SCAI

Summary

SCAI (suppressor of cancer cell invasion, HGNC:26709) is a protein-coding gene on chromosome 9q33.3, encoding Protein SCAI (Q8N9R8). Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity.

This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described.

Source: NCBI Gene 286205 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 63 total
• MANE Select transcript: NM_001144877

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26709
Approved symbol	SCAI
Name	suppressor of cancer cell invasion
Location	9q33.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ36664, NET40
Ensembl gene	ENSG00000173611
Ensembl biotype	protein_coding
OMIM	619222
Entrez	286205

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 7 protein_coding, 3 nonsense_mediated_decay, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000336505, ENST00000373549, ENST00000467917, ENST00000468569, ENST00000477186, ENST00000487795, ENST00000494102, ENST00000858985, ENST00000858986, ENST00000858987, ENST00000923997, ENST00000952247

RefSeq mRNA: 2 — MANE Select: NM_001144877 NM_001144877, NM_173690

CCDS: CCDS43877, CCDS48017

Canonical transcript exons

ENST00000336505 — 18 exons

Exon	Start	End
ENSE00000000277	125143385	125143528
ENSE00001182054	124976114	124976186
ENSE00001182059	124994934	124995015
ENSE00001182069	125003469	125003570
ENSE00001182077	125019107	125019205
ENSE00001182080	125020673	125020769
ENSE00001182083	125026812	125026910
ENSE00001274967	124999891	124999990
ENSE00001274989	125018799	125018951
ENSE00001275008	125028392	125028478
ENSE00001335371	125055876	125056007
ENSE00001344919	125029644	125029739
ENSE00001460837	125142633	125142677
ENSE00001953263	124942608	124952953
ENSE00003518228	124971671	124971844
ENSE00003521292	124971370	124971470
ENSE00003534160	125003114	125003215
ENSE00003671369	125001965	125002043

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 97.15.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.6263 / max 173.3128, expressed in 1739 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
102460	10.5233	1722
102461	1.1031	633

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	97.15	gold quality
Brodmann (1909) area 23	UBERON:0013554	96.59	gold quality
middle temporal gyrus	UBERON:0002771	95.41	gold quality
pigmented layer of retina	UBERON:0001782	93.73	gold quality
oocyte	CL:0000023	89.17	gold quality
postcentral gyrus	UBERON:0002581	88.26	gold quality
buccal mucosa cell	CL:0002336	88.09	gold quality
parietal lobe	UBERON:0001872	87.81	gold quality
superior frontal gyrus	UBERON:0002661	87.71	gold quality
secondary oocyte	CL:0000655	87.45	gold quality
primary visual cortex	UBERON:0002436	87.36	gold quality
occipital lobe	UBERON:0002021	86.22	gold quality
entorhinal cortex	UBERON:0002728	85.67	gold quality
visceral pleura	UBERON:0002401	84.84	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.65	gold quality
cortical plate	UBERON:0005343	82.29	gold quality
sural nerve	UBERON:0015488	81.08	gold quality
pleura	UBERON:0000977	80.89	gold quality
parietal pleura	UBERON:0002400	80.66	gold quality
germinal epithelium of ovary	UBERON:0001304	80.01	gold quality
lateral nuclear group of thalamus	UBERON:0002736	79.18	gold quality
calcaneal tendon	UBERON:0003701	79.06	gold quality
prefrontal cortex	UBERON:0000451	78.73	gold quality
corpus callosum	UBERON:0002336	78.18	gold quality
adrenal tissue	UBERON:0018303	78.16	gold quality
frontal cortex	UBERON:0001870	78.15	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	77.94	gold quality
cerebral cortex	UBERON:0000956	77.60	gold quality
stromal cell of endometrium	CL:0002255	77.49	gold quality
neocortex	UBERON:0001950	77.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): HOXB4, MRTFA

miRNA regulators (miRDB)

548 targeting SCAI, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-5692A	100.00	74.40	6850
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-3134	100.00	66.43	777
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-4673	100.00	66.64	1490

Literature-anchored findings (GeneRIF, showing 17)

• Genome-wide expression analysis surprisingly reveals that one of the strongest upregulated genes after suppression of SCAI is beta1-integrin (PMID:19350017)
• SCAI is a novel transcriptional cofactor that regulates epithelial-to-mesenchymal transition and renal fibrosis. (PMID:23178076)
• SCAI is a specific interaction partner for KMD3B. (PMID:23593242)
• Downregulation of SCAI enhances glioma cell invasion and cancer stem cell like phenotype.Downregulation of SCAI activates the Wnt/beta-catenin signaling. (PMID:24785374)
• miR-1228 promoted breast cancer proliferation, invasion and migration was mediated by MOAP1 and SCAI. (PMID:26261546)
• miR-625-3p exerts its oncogenic functions through regulation of SCAI/E-cadherin/MMP-9 pathways (PMID:26314959)
• Data suggest that SCAI inhibits RIF1 function to allow BRCA1-mediated repair, which possibly includes alt-NHEJ and resection-dependent NHEJ in G1, as well as HDR in S/G2. (PMID:28700933)
• High SCAI expression is associated with gastric, prostate, and colorectal cancer. (PMID:28815470)
• Whole-genome sequencing and confirmatory Sanger sequencing of junction PCR products were used to show that in each of the 5 cases, the SMAD4 processed gene was integrated at the same position on chromosome 9, located within the last intron of the SCAI gene (PMID:28867604)
• This study provides evidence that CAF exosomal miR-1228 is able to promote osteosarcoma invasion and migration by targeting SCAI. (PMID:30180920)
• SCAI binds to miR-1270 which inversely regulates SCAI gene expression in papillary thyroid cancer cells. (PMID:30551495)
• MicroRNA-625-3p was highly expressed in oral squamous cell carcinoma (OSCC) tissues. OSCC patients with T3+T4 stage had higher expression of microRNA-625-3p than those with T1+T2 stage. SCAI was identified as a target gene of microRNA-625-3p. ROC curve showed that microRNA-625-3p and SCAI exert certain values in diagnosing OSCC. MicroRNA-625-3p promoted migration of OSCC cells, which was reversed by SCAI knockdown. (PMID:30720172)
• Mir-5100 Mediates Proliferation, Migration and Invasion of Oral Squamous Cell Carcinoma Cells Via Targeting SCAI. (PMID:31851859)
• miR-371b-5p promotes cell proliferation, migration and invasion in non-small cell lung cancer via SCAI. (PMID:33103723)
• The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair. (PMID:34597596)
• Bridging Gaps in HDR Improvement: The Role of MAD2L2, SCAI, and SCR7. (PMID:37047677)
• Hsa_circ_0052611 and mir-767-5p guide the warburg effect, migration, and invasion of BRCA cells through modulating SCAI. (PMID:37743442)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	scai	ENSDARG00000060865
mus_musculus	Scai	ENSMUSG00000035236
rattus_norvegicus	Scai	ENSRNOG00000025278
drosophila_melanogaster	CG13293	FBGN0035677

Protein

Protein identifiers

Protein SCAI — Q8N9R8 (reviewed: Q8N9R8)

Alternative names: Suppressor of cancer cell invasion protein

All UniProt accessions (4): Q8N9R8, H7C4U2, H7C5A3, Q3SXZ0

UniProt curated annotations — full annotation on UniProt →

Function. Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.

Subunit / interactions. Interacts with DIAPH1. Forms a nuclear ternary complex with MRTFA and SRF.

Subcellular location. Membrane. Nucleus. Cytoplasm.

Similarity. Belongs to the SCAI family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8N9R8-1	1	yes
Q8N9R8-2	2

RefSeq proteins (2): NP_001138349, NP_775961 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR016607	SCAI_metazoan/Viridiplantae	Family
IPR022709	SCAI	Family

Pfam: PF12070

UniProt features (10 total): region of interest 3, sequence conflict 2, chain 1, transmembrane region 1, modified residue 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N9R8-F1	86.01	0.73

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 64

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-5663220	RHO GTPases Activate Formins
R-HSA-162582	Signal Transduction
R-HSA-194315	Signaling by Rho GTPases
R-HSA-195258	RHO GTPase Effectors
R-HSA-9716542	Signaling by Rho GTPases, Miro GTPases and RHOBTB3

MSigDB gene sets: 309 (showing top): GOBP_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, RACCACAR_AML_Q6, TGACCTY_ERR1_Q2, MEF2_02, GOBP_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, PID_RHOA_PATHWAY, YGACNNYACAR_UNKNOWN, GOBP_NEGATIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION, WTGAAAT_UNKNOWN, GOBP_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION, AFP1_Q6, DODD_NASOPHARYNGEAL_CARCINOMA_UP, AACTTT_UNKNOWN

GO Biological Process (5): DNA-templated transcription (GO:0006351), negative regulation of cell migration (GO:0030336), negative regulation of Rho protein signal transduction (GO:0035024), negative regulation of signal transduction (GO:0009968), negative regulation of DNA-templated transcription (GO:0045892)

GO Molecular Function (2): transcription corepressor activity (GO:0003714), protein binding (GO:0005515)

GO Cellular Component (5): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), nuclear membrane (GO:0031965), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
RHO GTPase Effectors	1
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	1
Signaling by Rho GTPases	1
Signal Transduction	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
gene expression	1
RNA biosynthetic process	1
cell migration	1
regulation of cell migration	1
negative regulation of cell motility	1
Rho protein signal transduction	1
regulation of Rho protein signal transduction	1
negative regulation of small GTPase mediated signal transduction	1
signal transduction	1
regulation of signal transduction	1
negative regulation of cell communication	1
negative regulation of signaling	1
negative regulation of response to stimulus	1
DNA-templated transcription	1
regulation of DNA-templated transcription	1
negative regulation of RNA biosynthetic process	1
transcription coregulator activity	1
negative regulation of DNA-templated transcription	1
binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1
nucleus	1
nuclear envelope	1
organelle membrane	1

Protein interactions and networks

STRING

828 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SCAI	TP53BP1	Q12888	686
SCAI	ADCY10	Q96PN6	654
SCAI	PYDC1	Q8WXC3	446
SCAI	SERPINA5	P05154	440
SCAI	BRCA2	P51587	409
SCAI	POLG	P54098	402
SCAI	RBMX2	Q9Y388	398
SCAI	HOMER1	Q86YM7	393
SCAI	SNX25	Q9H3E2	388
SCAI	ALB	P02768	380
SCAI	NAALADL2	Q58DX5	380
SCAI	NANS	Q9NR45	370
SCAI	ZNF354C	Q86Y25	353
SCAI	SLC25A14	O95258	353
SCAI	TLE3	Q04726	353
SCAI	GPR101	Q96P66	353

IntAct

45 interactions, top by confidence:

A	B	Type	Score
ITPKB	SCAI	psi-mi:“MI:0915”(physical association)	0.560
PIN1	SCAI	psi-mi:“MI:0915”(physical association)	0.560
SCAI	SOX7	psi-mi:“MI:0915”(physical association)	0.560
OGT	SCAI	psi-mi:“MI:0915”(physical association)	0.560
CDIPT	SCAI	psi-mi:“MI:0915”(physical association)	0.560
CBX1	ZNF292	psi-mi:“MI:0914”(association)	0.530
CACNG5	ZNF316	psi-mi:“MI:0914”(association)	0.530
APBA3	DUSP11	psi-mi:“MI:0914”(association)	0.530
NPTN	TNPO2	psi-mi:“MI:0914”(association)	0.530
APBA3	CLSTN1	psi-mi:“MI:0914”(association)	0.530
Cbx1		psi-mi:“MI:0914”(association)	0.350
CDCA5	BDP1	psi-mi:“MI:0914”(association)	0.350
HNRNPA1	MATR3	psi-mi:“MI:0914”(association)	0.350
ORF73	ECI2	psi-mi:“MI:0914”(association)	0.350
APBB1	SSPOP	psi-mi:“MI:0914”(association)	0.350
	BTAF1	psi-mi:“MI:0914”(association)	0.350
CBX5	ZNF568	psi-mi:“MI:0914”(association)	0.350
RIMS1	KIF2A	psi-mi:“MI:0914”(association)	0.350
CCDC85A	CIBAR1	psi-mi:“MI:0914”(association)	0.350
FAXC	METTL15	psi-mi:“MI:0914”(association)	0.350
INSYN1	CCDC85C	psi-mi:“MI:0914”(association)	0.350
TNFRSF1A	KHNYN	psi-mi:“MI:0914”(association)	0.350
CSRNP1	TAF5L	psi-mi:“MI:0914”(association)	0.350
BTNL9	TNPO2	psi-mi:“MI:0914”(association)	0.350
AFG2A	ESYT2	psi-mi:“MI:0914”(association)	0.350
CACNG5		psi-mi:“MI:0914”(association)	0.350
	PHF20L1	psi-mi:“MI:0914”(association)	0.350
CBX3	MYL12B	psi-mi:“MI:0914”(association)	0.350

BioGRID (72): SCAI (Affinity Capture-MS), SCAI (Affinity Capture-MS), SCAI (Affinity Capture-MS), SCAI (Affinity Capture-Western), SCAI (Affinity Capture-Western), SCAI (Affinity Capture-MS), SCAI (Affinity Capture-MS), SCAI (Affinity Capture-MS), SCAI (Affinity Capture-MS), SCAI (Affinity Capture-MS), SCAI (Affinity Capture-MS), SCAI (Affinity Capture-MS), SCAI (Affinity Capture-MS), SCAI (Affinity Capture-MS), SCAI (Proximity Label-MS)

ESM2 similar proteins: A1L1C7, O08873, O42611, O60716, O94776, O94967, P83094, Q01826, Q0P5J8, Q15542, Q3UHE1, Q3UVG3, Q4R8N2, Q58A45, Q5EY87, Q5JSJ4, Q5M7R9, Q5R7S4, Q5RAR8, Q5TKA1, Q60611, Q640Q5, Q658Y4, Q68FH0, Q6ISB3, Q6NT76, Q6TEP1, Q80U28, Q8BIE6, Q8BJA3, Q8C092, Q8C0V0, Q8C735, Q8C8N2, Q8CGF6, Q8K5C0, Q8N9R8, Q8VI24, Q8WXG6, Q90ZY6

Diamond homologs: Q54YY1, Q8C8N2, Q8N9R8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

63 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	51
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3954 predictions. Top by Δscore:

Variant	Effect	Δscore
9:124952850:T:TA	donor_gain	1.0000
9:124971466:CTGAT:C	acceptor_gain	1.0000
9:124971705:A:AC	donor_gain	1.0000
9:124975372:C:CT	acceptor_gain	1.0000
9:124975372:C:T	acceptor_gain	1.0000
9:124975390:C:CC	acceptor_gain	1.0000
9:124975400:T:TC	acceptor_gain	1.0000
9:124994927:AACTC:A	donor_loss	1.0000
9:124994929:CTCAC:C	donor_loss	1.0000
9:124994930:TCAC:T	donor_loss	1.0000
9:124994931:CA:C	donor_loss	1.0000
9:124994932:A:AT	donor_loss	1.0000
9:124994933:CCTTA:C	donor_loss	1.0000
9:124999886:CATA:C	donor_loss	1.0000
9:124999887:ATA:A	donor_loss	1.0000
9:124999888:TA:T	donor_loss	1.0000
9:124999889:A:AC	donor_gain	1.0000
9:124999889:AC:A	donor_gain	1.0000
9:124999890:C:CT	donor_gain	1.0000
9:124999890:CC:C	donor_gain	1.0000
9:124999890:CCA:C	donor_gain	1.0000
9:124999890:CCAG:C	donor_gain	1.0000
9:124999991:C:CC	acceptor_gain	1.0000
9:124999991:C:CG	acceptor_loss	1.0000
9:125001367:T:C	donor_gain	1.0000
9:125001952:T:A	donor_gain	1.0000
9:125003110:ATACC:A	donor_loss	1.0000
9:125003111:TACCT:T	donor_loss	1.0000
9:125003112:A:AC	donor_gain	1.0000
9:125003112:A:AG	donor_loss	1.0000

AlphaMissense

3972 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:124976155:A:T	V453D	1.000
9:124994982:C:A	R426S	1.000
9:124994982:C:G	R426S	1.000
9:124994983:C:A	R426M	1.000
9:124994983:C:G	R426T	1.000
9:124999972:C:T	G388D	1.000
9:124999973:C:G	G388R	1.000
9:124999975:C:T	G387E	1.000
9:125002018:A:G	L364P	1.000
9:125003157:G:C	P341R	1.000
9:125003157:G:T	P341Q	1.000
9:125003166:A:G	L338P	1.000
9:125003169:A:G	L337P	1.000
9:125003174:C:A	K335N	1.000
9:125003174:C:G	K335N	1.000
9:125003176:T:C	K335E	1.000
9:125003181:G:T	P333H	1.000
9:125003183:G:C	N332K	1.000
9:125003183:G:T	N332K	1.000
9:125003521:A:G	L304P	1.000
9:125003536:C:G	R299P	1.000
9:125003545:T:A	D296V	1.000
9:125003546:C:G	D296H	1.000
9:125003551:G:A	T294I	1.000
9:125003554:A:G	L293P	1.000
9:125003557:T:A	E292V	1.000
9:125003558:C:T	E292K	1.000
9:125003559:A:C	S291R	1.000
9:125003559:A:T	S291R	1.000
9:125003560:C:A	S291I	1.000

dbSNP variants (sampled 300 via entrez): RS1000019428 (9:125097075 G>C,T), RS1000019576 (9:125107245 C>A,T), RS1000026900 (9:125064893 T>C), RS1000034955 (9:125107726 C>T), RS1000052846 (9:125014392 G>C), RS1000063129 (9:125076782 C>G), RS1000081283 (9:124972366 G>C), RS1000082104 (9:124984970 C>T), RS1000102531 (9:125032087 A>G), RS1000112735 (9:125145125 C>T), RS1000127518 (9:124969062 C>A), RS1000129904 (9:125100106 C>T), RS1000140920 (9:124965749 T>C,G), RS1000143117 (9:125143253 C>A,G,T), RS1000167110 (9:125111816 C>A)

Disease associations

OMIM: gene MIM:619222 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST004278_6	Pulse pressure	3.000000e-14
GCST006946_2	Worry too long after an embarrassing experience	7.000000e-10
GCST007269_181	Pulse pressure	2.000000e-14
GCST010002_280	Refractive error	1.000000e-13
GCST011702_11	Smoking cessation	4.000000e-09
GCST90000047_201	Age at first sexual intercourse	1.000000e-08

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0005763	pulse pressure measurement
EFO:0009589	worry measurement
EFO:0004319	smoking cessation
EFO:0009749	age at first sexual intercourse measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression	6
Cadmium Chloride	decreases expression, increases abundance, increases expression	3
Aflatoxin B1	affects methylation, decreases methylation	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	increases expression	1
triphenyl phosphate	affects expression	1
arsenite	affects binding, decreases reaction	1
butyraldehyde	decreases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
torcetrapib	increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
Irinotecan	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Benzo(a)pyrene	increases methylation	1
Cadmium	increases abundance, increases expression	1
Doxorubicin	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Methyl Methanesulfonate	increases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Tobacco Smoke Pollution	decreases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Cyclosporine	decreases expression	1
Antirheumatic Agents	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.