SATB2-AS1

Summary

SATB2-AS1 (SATB2 antisense RNA 1, HGNC:26490) is a long non-coding RNA gene on chromosome 2q33.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26490
Approved symbol	SATB2-AS1
Name	SATB2 antisense RNA 1
Location	2q33.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225953
Ensembl biotype	lncRNA
Entrez	150538
RNAcentral	URS000075CE4D — lncRNA, 3397 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 23 lncRNA

ENST00000416200, ENST00000441234, ENST00000442967, ENST00000446911, ENST00000450728, ENST00000666719, ENST00000668832, ENST00000685797, ENST00000731625, ENST00000731626, ENST00000731627, ENST00000731628, ENST00000731629, ENST00000731630, ENST00000731631, ENST00000731632, ENST00000731633, ENST00000731634, ENST00000731635, ENST00000731636, ENST00000731637, ENST00000731638, ENST00000731639

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000416200 — 2 exons

Exon	Start	End
ENSE00004061241	199476477	199477035
ENSE00004061256	199469896	199472633

Expression profiles

Bgee: expression breadth ubiquitous, 175 present calls, max score 98.57.

FANTOM5 (CAGE): breadth broad, TPM avg 1.7754 / max 131.3046, expressed in 806 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
24511	1.0537	671
24506	0.5606	119
24512	0.1308	55
24514	0.0303	7

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	98.57	gold quality
endothelial cell	CL:0000115	97.39	gold quality
mucosa of transverse colon	UBERON:0004991	93.17	gold quality
rectum	UBERON:0001052	92.62	gold quality
tibia	UBERON:0000979	91.73	gold quality
ganglionic eminence	UBERON:0004023	91.70	gold quality
Brodmann (1909) area 23	UBERON:0013554	90.44	gold quality
ileal mucosa	UBERON:0000331	88.43	gold quality
primary visual cortex	UBERON:0002436	86.56	gold quality
colonic mucosa	UBERON:0000317	86.54	gold quality
transverse colon	UBERON:0001157	86.44	gold quality
prefrontal cortex	UBERON:0000451	86.37	gold quality
mucosa of sigmoid colon	UBERON:0004993	85.67	gold quality
colonic epithelium	UBERON:0000397	84.09	gold quality
Brodmann (1909) area 9	UBERON:0013540	83.96	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	83.88	gold quality
neocortex	UBERON:0001950	82.42	gold quality
frontal cortex	UBERON:0001870	82.17	gold quality
right frontal lobe	UBERON:0002810	82.07	gold quality
anterior cingulate cortex	UBERON:0009835	81.79	gold quality
Brodmann (1909) area 46	UBERON:0006483	80.91	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.20	gold quality
cerebral cortex	UBERON:0000956	79.15	gold quality
middle temporal gyrus	UBERON:0002771	78.87	gold quality
occipital lobe	UBERON:0002021	78.18	gold quality
stromal cell of endometrium	CL:0002255	76.73	gold quality
large intestine	UBERON:0000059	75.27	gold quality
colon	UBERON:0001155	75.13	gold quality
superior frontal gyrus	UBERON:0002661	73.88	gold quality
calcaneal tendon	UBERON:0003701	73.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.90

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• data demonstrate that an antisense non-coding RNA regulates the expression of its sense gene, and increases the cell growth, therefore pointing the pivotal functions of SATB2-AS1 in osteosarcoma. (PMID:28190168)
• This study reveals the functions of SATB2-AS1 in CRC tumorigenesis and progression, suggesting new biomarkers and therapeutic targets in CRC. (PMID:31492160)
• The lncRNAs RP1-261G23.7, RP11-69E11.4 and SATB2-AS1 are a novel clinical signature for predicting recurrent osteosarcoma. (PMID:31850493)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.