SCARNA10

Summary

SCARNA10 (small Cajal body-specific RNA 10, HGNC:32567) is a small nucleolar RNA gene on chromosome 12p13.31.

Predicted to be involved in RNA processing. Located in Cajal body.

Source: NCBI Gene 692148 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32567
Approved symbol	SCARNA10
Name	small Cajal body-specific RNA 10
Location	12p13.31
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U85, lnc, MBI, 52
Ensembl gene	ENSG00000239002
Ensembl biotype	snoRNA
OMIM	615639
Entrez	692148
RNAcentral	URS0000569A4A — snoRNA, 330 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000459255

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000459255 — 1 exons

Exon	Start	End
ENSE00001807925	6510222	6510551

Expression profiles

Bgee: expression breadth ubiquitous, 122 present calls, max score 99.95.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.2218 / max 379.9191, expressed in 1362 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
123682	7.2218	1362

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	99.95	gold quality
colonic epithelium	UBERON:0000397	99.89	gold quality
bone marrow cell	CL:0002092	99.88	gold quality
adrenal tissue	UBERON:0018303	99.82	gold quality
sural nerve	UBERON:0015488	99.13	gold quality
calcaneal tendon	UBERON:0003701	98.15	gold quality
skeletal muscle tissue	UBERON:0001134	93.82	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.56	gold quality
bone marrow	UBERON:0002371	88.23	gold quality
hindlimb stylopod muscle	UBERON:0004252	86.23	gold quality
tonsil	UBERON:0002372	85.45	gold quality
urinary bladder	UBERON:0001255	81.82	gold quality
liver	UBERON:0002107	77.82	gold quality
ganglionic eminence	UBERON:0004023	77.64	gold quality
primary visual cortex	UBERON:0002436	77.52	gold quality
ventricular zone	UBERON:0003053	76.59	gold quality
blood	UBERON:0000178	75.44	gold quality
cortex of kidney	UBERON:0001225	73.26	gold quality
superior frontal gyrus	UBERON:0002661	72.66	gold quality
kidney	UBERON:0002113	72.57	gold quality
cortical plate	UBERON:0005343	71.56	gold quality
monocyte	CL:0000576	71.19	gold quality
prefrontal cortex	UBERON:0000451	70.01	gold quality
lung	UBERON:0002048	68.07	gold quality
uterine cervix	UBERON:0000002	67.62	gold quality
endometrium	UBERON:0001295	66.88	gold quality
islet of Langerhans	UBERON:0000006	66.82	gold quality
stomach	UBERON:0000945	65.36	gold quality
muscle of leg	UBERON:0001383	65.10	gold quality
pancreas	UBERON:0001264	64.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.78

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• The authors observed that the transcript of SCARNA10 was increased in the serum and liver from patients with advanced hepatic fibrosis. Furthermore, we found that SCARNA10 promoted liver fibrosis both in vitro and in vivo through inducing hepatocyte apoptosis and hepatic stellate cell activation. (PMID:31281502)
• Serum long non-coding RNA SCARNA10 serves as a potential diagnostic biomarker for hepatocellular carcinoma. (PMID:35443674)
• SCARNA10 regulates p53 acetylation-dependent transcriptional activity. (PMID:37262951)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000081126
danio_rerio		ENSDARG00000083325
mus_musculus	Scarna10	ENSMUSG00000089617
rattus_norvegicus	Scarna10	ENSRNOG00000060559

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.