SCAMP2

Summary

SCAMP2 (secretory carrier membrane protein 2, HGNC:10564) is a protein-coding gene on chromosome 15q24.1, encoding Secretory carrier-associated membrane protein 2 (O15127). Functions in post-Golgi recycling pathways.

This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. Alternate splicing results in multiple transcript variants.

Source: NCBI Gene 10066 — RefSeq curated summary.

At a glance

• GWAS associations: 14
• Clinical variants (ClinVar): 64 total — 1 pathogenic
• Druggable target: yes
• MANE Select transcript: NM_005697

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10564
Approved symbol	SCAMP2
Name	secretory carrier membrane protein 2
Location	15q24.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000140497
Ensembl biotype	protein_coding
OMIM	606912
Entrez	10066

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 13 protein_coding, 5 retained_intron, 2 nonsense_mediated_decay

ENST00000268099, ENST00000562363, ENST00000563663, ENST00000563829, ENST00000564529, ENST00000565345, ENST00000566480, ENST00000566557, ENST00000567638, ENST00000569124, ENST00000569251, ENST00000569904, ENST00000894364, ENST00000894365, ENST00000894366, ENST00000894367, ENST00000894368, ENST00000894369, ENST00000894370, ENST00000960462

RefSeq mRNA: 2 — MANE Select: NM_005697 NM_001320778, NM_005697

CCDS: CCDS10271

Canonical transcript exons

ENST00000268099 — 9 exons

Exon	Start	End
ENSE00001320465	74843730	74845217
ENSE00003466413	74854021	74854119
ENSE00003467083	74873199	74873365
ENSE00003489132	74852069	74852186
ENSE00003529342	74845473	74845593
ENSE00003570128	74850514	74850673
ENSE00003626704	74854581	74854649
ENSE00003648570	74848600	74848701
ENSE00003684480	74851353	74851481

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 97.65.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 89.8819 / max 353.0673, expressed in 1821 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
150935	89.8819	1821

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
rectum	UBERON:0001052	97.65	gold quality
mucosa of transverse colon	UBERON:0004991	97.64	gold quality
lower esophagus mucosa	UBERON:0035834	97.43	gold quality
granulocyte	CL:0000094	97.03	gold quality
esophagus mucosa	UBERON:0002469	96.57	gold quality
transverse colon	UBERON:0001157	96.51	gold quality
islet of Langerhans	UBERON:0000006	96.40	gold quality
minor salivary gland	UBERON:0001830	96.38	gold quality
saliva-secreting gland	UBERON:0001044	96.26	gold quality
ileal mucosa	UBERON:0000331	96.12	gold quality
small intestine Peyer’s patch	UBERON:0003454	95.93	gold quality
lymph node	UBERON:0000029	95.87	gold quality
body of stomach	UBERON:0001161	95.83	gold quality
right lung	UBERON:0002167	95.74	gold quality
mouth mucosa	UBERON:0003729	95.69	gold quality
gall bladder	UBERON:0002110	95.62	gold quality
upper lobe of left lung	UBERON:0008952	95.61	gold quality
skin of leg	UBERON:0001511	95.59	gold quality
esophagus	UBERON:0001043	95.51	gold quality
spleen	UBERON:0002106	95.50	gold quality
small intestine	UBERON:0002108	95.41	gold quality
right adrenal gland	UBERON:0001233	95.30	gold quality
upper lobe of lung	UBERON:0008948	95.25	gold quality
smooth muscle tissue	UBERON:0001135	95.19	gold quality
skin of abdomen	UBERON:0001416	95.17	gold quality
right adrenal gland cortex	UBERON:0035827	95.17	gold quality
right testis	UBERON:0004534	95.09	gold quality
left testis	UBERON:0004533	95.06	gold quality
leukocyte	CL:0000738	95.05	gold quality
left adrenal gland	UBERON:0001234	95.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	12.97

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

76 targeting SCAMP2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-4525	99.94	64.38	675
HSA-MIR-5010-5P	99.94	64.11	705
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-17-5P	99.89	73.83	2665
HSA-MIR-20B-5P	99.88	74.01	2621
HSA-MIR-519D-3P	99.88	73.97	2607
HSA-MIR-93-5P	99.88	73.98	2606
HSA-MIR-106B-5P	99.88	74.72	2795
HSA-MIR-20A-5P	99.88	74.76	2769
HSA-MIR-526B-3P	99.88	74.06	2587
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-MIR-4447	99.85	67.81	2900
HSA-LET-7G-3P	99.85	70.43	1929
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6842-5P	99.80	67.54	1587

Literature-anchored findings (GeneRIF, showing 5)

• SCAMP2 plays an important role in the regulation of the subcellular distribution of SERT (PMID:16870614)
• The strong correlation between SCAMP2 E interactions with PIP2 and inhibition of exocytosis, particularly by SC2-R204A, led us to propose that SCAMP2 interaction with PIP2 within the membrane interface regulates fusion pore formation during exocytosis. (PMID:17713930)
• SCAMP2 regulates NHE5 transit through recycling endosomes and promotes its surface targeting in an Arf6-dependent manner. (PMID:19276089)
• this finding that SCAMP2 interacts with and regulates the subcellular distribution of both DAT and SERT suggests that interaction with SCAMP2 may constitute an important mechanism for coordinating cell surface expression of monoamine transporters. (PMID:21295544)
• SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia. (PMID:34426610)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	scamp2	ENSDARG00000010279
danio_rerio	scamp2l	ENSDARG00000017010
mus_musculus	Scamp2	ENSMUSG00000040188
rattus_norvegicus	Scamp2	ENSRNOG00000019136
drosophila_melanogaster	Scamp	FBGN0040285
caenorhabditis_elegans	scm-1	WBGENE00004743

Paralogs (4): SCAMP1 (ENSG00000085365), SCAMP3 (ENSG00000116521), SCAMP5 (ENSG00000198794), SCAMP4 (ENSG00000227500)

Protein

Protein identifiers

Secretory carrier-associated membrane protein 2 — O15127 (reviewed: O15127)

All UniProt accessions (8): A0A140VK92, O15127, H3BMN2, H3BN93, H3BPL9, H3BQW2, H3BUB6, H3BV04

UniProt curated annotations — full annotation on UniProt →

Function. Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

Subunit / interactions. Interacts with SLC6A4 and SLC9A7. Interacts with SLC9A5; this interaction regulates SLC9A5 cell-surface targeting and SLC9A5 activity.

Subcellular location. Golgi apparatus. trans-Golgi network membrane. Recycling endosome membrane.

Tissue specificity. Widely expressed.

Similarity. Belongs to the SCAMP family.

RefSeq proteins (2): NP_001307707, NP_005688* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007273	SCAMP	Family

Pfam: PF04144

UniProt features (15 total): topological domain 5, transmembrane region 4, region of interest 3, modified residue 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O15127-F1	77.30	0.47

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 319, 320

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 185 (showing top): TGCACTT_MIR519C_MIR519B_MIR519A, GOBP_VESICLE_MEDIATED_TRANSPORT, GTGCCTT_MIR506, MISSIAGLIA_REGULATED_BY_METHYLATION_UP, GOBP_EXOCYTOSIS, RICKMAN_METASTASIS_DN, GOCC_TRANS_GOLGI_NETWORK, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP, BLALOCK_ALZHEIMERS_DISEASE_UP, GOBP_SECRETION, GCM_DDX11, HIF1_Q3, NRF2_01, GCM_NF2, TGCCTTA_MIR124A

GO Biological Process (3): exocytosis (GO:0006887), post-Golgi vesicle-mediated transport (GO:0006892), protein transport (GO:0015031)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (8): Golgi apparatus (GO:0005794), membrane (GO:0016020), trans-Golgi network membrane (GO:0032588), recycling endosome membrane (GO:0055038), extracellular exosome (GO:0070062), sperm midpiece (GO:0097225), sperm principal piece (GO:0097228), endosome (GO:0005768)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
endomembrane system	2
sperm flagellum	2
vesicle-mediated transport	1
secretion by cell	1
vesicle fusion to plasma membrane	1
Golgi vesicle transport	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
trans-Golgi network	1
organelle membrane	1
endosome membrane	1
recycling endosome	1
extracellular vesicle	1
cytoplasmic vesicle	1

Protein interactions and networks

STRING

924 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SCAMP2	ARF6	P26438	805
SCAMP2	ARHGAP1	Q07960	580
SCAMP2	PLD1	Q13393	563
SCAMP2	FAM219B	Q5XKK7	506
SCAMP2	HDDC3	Q8N4P3	463
SCAMP2	BORCS7	Q96B45	460
SCAMP2	WBP1L	Q9NX94	441
SCAMP2	NET1	Q7Z628	440
SCAMP2	STX4	Q12846	437
SCAMP2	LMAN1L	Q9HAT1	435
SCAMP2	SLC6A3	Q01959	424
SCAMP2	STX1A	Q16623	420
SCAMP2	GPA33	Q99795	413
SCAMP2	MBLAC2	Q68D91	411
SCAMP2	JAGN1	Q8N5M9	395

IntAct

93 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
NIPAL1	ESYT2	psi-mi:“MI:0914”(association)	0.640
SLC9A7	SCAMP2	psi-mi:“MI:0915”(physical association)	0.600
SLC9A7	SCAMP2	psi-mi:“MI:0403”(colocalization)	0.600
SLC41A1	SCAMP2	psi-mi:“MI:0915”(physical association)	0.560
SCAMP2	SLC41A1	psi-mi:“MI:0915”(physical association)	0.560
SCAMP2	FLNA	psi-mi:“MI:0915”(physical association)	0.560
LPAR1	TMEM223	psi-mi:“MI:0914”(association)	0.530
DLK1	TCAF2	psi-mi:“MI:0914”(association)	0.530
SCAMP2	SCAMP3	psi-mi:“MI:0914”(association)	0.530
ATP5F1B	SCAMP2	psi-mi:“MI:0914”(association)	0.530
SCAMP2	SCAMP2	psi-mi:“MI:0915”(physical association)	0.460
SCAMP2	SCAMP2	psi-mi:“MI:0403”(colocalization)	0.460
SYNDIG1	SCAMP2	psi-mi:“MI:0915”(physical association)	0.400
SCAMP2	YWHAZ	psi-mi:“MI:0915”(physical association)	0.400
NCAPH	SCAMP2	psi-mi:“MI:0914”(association)	0.350
REEP5	CNOT1	psi-mi:“MI:0914”(association)	0.350

BioGRID (173): SCAMP2 (Affinity Capture-MS), SCAMP2 (Affinity Capture-MS), SCAMP2 (Affinity Capture-MS), SCAMP2 (Affinity Capture-MS), SCAMP2 (Affinity Capture-MS), SCAMP2 (Affinity Capture-MS), SCAMP2 (Affinity Capture-MS), SCAMP2 (Affinity Capture-MS), BCAP31 (Co-fractionation), JAGN1 (Co-fractionation), PHB (Co-fractionation), RPN1 (Co-fractionation), SCAMP2 (Co-fractionation), SCAMP2 (Proximity Label-MS), SCAMP2 (Proximity Label-MS)

ESM2 similar proteins: A5D7K7, B4DJY2, D3Z1U7, D3ZWZ9, O09117, O15126, O15127, O46521, O62646, O77735, O89104, P13164, P13498, P17971, P52650, P56603, P59995, Q05B54, Q0VBF8, Q16563, Q28CV2, Q2MHH0, Q5TYP8, Q5VSE6, Q5VXT5, Q61462, Q62737, Q63881, Q66IQ1, Q69YW2, Q6DFT4, Q6GQE1, Q8BGA2, Q8BLV3, Q8C838, Q8HYZ1, Q8IXB3, Q8K021, Q91499, Q95L73

Diamond homologs: O14828, O15126, O15127, O35609, O77735, P56603, Q17QF8, Q28F21, Q58DF6, Q58DR5, Q5R5Z8, Q5RCY9, Q6GM42, Q6GPA8, Q6P0C7, Q8K021, Q8TAC9, Q969E2, Q9ERN0, Q9ET20, Q9JKD3, Q9JKE3, Q9JKV5, Q9LR68, Q0JAI9, Q6Z8F5, Q9SXA5, Q9SKT3, A2YMP7, Q60EA5, Q75IC7, Q7F613, Q8H5X5, Q9C6X2, Q9M5P2, Q9ZTX0

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 94 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Class A/1 (Rhodopsin-like receptors)	9	10.6×	5e-05
GPCR ligand binding	7	7.1×	3e-03
Neutrophil degranulation	12	4.4×	1e-03

GO biological processes:

GO term	Partners	Fold	FDR
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	8	19.7×	4e-06
phospholipase C-activating G protein-coupled receptor signaling pathway	8	11.8×	1e-04
positive regulation of cytosolic calcium ion concentration	8	10.5×	2e-04
adenylate cyclase-activating G protein-coupled receptor signaling pathway	6	7.6×	7e-03
G protein-coupled receptor signaling pathway	12	4.9×	6e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

64 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	47
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
564218	GRCh37/hg19 15q24.1-24.2(chr15:75078195-75862756)x1	Pathogenic

SpliceAI

1349 predictions. Top by Δscore:

Variant	Effect	Δscore
15:74845472:CCCG:C	donor_gain	1.0000
15:74845591:CCG:C	acceptor_gain	1.0000
15:74845592:CGCTA:C	acceptor_gain	1.0000
15:74845594:C:CC	acceptor_gain	1.0000
15:74850674:C:CC	acceptor_gain	1.0000
15:74851351:A:AC	donor_gain	1.0000
15:74851352:C:CC	donor_gain	1.0000
15:74851352:CA:C	donor_gain	1.0000
15:74851352:CACAT:C	donor_gain	1.0000
15:74851478:CTCA:C	acceptor_gain	1.0000
15:74851480:CA:C	acceptor_gain	1.0000
15:74851482:C:CC	acceptor_gain	1.0000
15:74852066:TACC:T	donor_loss	1.0000
15:74852067:A:AC	donor_gain	1.0000
15:74852067:AC:A	donor_gain	1.0000
15:74852067:ACCA:A	donor_loss	1.0000
15:74852068:C:CC	donor_gain	1.0000
15:74852068:CC:C	donor_gain	1.0000
15:74852068:CCATG:C	donor_gain	1.0000
15:74852183:CGGC:C	acceptor_gain	1.0000
15:74852185:GC:G	acceptor_gain	1.0000
15:74852186:CC:C	acceptor_gain	1.0000
15:74852187:C:CC	acceptor_gain	1.0000
15:74852197:C:CT	acceptor_gain	1.0000
15:74854115:TTTGT:T	acceptor_gain	1.0000
15:74854116:TTGT:T	acceptor_gain	1.0000
15:74854117:TGT:T	acceptor_gain	1.0000
15:74854119:TCTA:T	acceptor_loss	1.0000
15:74854120:C:CC	acceptor_gain	1.0000
15:74854120:CT:C	acceptor_loss	1.0000

AlphaMissense

2138 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:74845589:A:G	W247R	0.997
15:74845589:A:T	W247R	0.997
15:74848671:G:C	F221L	0.996
15:74848671:G:T	F221L	0.996
15:74848673:A:G	F221L	0.996
15:74850542:A:G	W202R	0.996
15:74850542:A:T	W202R	0.996
15:74850648:G:C	N166K	0.996
15:74850648:G:T	N166K	0.996
15:74851359:A:G	W156R	0.996
15:74851359:A:T	W156R	0.996
15:74848655:A:G	C227R	0.994
15:74850545:A:G	C201R	0.994
15:74850557:A:G	C197R	0.994
15:74852126:C:G	A96P	0.994
15:74873203:A:C	F18C	0.994
15:74848680:G:C	F218L	0.992
15:74848680:G:T	F218L	0.992
15:74848682:A:G	F218L	0.992
15:74851378:G:C	C149W	0.992
15:74851467:A:G	W120R	0.992
15:74851467:A:T	W120R	0.992
15:74845591:C:T	G246D	0.991
15:74850586:G:A	S187F	0.991
15:74851403:A:G	I141T	0.991
15:74851465:C:A	W120C	0.991
15:74851465:C:G	W120C	0.991
15:74850586:G:T	S187Y	0.990
15:74850592:C:T	G185D	0.990
15:74851403:A:C	I141S	0.990

dbSNP variants (sampled 300 via entrez): RS1000142415 (15:74873041 T>G), RS1000261123 (15:74859220 TG>T), RS1000350021 (15:74873075 C>T), RS1000392905 (15:74866071 A>G), RS1000423999 (15:74865583 T>C,G), RS1000451280 (15:74864855 G>C), RS1000485545 (15:74871355 A>G), RS1000728336 (15:74852508 T>G), RS1001174144 (15:74864726 C>A), RS1001367466 (15:74872360 C>A,T), RS1001377418 (15:74872002 G>A,C), RS1001626689 (15:74864515 C>T), RS1001700948 (15:74851355 A>G), RS1001741151 (15:74871726 TGGGCAACAA>T), RS1001813679 (15:74844831 G>C)

Disease associations

OMIM: gene MIM:606912 | disease phenotypes: MIM:604416

GenCC curated gene-disease

Mondo (1): pyogenic arthritis-pyoderma gangrenosum-acne syndrome (MONDO:0011462)

Orphanet (1): PAPA syndrome (Orphanet:69126)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

14 associations (top):

Study	Trait	p-value
GCST001032_3	Caffeine consumption	6.000000e-07
GCST004608_199	Granulocyte percentage of myeloid white cells	1.000000e-14
GCST004609_216	Monocyte percentage of white cells	5.000000e-11
GCST006166_39	Diastolic blood pressure x alcohol consumption interaction (2df test)	2.000000e-36
GCST006190_2	Diastolic blood pressure x smoking status (ever vs never) interaction (2df test)	8.000000e-21
GCST006190_53	Diastolic blood pressure x smoking status (ever vs never) interaction (2df test)	1.000000e-21
GCST006192_50	Systolic blood pressure x smoking status (ever vs never) interaction (2df test)	5.000000e-15
GCST006192_73	Systolic blood pressure x smoking status (ever vs never) interaction (2df test)	1.000000e-12
GCST006193_35	Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test)	2.000000e-24
GCST006193_74	Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test)	4.000000e-24
GCST006195_17	Systolic blood pressure x smoking status (current vs non-current) interaction (2df test)	1.000000e-16
GCST006195_66	Systolic blood pressure x smoking status (current vs non-current) interaction (2df test)	3.000000e-15
GCST009597_253	Multiple sclerosis	3.000000e-07
GCST90002394_495	Monocyte percentage of white cells	2.000000e-28

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0004330	coffee consumption
EFO:0007997	granulocyte percentage of myeloid white cells
EFO:0007989	monocyte percentage of leukocytes
EFO:0004329	alcohol drinking
EFO:0006336	diastolic blood pressure
EFO:0006527	smoking status measurement
EFO:0006335	systolic blood pressure

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C536253	Pyogenic arthritis, pyoderma gangrenosum, and acne (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066474 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.17	Kd	6766	nM	CHEMBL3752910
5.17	ED50	6766	nM	CHEMBL3752910

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149347: Binding affinity to human SCAMP2 incubated for 45 mins by Kinobead based pull down assay	kd	6.7663	uM

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
FR900359	increases phosphorylation	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
bisphenol A	decreases methylation	1
sodium arsenite	increases abundance, increases expression	1
2-bromopalmitate	decreases reaction, increases abundance, increases palmitoylation	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Acetaminophen	increases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Air Pollutants	affects cotreatment, increases abundance, increases oxidation	1
Arsenic	increases abundance, increases expression	1
Atrazine	increases expression	1
Cadmium	decreases reaction, increases abundance, increases palmitoylation	1
Doxorubicin	decreases expression	1
Ivermectin	decreases expression	1
Lead	decreases expression	1
Ozone	affects cotreatment, increases oxidation, increases abundance	1
Plant Extracts	affects cotreatment, decreases expression	1
Rotenone	increases expression	1
Smoke	decreases expression	1
Valproic Acid	increases methylation	1
Vincristine	decreases expression	1
Cyclosporine	increases expression	1
Sodium Selenite	increases expression	1
Cadmium Chloride	decreases reaction, increases abundance, increases palmitoylation	1
Lactic Acid	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652389	Binding	Binding affinity to human SCAMP2 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_F1US	HyCyte U-251MG KO-hSCAMP2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.