SAPCD2

Summary

SAPCD2 (suppressor APC domain containing 2, HGNC:28055) is a protein-coding gene on chromosome 9q34.3, encoding Suppressor APC domain-containing protein 2 (Q86UD0). Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions.

Involved in negative regulation of protein localization to cell cortex and positive regulation of cell population proliferation. Located in several cellular components, including apical cortex; apical junction complex; and nuclear lumen.

Source: NCBI Gene 89958 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 61 total
• MANE Select transcript: NM_178448

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28055
Approved symbol	SAPCD2
Name	suppressor APC domain containing 2
Location	9q34.3
Locus type	gene with protein product
Status	Approved
Aliases	p42.3
Ensembl gene	ENSG00000186193
Ensembl biotype	protein_coding
OMIM	612057
Entrez	89958

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000409687, ENST00000879034, ENST00000879035, ENST00000940023

RefSeq mRNA: 1 — MANE Select: NM_178448 NM_178448

CCDS: CCDS7027

Canonical transcript exons

ENST00000409687 — 6 exons

Exon	Start	End
ENSE00001332484	137064863	137064979
ENSE00001332487	137065078	137065185
ENSE00001332492	137065522	137065668
ENSE00001332496	137066262	137066374
ENSE00001413685	137062127	137064787
ENSE00001856953	137069890	137070557

Expression profiles

Bgee: expression breadth ubiquitous, 191 present calls, max score 92.23.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.2600 / max 70.5986, expressed in 1210 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
103302	6.0670	1165
103301	1.1931	537

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	92.23	gold quality
pancreatic ductal cell	CL:0002079	86.58	silver quality
ileal mucosa	UBERON:0000331	85.98	gold quality
vena cava	UBERON:0004087	85.93	gold quality
cerebellar vermis	UBERON:0004720	84.17	gold quality
ventricular zone	UBERON:0003053	84.16	gold quality
upper arm skin	UBERON:0004263	83.53	gold quality
pharyngeal mucosa	UBERON:0000355	83.32	silver quality
thymus	UBERON:0002370	83.23	gold quality
pylorus	UBERON:0001166	82.79	gold quality
inferior vagus X ganglion	UBERON:0005363	82.56	gold quality
esophagus squamous epithelium	UBERON:0006920	82.02	gold quality
lower esophagus mucosa	UBERON:0035834	81.84	gold quality
tongue	UBERON:0001723	81.79	silver quality
parotid gland	UBERON:0001831	81.75	gold quality
mucosa of transverse colon	UBERON:0004991	81.74	gold quality
nipple	UBERON:0002030	81.66	gold quality
subthalamic nucleus	UBERON:0001906	81.62	silver quality
gingival epithelium	UBERON:0001949	81.20	silver quality
ventral tegmental area	UBERON:0002691	80.86	silver quality
substantia nigra pars reticulata	UBERON:0001966	80.80	silver quality
dorsal plus ventral thalamus	UBERON:0001897	80.65	silver quality
superior surface of tongue	UBERON:0007371	80.59	gold quality
amygdala	UBERON:0001876	80.56	gold quality
pericardium	UBERON:0002407	79.96	gold quality
tibialis anterior	UBERON:0001385	79.84	silver quality
pons	UBERON:0000988	79.82	silver quality
lateral globus pallidus	UBERON:0002476	79.81	gold quality
medulla oblongata	UBERON:0001896	79.78	silver quality
mammalian vulva	UBERON:0000997	79.60	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-7249	yes	70.39
E-ANND-3	no	2.81

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

57 targeting SAPCD2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-4648	99.91	67.00	710
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-3065-3P	99.87	70.25	1407
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-6817-3P	99.79	68.35	2126
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-1200	99.71	70.42	1838
HSA-MIR-1197	99.70	67.75	1027
HSA-MIR-670-5P	99.67	69.94	1565
HSA-MIR-1915-3P	99.58	66.79	1988
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-6727-3P	99.49	65.92	1333
HSA-MIR-130A-5P	99.33	70.26	2623
HSA-MIR-3692-5P	99.29	67.04	1421
HSA-MIR-6837-5P	99.25	65.47	1632
HSA-MIR-4293	99.22	65.46	1263
HSA-MIR-6852-5P	99.17	66.69	2073
HSA-MIR-4292	99.16	65.57	1767
HSA-MIR-6791-5P	99.16	65.92	1844
HSA-MIR-146A-3P	99.13	68.99	1881
HSA-MIR-661	99.09	65.94	2062
HSA-MIR-4324	99.04	70.14	1569
HSA-MIR-4326	98.97	67.63	962
HSA-MIR-939-3P	98.97	65.07	2347
HSA-MIR-367-5P	98.84	67.18	902
HSA-MIR-4656	98.79	66.22	1306

Literature-anchored findings (GeneRIF, showing 19)

• the regulatory relationship between miRNAs and the p42.3 gene (PMID:21998710)
• p42.3 overexpression is associated with mitotic progression in malignant transformed cells. (PMID:23192843)
• p42.3 protein plays an important role in the generation and development of gastric cancer. (PMID:23228105)
• p42.3 might play an important role in the progression of colorectal cancer. (PMID:23576022)
• Up-regulation of p42.3 in hepatocellular carcinoma promotes tumorigenicity and tumor growth. (PMID:23704824)
• Role of C9orf140 in the promotion of colorectal cancer progression and mechanisms of its upregulation via activation of STAT5, beta-catenin and EZH2. (PMID:24608043)
• Overexpression of the p42.3 gene is associated with gliomas. (PMID:24927751)
• p42.3 has a role in the pathogenesis of gastric carcinoma (PMID:26106439)
• p42.3 gene expression is associated with gastric mucosal inflammation that can be upregulated by TNF-alpha and H. pylori infection. (PMID:26316259)
• results uncover SAPCD2 as a key regulator of the ternary complex controlling spindle orientation during morphogenesis and asymmetric cell divisions (PMID:26766442)
• Data show that overexpressed p42.3 protein is correlated with gastric cancer cell proliferation, migration, and invasion, suggesting its use as a biological marker in gastric cancer. (PMID:27449033)
• p42.3 protein was related to the occurrence and development of gastric carcinoma. (PMID:27461626)
• Study showed C9orf140 as a novel Axin1-interacting protein and a negative regulator of Wnt/beta-catenin signaling. It functions upstream of beta-catenin, outcompetes PP2A for binding to Axin1, influences the balance between phosphorylation and de-phosphorylation of beta-catenin compromising Wnt3A-induced beta-catenin accumulation. C9orf140 seems to mediate a negative feedback loop of Wnt/beta-catenin signaling by bindi… (PMID:29531269)
• SAPCD2 is increased and positively associated with that of PXN-AS1-L isoform in nasopharyngeal carcinoma (NPC). Gain and loss-of-function experiments demonstrated that SAPCD2 promotes NPC cell proliferation, migration, and invasion. Furthermore, depletion of SAPCD2 significantly reverses the roles of PXN-AS1-L in promoting NPC cell proliferation, migration, and invasion in vitro, and NPC tumor growth in vivo. (PMID:31173488)
• SAPCD2 promotes invasiveness and migration ability of breast cancer cells via YAP/TAZ. (PMID:32329855)
• YY1-inudced activation of lncRNA DUXAP8 promotes proliferation and suppresses apoptosis of triple negative breast cancer cells through upregulating SAPCD2. (PMID:33683171)
• SAPCD2 promotes neuroblastoma progression by altering the subcellular distribution of E2F7. (PMID:35197448)
• MiR-486-5p specifically suppresses SAPCD2 expression, which attenuates the aggressive phenotypes of lung adenocarcinoma cells. (PMID:35467005)
• Homologous proteins SAPCD2X1 and SAPCD2 have significantly different carcinogenic capacities in human colorectal cancer cells based on structural prediction and functional verification. (PMID:38158695)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
		ENSDARG00000115167
mus_musculus	Sapcd2	ENSMUSG00000026955
rattus_norvegicus	Sapcd2	ENSRNOG00000013069

Paralogs (1): SAPCD1 (ENSG00000228727)

Protein

Protein identifiers

Suppressor APC domain-containing protein 2 — Q86UD0 (reviewed: Q86UD0)

Alternative names: Tumor specificity and mitosis phase-dependent expression protein, p42.3

All UniProt accessions (1): Q86UD0

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions. Negatively regulates the mitotic apical cortex localization of GPSM2. Involved also in positive regulation of cell proliferation and tumor cell growth.

Subunit / interactions. Interacts with a spindle orientation complex at least composed of GNAI1, GPSM2 and NUMA1. Interacts with GPSM2 (via TPR motifs); this interaction is required to prevent GPSM2 anchoring at the mitotic apical cortex and is inhibited in presence of NUMA1 in a dose dependent manner. Interacts with PARD3.

Subcellular location. Cytoplasm. Nucleus. Cell cortex. Apical cell membrane. Cell junction. Tight junction.

Tissue specificity. Expressed in 5-month-old fetal tissues, including stomach, intestine, colon, liver, brain, lung, heart, spleen and kidney. Undetectable in non-cancerous adult tissues. Expressed in many primary gastric carcinoma, but almost not in adjacent normal mucosa. Expressed preferentially in M and G1 phases, compared to S and G2 phases. Expression is up-regulated in hepatocellular carcinoma (HCC) and colorectal cancer (CRC) tissues (at protein level).

RefSeq proteins (1): NP_848543* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026828	SAPC2_1/2	Family
IPR057953	SAPC2_N	Domain

Pfam: PF11414, PF25825

UniProt features (9 total): region of interest 3, coiled-coil region 2, modified residue 2, chain 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86UD0-F1	69.70	0.34

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 219, 284

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 128 (showing top): GOBP_MORPHOGENESIS_OF_AN_EPITHELIUM, GOBP_ESTABLISHMENT_OF_SPINDLE_ORIENTATION, GOBP_EPITHELIUM_DEVELOPMENT, GOBP_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY, GOBP_SPINDLE_LOCALIZATION, GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY, GOBP_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION, YORDY_RECIPROCAL_REGULATION_BY_ETS1_AND_SP100_UP, GOBP_ESTABLISHMENT_OF_CELL_POLARITY, GOBP_ANIMAL_ORGAN_MORPHOGENESIS, FISCHER_G2_M_CELL_CYCLE, GOBP_MITOTIC_CELL_CYCLE, GOCC_APICAL_PLASMA_MEMBRANE, FISCHER_DREAM_TARGETS, GOBP_MORPHOGENESIS_OF_A_POLARIZED_EPITHELIUM

GO Biological Process (6): establishment of mitotic spindle orientation (GO:0000132), positive regulation of cell population proliferation (GO:0008284), regulation of establishment of planar polarity (GO:0090175), symmetric cell division (GO:0098725), negative regulation of protein localization to cell cortex (GO:1904777), cell division (GO:0051301)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (13): nucleoplasm (GO:0005654), nucleolus (GO:0005730), cytosol (GO:0005829), bicellular tight junction (GO:0005923), apical plasma membrane (GO:0016324), apical junction complex (GO:0043296), apical cortex (GO:0045179), nucleus (GO:0005634), cytoplasm (GO:0005737), plasma membrane (GO:0005886), cell cortex (GO:0005938), membrane (GO:0016020), anchoring junction (GO:0070161)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
nuclear lumen	2
cytoplasm	2
cell periphery	2
mitotic cell cycle	1
establishment of mitotic spindle localization	1
establishment of spindle orientation	1
cell population proliferation	1
regulation of cell population proliferation	1
positive regulation of cellular process	1
establishment of planar polarity	1
regulation of animal organ morphogenesis	1
cell division	1
protein localization to cell cortex	1
negative regulation of protein localization to cell periphery	1
regulation of protein localization to cell cortex	1
cellular process	1
binding	1
intracellular membraneless organelle	1
apical junction complex	1
tight junction	1
apical part of cell	1
plasma membrane region	1
cell-cell junction	1
cell cortex region	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
membrane	1
cell junction	1

Protein interactions and networks

STRING

772 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SAPCD2	MISP	Q8IVT2	511
SAPCD2	AXIN1	O15169	434
SAPCD2	PROSER2	Q86WR7	410
SAPCD2	LRRN4CL	Q8ND94	396
SAPCD2	TMEM45B	Q96B21	384
SAPCD2	PDCL2	Q8N4E4	368
SAPCD2	ITSN2	Q9NZM3	356
SAPCD2	RIC8A	Q9NPQ8	345
SAPCD2	FAM107A	O95990	341
SAPCD2	CHST9	Q7L1S5	339
SAPCD2	SLC44A4	Q53GD3	338
SAPCD2	STARD13	Q9Y3M8	333
SAPCD2	ARHGEF38	Q9NXL2	328
SAPCD2	DUXA	A6NLW8	324
SAPCD2	UAP1L1	Q3KQV9	324

IntAct

78 interactions, top by confidence:

A	B	Type	Score
RALBP1	SAPCD2	psi-mi:“MI:0915”(physical association)	0.800
RALBP1	JUN	psi-mi:“MI:0914”(association)	0.640
MPDZ	SMCHD1	psi-mi:“MI:0914”(association)	0.590
VCL	SAPCD2	psi-mi:“MI:0915”(physical association)	0.560
GMNN	SAPCD2	psi-mi:“MI:0915”(physical association)	0.560
CYSRT1	SAPCD2	psi-mi:“MI:0915”(physical association)	0.560
SAPCD2	GPRASP2	psi-mi:“MI:0915”(physical association)	0.560
SAPCD2	MDFI	psi-mi:“MI:0915”(physical association)	0.560
KRTAP1-3	SAPCD2	psi-mi:“MI:0915”(physical association)	0.560
ATF4	SAPCD2	psi-mi:“MI:0915”(physical association)	0.560
SAPCD2	USHBP1	psi-mi:“MI:0915”(physical association)	0.560
SAPCD2	AIRIM	psi-mi:“MI:0915”(physical association)	0.560
KRT3	SAPCD2	psi-mi:“MI:0915”(physical association)	0.560
SAPCD2	EXOC7	psi-mi:“MI:0915”(physical association)	0.560
BFSP2	SAPCD2	psi-mi:“MI:0915”(physical association)	0.560
PLIN5	INPPL1	psi-mi:“MI:0914”(association)	0.530
CHGA	DENR	psi-mi:“MI:0914”(association)	0.530
ZNRD2	CCDC85C	psi-mi:“MI:0914”(association)	0.530
Cep350	CCDC85C	psi-mi:“MI:0915”(physical association)	0.400
UBA1	NVL	psi-mi:“MI:0914”(association)	0.350
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
TANK	CNOT1	psi-mi:“MI:0914”(association)	0.350
GPSM1	BRD4	psi-mi:“MI:0914”(association)	0.350
RALBP1	AP2A1	psi-mi:“MI:0914”(association)	0.350
CBY2	KIF11	psi-mi:“MI:0914”(association)	0.350
DEPDC1	SAPCD2	psi-mi:“MI:0914”(association)	0.350
	ZFC3H1	psi-mi:“MI:0914”(association)	0.350

BioGRID (51): SAPCD2 (Affinity Capture-MS), SAPCD2 (Affinity Capture-MS), SAPCD2 (Affinity Capture-MS), SAPCD2 (Affinity Capture-MS), SAPCD2 (Affinity Capture-MS), SAPCD2 (Affinity Capture-MS), SAPCD2 (Affinity Capture-MS), SAPCD2 (Affinity Capture-MS), SAPCD2 (Affinity Capture-MS), SAPCD2 (Affinity Capture-MS), SAPCD2 (Affinity Capture-MS), SAPCD2 (Affinity Capture-RNA), SAPCD2 (Affinity Capture-MS), SAPCD2 (Two-hybrid), SAPCD2 (Two-hybrid)

ESM2 similar proteins: A0A8I5KY20, A2A9T0, A2IDD5, B0BNK9, B8ZZ34, C9JI98, C9JLR9, F5GYI3, O18734, P0CG25, P84157, Q0IIA6, Q0PHV7, Q0X0E2, Q13387, Q1RMK9, Q2M3D2, Q2TAM9, Q3ZCQ3, Q4VA45, Q673H1, Q69YZ2, Q6NS60, Q6P6N5, Q6PJ61, Q7Z6J2, Q80ZJ8, Q810I0, Q86SX3, Q86UD0, Q86XT2, Q8BNN1, Q8IUW3, Q8N4Y2, Q8N6N2, Q8QZV0, Q8R4T5, Q8TF61, Q8VCR9, Q8WXF8

Diamond homologs: Q5SSQ6, Q86UD0, Q9CY86, Q9D818

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

61 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	53
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

810 predictions. Top by Δscore:

Variant	Effect	Δscore
9:137064976:GGGCC:G	acceptor_loss	1.0000
9:137064978:GCCTG:G	acceptor_loss	1.0000
9:137065073:CTCA:C	donor_loss	1.0000
9:137065074:TCA:T	donor_loss	1.0000
9:137065075:CA:C	donor_loss	1.0000
9:137065076:A:AC	donor_gain	1.0000
9:137065076:AC:A	donor_gain	1.0000
9:137065077:C:CC	donor_gain	1.0000
9:137065077:CC:C	donor_gain	1.0000
9:137065077:CCCGG:C	donor_gain	1.0000
9:137065181:AAGTC:A	acceptor_gain	1.0000
9:137065182:AGTC:A	acceptor_gain	1.0000
9:137065183:GTC:G	acceptor_gain	1.0000
9:137065184:TC:T	acceptor_gain	1.0000
9:137065185:CC:C	acceptor_gain	1.0000
9:137065186:C:CC	acceptor_gain	1.0000
9:137065186:C:T	acceptor_gain	1.0000
9:137065187:T:C	acceptor_loss	1.0000
9:137065514:GCACT:G	donor_loss	1.0000
9:137065515:CACTC:C	donor_loss	1.0000
9:137065516:ACTCA:A	donor_loss	1.0000
9:137065517:CTCAC:C	donor_loss	1.0000
9:137065518:TCA:T	donor_loss	1.0000
9:137065519:CAC:C	donor_loss	1.0000
9:137065520:A:AC	donor_gain	1.0000
9:137065520:A:AT	donor_loss	1.0000
9:137065520:ACGG:A	donor_gain	1.0000
9:137065521:C:CC	donor_gain	1.0000
9:137065521:CG:C	donor_gain	1.0000
9:137065521:CGG:C	donor_gain	1.0000

AlphaMissense

2481 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:137064753:A:G	L364P	0.998
9:137070377:G:C	F28L	0.998
9:137070377:G:T	F28L	0.998
9:137070379:A:G	F28L	0.998
9:137064716:A:C	F376L	0.997
9:137064716:A:T	F376L	0.997
9:137064718:A:G	F376L	0.997
9:137064732:A:G	L371P	0.997
9:137070246:A:G	L72S	0.997
9:137070293:C:A	W56C	0.997
9:137070293:C:G	W56C	0.997
9:137070295:A:G	W56R	0.997
9:137070295:A:T	W56R	0.997
9:137070378:A:G	F28S	0.997
9:137064665:G:C	F393L	0.996
9:137064665:G:T	F393L	0.996
9:137064667:A:G	F393L	0.996
9:137064720:A:G	L375P	0.996
9:137070201:A:G	F87S	0.996
9:137070209:G:C	F84L	0.996
9:137070209:G:T	F84L	0.996
9:137070211:A:G	F84L	0.996
9:137070306:A:T	I52N	0.995
9:137070366:A:G	L32P	0.995
9:137064870:A:G	L350P	0.994
9:137070306:A:C	I52S	0.994
9:137070348:A:G	I38T	0.994
9:137070378:A:C	F28C	0.994
9:137064742:T:C	K368E	0.993
9:137070353:G:C	F36L	0.993

dbSNP variants (sampled 300 via entrez): RS1000077145 (9:137067706 G>A), RS1000805957 (9:137064559 G>A,T), RS1001047509 (9:137064383 A>T), RS1001155899 (9:137069226 A>G,T), RS1001828812 (9:137066894 C>A,T), RS1002024753 (9:137064250 C>T), RS1002592492 (9:137063010 C>T), RS1002621722 (9:137069361 C>G), RS1002652716 (9:137069551 G>A), RS1002916150 (9:137061687 T>C), RS1002975183 (9:137067600 C>T), RS1003456329 (9:137062114 A>G), RS1003656446 (9:137071825 G>A), RS1003694071 (9:137063274 C>G,T), RS1003978698 (9:137066994 CT>C,CTT)

Disease associations

OMIM: gene MIM:612057 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST90002402_80	Platelet count	4.000000e-10
GCST90011899_10	Aspartate aminotransferase levels	1.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004309	platelet count
EFO:0004736	aspartate aminotransferase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

50 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	4
Benzo(a)pyrene	decreases expression	4
Cyclosporine	decreases expression	3
Cisplatin	affects expression, decreases expression	2
Tobacco Smoke Pollution	decreases expression	2
Tunicamycin	decreases expression	2
Valproic Acid	affects expression, increases expression	2
aristolochic acid I	decreases expression	1
triphenyl phosphate	affects expression	1
lead acetate	increases expression	1
arsenite	affects binding, decreases reaction	1
sulforaphane	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
zinc chromate	decreases expression, increases abundance	1
diallyl trisulfide	decreases expression	1
chromium hexavalent ion	decreases expression, increases abundance	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	decreases expression	1
abrine	decreases expression	1
palbociclib	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	increases expression	1
NSC 689534	affects binding, decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Decitabine	affects expression	1
Sunitinib	decreases expression	1
Zoledronic Acid	decreases expression	1
Arsenic Trioxide	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Azathioprine	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.