SCARF1

Summary

SCARF1 (scavenger receptor class F member 1, HGNC:16820) is a protein-coding gene on chromosome 17p13.3, encoding Scavenger receptor class F member 1 (Q14162). Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL).

The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 8578 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 164 total
• MANE Select transcript: NM_003693

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16820
Approved symbol	SCARF1
Name	scavenger receptor class F member 1
Location	17p13.3
Locus type	gene with protein product
Status	Approved
Aliases	SREC, KIAA0149, SREC1
Ensembl gene	ENSG00000074660
Ensembl biotype	protein_coding
OMIM	607873
Entrez	8578

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 7 protein_coding, 3 retained_intron, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000263071, ENST00000434376, ENST00000570902, ENST00000571272, ENST00000573852, ENST00000573867, ENST00000574545, ENST00000576012, ENST00000860042, ENST00000933909, ENST00000955298, ENST00000955299, ENST00000955300

RefSeq mRNA: 2 — MANE Select: NM_003693 NM_003693, NM_145350

CCDS: CCDS11007, CCDS45564

Canonical transcript exons

ENST00000263071 — 11 exons

Exon	Start	End
ENSE00001327751	1645597	1645732
ENSE00001624103	1633858	1635617
ENSE00003532763	1636941	1637062
ENSE00003545150	1645178	1645239
ENSE00003556492	1638806	1638926
ENSE00003604418	1640448	1640666
ENSE00003623304	1639912	1640040
ENSE00003642596	1639639	1639742
ENSE00003670162	1636709	1636855
ENSE00003678004	1644834	1644935
ENSE00003688251	1643442	1643967

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 91.78.

FANTOM5 (CAGE): breadth broad, TPM avg 4.4257 / max 181.9079, expressed in 524 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
163758	4.1234	521
163757	0.3023	47

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
spleen	UBERON:0002106	91.78	gold quality
right lobe of thyroid gland	UBERON:0001119	91.12	gold quality
left lobe of thyroid gland	UBERON:0001120	89.95	gold quality
thyroid gland	UBERON:0002046	89.44	gold quality
apex of heart	UBERON:0002098	89.33	gold quality
sural nerve	UBERON:0015488	88.82	gold quality
upper lobe of left lung	UBERON:0008952	87.80	gold quality
subcutaneous adipose tissue	UBERON:0002190	87.13	gold quality
adipose tissue	UBERON:0001013	86.92	gold quality
omental fat pad	UBERON:0010414	86.78	gold quality
heart left ventricle	UBERON:0002084	85.46	gold quality
lung	UBERON:0002048	85.41	gold quality
right lung	UBERON:0002167	85.18	gold quality
blood	UBERON:0000178	84.95	gold quality
thoracic mammary gland	UBERON:0005200	83.78	gold quality
right lobe of liver	UBERON:0001114	83.36	gold quality
heart	UBERON:0000948	82.47	gold quality
monocyte	CL:0000576	82.39	gold quality
leukocyte	CL:0000738	81.96	gold quality
myometrium	UBERON:0001296	81.63	gold quality
right atrium auricular region	UBERON:0006631	81.46	gold quality
placenta	UBERON:0001987	81.15	gold quality
metanephros cortex	UBERON:0010533	81.03	gold quality
granulocyte	CL:0000094	80.71	gold quality
body of uterus	UBERON:0009853	80.43	gold quality
vermiform appendix	UBERON:0001154	80.20	gold quality
gastrocnemius	UBERON:0001388	80.20	gold quality
muscle of leg	UBERON:0001383	80.03	gold quality
liver	UBERON:0002107	79.92	gold quality
left uterine tube	UBERON:0001303	79.79	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.01
E-GEOD-75367	no	132.14

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): E2F1, SP1, ZNF444

miRNA regulators (miRDB)

60 targeting SCARF1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-3617-3P	99.98	67.86	918
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-6888-3P	99.97	65.95	1170
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AQ-5P	99.94	71.34	3426
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482
HSA-MIR-548AU-5P	99.94	71.24	3488
HSA-MIR-548AY-5P	99.94	71.23	3502
HSA-MIR-548B-5P	99.94	71.23	3502

Literature-anchored findings (GeneRIF, showing 10)

• Characterization of the gene and its regulation by a novel transcription factor, endothelial zinc protein-2 (PMID:11978792)
• SRECI binds to SRECII and has a similar tissue distribution pattern (PMID:12154095)
• GP2 is a binding partner of the scavenger receptor expressed on endothelial cells I (SREC-I) but not of SR-AI and SR-BI. Dendritic cells express SREC-I and also bind and internalize GP2. (PMID:21190681)
• In several assay systems this type F-scavenger receptor, termed SREC-I, bound to cell wall techoic acid in a charge dependent manner and mediated adhesion to nasal epithelial cells in vitro. (PMID:24788600)
• These studies in addition to our earlier findings showed SREC-I to play a primary role in chaperone-associated antigen uptake both through cross priming of MHC class I molecules and entry into the class II pathway. (PMID:25155057)
• Scavenger receptor SREC-I promotes double stranded RNA-mediated TLR3 activation in human monocytes (PMID:25641411)
• SCARF-1 promotes adhesion of CD4(+) T cells to human hepatic sinusoidal endothelium under conditions of shear stress (PMID:29242513)
• Molecular and Cellular Interactions of Scavenger Receptor SR-F1 With Complement C1q Provide Insights Into Its Role in the Clearance of Apoptotic Cells. (PMID:32296440)
• The Role of SREC- in Innate Immunity to Aspergillus fumigatus Keratitis. (PMID:34236384)
• SCARF1-Induced Efferocytosis Plays an Immunomodulatory Role in Humans, and Autoantibodies Targeting SCARF1 Are Produced in Patients with Systemic Lupus Erythematosus. (PMID:35082161)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	scarf1	ENSDARG00000077285
mus_musculus	Scarf1	ENSMUSG00000038188
rattus_norvegicus	Scarf1	ENSRNOG00000059618

Paralogs (3): CRB3 (ENSG00000130545), CRB2 (ENSG00000148204), SCARF2 (ENSG00000244486)

Protein

Protein identifiers

Scavenger receptor class F member 1 — Q14162 (reviewed: Q14162)

Alternative names: Acetyl LDL receptor, Scavenger receptor expressed by endothelial cells 1

All UniProt accessions (2): Q14162, I3L4R9

UniProt curated annotations — full annotation on UniProt →

Function. Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth.

Subunit / interactions. Heterophilic interaction with SREC2 via its extracellular domain. The heterophilic interaction is suppressed by the presence of ligand such as Ac-LDL. Interacts with AVIL.

Subcellular location. Membrane.

Tissue specificity. Endothelial cells.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoforms (5)

UniProt ID	Names	Canonical?
Q14162-1	1, SREC-1	yes
Q14162-2	2, SREC-5
Q14162-3	3, SREC-3
Q14162-4	4, SREC-4
Q14162-5	5, SREC-2

RefSeq proteins (2): NP_003684, NP_663325 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000742	EGF	Domain
IPR002049	LE_dom	Domain
IPR009030	Growth_fac_rcpt_cys_sf	Homologous_superfamily
IPR042635	MEGF10/SREC1/2-like	Family

Pfam: PF00053

UniProt features (74 total): disulfide bond 18, strand 16, domain 6, splice variant 6, sequence variant 6, turn 5, region of interest 3, glycosylation site 3, compositionally biased region 2, modified residue 2, topological domain 2, signal peptide 1, chain 1, transmembrane region 1, sequence conflict 1, helix 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
8HN0	X-RAY DIFFRACTION	2.2
8HNA	X-RAY DIFFRACTION	2.6

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q14162-F1	65.06	0.35

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 589, 606

Disulfide bonds (18): 57–69, 63–75, 77–86, 99–111, 105–118, 120–129, 159–172, 165–179, 181–190, 219–230, 225–237, 239–248, 306–319, 313–326, 329–338, 355–363, 358–370, 372–381

Glycosylation sites (3): 289, 382, 393

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-3000484	Scavenging by Class F Receptors
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors
R-HSA-5653656	Vesicle-mediated transport

MSigDB gene sets: 203 (showing top): GOBP_DENDRITE_DEVELOPMENT, GOBP_HETEROPHILIC_CELL_CELL_ADHESION, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, GOBP_NEURON_MATURATION, GOBP_REGENERATION, GOBP_NEUROGENESIS, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_RESPONSE_TO_AXON_INJURY, GGGTGGRR_PAX4_03, GOBP_CELL_CELL_ADHESION, GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS, GOBP_ANATOMICAL_STRUCTURE_MATURATION, GOBP_REGULATION_OF_CELL_PROJECTION_ORGANIZATION, GOBP_CELL_MATURATION, GOBP_REGULATION_OF_RESPONSE_TO_WOUNDING

GO Biological Process (8): cholesterol catabolic process (GO:0006707), receptor-mediated endocytosis (GO:0006898), heterophilic cell-cell adhesion (GO:0007157), positive regulation of neuron projection development (GO:0010976), neuron remodeling (GO:0016322), dendrite development (GO:0016358), positive regulation of axon regeneration (GO:0048680), cell adhesion (GO:0007155)

GO Molecular Function (4): transmembrane signaling receptor activity (GO:0004888), scavenger receptor activity (GO:0005044), low-density lipoprotein particle binding (GO:0030169), protein binding (GO:0005515)

GO Cellular Component (3): plasma membrane (GO:0005886), membrane (GO:0016020), endocytic vesicle membrane (GO:0030666)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Binding and Uptake of Ligands by Scavenger Receptors	1
Vesicle-mediated transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
neuron projection development	2
cholesterol metabolic process	1
sterol catabolic process	1
alcohol catabolic process	1
endocytosis	1
cell-cell adhesion	1
regulation of neuron projection development	1
positive regulation of cell projection organization	1
neuron maturation	1
anatomical structure development	1
axon regeneration	1
positive regulation of response to external stimulus	1
regulation of axon regeneration	1
positive regulation of neuron projection regeneration	1
positive regulation of response to wounding	1
cellular process	1
signaling receptor activity	1
cargo receptor activity	1
lipoprotein particle binding	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1
endocytic vesicle	1
cytoplasmic vesicle membrane	1
bounding membrane of organelle	1

Protein interactions and networks

STRING

772 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SCARF1	STAB1	Q9NY15	861
SCARF1	PITPNA	Q00169	857
SCARF1	HYOU1	Q9Y4L1	855
SCARF1	SCARB1	Q8WTV0	835
SCARF1	SCARB2	Q14108	832
SCARF1	CD36	P16671	830
SCARF1	TLR2	O60603	799
SCARF1	YWHAE	P29360	790
SCARF1	ZNF444	Q8N0Y2	789
SCARF1	CRK	P46108	776
SCARF1	BHLHA9	Q7RTU4	759
SCARF1	HSPA4	P34932	754
SCARF1	PAFAH1B1	P43034	754
SCARF1	CALR	P27797	752
SCARF1	CLEC7A	Q9BXN2	739

IntAct

62 interactions, top by confidence:

A	B	Type	Score
SCARF1	HSD17B13	psi-mi:“MI:0915”(physical association)	0.560
SCARF1	GJA8	psi-mi:“MI:0915”(physical association)	0.560
SCARF1	MRM3	psi-mi:“MI:0915”(physical association)	0.560
SCARF1	TGM1	psi-mi:“MI:0915”(physical association)	0.560
SCARF1	KRTAP5-7	psi-mi:“MI:0915”(physical association)	0.560
CYSRT1	SCARF1	psi-mi:“MI:0915”(physical association)	0.560
SCARF1	MEOX2	psi-mi:“MI:0915”(physical association)	0.560
SCARF1	LCE1D	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-8	SCARF1	psi-mi:“MI:0915”(physical association)	0.560
KRTAP1-1	SCARF1	psi-mi:“MI:0915”(physical association)	0.560
SCARF1	CREB3L1	psi-mi:“MI:0915”(physical association)	0.560
SCARF1	FAM209A	psi-mi:“MI:0915”(physical association)	0.560
GJA8	SCARF1	psi-mi:“MI:0915”(physical association)	0.560
SCARF1	LHFPL2	psi-mi:“MI:0915”(physical association)	0.560
KCNJ6	SCARF1	psi-mi:“MI:0915”(physical association)	0.560
CLDN7	SCARF1	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	SCARF1	psi-mi:“MI:0915”(physical association)	0.560
COQ9	SCARF1	psi-mi:“MI:0915”(physical association)	0.560
SCARF1	GPX8	psi-mi:“MI:0915”(physical association)	0.560
NEMP1	SCARF1	psi-mi:“MI:0915”(physical association)	0.560
SCARF1	SLC7A14	psi-mi:“MI:0915”(physical association)	0.560
TAGLN	LOC392647	psi-mi:“MI:0914”(association)	0.350
SCARF1	TGM1	psi-mi:“MI:0915”(physical association)	0.000
SCARF1	KRTAP5-7	psi-mi:“MI:0915”(physical association)	0.000
SCARF1	CYSRT1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (20): SCARF1 (Two-hybrid), COQ9 (Two-hybrid), TGM1 (Two-hybrid), MEOX2 (Two-hybrid), GJA8 (Two-hybrid), FAM209A (Two-hybrid), LHFPL2 (Two-hybrid), KCNJ6 (Two-hybrid), CREB3L1 (Two-hybrid), GPX8 (Two-hybrid), TMEM194A (Two-hybrid), GPR37L1 (Two-hybrid), HSD17B13 (Two-hybrid), RNMTL1 (Two-hybrid), LCE1D (Two-hybrid)

ESM2 similar proteins: A4FV93, A5A8Y8, B2LW77, D3ZUK3, O00468, O70534, O75074, O88204, O88839, O95407, P06579, P07204, P15306, P60882, P80370, Q09163, Q13444, Q14162, Q3SWY4, Q501P1, Q53RD9, Q5ND28, Q5VY43, Q5W7P8, Q61810, Q6AZ60, Q6GUQ1, Q6MG84, Q6UY11, Q71U07, Q75N90, Q7Z7M0, Q8K1E3, Q8K1S7, Q8K4G1, Q8NCW0, Q8ND94, Q8VIK5, Q8WUT4, Q93038

Diamond homologs: P59222, Q14162, Q5ND28, Q6AZ60, Q96GP6, Q9QXT5, Q14766, Q8CG19, A0JM12, A6BM72, E9QJQ6, Q6DIB5, Q80T91, Q96KG7

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 22 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Keratinization	5	18.6×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

164 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	135
Likely benign	12
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1515 predictions. Top by Δscore:

Variant	Effect	Δscore
17:1636856:C:CC	acceptor_gain	1.0000
17:1637058:CTGGC:C	acceptor_gain	1.0000
17:1637059:TGGC:T	acceptor_gain	1.0000
17:1637063:C:CC	acceptor_gain	1.0000
17:1637063:CTG:C	acceptor_loss	1.0000
17:1637064:T:C	acceptor_loss	1.0000
17:1639633:CCTTA:C	donor_loss	1.0000
17:1639634:CTTAC:C	donor_loss	1.0000
17:1639635:TTAC:T	donor_loss	1.0000
17:1639636:TACCT:T	donor_loss	1.0000
17:1639637:A:AG	donor_loss	1.0000
17:1639743:C:CC	acceptor_gain	1.0000
17:1635616:CCCTG:C	acceptor_loss	0.9900
17:1635618:CTG:C	acceptor_loss	0.9900
17:1635619:T:A	acceptor_loss	0.9900
17:1636711:T:A	donor_gain	0.9900
17:1636743:ATCTG:A	donor_gain	0.9900
17:1636744:T:C	donor_gain	0.9900
17:1636854:GA:G	acceptor_gain	0.9900
17:1636937:TGAC:T	donor_loss	0.9900
17:1636938:GACC:G	donor_loss	0.9900
17:1636939:A:C	donor_loss	0.9900
17:1636940:CCT:C	donor_loss	0.9900
17:1636940:CCTG:C	donor_gain	0.9900
17:1636942:TGTC:T	donor_gain	0.9900
17:1637060:GGC:G	acceptor_gain	0.9900
17:1637061:GC:G	acceptor_gain	0.9900
17:1637062:CC:C	acceptor_gain	0.9900
17:1638340:T:A	donor_gain	0.9900
17:1639638:CCTGG:C	donor_gain	0.9900

AlphaMissense

5367 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:1645206:C:A	W45C	0.998
17:1645206:C:G	W45C	0.998
17:1643675:C:A	W186C	0.997
17:1643675:C:G	W186C	0.997
17:1643948:C:A	W95C	0.997
17:1643948:C:G	W95C	0.997
17:1643858:C:A	W125C	0.996
17:1643858:C:G	W125C	0.996
17:1643768:C:A	W155C	0.995
17:1643768:C:G	W155C	0.995
17:1644869:C:G	C77S	0.994
17:1644870:A:T	C77S	0.994
17:1645186:C:G	C52S	0.994
17:1645187:A:T	C52S	0.994
17:1635475:G:C	F592L	0.993
17:1635475:G:T	F592L	0.993
17:1635477:A:G	F592L	0.993
17:1643588:C:A	W215C	0.993
17:1643588:C:G	W215C	0.993
17:1643901:C:G	C111S	0.993
17:1643902:A:T	C111S	0.993
17:1643964:C:G	C90S	0.993
17:1643965:A:T	C90S	0.993
17:1643936:G:C	C99W	0.992
17:1643937:C:G	C99S	0.992
17:1643938:A:T	C99S	0.992
17:1644841:G:C	C86W	0.992
17:1644842:C:G	C86S	0.992
17:1644843:A:T	C86S	0.992
17:1643704:C:A	G177C	0.991

dbSNP variants (sampled 300 via entrez): RS1000198744 (17:1643779 G>C,T), RS1000464998 (17:1647198 G>A), RS1000571232 (17:1642499 A>G), RS1001023622 (17:1641725 A>T), RS1001289560 (17:1647276 A>G), RS1001540968 (17:1641802 A>G), RS1001590531 (17:1647510 GAAT>G), RS1001690931 (17:1637500 C>A), RS1001692572 (17:1637206 T>A,C,G), RS1001743173 (17:1637764 G>A), RS1002006792 (17:1636361 G>A,T), RS1002059105 (17:1636550 T>C), RS1002205595 (17:1647094 G>A), RS1002318513 (17:1646891 C>T), RS1002478704 (17:1634650 T>C)

Disease associations

OMIM: gene MIM:607873 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST006585_1671	Blood protein levels	7.000000e-60
GCST007354_17	Intracranial aneurysm	6.000000e-09
GCST90002405_325	Reticulocyte count	3.000000e-22
GCST90002406_449	Reticulocyte fraction of red cells	2.000000e-22

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007986	reticulocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression, increases methylation	3
aristolochic acid I	increases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	affects splicing	1
sotorasib	affects cotreatment, decreases expression	1
TL8-506	increases expression, affects cotreatment	1
triphenyl phosphate	affects expression	1
bisphenol A	affects expression	1
titanium dioxide	affects expression	1
di-n-butylphosphoric acid	affects expression	1
abrine	increases expression	1
jinfukang	increases expression, affects cotreatment	1
trametinib	affects cotreatment, decreases expression	1
(+)-JQ1 compound	decreases expression	1
NVP-BKM120	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	affects methylation	1
Cadmium	decreases expression, increases abundance	1
Cisplatin	affects cotreatment, increases expression	1
Hydralazine	affects cotreatment, increases expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Triclosan	decreases expression	1
1-Methyl-4-phenylpyridinium	increases expression	1
Cadmium Chloride	decreases expression, increases abundance	1
Okadaic Acid	decreases expression	1

Cellosaurus cell lines

2 cell lines: 2 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D7HF	Ubigene HEK293T SCARF1 KO	Transformed cell line	Female
CVCL_D9RB	Ubigene HEK293 SCARF1 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.