00001747504	127996350	127996491
ENSE00001774386	128000307	128000454
ENSE00003650801	128026181	128026298
ENSE00003903745	127941222	127942164

Expression profiles

Bgee: expression breadth ubiquitous, 263 present calls, max score 93.92.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.3209 / max 154.5431, expressed in 1802 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
30587	8.9247	1752
30588	3.9239	1577
30586	2.0275	1269
30589	0.4448	218

Top tissues by expression

282 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	93.92	gold quality
male germ cell	CL:0000015	92.71	gold quality
adult organism	UBERON:0007023	92.62	gold quality
left testis	UBERON:0004533	91.49	gold quality
right testis	UBERON:0004534	91.24	gold quality
testis	UBERON:0000473	90.53	gold quality
cortical plate	UBERON:0005343	88.24	gold quality
secondary oocyte	CL:0000655	87.52	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.02	gold quality
ventricular zone	UBERON:0003053	86.06	gold quality
ganglionic eminence	UBERON:0004023	86.05	gold quality
stromal cell of endometrium	CL:0002255	85.55	gold quality
esophagus squamous epithelium	UBERON:0006920	84.65	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.44	gold quality
popliteal artery	UBERON:0002250	83.92	gold quality
tibial artery	UBERON:0007610	83.91	gold quality
embryo	UBERON:0000922	83.38	gold quality
granulocyte	CL:0000094	83.04	gold quality
islet of Langerhans	UBERON:0000006	82.95	gold quality
aorta	UBERON:0000947	82.77	gold quality
gastrocnemius	UBERON:0001388	82.62	gold quality
epithelium of esophagus	UBERON:0001976	82.61	gold quality
adenohypophysis	UBERON:0002196	82.58	gold quality
pituitary gland	UBERON:0000007	82.27	gold quality
skin of leg	UBERON:0001511	82.27	gold quality
muscle of leg	UBERON:0001383	82.18	gold quality
descending thoracic aorta	UBERON:0002345	82.11	gold quality
blood	UBERON:0000178	82.06	gold quality
gingival epithelium	UBERON:0001949	81.99	gold quality
mucosa of transverse colon	UBERON:0004991	81.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.74

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
IFNB1	Unknown

miRNA regulators (miRDB)

51 targeting SAP130, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-574-5P	100.00	66.01	989
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349
HSA-MIR-548Z	99.84	70.80	4349
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-3681-5P	99.82	66.88	387
HSA-MIR-6745	99.74	65.33	1321
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-6849-5P	99.64	66.00	352
HSA-MIR-425-5P	99.59	67.67	900
HSA-MIR-891B	99.59	69.81	1083
HSA-MIR-24-3P	99.59	69.97	1934
HSA-MIR-516B-5P	99.56	66.33	1495
HSA-MIR-6716-5P	99.56	68.62	1244
HSA-MIR-363-5P	99.46	64.51	1015
HSA-MIR-150-3P	99.43	70.51	920
HSA-MIR-3614-5P	99.30	65.25	837
HSA-MIR-548V	99.29	69.47	1157
HSA-MIR-6719-3P	99.29	67.78	1387
HSA-MIR-642A-3P	99.23	67.67	1258
HSA-MIR-642B-3P	99.23	67.67	1258

Literature-anchored findings (GeneRIF, showing 2)

• the TGFbeta pathway activation leads to recruitment of a KLF14-mSin3A-HDAC2 repressor complex to the TGFbetaRII promoter, as well as the remodeling of chromatin to increase histone marks that associate with transcriptional silencing. (PMID:19088080)
• Ambiguity about Splicing Factor 3b Subunit 3 (SF3B3) and Sin3A Associated Protein 130 (SAP130). (PMID:33800128)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	sap130a	ENSDARG00000056924
danio_rerio	sap130b	ENSDARG00000079352
mus_musculus	Sap130	ENSMUSG00000024260
rattus_norvegicus	Sap130	ENSRNOG00000016773
drosophila_melanogaster	Sap130	FBGN0262714

Protein

Protein identifiers

Histone deacetylase complex subunit SAP130 — Q9H0E3 (reviewed: Q9H0E3)

Alternative names: 130 kDa Sin3-associated polypeptide, Sin3-associated polypeptide p130

All UniProt accessions (5): A0A2R8YDB8, C9J683, C9JTJ5, Q9H0E3, H7BXF5

UniProt curated annotations — full annotation on UniProt →

Function. Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.

Subunit / interactions. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts (released by dead or dying cells) with CLEC4E.

Subcellular location. Nucleus.

Tissue specificity. Expressed in various cancer cell ines.

Post-translational modifications. Acetylated. Sumoylated with SUMO1.

Domain organisation. The N-terminus may interact with a transcriptional coactivator. The C-terminus may interact with HDAC-dependent and HDAC-independent corepressors.

Similarity. Belongs to the SAP130 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9H0E3-1	1	yes
Q9H0E3-2	2
Q9H0E3-3	3

RefSeq proteins (7): NP_001139400, NP_001317228, NP_001317229, NP_001317230, NP_001317231, NP_001317232, NP_078821 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR024137	His_deAcase_cplx_SAP130	Family
IPR031963	SAP130_C	Domain

Pfam: PF16014

UniProt features (23 total): modified residue 7, region of interest 6, compositionally biased region 4, cross-link 3, splice variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H0E3-F1	45.33	0.08

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (10): 232, 355, 442, 465, 855, 856, 875, 785, 864, 869

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-3214847	HATs acetylate histones
R-HSA-427413	NoRC negatively regulates rRNA expression
R-HSA-212165	Epigenetic regulation of gene expression
R-HSA-3247509	Chromatin modifying enzymes
R-HSA-4839726	Chromatin organization
R-HSA-5250941	Negative epigenetic regulation of rRNA expression
R-HSA-74160	Gene expression (Transcription)

MSigDB gene sets: 130 (showing top): GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE18804_SPLEEN_MACROPHAGE_VS_TUMORAL_MACROPHAGE_UP, RNGTGGGC_UNKNOWN, GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS, PAX4_01, NAGY_STAGA_COMPONENTS_HUMAN, GCM_GSPT1, BOYAULT_LIVER_CANCER_SUBCLASS_G2, GGGTGGRR_PAX4_03, GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS, GOBP_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY, GOBP_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA, ZIC1_01, GCM_NUMA1, GOBP_MAINTENANCE_OF_CELL_NUMBER

GO Biological Process (8): negative regulation of transcription by RNA polymerase II (GO:0000122), negative regulation of cell migration (GO:0030336), negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512), negative regulation of stem cell population maintenance (GO:1902455), positive regulation of stem cell population maintenance (GO:1902459), in utero embryonic development (GO:0001701), embryonic placenta development (GO:0001892), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (0):

GO Cellular Component (3): nucleus (GO:0005634), nuclear speck (GO:0016607), Sin3-type complex (GO:0070822)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
Chromatin modifying enzymes	1
Negative epigenetic regulation of rRNA expression	1
Gene expression (Transcription)	1
Chromatin organization	1
Epigenetic regulation of gene expression	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
stem cell population maintenance	2
regulation of stem cell population maintenance	2
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
cell migration	1
regulation of cell migration	1
negative regulation of cell motility	1
transforming growth factor beta receptor signaling pathway	1
regulation of transforming growth factor beta receptor signaling pathway	1
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	1
negative regulation of developmental process	1
negative regulation of multicellular organismal process	1
positive regulation of developmental process	1
positive regulation of multicellular organismal process	1
chordate embryonic development	1
in utero embryonic development	1
placenta development	1
embryonic organ development	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
intracellular membrane-bounded organelle	1
nuclear ribonucleoprotein granule	1
histone deacetylase complex	1
nuclear chromosome	1
chromatin	1

Protein interactions and networks

STRING

1485 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SAP130	CLEC4E	Q9ULY5	708
SAP130	OR52W1	Q6IF63	606
SAP130	MSANTD1	Q6ZTZ1	570
SAP130	SAP30L	Q9HAJ7	514
SAP130	TADA2B	Q86TJ2	512
SAP130	CLEC7A	Q9BXN2	497
SAP130	CATSPER3	Q86XQ3	490
SAP130	OR52B2	Q96RD2	482
SAP130	CNGA4	Q8IV77	470
SAP130	TAF10	Q12962	459
SAP130	SNUPN	O95149	451
SAP130	SUDS3	Q9H7L9	445
SAP130	SAP30	O75446	434
SAP130	BRMS1L	Q5PSV4	414
SAP130	DMP1	Q13316	414

IntAct

109 interactions, top by confidence:

A	B	Type	Score
HDAC2	KDM1A	psi-mi:“MI:0914”(association)	0.890
HDAC1	CDK2AP1	psi-mi:“MI:0914”(association)	0.840
RBBP7	CDK2AP1	psi-mi:“MI:0914”(association)	0.840
HDAC1	TNRC18	psi-mi:“MI:0914”(association)	0.790
RBBP4	CDK2AP1	psi-mi:“MI:0914”(association)	0.790
HDAC1	ZNF609	psi-mi:“MI:0914”(association)	0.730
RBBP7	HAT1	psi-mi:“MI:0914”(association)	0.730
NFIC	NFIB	psi-mi:“MI:2364”(proximity)	0.690
FOXK2	DVL2	psi-mi:“MI:0914”(association)	0.640
SINHCAF	TNRC18	psi-mi:“MI:0914”(association)	0.640
ZNF704	SAP30	psi-mi:“MI:0914”(association)	0.640
ILF3	ADAR	psi-mi:“MI:0914”(association)	0.640
SIN3B	TNRC18	psi-mi:“MI:0914”(association)	0.530
FHL2	CNOT1	psi-mi:“MI:0914”(association)	0.530
RBBP4	TNRC18	psi-mi:“MI:0914”(association)	0.530
RBBP7	SMARCA5	psi-mi:“MI:0914”(association)	0.530
RBBP7	EPOP	psi-mi:“MI:0914”(association)	0.530
SAP30	TNRC18	psi-mi:“MI:0914”(association)	0.530
DAXX	TNRC18	psi-mi:“MI:0914”(association)	0.530

BioGRID (248): SAP130 (Affinity Capture-Western), SAP130 (Affinity Capture-Western), CUL4B (Affinity Capture-Western), DDB1 (Affinity Capture-Western), SAP130 (Co-fractionation), SAP130 (Affinity Capture-MS), SAP130 (Affinity Capture-MS), SAP130 (Co-fractionation), SIN3A (Co-fractionation), SAP130 (Affinity Capture-Western), SAP130 (Reconstituted Complex), SAP130 (Proximity Label-MS), SAP130 (Affinity Capture-MS), SAP130 (Affinity Capture-MS), SAP130 (Affinity Capture-MS)

ESM2 similar proteins: A0JME2, A2AUY4, D3ZKB9, D4A666, E1B7L7, F1QZ88, F6NSX9, F8VPJ6, P59759, P78364, Q08CM4, Q0IHV2, Q15723, Q2IBE6, Q2IBF7, Q2QLB3, Q3TUF7, Q4G0F8, Q5DTH5, Q5U4Q0, Q5ZIE8, Q5ZM88, Q63HK5, Q641Z1, Q6P4L9, Q6P4R8, Q6PIJ4, Q6ZPK0, Q6ZSZ6, Q6ZU65, Q76L83, Q7ZUK7, Q7ZUV7, Q80WC1, Q8AYC1, Q8BZ32, Q8C966, Q8CGV9, Q8CHP6, Q8NDX5

Diamond homologs: Q5F3U0, Q5M7C3, Q6DDH6, Q8BIH0, Q9H0E3

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 119 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Regulation of TP53 Activity through Acetylation	6	32.6×	1e-05
Deactivation of the beta-catenin transactivating complex	5	13.9×	1e-03
Regulation of PTEN gene transcription	6	12.8×	6e-04
HDACs deacetylate histones	7	10.0×	6e-04
Negative Regulation of CDH1 Gene Transcription	7	10.0×	6e-04
TCF dependent signaling in response to WNT	7	9.8×	6e-04
Potential therapeutics for SARS	7	9.5×	6e-04
Transcriptional regulation by RUNX1	5	8.7×	7e-03

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of stem cell population maintenance	9	61.0×	2e-12
positive regulation of stem cell population maintenance	10	30.4×	1e-10
negative regulation of transforming growth factor beta receptor signaling pathway	9	13.8×	2e-06
somatic stem cell population maintenance	6	13.2×	4e-04
negative regulation of cell migration	10	9.9×	8e-06
DNA replication	6	8.8×	4e-03
transcription by RNA polymerase II	12	7.5×	8e-06
chromatin remodeling	11	7.1×	4e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

136 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	112
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
808800	NM_001330301.2(SAP130):c.181C>T (p.Gln61Ter)	Likely pathogenic

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

6808 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:127942067:A:G	L1029P	1.000
2:127942076:A:T	V1026D	1.000
2:127942119:C:G	A1012P	1.000
2:127942130:T:G	Q1008P	1.000
2:127942142:A:G	L1004P	1.000
2:127942147:A:C	C1002W	1.000
2:127942150:C:A	R1001S	1.000
2:127942150:C:G	R1001S	1.000
2:127942151:C:A	R1001M	1.000
2:127942151:C:G	R1001T	1.000
2:127942153:C:A	Q1000H	1.000
2:127942153:C:G	Q1000H	1.000
2:127942154:T:G	Q1000P	1.000
2:127942159:A:C	N998K	1.000
2:127942159:A:T	N998K	1.000
2:127942163:C:T	G997E	1.000
2:127942164:C:G	G997R	1.000
2:127942164:C:T	G997R	1.000
2:127942431:A:G	L994P	1.000
2:127942497:A:G	L972P	1.000
2:127942506:A:G	L969P	1.000
2:127945457:A:G	L958P	1.000
2:127945481:A:G	L950P	1.000
2:127945492:C:A	W946C	1.000
2:127945492:C:G	W946C	1.000
2:127945493:C:G	W946S	1.000
2:127945494:A:G	W946R	1.000
2:127945494:A:T	W946R	1.000
2:127945496:C:T	G945D	1.000
2:127945497:C:G	G945R	1.000

dbSNP variants (sampled 300 via entrez): RS1000029976 (2:127975425 T>C), RS1000110688 (2:128016658 C>T), RS1000129196 (2:128022778 C>T), RS1000150497 (2:128020163 T>A,C), RS1000182219 (2:128019831 A>C,T), RS1000224546 (2:128022446 T>C), RS1000246311 (2:127979784 G>A), RS1000254962 (2:127945013 T>G), RS1000257930 (2:127982116 G>A,T), RS1000367822 (2:127945809 T>C), RS1000377873 (2:127974526 A>C), RS1000388147 (2:127988448 A>C,T), RS1000418017 (2:127945567 C>G,T), RS1000429761 (2:128014154 A>G), RS1000461461 (2:128016858 C>T)

Disease associations

OMIM: gene MIM:609697 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (2): CHEMBL1229012 (SINGLE PROTEIN), CHEMBL3885592 (PROTEIN COMPLEX)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases abundance, increases expression	2
Benzo(a)pyrene	affects methylation, decreases methylation	2
Particulate Matter	decreases expression, increases abundance, affects expression	2
aristolochic acid I	decreases expression	1
FR900359	affects phosphorylation	1
TAK-243	decreases sumoylation	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
trichostatin A	affects expression	1
cobaltous chloride	increases expression	1
benzo(e)pyrene	decreases methylation	1
aflatoxin B2	decreases methylation	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	increases reaction, affects binding	1
Acetaminophen	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	increases abundance, increases expression	1
Vehicle Emissions	affects expression, increases abundance	1
Cadmium	decreases expression, increases abundance	1
Caffeine	increases phosphorylation	1
Carbamazepine	affects expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Ivermectin	decreases expression	1
Methapyrilene	decreases methylation	1
Dronabinol	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Urethane	increases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	decreases methylation	1

ChEMBL screening assays

4 unique, capped per target: 4 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL1226396	Binding	Binding affinity to SAP130 in human HeLa cells at 2 uM by LC-MS/MS analysis	Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. — Nat Chem Biol

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.