SAP30

Summary

SAP30 (Sin3A associated protein 30, HGNC:10532) is a protein-coding gene on chromosome 4q34.1, encoding Histone deacetylase complex subunit SAP30 (O75446). Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes.

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3.

Source: NCBI Gene 8819 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 28 total
• MANE Select transcript: NM_003864

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10532
Approved symbol	SAP30
Name	Sin3A associated protein 30
Location	4q34.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000164105
Ensembl biotype	protein_coding
OMIM	603378
Entrez	8819

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000296504, ENST00000504618, ENST00000932477

RefSeq mRNA: 1 — MANE Select: NM_003864 NM_003864

CCDS: CCDS3817

Canonical transcript exons

ENST00000296504 — 4 exons

Exon	Start	End
ENSE00001081471	173370954	173371497
ENSE00001081472	173377205	173377532
ENSE00001081473	173373939	173374037
ENSE00001081474	173373390	173373515

Expression profiles

Bgee: expression breadth ubiquitous, 268 present calls, max score 98.22.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 26.0593 / max 242.8450, expressed in 1812 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
50622	24.5892	1811
50623	0.7963	480
50621	0.4462	214
50624	0.2276	76

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	98.22	gold quality
ventricular zone	UBERON:0003053	95.56	gold quality
oocyte	CL:0000023	95.22	gold quality
ganglionic eminence	UBERON:0004023	93.77	gold quality
tibial artery	UBERON:0007610	92.32	gold quality
popliteal artery	UBERON:0002250	92.30	gold quality
calcaneal tendon	UBERON:0003701	91.74	gold quality
monocyte	CL:0000576	91.58	gold quality
embryo	UBERON:0000922	91.51	gold quality
mononuclear cell	CL:0000842	91.38	gold quality
aorta	UBERON:0000947	91.21	gold quality
leukocyte	CL:0000738	90.74	gold quality
adult organism	UBERON:0007023	90.63	gold quality
tendon of biceps brachii	UBERON:0008188	90.38	gold quality
descending thoracic aorta	UBERON:0002345	90.23	gold quality
tendon	UBERON:0000043	90.05	gold quality
thoracic aorta	UBERON:0001515	89.91	gold quality
ascending aorta	UBERON:0001496	89.88	gold quality
medial globus pallidus	UBERON:0002477	89.68	gold quality
left coronary artery	UBERON:0001626	89.52	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	89.33	gold quality
lower esophagus muscularis layer	UBERON:0035833	89.25	gold quality
lower esophagus	UBERON:0013473	89.20	gold quality
muscle layer of sigmoid colon	UBERON:0035805	89.16	gold quality
sural nerve	UBERON:0015488	89.13	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	88.90	gold quality
coronary artery	UBERON:0001621	88.47	gold quality
right atrium auricular region	UBERON:0006631	88.41	gold quality
right lung	UBERON:0002167	88.40	gold quality
right testis	UBERON:0004534	88.37	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	12.05
E-MTAB-9388	no	9.96

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
IFNB1

Upstream regulators (CollecTRI, top): ESR1, HESX1, LHX2, NCOR1, POU1F1, POU4F2, THRA, YY1, ZNF395

miRNA regulators (miRDB)

18 targeting SAP30, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-3919	99.87	69.45	2489
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-545-5P	99.66	70.18	2308
HSA-MIR-32-3P	99.36	68.20	2517
HSA-MIR-4801	98.96	69.42	2096
HSA-MIR-6780A-3P	98.42	67.49	1518
HSA-MIR-3691-3P	97.90	65.97	791
HSA-MIR-3129-3P	97.85	67.63	1246
HSA-MIR-5583-5P	97.85	67.61	1243
HSA-MIR-5702	96.68	68.21	958
HSA-MIR-4474-5P	94.23	67.95	568

Literature-anchored findings (GeneRIF, showing 10)

• The interaction domains between YY1 and SAP30 were mapped to the C-terminal segment of YY1 (295-414) and the C-terminal 91 amino acid region of SAP30. (PMID:12788099)
• The SAP30 gene may be involved in basal cell carcinogenesis. (PMID:15005689)
• occurrence of an unusual TG 3’ splice site in intron 1 (PMID:17672918)
• PBF binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex (PMID:17897615)
• findings demonstrate new functions for SAP30L and SAP30 by showing that they can associate directly with core histones as well as naked DNA (PMID:19015240)
• In the nucleus, SLy2 interacts with the SAP30/HDAC1 complex and regulates the activity of HDAC1. (PMID:20478393)
• upregulation of NETO2 gene is first stipulated by the isoform 1 (NM_018092.4), and the probable mechanism of its activation is associated with the increased expression of SAP30 transcription factor. (PMID:29989576)
• Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia. (PMID:36302855)
• SAP30 promotes breast tumor progression by bridging the transcriptional corepressor SIN3 complex and MLL1. (PMID:37655663)
• Reveal the correlation between hub hypoxia/immune-related genes and immunity and diagnosis, and the effect of SAP30 on cell apoptosis, ROS and MDA production in cerebral ischemic stroke. (PMID:38154101)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Sap30	ENSMUSG00000031609
rattus_norvegicus	Sap30	ENSRNOG00000013218
drosophila_melanogaster	Sap30	FBGN0030788

Paralogs (1): SAP30L (ENSG00000164576)

Protein

Protein identifiers

Histone deacetylase complex subunit SAP30 — O75446 (reviewed: O75446)

Alternative names: 30 kDa Sin3-associated polypeptide, Sin3 corepressor complex subunit SAP30, Sin3-associated polypeptide p30

All UniProt accessions (1): O75446

UniProt curated annotations — full annotation on UniProt →

Function. Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC.

Subunit / interactions. Component of the histone deacetylase complex that includes at least SIN3A, HDAC1 and HDAC2. Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1. Interacts with HDAC1. Interacts with SIN3A, SIN3B, HDAC2, RBBP4 and NCOR1. Interacts with SAMSN1. Interacts with HCFC1. Interacts with SAP30BP.

Subcellular location. Nucleus.

Tissue specificity. Expressed in all tissues tested with highest levels in pancreas, ovary, PBL, spleen and thymus; lowest levels in brain, placenta, lung and kidney.

Similarity. Belongs to the SAP30 family.

RefSeq proteins (1): NP_003855* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR024145	His_deAcase_SAP30/SAP30L	Family
IPR025717	SAP30_zn-finger	Domain
IPR025718	SAP30_Sin3-bd	Domain
IPR038291	SAP30_C_sf	Homologous_superfamily

Pfam: PF13866, PF13867

UniProt features (23 total): cross-link 4, mutagenesis site 4, strand 4, modified residue 4, region of interest 3, helix 2, chain 1, zinc finger region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2KDP	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75446-F1	69.73	0.03

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (8): 194, 205, 214, 5, 131, 138, 145, 87

Mutagenesis-validated functional residues (4):

Position	Phenotype
67	abolishes zinc-binding.
68	retains zinc-binding.
108	retains zinc-binding.
112	abolishes zinc-binding.

Function

Pathways and Gene Ontology

Reactome pathways

12 pathways

ID	Pathway
R-HSA-3214815	HDACs deacetylate histones
R-HSA-427413	NoRC negatively regulates rRNA expression
R-HSA-9679191	Potential therapeutics for SARS
R-HSA-1643685	Disease
R-HSA-212165	Epigenetic regulation of gene expression
R-HSA-3247509	Chromatin modifying enzymes
R-HSA-4839726	Chromatin organization
R-HSA-5250941	Negative epigenetic regulation of rRNA expression
R-HSA-5663205	Infectious disease
R-HSA-74160	Gene expression (Transcription)
R-HSA-9679506	SARS-CoV Infections
R-HSA-9824446	Viral Infection Pathways

MSigDB gene sets: 317 (showing top): PID_HDAC_CLASSI_PATHWAY, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS, GOBP_MUSCLE_TISSUE_DEVELOPMENT, PID_TELOMERASE_PATHWAY, MATTIOLI_MGUS_VS_PCL, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, chr4q34, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, AACYNNNNTTCCS_UNKNOWN, BROWNE_HCMV_INFECTION_16HR_UP, WEI_MYCN_TARGETS_WITH_E_BOX, GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS, ONKEN_UVEAL_MELANOMA_UP, GOBP_MUSCLE_STRUCTURE_DEVELOPMENT

GO Biological Process (7): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of DNA-templated transcription (GO:0006355), negative regulation of cell migration (GO:0030336), negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512), skeletal muscle cell differentiation (GO:0035914), negative regulation of stem cell population maintenance (GO:1902455), positive regulation of stem cell population maintenance (GO:1902459)

GO Molecular Function (6): DNA binding (GO:0003677), transcription coregulator activity (GO:0003712), transcription corepressor activity (GO:0003714), zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (4): histone deacetylase complex (GO:0000118), nucleus (GO:0005634), nucleoplasm (GO:0005654), Sin3-type complex (GO:0070822)

Reactome top-level categories

Rollup of top-9 pathways:

Category	Pathways
Chromatin modifying enzymes	1
Negative epigenetic regulation of rRNA expression	1
SARS-CoV Infections	1
Gene expression (Transcription)	1
Chromatin organization	1
Epigenetic regulation of gene expression	1
Disease	1
Viral Infection Pathways	1
Infectious disease	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
negative regulation of DNA-templated transcription	2
stem cell population maintenance	2
regulation of stem cell population maintenance	2
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cell migration	1
regulation of cell migration	1
negative regulation of cell motility	1
transforming growth factor beta receptor signaling pathway	1
regulation of transforming growth factor beta receptor signaling pathway	1
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	1
skeletal muscle tissue development	1
cell differentiation	1
negative regulation of developmental process	1
negative regulation of multicellular organismal process	1
positive regulation of developmental process	1
positive regulation of multicellular organismal process	1
nucleic acid binding	1
transcription regulator activity	1
transcription coregulator activity	1
transition metal ion binding	1
binding	1
cation binding	1
nucleoplasm	1
nuclear protein-containing complex	1
catalytic complex	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1
histone deacetylase complex	1
nuclear chromosome	1
chromatin	1

Protein interactions and networks

STRING

884 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SAP30	SAP18	O00422	999
SAP30	SUDS3	Q9H7L9	999
SAP30	RBBP4	P31149	998
SAP30	SIN3A	Q96ST3	998
SAP30	HDAC1	Q13547	997
SAP30	RBBP7	Q16576	997
SAP30	HDAC2	Q92769	997
SAP30	SIN3B	O75182	996
SAP30	BRMS1L	Q5PSV4	948
SAP30	ARID4B	Q4LE39	939
SAP30	ARID4A	P29374	921
SAP30	ING2	Q9H160	902
SAP30	BRMS1	Q9HCU9	880
SAP30	NCOR1	O75376	873
SAP30	ING3	Q9NXR8	847

IntAct

112 interactions, top by confidence:

A	B	Type	Score
NCOR2	HDAC3	psi-mi:“MI:0915”(physical association)	0.950
HDAC1	KDM1A	psi-mi:“MI:0914”(association)	0.910
HDAC2	KDM1A	psi-mi:“MI:0914”(association)	0.890
HDAC1	CDK2AP1	psi-mi:“MI:0914”(association)	0.840
RBBP7	CDK2AP1	psi-mi:“MI:0914”(association)	0.840
RBBP4	CDK2AP1	psi-mi:“MI:0914”(association)	0.790
HDAC1	TNRC18	psi-mi:“MI:0914”(association)	0.790
HDAC1	ZNF609	psi-mi:“MI:0914”(association)	0.730
RBBP7	HAT1	psi-mi:“MI:0914”(association)	0.730
SINHCAF	TNRC18	psi-mi:“MI:0914”(association)	0.640
ZNF704	SAP30	psi-mi:“MI:0914”(association)	0.640
SIN3A	SAP30	psi-mi:“MI:0914”(association)	0.640
SAP30	APBB2	psi-mi:“MI:0915”(physical association)	0.560
DR1	SAP30	psi-mi:“MI:0915”(physical association)	0.560
	SAP30	psi-mi:“MI:0915”(physical association)	0.560
ELAVL4	SAP30	psi-mi:“MI:0915”(physical association)	0.560
GTF2B	SAP30	psi-mi:“MI:0915”(physical association)	0.560
GTF3C3	SAP30	psi-mi:“MI:0915”(physical association)	0.560
BAG3	SAP30	psi-mi:“MI:0915”(physical association)	0.560
NDRG1	SAP30	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (355): SAP30 (Affinity Capture-Western), SAP30 (Affinity Capture-Western), CUL4B (Affinity Capture-Western), DDB1 (Affinity Capture-Western), SAP30 (Affinity Capture-Western), BRMS1 (Affinity Capture-Western), SAP30 (Affinity Capture-MS), SAP30 (Co-fractionation), SAP30 (Affinity Capture-Western), LYST (Affinity Capture-MS), HDAC1 (Affinity Capture-MS), HDAC2 (Affinity Capture-MS), FOXK2 (Affinity Capture-MS), ING1 (Affinity Capture-MS), ING2 (Affinity Capture-MS)

ESM2 similar proteins: A4FVD8, A5D7H2, O14795, O43237, O55047, O70585, O75446, O88574, P58405, P84060, Q02241, Q0VA03, Q13033, Q14161, Q28H91, Q2TAD4, Q4KUS2, Q4R5P6, Q5EA89, Q5HYJ3, Q5R7U7, Q5RE09, Q5SQF8, Q5ZJ65, Q62768, Q6NYV5, Q6PBM7, Q6PDL0, Q80XP8, Q80YA9, Q811S7, Q86UE8, Q8BIK4, Q8C0V0, Q8CBY8, Q8TAV0, Q8WXI2, Q90ZY6, Q922G2, Q96EZ8

Diamond homologs: A4FVD8, O75446, O88574, Q17Q39, Q28H91, Q29IK8, Q2TAD4, Q5SQF8, Q6NYV5, Q7PXY4, Q9HAJ7, Q9VXB3

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 79 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Regulation of TP53 Activity through Acetylation	5	40.8×	1e-05
Regulation of MECP2 expression and activity	6	39.5×	3e-06
Downregulation of SMAD2/3:SMAD4 transcriptional activity	5	32.9×	3e-05
Regulation of PTEN gene transcription	6	19.1×	4e-05
Constitutive Signaling by NOTCH1 PEST Domain Mutants	5	17.6×	3e-04
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	5	17.6×	3e-04
HDACs deacetylate histones	8	17.2×	3e-06
Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells)	6	15.7×	1e-04

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of stem cell population maintenance	9	98.5×	6e-14
positive regulation of stem cell population maintenance	9	44.2×	8e-11
negative regulation of transforming growth factor beta receptor signaling pathway	9	22.3×	4e-08
heterochromatin formation	5	18.2×	5e-04
negative regulation of cell migration	10	15.9×	8e-08
negative regulation of apoptotic process	10	5.0×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

28 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	24
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

638 predictions. Top by Δscore:

Variant	Effect	Δscore
4:173371493:AGAGC:A	donor_gain	1.0000
4:173371494:GAGC:G	donor_gain	1.0000
4:173371494:GAGCG:G	donor_gain	1.0000
4:173371495:AGC:A	donor_gain	1.0000
4:173371496:GC:G	donor_gain	1.0000
4:173371496:GCG:G	donor_gain	1.0000
4:173371497:CGTA:C	donor_loss	1.0000
4:173371498:G:GG	donor_gain	1.0000
4:173371498:GT:G	donor_loss	1.0000
4:173371499:T:A	donor_loss	1.0000
4:173373523:G:GT	donor_gain	1.0000
4:173373933:TTCTA:T	acceptor_loss	1.0000
4:173373934:TCTAG:T	acceptor_loss	1.0000
4:173373935:CTAG:C	acceptor_loss	1.0000
4:173373936:TA:T	acceptor_loss	1.0000
4:173373937:AGG:A	acceptor_loss	1.0000
4:173377204:GATA:G	acceptor_gain	1.0000
4:173371502:G:GG	donor_gain	0.9900
4:173373513:GAG:G	donor_gain	0.9900
4:173373523:G:T	donor_gain	0.9900
4:173373937:A:AG	acceptor_gain	0.9900
4:173373937:AGGTT:A	acceptor_gain	0.9900
4:173373938:G:GG	acceptor_gain	0.9900
4:173373938:GGTT:G	acceptor_gain	0.9900
4:173373938:GGTTG:G	acceptor_gain	0.9900
4:173374012:GACT:G	donor_gain	0.9900
4:173374033:TTGAG:T	donor_loss	0.9900
4:173374034:TGAG:T	donor_loss	0.9900
4:173374038:G:A	donor_loss	0.9900
4:173374039:T:G	donor_loss	0.9900

AlphaMissense

1432 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:173371381:T:C	C67R	1.000
4:173371382:G:A	C67Y	1.000
4:173371383:C:G	C67W	1.000
4:173371388:T:A	L69Q	1.000
4:173371388:T:C	L69P	1.000
4:173371408:T:A	C76S	1.000
4:173371408:T:C	C76R	1.000
4:173371409:G:A	C76Y	1.000
4:173371409:G:C	C76S	1.000
4:173371410:C:G	C76W	1.000
4:173371424:G:A	G81D	1.000
4:173371430:C:A	A83D	1.000
4:173371435:T:C	F85L	1.000
4:173371436:T:C	F85S	1.000
4:173371436:T:G	F85C	1.000
4:173371437:C:A	F85L	1.000
4:173371437:C:G	F85L	1.000
4:173371438:A:C	S86R	1.000
4:173371439:G:T	S86I	1.000
4:173371440:C:A	S86R	1.000
4:173371440:C:G	S86R	1.000
4:173371445:G:C	R88T	1.000
4:173371445:G:T	R88M	1.000
4:173371446:G:C	R88S	1.000
4:173371446:G:T	R88S	1.000
4:173371448:T:A	I89N	1.000
4:173371448:T:C	I89T	1.000
4:173371448:T:G	I89S	1.000
4:173373402:T:C	Y110H	1.000
4:173373402:T:G	Y110D	1.000

dbSNP variants (sampled 300 via entrez): RS1000691525 (4:173377592 A>T), RS1000723553 (4:173377901 C>G), RS1000872642 (4:173372457 C>A,G,T), RS1001090751 (4:173372706 A>T), RS1001211127 (4:173372380 T>C), RS1001831783 (4:173377113 C>A), RS1001985771 (4:173370476 G>A), RS1002329786 (4:173372133 C>T), RS1003155416 (4:173375945 A>G), RS1003230286 (4:173377343 G>A), RS10032507 (4:173371807 G>A), RS1003341215 (4:173370736 G>T), RS1003348457 (4:173369548 C>G), RS1003560851 (4:173370896 C>G), RS1003899826 (4:173377840 T>C)

Disease associations

OMIM: gene MIM:603378 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

47 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cisplatin	increases expression, decreases expression	3
sodium arsenite	decreases expression, increases stability	2
cobaltous chloride	increases expression, decreases reaction	2
Tretinoin	decreases expression	2
Valproic Acid	increases expression	2
Cyclosporine	affects expression, decreases expression	2
GSK-J4	increases expression	1
FR900359	increases phosphorylation	1
Batroxase, Bothrops atrox	increases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
bisphenol A	affects cotreatment, increases expression	1
arsenite	affects binding, increases reaction	1
zinc chloride	decreases reaction, increases expression	1
manganese chloride	increases abundance, increases expression	1
perfluorodecanoic acid	increases expression	1
beta-methylcholine	affects expression	1
tamibarotene	decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
ICG 001	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Temozolomide	decreases expression	1
Air Pollutants	affects expression, increases abundance	1
Amphotericin B	increases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Fluorouracil	affects reaction, decreases expression	1
Hydrogen Peroxide	affects expression	1
Indomethacin	affects cotreatment, increases expression	1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A6B2	SEES3-1V human SAP30, clone1	Embryonic stem cell	Male
CVCL_A6B3	SEES3-1V human SAP30, clone2	Embryonic stem cell	Male
CVCL_A6B4	SEES3-1V human SAP30, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.