SBF2-AS1

Summary

SBF2-AS1 (SBF2 antisense RNA 1, HGNC:27438) is a long non-coding RNA gene on chromosome 11p15.4.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27438
Approved symbol	SBF2-AS1
Name	SBF2 antisense RNA 1
Location	11p15.4
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000246273
Ensembl biotype	lncRNA
Entrez	283104
RNAcentral	URS000075CBAD — lncRNA, 2708 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 19 lncRNA

ENST00000498905, ENST00000499953, ENST00000525636, ENST00000526617, ENST00000527406, ENST00000534671, ENST00000650092, ENST00000658574, ENST00000663578, ENST00000664105, ENST00000702946, ENST00000731154, ENST00000731155, ENST00000731156, ENST00000731157, ENST00000731158, ENST00000731159, ENST00000731160, ENST00000731161

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000498905 — 3 exons

Exon	Start	End
ENSE00001964414	9810260	9811319
ENSE00001970254	9807848	9809284
ENSE00002197312	9758292	9758503

Expression profiles

Bgee: expression breadth ubiquitous, 165 present calls, max score 84.98.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.6206 / max 255.1267, expressed in 1685 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
113010	3.4192	1468
113012	1.9740	317
113011	0.9761	623
113013	0.1535	60
113014	0.0977	45

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.98	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.38	gold quality
stromal cell of endometrium	CL:0002255	79.36	gold quality
colonic epithelium	UBERON:0000397	77.59	gold quality
islet of Langerhans	UBERON:0000006	76.94	gold quality
calcaneal tendon	UBERON:0003701	76.46	gold quality
bone marrow cell	CL:0002092	76.13	gold quality
amniotic fluid	UBERON:0000173	75.37	gold quality
ventricular zone	UBERON:0003053	74.91	gold quality
ganglionic eminence	UBERON:0004023	74.43	gold quality
cortical plate	UBERON:0005343	74.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	74.31	gold quality
skin of abdomen	UBERON:0001416	72.91	gold quality
pancreas	UBERON:0001264	72.74	gold quality
nucleus accumbens	UBERON:0001882	72.52	gold quality
skin of leg	UBERON:0001511	72.03	gold quality
right atrium auricular region	UBERON:0006631	71.97	gold quality
minor salivary gland	UBERON:0001830	71.93	gold quality
adrenal tissue	UBERON:0018303	71.76	gold quality
body of pancreas	UBERON:0001150	71.58	gold quality
caudate nucleus	UBERON:0001873	71.56	gold quality
lower esophagus mucosa	UBERON:0035834	71.35	gold quality
cardiac atrium	UBERON:0002081	71.26	gold quality
body of uterus	UBERON:0009853	71.09	gold quality
putamen	UBERON:0001874	71.08	gold quality
heart left ventricle	UBERON:0002084	70.98	gold quality
prefrontal cortex	UBERON:0000451	70.79	gold quality
ectocervix	UBERON:0012249	70.47	gold quality
cardiac ventricle	UBERON:0002082	70.31	gold quality
rectum	UBERON:0001052	69.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.40

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 20)

• Study identified a novel lncRNA SBF2-AS1 in non-small cell lung cancer (NSCLC) that is upregulated and correlated with advanced TNM stage. SBF2-AS1 could promote proliferation of NSCLC cells in vitro and in vivo, suggesting that it might be an oncogenic lncRNA in NSCLC. (PMID:27154193)
• Long non-coding RNA SBF2-AS1 modulated TGFBR1 through sponging miR-140-5p in hepatocellular carcinoma development and progression. (PMID:30115383)
• LncRNA SBF2-AS1 promotes hepatocellular carcinoma metastasis by regulating epithelial mesenchymal transformation. (PMID:30338801)
• LncRNA SBF2-AS1 expression is increased in cervical cancer (CC). High SBF2-AS1 expression was associated with advanced FIGO stage and lymph node metastasis of CC patients. Function assays shows that SBF2-AS1 inhibition significantly reduces CC cells proliferation both in vitro and in vivo. SBF2-AS1 upregulation restrain the activity of miR-361-5p and leads to overexpression of Forkhead Box Protein M1 in CC cells. (PMID:30856345)
• downregulation of miR-619-5p or HDAC3 overexpression reversed SBF2-AS1-silencing-caused suppression on proliferation and metastasis. (PMID:30912164)
• Transcription factor ZEB1 was found to directly bind to the SBF2-AS1 promoter region to regulate SBF2-AS1 level and affected TMZ resistance in GBM cells. SBF2-AS1 functions as a ceRNA for miR-151a-3p, leading to the disinhibition of its endogenous target, X-ray repair cross complementing 4 (XRCC4), which enhances DSB repair in GBM cells. (PMID:30992025)
• SBF2-AS1: An oncogenic lncRNA in small-cell lung cancer. (PMID:31050364)
• SBF2-AS1 could act as a miRNA sponge in AML progression (PMID:31062614)
• LncRNA SBF2-AS1 affects the radiosensitivity of non-small cell lung cancer via modulating microRNA-302a/MBNL3 axis. (PMID:31928130)
• Down-regulated lncRNA SBF2-AS1 in M2 macrophage-derived exosomes elevates miR-122-5p to restrict XIAP, thereby limiting pancreatic cancer development. (PMID:32301277)
• E2F1-induced overexpression of SBF2-AS1 promotes the expression of GRB2 by targeting miR-362-3p to facilitate the metastasis of NSCLC (PMID:32364763)
• Long Noncoding RNASBF2-AS1 Promotes Gastric Cancer Progression via Regulating miR-545/EMS1 Axis. (PMID:32626753)
• The molecular mechanisms of the long noncoding RNA SBF2-AS1 in regulating the proliferation of oesophageal squamous cell carcinoma. (PMID:33436941)
• The Clinical Prognostic Value of lncRNA SBF2-AS1 in Cancer Patients: A Meta-Analysis. (PMID:33906548)
• Downregulation of lncRNA SBF2-AS1 inhibits hepatocellular carcinoma proliferation and migration by regulating the miR-361-5p/TGF-beta1 signaling pathway. (PMID:34341185)
• Low expression of lncRNA SBF2-AS1 regulates the miR-302b-3p/TGFBR2 axis, promoting metastasis in laryngeal cancer. (PMID:34644425)
• Silencing of SBF2-AS1 inhibits cell growth and invasion by sponging microRNA-338-3p in serous ovarian carcinoma. (PMID:34850542)
• LncRNA SBF2-AS1: A Budding Star in Various Cancers. (PMID:35440300)
• Knockdown of LncRNA SBF2-AS1 Inhibited Gastric Cancer Tumorigenesis via the Wnt/LRP5 Signaling Pathway. (PMID:36549764)
• SBF2-AS1 and TreRNA: novel lncRNA players in triple-negative breast cancer pathogenesis. (PMID:37286777)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.