SATB1-AS1

Summary

SATB1-AS1 (SATB1 antisense RNA 1, HGNC:50687) is a long non-coding RNA gene on chromosome 3p24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50687
Approved symbol	SATB1-AS1
Name	SATB1 antisense RNA 1
Location	3p24.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	uc.114, uc.113
Ensembl gene	ENSG00000228956
Ensembl biotype	lncRNA
Entrez	101927777
RNAcentral	URS00007E4615 — lncRNA, 843 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 98 — 94 lncRNA, 4 retained_intron

ENST00000414198, ENST00000425799, ENST00000438418, ENST00000453361, ENST00000456253, ENST00000593444, ENST00000593741, ENST00000595250, ENST00000595388, ENST00000595865, ENST00000596139, ENST00000596152, ENST00000596277, ENST00000596307, ENST00000596850, ENST00000598149, ENST00000598390, ENST00000598498, ENST00000598688, ENST00000598740, ENST00000599762, ENST00000600177, ENST00000609327, ENST00000610002, ENST00000616514, ENST00000625515, ENST00000625533, ENST00000625591, ENST00000626023, ENST00000626217, ENST00000626526, ENST00000626606, ENST00000626737, ENST00000626809, ENST00000626869, ENST00000626921, ENST00000626982, ENST00000627157, ENST00000627192, ENST00000627379, ENST00000627407, ENST00000627496, ENST00000627546, ENST00000627668, ENST00000627829, ENST00000627923, ENST00000628055, ENST00000628209, ENST00000628248, ENST00000628425, ENST00000628431, ENST00000628491, ENST00000628778, ENST00000628891, ENST00000628963, ENST00000629109, ENST00000629177, ENST00000629405, ENST00000629477, ENST00000629516, ENST00000629783, ENST00000629984, ENST00000630022, ENST00000630073, ENST00000630271, ENST00000630609, ENST00000630749, ENST00000630766, ENST00000631058, ENST00000631076, ENST00000631123, ENST00000631285, ENST00000683051, ENST00000683471, ENST00000734157, ENST00000734158, ENST00000734159, ENST00000734160, ENST00000734161, ENST00000734162, ENST00000734163, ENST00000734164, ENST00000734165, ENST00000734166, ENST00000734167, ENST00000734168, ENST00000734169, ENST00000734170, ENST00000734171, ENST00000734172, ENST00000734173, ENST00000768820, ENST00000768821, ENST00000768822, ENST00000768823, ENST00000768824, ENST00000768825, ENST00000768826

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414198 — 7 exons

Exon	Start	End
ENSE00001637768	18463480	18463545
ENSE00001799310	18464287	18464339
ENSE00001803745	18465963	18466039
ENSE00003983268	18445024	18445442
ENSE00003983269	18527174	18527326
ENSE00003983270	18529981	18531247
ENSE00003983271	18526387	18526540

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 92.12.

FANTOM5 (CAGE): breadth broad, TPM avg 2.9492 / max 171.8581, expressed in 474 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
35622	0.9475	224
35621	0.6922	252
35623	0.4318	183
35631	0.3568	48
35624	0.3263	176
35632	0.1364	37
35630	0.0473	27
35633	0.0108	6

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.12	gold quality
lymph node	UBERON:0000029	86.97	gold quality
cortical plate	UBERON:0005343	86.53	gold quality
islet of Langerhans	UBERON:0000006	84.56	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.15	gold quality
granulocyte	CL:0000094	83.09	gold quality
corpus callosum	UBERON:0002336	82.29	gold quality
colonic epithelium	UBERON:0000397	81.88	gold quality
blood	UBERON:0000178	81.40	gold quality
vermiform appendix	UBERON:0001154	81.39	gold quality
primary visual cortex	UBERON:0002436	81.19	gold quality
pancreas	UBERON:0001264	80.86	gold quality
tonsil	UBERON:0002372	79.85	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	79.61	gold quality
bone marrow	UBERON:0002371	79.56	gold quality
anterior cingulate cortex	UBERON:0009835	79.27	gold quality
body of pancreas	UBERON:0001150	79.19	gold quality
Brodmann (1909) area 9	UBERON:0013540	79.14	gold quality
superior frontal gyrus	UBERON:0002661	78.45	gold quality
prefrontal cortex	UBERON:0000451	78.13	gold quality
cerebral cortex	UBERON:0000956	78.08	gold quality
frontal cortex	UBERON:0001870	77.82	gold quality
spleen	UBERON:0002106	77.51	gold quality
bone marrow cell	CL:0002092	77.43	gold quality
right frontal lobe	UBERON:0002810	77.24	gold quality
rectum	UBERON:0001052	76.86	gold quality
pituitary gland	UBERON:0000007	76.38	gold quality
transverse colon	UBERON:0001157	75.54	gold quality
amygdala	UBERON:0001876	75.08	gold quality
ventricular zone	UBERON:0003053	74.99	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	61.92
E-ANND-3	no	6.96

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long noncoding RNA SATB1-AS1 contributes to the chemotherapy resistance through the microRNA-580/ 2’-5’-oligoadenylate synthetase 2 axis in acute myeloid leukemia. (PMID:34516354)
• MiR-125b and SATB1-AS1 might be shear stress-mediated therapeutic targets. (PMID:36623676)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.