SAP30BP

Summary

SAP30BP (SAP30 binding protein, HGNC:30785) is a protein-coding gene on chromosome 17q25.1, encoding SAP30-binding protein (Q9UHR5). Plays a role in transcriptional repression by promoting histone deacetylase activity, leading to deacetylation of histone H3. It is a common-essential gene (DepMap: required in 99.8% of cancer cell lines).

Predicted to be involved in regulation of DNA-templated transcription. Located in intermediate filament cytoskeleton and nucleoplasm.

Source: NCBI Gene 29115 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 39 total
• Druggable target: yes — 1 molecules with ChEMBL bioactivity
• Cancer dependency (DepMap): dependent in 99.8% of screened cell lines (common-essential)
• MANE Select transcript: NM_013260

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30785
Approved symbol	SAP30BP
Name	SAP30 binding protein
Location	17q25.1
Locus type	gene with protein product
Status	Approved
Aliases	HCNGP, HTRG, HTRP
Ensembl gene	ENSG00000161526
Ensembl biotype	protein_coding
OMIM	610218
Entrez	29115

Gene structure

Transcript identifiers

Ensembl transcripts: 33 — 13 protein_coding, 10 retained_intron, 7 nonsense_mediated_decay, 3 protein_coding_CDS_not_defined

ENST00000293208, ENST00000355423, ENST00000542343, ENST00000577292, ENST00000578288, ENST00000578354, ENST00000578756, ENST00000578909, ENST00000579005, ENST00000579864, ENST00000579877, ENST00000580322, ENST00000580484, ENST00000580601, ENST00000581207, ENST00000581385, ENST00000582022, ENST00000583063, ENST00000583170, ENST00000583329, ENST00000583536, ENST00000583737, ENST00000584240, ENST00000584557, ENST00000584667, ENST00000584861, ENST00000868399, ENST00000868400, ENST00000868401, ENST00000868402, ENST00000868403, ENST00000920522, ENST00000963357

RefSeq mRNA: 3 — MANE Select: NM_013260 NM_001301839, NM_001301855, NM_013260

CCDS: CCDS11726, CCDS77115

Canonical transcript exons

ENST00000584667 — 11 exons

Exon	Start	End
ENSE00001300697	75706340	75708059
ENSE00002717080	75667338	75667478
ENSE00003459183	75706008	75706092
ENSE00003481792	75702480	75702571
ENSE00003546434	75668516	75668625
ENSE00003572997	75693440	75693482
ENSE00003574700	75703311	75703371
ENSE00003581403	75703808	75703859
ENSE00003605813	75671816	75671863
ENSE00003689414	75699783	75699871
ENSE00003788906	75704756	75704814

Expression profiles

Bgee: expression breadth ubiquitous, 291 present calls, max score 98.36.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 45.9591 / max 1506.8661, expressed in 1822 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
162765	45.1150	1822
162766	0.6270	246
162770	0.1343	68
162771	0.0828	36

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.36	gold quality
peripheral nervous system	UBERON:0000010	97.67	gold quality
nerve	UBERON:0001021	97.67	gold quality
tibial nerve	UBERON:0001323	97.67	gold quality
granulocyte	CL:0000094	97.35	gold quality
mucosa of stomach	UBERON:0001199	97.24	gold quality
monocyte	CL:0000576	97.21	gold quality
skin of leg	UBERON:0001511	96.99	gold quality
minor salivary gland	UBERON:0001830	96.86	gold quality
mononuclear cell	CL:0000842	96.79	gold quality
tibial artery	UBERON:0007610	96.78	gold quality
popliteal artery	UBERON:0002250	96.77	gold quality
skin of abdomen	UBERON:0001416	96.76	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	96.76	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	96.75	gold quality
leukocyte	CL:0000738	96.73	gold quality
ectocervix	UBERON:0012249	96.64	gold quality
lower esophagus	UBERON:0013473	96.63	gold quality
lower esophagus muscularis layer	UBERON:0035833	96.63	gold quality
endocervix	UBERON:0000458	96.62	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	96.61	gold quality
ventricular zone	UBERON:0003053	96.60	gold quality
colonic epithelium	UBERON:0000397	96.51	gold quality
muscle layer of sigmoid colon	UBERON:0035805	96.51	gold quality
body of uterus	UBERON:0009853	96.45	gold quality
left uterine tube	UBERON:0001303	96.34	gold quality
body of stomach	UBERON:0001161	96.29	gold quality
calcaneal tendon	UBERON:0003701	96.26	gold quality
lower esophagus mucosa	UBERON:0035834	96.26	gold quality
aorta	UBERON:0000947	96.22	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.40
E-MTAB-6379	no	387.70

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): FOXC1

miRNA regulators (miRDB)

63 targeting SAP30BP, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-3151-5P	99.86	63.83	1069
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-3150A-3P	99.76	64.44	1640
HSA-MIR-6763-5P	99.76	64.68	1767
HSA-MIR-1825	99.72	68.11	1089
HSA-MIR-3175	99.65	66.30	2031
HSA-MIR-875-3P	99.63	69.47	2548
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-582-5P	99.47	70.79	2635
HSA-MIR-12132	99.47	68.90	1341
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-6513-5P	99.43	67.81	1071
HSA-MIR-532-3P	99.34	65.76	1195
HSA-MIR-4505	99.27	67.81	2678
HSA-MIR-5787	99.22	67.86	2628
HSA-MIR-491-5P	99.13	65.98	1468
HSA-MIR-4651	99.06	67.57	2002

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 99.8% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 7)

• HTRP is involved in cellular co-repressors (PMID:15496587)
• The results indicate that HTRP could inhibit the transcription of a viral promoter, whose interaction with SAP30 synergistically affects transcriptional inhibition of the herpes simplex virus type 1 genes, and is related to HDAC enzyme activity. (PMID:21221920)
• Two SNPs were significantly associated with rotator cuff tearing, residing in SAP30BP on chromosome 17 and SASH1 on chromosome 6. (PMID:26350878)
• we proposed that four newly identified peripheral blood mononuclear cells-derived genes( DHRS3, TTC38, SAP30BP and LPIN2 )could be integrated with previously reported rheumatoid arthritis (RA)-associated genes to monitor and/or diagnose RA. (PMID:28371410)
• SAP30BP gene is associated with the susceptibility of rotator cuff tear: a case-control study based on Han Chinese population. (PMID:32843068)
• Association between the rs820218 Variant within the SAP30BP Gene and Rotator Cuff Rupture in an Amazonian Population. (PMID:36833294)
• SAP30BP interacts with RBM17/SPF45 to promote splicing in a subset of human short introns. (PMID:38065098)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	sap30bp	ENSDARG00000031261
mus_musculus	Sap30bp	ENSMUSG00000020755
rattus_norvegicus	Sap30bp	ENSRNOG00000005482
drosophila_melanogaster	CG2063	FBGN0033400
caenorhabditis_elegans		WBGENE00022057

Protein

Protein identifiers

SAP30-binding protein — Q9UHR5 (reviewed: Q9UHR5)

Alternative names: Transcriptional regulator protein HCNGP

All UniProt accessions (11): Q9UHR5, F5H478, J3KRR6, J3KRU5, J3KS14, J3QKW0, J3QLH3, J3QLM2, J3QQJ0, J3QS04, X6R3T8

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in transcriptional repression by promoting histone deacetylase activity, leading to deacetylation of histone H3. Acts as a regulator of pre-mRNA splicing by facilitating assembly of the cyclin-L-CDK11 cyclin-dependent protein kinase complex, thereby promoting phosphorylation of SF3B1. May be involved in the regulation of beta-2-microglobulin genes. (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC.

Subunit / interactions. Interacts with histone deacetylase complex subunit SAP30. Interacts with CDK11 (CDK11A and/or CDK11B), CCNL1 and CCNL2.

Subcellular location. Nucleus. Nucleus speckle.

Induction. (Microbial infection) In fibroblasts by binding of HSV1.

Similarity. Belongs to the HCNGP family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9UHR5-1	1	yes
Q9UHR5-2	2

RefSeq proteins (3): NP_001288768, NP_001288784, NP_037392* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR012479	SAP30BP	Family

Pfam: PF07818

UniProt features (19 total): modified residue 5, cross-link 4, sequence conflict 4, compositionally biased region 3, chain 1, region of interest 1, splice variant 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
9QKZ	ELECTRON MICROSCOPY	2.3
9QKT	ELECTRON MICROSCOPY	2.4
9QL1	ELECTRON MICROSCOPY	2.4

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UHR5-F1	66.32	0.19

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (9): 95, 220, 304, 305, 18, 22, 43, 52, 113

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-427413	NoRC negatively regulates rRNA expression
R-HSA-212165	Epigenetic regulation of gene expression
R-HSA-5250941	Negative epigenetic regulation of rRNA expression
R-HSA-74160	Gene expression (Transcription)

MSigDB gene sets: 133 (showing top): GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, WANG_LMO4_TARGETS_DN, BLALOCK_ALZHEIMERS_DISEASE_UP, GOBP_RNA_SPLICING, CREB_Q2_01, CREB_Q3, GOBP_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME, NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON, GOBP_RESPONSE_TO_VIRUS, GOBP_REGULATION_OF_RNA_SPLICING, OSMAN_BLADDER_CANCER_DN, GOCC_NUCLEAR_SPECK, GOCC_NUCLEAR_BODY, GOCC_RIBONUCLEOPROTEIN_GRANULE, BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP

GO Biological Process (2): regulation of DNA-templated transcription (GO:0006355), response to virus (GO:0009615)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (3): nucleus (GO:0005634), nucleoplasm (GO:0005654), intermediate filament cytoskeleton (GO:0045111)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Negative epigenetic regulation of rRNA expression	1
Gene expression (Transcription)	1
Epigenetic regulation of gene expression	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
response to other organism	1
binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1
cytoskeleton	1

Protein interactions and networks

STRING

1498 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SAP30BP	SAP30	O75446	585
SAP30BP	NCOR1	O75376	547
SAP30BP	SASH1	O94885	506
SAP30BP	RBL1	P28749	439
SAP30BP	LAPTM4A	Q15012	430
SAP30BP	SART3	Q15020	419
SAP30BP	IWS1	Q96ST2	386
SAP30BP	ZSWIM7	Q19AV6	383
SAP30BP	PPP6R3	Q5H9R7	378
SAP30BP	HIP1R	O75146	373
SAP30BP	FAU	P35544	360
SAP30BP	ZNF530	Q6P9A1	356
SAP30BP	OR4C46	A6NHA9	355
SAP30BP	FZR1	Q9UM11	342
SAP30BP	NCKAP5L	Q9HCH0	336

IntAct

80 interactions, top by confidence:

A	B	Type	Score
SAP30BP	PUF60	psi-mi:“MI:0915”(physical association)	0.900
PUF60	SAP30BP	psi-mi:“MI:0915”(physical association)	0.900
SAP30BP	CCNL1	psi-mi:“MI:0915”(physical association)	0.740
SAP30BP	FHL3	psi-mi:“MI:0915”(physical association)	0.720
FHL3	SAP30BP	psi-mi:“MI:0915”(physical association)	0.720
SAP30BP	TFIP11	psi-mi:“MI:0915”(physical association)	0.670
TFIP11	SAP30BP	psi-mi:“MI:0915”(physical association)	0.670
CDK11B	CDC37	psi-mi:“MI:0914”(association)	0.640
GOLGA2	SAP30BP	psi-mi:“MI:0915”(physical association)	0.560
SAP30BP	THAP1	psi-mi:“MI:0915”(physical association)	0.560
THAP1	SAP30BP	psi-mi:“MI:0915”(physical association)	0.560
SAP30BP	GOLGA2	psi-mi:“MI:0915”(physical association)	0.560
PRKAR1B	SAP30BP	psi-mi:“MI:0915”(physical association)	0.560
OGT	SAP30BP	psi-mi:“MI:0915”(physical association)	0.560
CDK11A	HSP90AA1	psi-mi:“MI:0914”(association)	0.530
SAP30BP	E7	psi-mi:“MI:0915”(physical association)	0.490
USP7	SAP30BP	psi-mi:“MI:0407”(direct interaction)	0.440

BioGRID (156): SAP30BP (Affinity Capture-MS), SAP30BP (Two-hybrid), SAP30BP (Two-hybrid), SAP30BP (Two-hybrid), SAP30BP (Two-hybrid), THAP1 (Two-hybrid), SAP30BP (Affinity Capture-RNA), SAP30BP (Affinity Capture-RNA), SAP30BP (Affinity Capture-RNA), SAP30BP (Two-hybrid), SAP30BP (Co-fractionation), SAP30BP (Affinity Capture-MS), SAP30BP (Proximity Label-MS), SAP30BP (Two-hybrid), SAP30BP (Affinity Capture-MS)

ESM2 similar proteins: A0JPM9, A2AQ19, O43395, O75391, O75822, P04973, P09496, P29084, P29540, Q02614, Q0VCU8, Q13123, Q15650, Q2HJ41, Q2KIA6, Q2KJF9, Q3MHJ0, Q3UGC7, Q5BK07, Q5I0B5, Q5NVI3, Q5R5F1, Q5R8D1, Q5RAD5, Q5RE03, Q5ZJ85, Q5ZJ97, Q5ZK25, Q5ZKA4, Q66HG8, Q66JS6, Q6GMH0, Q6INR1, Q6P320, Q7SXU0, Q7SYJ9, Q7TNE3, Q8BM39, Q91WE2, Q922U1

Diamond homologs: Q02614, Q9UHR5

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 60 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA Polyadenylation	5	9.3×	3e-03
mRNA Splicing - Major Pathway	8	9.3×	7e-04
Processing of Capped Intron-Containing Pre-mRNA	5	8.7×	4e-03
Metabolism of RNA	7	6.2×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of proteasomal ubiquitin-dependent protein catabolic process	7	49.3×	5e-08
mRNA splicing, via spliceosome	6	9.6×	4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

39 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	23
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2501 predictions. Top by Δscore:

Variant	Effect	Δscore
17:75667319:G:GT	donor_gain	1.0000
17:75667474:GGCTG:G	donor_gain	1.0000
17:75667475:GCTG:G	donor_gain	1.0000
17:75667475:GCTGG:G	donor_gain	1.0000
17:75667477:TGG:T	donor_loss	1.0000
17:75667479:G:GG	donor_gain	1.0000
17:75668498:T:TA	acceptor_gain	1.0000
17:75668506:A:AG	acceptor_gain	1.0000
17:75668507:A:AG	acceptor_gain	1.0000
17:75668508:C:G	acceptor_gain	1.0000
17:75668511:TTCA:T	acceptor_loss	1.0000
17:75668512:TCA:T	acceptor_loss	1.0000
17:75668513:CA:C	acceptor_loss	1.0000
17:75668514:A:AG	acceptor_gain	1.0000
17:75668514:AGAG:A	acceptor_gain	1.0000
17:75668515:G:GG	acceptor_gain	1.0000
17:75668515:GA:G	acceptor_gain	1.0000
17:75668515:GAGG:G	acceptor_gain	1.0000
17:75668515:GAGGA:G	acceptor_gain	1.0000
17:75668622:GTCG:G	donor_gain	1.0000
17:75668626:G:GG	donor_gain	1.0000
17:75668626:GTA:G	donor_loss	1.0000
17:75668627:T:A	donor_loss	1.0000
17:75693438:AG:A	acceptor_gain	1.0000
17:75693439:GG:G	acceptor_gain	1.0000
17:75693479:GTGG:G	donor_gain	1.0000
17:75693480:TGG:T	donor_gain	1.0000
17:75693481:GG:G	donor_gain	1.0000
17:75693481:GGG:G	donor_gain	1.0000
17:75693482:GG:G	donor_gain	1.0000

AlphaMissense

2027 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:75699854:T:C	C127R	1.000
17:75702496:T:C	L138P	1.000
17:75702533:C:A	N150K	1.000
17:75702533:C:G	N150K	1.000
17:75702541:T:A	I153N	1.000
17:75702541:T:G	I153S	1.000
17:75702544:A:C	Q154P	1.000
17:75702553:A:T	K157I	1.000
17:75702554:A:C	K157N	1.000
17:75702554:A:T	K157N	1.000
17:75702558:T:C	F159L	1.000
17:75702559:T:C	F159S	1.000
17:75702559:T:G	F159C	1.000
17:75702560:T:A	F159L	1.000
17:75702560:T:G	F159L	1.000
17:75702562:G:C	R160P	1.000
17:75702564:A:G	N161D	1.000
17:75702566:C:A	N161K	1.000
17:75702566:C:G	N161K	1.000
17:75702567:C:A	P162T	1.000
17:75702567:C:T	P162S	1.000
17:75702568:C:A	P162H	1.000
17:75703313:T:A	I164N	1.000
17:75703313:T:C	I164T	1.000
17:75703313:T:G	I164S	1.000
17:75703315:T:C	Y165H	1.000
17:75703315:T:G	Y165D	1.000
17:75703321:A:G	K167E	1.000
17:75703325:T:A	L168Q	1.000
17:75703325:T:C	L168P	1.000

dbSNP variants (sampled 300 via entrez): RS1000008003 (17:75708133 C>A,T), RS1000013488 (17:75679232 G>A), RS1000222606 (17:75707237 A>C), RS1000256498 (17:75685025 G>A,C), RS1000278223 (17:75667385 A>T), RS1000309258 (17:75667610 G>T), RS1000387719 (17:75700641 A>C), RS1000612496 (17:75668682 T>C), RS1000613761 (17:75707040 T>C,G), RS1000645018 (17:75668999 T>C), RS1000725901 (17:75667867 G>T), RS1000771397 (17:75702116 A>C,G), RS1000799846 (17:75690517 C>G), RS1000824873 (17:75701265 C>T), RS1000972172 (17:75672814 G>A,C)

Disease associations

OMIM: gene MIM:610218 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST003115_1	Rotator cuff tears	4.000000e-09

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5725127 (SINGLE PROTEIN)

Molecules with ChEMBL bioactivity

1 molecules (phase ≥1), by development phase (incl. off-target/promiscuous compounds). Patent mentions across the top 20 by phase: 1,538 (via chembl_molecule»patent_compound — counts attach to the compound, not the gene–compound relationship, so off-target/promiscuous molecules can dominate).

Molecule	Name	Phase	Patents
CHEMBL1232461	MOLIBRESIB	2	1,538

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.01	Kd	98	nM	MOLIBRESIB
6.80	IC50	160	nM	MOLIBRESIB

PubChem BioAssay actives

2 with measured affinity, of 7 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide	2179167: Binding affinity against SAP30BP (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysis	kd	0.0980	uM

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression	2
Benzo(a)pyrene	affects methylation, decreases methylation	2
aristolochic acid I	increases expression	1
FR900359	increases phosphorylation	1
TAK-243	decreases sumoylation	1
triphenyl phosphate	affects expression	1
alpha-pinene	increases abundance, affects cotreatment, increases oxidation	1
beta-lapachone	increases expression, decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	increases expression	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	increases methylation	1
coumarin	decreases phosphorylation	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
CGP 52608	increases reaction, affects binding	1
abrine	increases expression	1
Temozolomide	increases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Air Pollutants	affects cotreatment, increases abundance, increases oxidation	1
Atrazine	decreases expression	1
Caffeine	decreases phosphorylation	1
Doxorubicin	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Ivermectin	decreases expression	1
Lead	affects splicing	1
Methapyrilene	increases methylation	1
Methyl Methanesulfonate	increases expression	1
Ozone	affects cotreatment, increases oxidation, increases abundance	1
Quercetin	increases phosphorylation	1
Silver	increases expression	1

ChEMBL screening assays

7 unique, capped per target: 7 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5697242	Binding	Inhibition of SAP30BP (unknown origin) assessed as fold change at 10 uM incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysis	Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. — Nature

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.