SAP30L-AS1

Summary

SAP30L-AS1 (SAP30L and GALNT10 antisense RNA 1, HGNC:26760) is a long non-coding RNA gene on chromosome 5q33.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26760
Approved symbol	SAP30L-AS1
Name	SAP30L and GALNT10 antisense RNA 1
Location	5q33.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ38109, GALNT10-AS1
Ensembl gene	ENSG00000245275
Ensembl biotype	lncRNA
Entrez	386627
RNAcentral	URS000075E493 — lncRNA, 3487 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000501280, ENST00000519727, ENST00000522312, ENST00000524264, ENST00000652895, ENST00000652933, ENST00000658072, ENST00000701461, ENST00000759380, ENST00000759381, ENST00000759382, ENST00000759383

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000501280 — 3 exons

Exon	Start	End
ENSE00001971595	154433782	154436336
ENSE00002127884	154445738	154445850
ENSE00002524079	154443362	154443480

Expression profiles

Bgee: expression breadth ubiquitous, 174 present calls, max score 99.84.

FANTOM5 (CAGE): breadth broad, TPM avg 1.0177 / max 22.8371, expressed in 584 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
64452	0.5293	282
64453	0.4884	275

Top tissues by expression

233 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	99.84	silver quality
parotid gland	UBERON:0001831	88.48	gold quality
tendon of biceps brachii	UBERON:0008188	84.43	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.11	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.11	gold quality
heart right ventricle	UBERON:0002080	80.11	silver quality
bone marrow cell	CL:0002092	78.11	gold quality
colonic epithelium	UBERON:0000397	76.68	gold quality
ileal mucosa	UBERON:0000331	76.40	silver quality
buccal mucosa cell	CL:0002336	76.03	gold quality
kidney epithelium	UBERON:0004819	75.53	gold quality
left ovary	UBERON:0002119	75.30	gold quality
tibialis anterior	UBERON:0001385	75.21	silver quality
right uterine tube	UBERON:0001302	74.95	gold quality
tendon	UBERON:0000043	74.54	gold quality
sural nerve	UBERON:0015488	74.24	gold quality
lateral nuclear group of thalamus	UBERON:0002736	73.92	silver quality
medial globus pallidus	UBERON:0002477	73.84	silver quality
right ovary	UBERON:0002118	73.37	gold quality
globus pallidus	UBERON:0001875	72.23	silver quality
calcaneal tendon	UBERON:0003701	72.09	gold quality
upper arm skin	UBERON:0004263	72.08	gold quality
right lobe of thyroid gland	UBERON:0001119	71.58	gold quality
middle temporal gyrus	UBERON:0002771	71.46	silver quality
skeletal muscle tissue	UBERON:0001134	71.01	gold quality
monocyte	CL:0000576	70.99	gold quality
mucosa of transverse colon	UBERON:0004991	70.95	gold quality
leukocyte	CL:0000738	70.89	gold quality
tibial nerve	UBERON:0001323	70.88	gold quality
left lobe of thyroid gland	UBERON:0001120	70.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.88

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Results show that SAP30L-AS1 is increased in prostate cancer tissues and cell lines. Moreover, increased expression of SAP30LAS1 indicates greater Gleason score, advanced pathological T stage, and poor overall survival. Functional experiments revealed that ectopic expression of SAP30L-AS1 promotes prostate cancer proliferation and inhibits apoptosis in vitro. (PMID:30599235)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.